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Aliases for AURKAIP1 Gene

Aliases for AURKAIP1 Gene

  • Aurora Kinase A Interacting Protein 1 2 3
  • AKIP 3 4 6
  • AIP 3 4 6
  • 28S Ribosomal Protein S38, Mitochondrial 3 4
  • AURKA-Interacting Protein 3 4
  • MRP-S38 3 4
  • Aurora Kinase A-Interacting Protein 3
  • Aurora-A Kinase Interacting Protein 3
  • MRPS38 4

External Ids for AURKAIP1 Gene

Previous GeneCards Identifiers for AURKAIP1 Gene

  • GC01M001350
  • GC01M001298
  • GC01M000581

Summaries for AURKAIP1 Gene

GeneCards Summary for AURKAIP1 Gene

AURKAIP1 (Aurora Kinase A Interacting Protein 1) is a Protein Coding gene. Diseases associated with AURKAIP1 include stomach cancer. Among its related pathways are AhR pathway (WikiPathways) and AHR Pathway (Qiagen).

UniProtKB/Swiss-Prot for AURKAIP1 Gene

  • May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKAIP1 Gene

Genomics for AURKAIP1 Gene

Regulatory Elements for AURKAIP1 Gene

Transcription factor binding sites by QIAGEN in the AURKAIP1 gene promoter:

Genomic Location for AURKAIP1 Gene

Start:
1,373,730 bp from pter
End:
1,375,495 bp from pter
Size:
1,766 bases
Orientation:
Minus strand

Genomic View for AURKAIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AURKAIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKAIP1 Gene

Proteins for AURKAIP1 Gene

  • Protein details for AURKAIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWT8-AKIP_HUMAN
    Recommended name:
    Aurora kinase A-interacting protein
    Protein Accession:
    Q9NWT8
    Secondary Accessions:
    • Q5TA36
    • Q8TBD3

    Protein attributes for AURKAIP1 Gene

    Size:
    199 amino acids
    Molecular mass:
    22354 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with Aurora-A.
    SequenceCaution:
    • Sequence=AAH22808.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AURKAIP1 Gene

Proteomics data for AURKAIP1 Gene at MOPED

Post-translational modifications for AURKAIP1 Gene

  • Ubiquitination at Lys193
  • Modification sites at PhosphoSitePlus

Other Protein References for AURKAIP1 Gene

No data available for DME Specific Peptides for AURKAIP1 Gene

Domains for AURKAIP1 Gene

Protein Domains for AURKAIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AURKAIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AURKAIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AURKAIP1 Gene

Function for AURKAIP1 Gene

Molecular function for AURKAIP1 Gene

UniProtKB/Swiss-Prot Function: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation

Gene Ontology (GO) - Molecular Function for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12244051
genes like me logo Genes that share ontologies with AURKAIP1: view

Phenotypes for AURKAIP1 Gene

GenomeRNAi human phenotypes for AURKAIP1:
genes like me logo Genes that share phenotypes with AURKAIP1: view

miRNA for AURKAIP1 Gene

miRTarBase miRNAs that target AURKAIP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AURKAIP1 Gene

Localization for AURKAIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKAIP1 Gene

Mitochondrion. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AURKAIP1 Gene COMPARTMENTS Subcellular localization image for AURKAIP1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 1

Gene Ontology (GO) - Cellular Components for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12244051
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with AURKAIP1: view

Pathways for AURKAIP1 Gene

genes like me logo Genes that share pathways with AURKAIP1: view

Pathways by source for AURKAIP1 Gene

1 Qiagen pathway for AURKAIP1 Gene
2 BioSystems pathways for AURKAIP1 Gene

Gene Ontology (GO) - Biological Process for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0045839 negative regulation of mitotic nuclear division NAS 12244051
GO:0045862 positive regulation of proteolysis IDA 12244051
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with AURKAIP1: view

Transcripts for AURKAIP1 Gene

Unigene Clusters for AURKAIP1 Gene

Aurora kinase A interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AURKAIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6:
SP7: -

Relevant External Links for AURKAIP1 Gene

GeneLoc Exon Structure for
AURKAIP1
ECgene alternative splicing isoforms for
AURKAIP1

Expression for AURKAIP1 Gene

mRNA expression in normal human tissues for AURKAIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AURKAIP1 Gene

SOURCE GeneReport for Unigene cluster for AURKAIP1 Gene Hs.632515

mRNA Expression by UniProt/SwissProt for AURKAIP1 Gene

Q9NWT8-AKIP_HUMAN
Tissue specificity: Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis
genes like me logo Genes that share expressions with AURKAIP1: view

No data available for mRNA differential expression in normal tissues for AURKAIP1 Gene

Orthologs for AURKAIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AURKAIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AURKAIP1 35
  • 99.5 (n)
  • 98.99 (a)
AURKAIP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AURKAIP1 35
  • 80.23 (n)
  • 74.37 (a)
AURKAIP1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AURKAIP1 35
  • 81.14 (n)
  • 75.76 (a)
AURKAIP1 36
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aurkaip1 35
  • 74.04 (n)
  • 68.84 (a)
Aurkaip1 16
Aurkaip1 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AURKAIP1 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AURKAIP1 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aurkaip1 35
  • 75.54 (n)
  • 71.86 (a)
chicken
(Gallus gallus)
Aves AURKAIP1 35
  • 58.25 (n)
  • 54.12 (a)
AURKAIP1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AURKAIP1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549720 35
  • 53.3 (n)
  • 45.31 (a)
zebrafish
(Danio rerio)
Actinopterygii aurkaip1 35
  • 56.33 (n)
  • 58.91 (a)
aurkaip1 36
  • 42 (a)
OneToOne
Species with no ortholog for AURKAIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AURKAIP1 Gene

ENSEMBL:
Gene Tree for AURKAIP1 (if available)
TreeFam:
Gene Tree for AURKAIP1 (if available)

Paralogs for AURKAIP1 Gene

Pseudogenes.org Pseudogenes for AURKAIP1 Gene

genes like me logo Genes that share paralogs with AURKAIP1: view

No data available for Paralogs for AURKAIP1 Gene

Variants for AURKAIP1 Gene

Sequence variations from dbSNP and Humsavar for AURKAIP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8146 -- 1,374,078(+) TTGTG(A/G)TGGTT reference, synonymous-codon
rs9554 -- 1,374,423(-) CCGT(C/T)TCTGG reference, synonymous-codon
rs10949 -- 1,374,124(+) ACTGA(A/G)TTTGA missense, reference
rs2242398 -- 1,375,288(-) CAGAA(A/G/T)CGGGG upstream-variant-2KB, utr-variant-5-prime
rs2477775 -- 1,373,248(+) CGGAA(A/G)GCTTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for AURKAIP1 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv2n67 CNV Gain 20364138
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv25n71 CNV Loss 21882294
dgv8e1 CNV Complex 17122850
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
dgv38n71 CNV Loss 21882294

Relevant External Links for AURKAIP1 Gene

HapMap Linkage Disequilibrium report
AURKAIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKAIP1 Gene

Disorders for AURKAIP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for AURKAIP1 Gene including...

Search for AURKAIP1 Gene in MalaCards »

Relevant External Links for AURKAIP1

Genetic Association Database (GAD)
AURKAIP1
Human Genome Epidemiology (HuGE) Navigator
AURKAIP1
genes like me logo Genes that share disorders with AURKAIP1: view

No data available for UniProtKB/Swiss-Prot for AURKAIP1 Gene

Publications for AURKAIP1 Gene

  1. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. (PMID: 12244051) Kiat L.S. … Gopalan G. (J. Biol. Chem. 2002) 2 3 4 23
  2. Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A. (PMID: 17452972) Lim S.K. … Gopalan G. (Oncogene 2007) 3 23
  3. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. (PMID: 17957726) Katayama H. … Sen S. (J. Cell. Biochem. 2007) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for AURKAIP1 Gene

Sources for AURKAIP1 Gene

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