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Aliases for AURKAIP1 Gene

Aliases for AURKAIP1 Gene

  • Aurora Kinase A Interacting Protein 1 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein MS38 3 4
  • 28S Ribosomal Protein S38, Mitochondrial 3 4
  • AURKA-Interacting Protein 3 4
  • MRP-S38 3 4
  • AKIP 3 4
  • AIP 3 4
  • Aurora Kinase A-Interacting Protein 3
  • Aurora-A Kinase Interacting Protein 3
  • MRPS38 4

External Ids for AURKAIP1 Gene

Previous GeneCards Identifiers for AURKAIP1 Gene

  • GC01M001350
  • GC01M001298
  • GC01M000581

Summaries for AURKAIP1 Gene

GeneCards Summary for AURKAIP1 Gene

AURKAIP1 (Aurora Kinase A Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for AURKAIP1 Gene

  • May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKAIP1 Gene

Genomics for AURKAIP1 Gene

Regulatory Elements for AURKAIP1 Gene


Enhancers around AURKAIP1 on UCSC Golden Path with GeneCards custom track

Promoters for AURKAIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000184 195 1801 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143

Transcription factor binding sites by QIAGEN in the AURKAIP1 gene promoter:

Genomic Location for AURKAIP1 Gene

Chromosome:
1
Start:
1,373,730 bp from pter
End:
1,375,495 bp from pter
Size:
1,766 bases
Orientation:
Minus strand

Genomic View for AURKAIP1 Gene

Genes around AURKAIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AURKAIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AURKAIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKAIP1 Gene

Proteins for AURKAIP1 Gene

  • Protein details for AURKAIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWT8-AKIP_HUMAN
    Recommended name:
    Aurora kinase A-interacting protein
    Protein Accession:
    Q9NWT8
    Secondary Accessions:
    • Q5TA36
    • Q8TBD3

    Protein attributes for AURKAIP1 Gene

    Size:
    199 amino acids
    Molecular mass:
    22354 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:23908630, PubMed:25838379). Interacts with Aurora-A (PubMed:12244051).
    SequenceCaution:
    • Sequence=AAH22808.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AURKAIP1 Gene

neXtProt entry for AURKAIP1 Gene

Post-translational modifications for AURKAIP1 Gene

  • Ubiquitination at posLast=193193
  • Modification sites at PhosphoSitePlus

Other Protein References for AURKAIP1 Gene

No data available for DME Specific Peptides for AURKAIP1 Gene

Domains & Families for AURKAIP1 Gene

Protein Domains for AURKAIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AURKAIP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWT8

UniProtKB/Swiss-Prot:

AKIP_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mS38 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mS38 family.
genes like me logo Genes that share domains with AURKAIP1: view

No data available for Gene Families for AURKAIP1 Gene

Function for AURKAIP1 Gene

Molecular function for AURKAIP1 Gene

UniProtKB/Swiss-Prot Function:
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

Gene Ontology (GO) - Molecular Function for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12244051
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with AURKAIP1: view
genes like me logo Genes that share phenotypes with AURKAIP1: view

Animal Model Products

CRISPR Products

miRNA for AURKAIP1 Gene

miRTarBase miRNAs that target AURKAIP1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AURKAIP1 Gene

Localization for AURKAIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKAIP1 Gene

Mitochondrion. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AURKAIP1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12244051
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with AURKAIP1: view

Pathways & Interactions for AURKAIP1 Gene

genes like me logo Genes that share pathways with AURKAIP1: view

Gene Ontology (GO) - Biological Process for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IBA --
GO:0016310 phosphorylation IEA --
GO:0045839 negative regulation of mitotic nuclear division NAS 12244051
GO:0045862 positive regulation of proteolysis IDA 12244051
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with AURKAIP1: view

No data available for SIGNOR curated interactions for AURKAIP1 Gene

Transcripts for AURKAIP1 Gene

Unigene Clusters for AURKAIP1 Gene

Aurora kinase A interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AURKAIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6:
SP7: -

Relevant External Links for AURKAIP1 Gene

GeneLoc Exon Structure for
AURKAIP1
ECgene alternative splicing isoforms for
AURKAIP1

Expression for AURKAIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AURKAIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AURKAIP1 Gene

This gene is overexpressed in Lung (35.9), Breast (16.9), and Pancreas (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AURKAIP1 Gene



Protein tissue co-expression partners for AURKAIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AURKAIP1 Gene:

AURKAIP1

SOURCE GeneReport for Unigene cluster for AURKAIP1 Gene:

Hs.632515

mRNA Expression by UniProt/SwissProt for AURKAIP1 Gene:

Q9NWT8-AKIP_HUMAN
Tissue specificity: Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.

Evidence on tissue expression from TISSUES for AURKAIP1 Gene

  • Pancreas(4.3)
  • Nervous system(3.2)
  • Lung(3)
  • Intestine(2.7)
  • Muscle(2.6)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with AURKAIP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AURKAIP1 Gene

Orthologs for AURKAIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AURKAIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AURKAIP1 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia AURKAIP1 34 35
  • 81.14 (n)
cow
(Bos Taurus)
Mammalia AURKAIP1 34 35
  • 80.23 (n)
rat
(Rattus norvegicus)
Mammalia Aurkaip1 34
  • 75.54 (n)
mouse
(Mus musculus)
Mammalia Aurkaip1 34 16 35
  • 74.04 (n)
oppossum
(Monodelphis domestica)
Mammalia AURKAIP1 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AURKAIP1 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves AURKAIP1 34 35
  • 58.25 (n)
lizard
(Anolis carolinensis)
Reptilia AURKAIP1 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549720 34
  • 53.3 (n)
zebrafish
(Danio rerio)
Actinopterygii aurkaip1 34 35
  • 56.33 (n)
Species where no ortholog for AURKAIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AURKAIP1 Gene

ENSEMBL:
Gene Tree for AURKAIP1 (if available)
TreeFam:
Gene Tree for AURKAIP1 (if available)

Paralogs for AURKAIP1 Gene

Pseudogenes.org Pseudogenes for AURKAIP1 Gene

genes like me logo Genes that share paralogs with AURKAIP1: view

No data available for Paralogs for AURKAIP1 Gene

Variants for AURKAIP1 Gene

Sequence variations from dbSNP and Humsavar for AURKAIP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000297776 -- 1,376,957(+) GCTGG(A/G)GAATT upstream-variant-2KB
rs1000639625 -- 1,375,720(+) GCTCA(C/G)GCCTG upstream-variant-2KB
rs1001558956 -- 1,375,854(+) GGCAG(C/G)CGCCT upstream-variant-2KB
rs1001885257 -- 1,376,068(+) TTTGG(C/T)TGAGC upstream-variant-2KB
rs1002260828 -- 1,375,124(+) CCTCA(A/G)GCCTC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for AURKAIP1 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
dgv7n100 CNV loss 25217958
esv2758912 CNV loss 17122850
esv3584994 CNV gain 21293372
nsv1009541 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160788 CNV deletion 26073780
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv544969 CNV loss 21841781
nsv950452 CNV deletion 24416366
nsv997291 CNV gain 25217958

Variation tolerance for AURKAIP1 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AURKAIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AURKAIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKAIP1 Gene

Disorders for AURKAIP1 Gene

Relevant External Links for AURKAIP1

Genetic Association Database (GAD)
AURKAIP1
Human Genome Epidemiology (HuGE) Navigator
AURKAIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AURKAIP1

No disorders were found for AURKAIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AURKAIP1 Gene

Publications for AURKAIP1 Gene

  1. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. (PMID: 12244051) Kiat L.S. … Gopalan G. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A. (PMID: 17452972) Lim S.K. … Gopalan G. (Oncogene 2007) 3 22 64
  4. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. (PMID: 17957726) Katayama H. … Sen S. (J. Cell. Biochem. 2007) 3 22 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for AURKAIP1 Gene

Sources for AURKAIP1 Gene

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