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Aliases for AURKAIP1 Gene

Aliases for AURKAIP1 Gene

  • Aurora Kinase A Interacting Protein 1 2 3 5
  • 28S Ribosomal Protein S38, Mitochondrial 3 4
  • AURKA-Interacting Protein 3 4
  • MRP-S38 3 4
  • AKIP 3 4
  • AIP 3 4
  • Aurora-A Kinase Interacting Protein 3
  • MRPS38 4

External Ids for AURKAIP1 Gene

Previous GeneCards Identifiers for AURKAIP1 Gene

  • GC01M001350
  • GC01M001298
  • GC01M000581

Summaries for AURKAIP1 Gene

GeneCards Summary for AURKAIP1 Gene

AURKAIP1 (Aurora Kinase A Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for AURKAIP1 Gene

  • May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKAIP1 Gene

Genomics for AURKAIP1 Gene

Regulatory Elements for AURKAIP1 Gene

Enhancers for AURKAIP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AURKAIP1 on UCSC Golden Path with GeneCards custom track

Promoters for AURKAIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AURKAIP1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the AURKAIP1 gene promoter:

Genomic Location for AURKAIP1 Gene

Chromosome:
1
Start:
1,373,730 bp from pter
End:
1,375,495 bp from pter
Size:
1,766 bases
Orientation:
Minus strand

Genomic View for AURKAIP1 Gene

Genes around AURKAIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AURKAIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AURKAIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKAIP1 Gene

Proteins for AURKAIP1 Gene

  • Protein details for AURKAIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWT8-AKIP_HUMAN
    Recommended name:
    Aurora kinase A-interacting protein
    Protein Accession:
    Q9NWT8
    Secondary Accessions:
    • Q5TA36
    • Q8TBD3

    Protein attributes for AURKAIP1 Gene

    Size:
    199 amino acids
    Molecular mass:
    22354 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with Aurora-A.
    SequenceCaution:
    • Sequence=AAH22808.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AURKAIP1 Gene

neXtProt entry for AURKAIP1 Gene

Proteomics data for AURKAIP1 Gene at MOPED

Post-translational modifications for AURKAIP1 Gene

  • Ubiquitination at Lys 193
  • Modification sites at PhosphoSitePlus

Other Protein References for AURKAIP1 Gene

No data available for DME Specific Peptides for AURKAIP1 Gene

Domains & Families for AURKAIP1 Gene

Protein Domains for AURKAIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AURKAIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AURKAIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AURKAIP1 Gene

Function for AURKAIP1 Gene

Molecular function for AURKAIP1 Gene

UniProtKB/Swiss-Prot Function:
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
genes like me logo Genes that share phenotypes with AURKAIP1: view

Animal Model Products

CRISPR Products

miRNA for AURKAIP1 Gene

miRTarBase miRNAs that target AURKAIP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AURKAIP1 Gene

Localization for AURKAIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKAIP1 Gene

Mitochondrion. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AURKAIP1 Gene COMPARTMENTS Subcellular localization image for AURKAIP1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with AURKAIP1: view

Pathways & Interactions for AURKAIP1 Gene

genes like me logo Genes that share pathways with AURKAIP1: view

Gene Ontology (GO) - Biological Process for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with AURKAIP1: view

No data available for SIGNOR curated interactions for AURKAIP1 Gene

Drugs & Compounds for AURKAIP1 Gene

No Compound Related Data Available

Transcripts for AURKAIP1 Gene

Unigene Clusters for AURKAIP1 Gene

Aurora kinase A interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AURKAIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6:
SP7: -

Relevant External Links for AURKAIP1 Gene

GeneLoc Exon Structure for
AURKAIP1
ECgene alternative splicing isoforms for
AURKAIP1

Expression for AURKAIP1 Gene

mRNA expression in normal human tissues for AURKAIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AURKAIP1 Gene

This gene is overexpressed in Lung (35.9), Breast (16.9), and Pancreas (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AURKAIP1 Gene



SOURCE GeneReport for Unigene cluster for AURKAIP1 Gene Hs.632515

mRNA Expression by UniProt/SwissProt for AURKAIP1 Gene

Q9NWT8-AKIP_HUMAN
Tissue specificity: Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.
genes like me logo Genes that share expression patterns with AURKAIP1: view

Protein tissue co-expression partners for AURKAIP1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for AURKAIP1 Gene

Orthologs for AURKAIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AURKAIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AURKAIP1 35
  • 80.23 (n)
  • 74.37 (a)
AURKAIP1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AURKAIP1 35
  • 81.14 (n)
  • 75.76 (a)
AURKAIP1 36
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aurkaip1 35
  • 74.04 (n)
  • 68.84 (a)
Aurkaip1 16
Aurkaip1 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AURKAIP1 35
  • 99.5 (n)
  • 98.99 (a)
AURKAIP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aurkaip1 35
  • 75.54 (n)
  • 71.86 (a)
oppossum
(Monodelphis domestica)
Mammalia AURKAIP1 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AURKAIP1 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves AURKAIP1 35
  • 58.25 (n)
  • 54.12 (a)
AURKAIP1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AURKAIP1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549720 35
  • 53.3 (n)
  • 45.31 (a)
zebrafish
(Danio rerio)
Actinopterygii aurkaip1 35
  • 56.33 (n)
  • 58.91 (a)
aurkaip1 36
  • 42 (a)
OneToOne
Species with no ortholog for AURKAIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AURKAIP1 Gene

ENSEMBL:
Gene Tree for AURKAIP1 (if available)
TreeFam:
Gene Tree for AURKAIP1 (if available)

Paralogs for AURKAIP1 Gene

Pseudogenes.org Pseudogenes for AURKAIP1 Gene

genes like me logo Genes that share paralogs with AURKAIP1: view

No data available for Paralogs for AURKAIP1 Gene

Variants for AURKAIP1 Gene

Sequence variations from dbSNP and Humsavar for AURKAIP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3736374 - 1,374,177(-) AGCCA(C/G)ATAGG reference, missense
rs8146 -- 1,374,078(+) TTGTG(A/G/T)TGGTT reference, synonymous-codon
rs9554 -- 1,374,423(-) CCGT(C/T)TCTGG reference, synonymous-codon
rs10949 -- 1,374,124(+) ACTGA(A/G)TTTGA reference, missense
rs2765015 -- 1,373,602(-) CTGGC(C/T)CTTGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for AURKAIP1 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv2n67 CNV Gain 20364138
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv25n71 CNV Loss 21882294
dgv8e1 CNV Complex 17122850
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
dgv38n71 CNV Loss 21882294

Variation tolerance for AURKAIP1 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AURKAIP1 Gene

Disorders for AURKAIP1 Gene

Relevant External Links for AURKAIP1

Genetic Association Database (GAD)
AURKAIP1
Human Genome Epidemiology (HuGE) Navigator
AURKAIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AURKAIP1

No disorders were found for AURKAIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AURKAIP1 Gene

Publications for AURKAIP1 Gene

  1. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. (PMID: 12244051) Kiat L.S. … Gopalan G. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A. (PMID: 17452972) Lim S.K. … Gopalan G. (Oncogene 2007) 3 23
  3. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. (PMID: 17957726) Katayama H. … Sen S. (J. Cell. Biochem. 2007) 3 23
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Probing nuclear pore complex architecture with proximity-dependent biotinylation. (PMID: 24927568) Kim D.I. … Roux K.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for AURKAIP1 Gene

Sources for AURKAIP1 Gene

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