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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AURKAIP1 Gene

protein-coding   GIFtS: 51
GCID: GC01M001298

Aurora Kinase A Interacting Protein 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aurora Kinase A Interacting Protein 11 2
AIP2 3 5
AKIP2 3 5
AURKA-Interacting Protein2 3
Aurora Kinase A-Interacting Protein2
Aurora-A Kinase Interacting Protein2

External Ids:    HGNC: 241141   Entrez Gene: 549982   Ensembl: ENSG000001757567   OMIM: 6091835   UniProtKB: Q9NWT83   

Export aliases for AURKAIP1 gene to outside databases

Previous GC identifers: GC01M001350 GC01M000581


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AURKAIP1 Gene: 
AURKAIP1 (aurora kinase A interacting protein 1) is a protein-coding gene. Diseases associated with AURKAIP1 include gastric cancer. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8
Function: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent
degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AURKAIP1 gene promoter:
         C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAURKAIP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AURKAIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AURKAIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

AURKAIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AURKAIP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001298:  view genomic region     (about GC identifiers)

Start:
1,309,110 bp from pter      End:
1,310,875 bp from pter
Size:
1,766 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8 (See protein sequence)
Recommended Name: Aurora kinase A-interacting protein  
Size: 199 amino acids; 22354 Da
Subunit: Interacts with Aurora-A
Subcellular location: Nucleus
Sequence caution: Sequence=AAH22808.1; Type=Erroneous initiation;
Secondary accessions: Q5TA36 Q8TBD3

Explore the universe of human proteins at neXtProt for AURKAIP1: NX_Q9NWT8

Explore proteomics data for AURKAIP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NWT8

  • AURKAIP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AURKAIP1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001120701.1  NP_001120702.1  NP_060370.1  

    ENSEMBL proteins: 
     ENSP00000342676   ENSP00000340656   ENSP00000319778   ENSP00000368130  

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    Cloud-Clone Corp. Proteins for AURKAIP1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    AURKAIP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013177 DUF1713_mit

    Graphical View of Domain Structure for InterPro Entry Q9NWT8

    ProtoNet protein and cluster: Q9NWT8


    AURKAIP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKIP_HUMAN, Q9NWT8
    Function: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent
    degradation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12244051
         
    AURKAIP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AURKAIP1:
     Gemcitabine induced cell-death  Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AURKAIP1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AURKAIP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Aurora A signaling
    Aurora A signaling


    1 BioSystems Pathway for AURKAIP1
        Aurora A signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AURKAIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for AURKAIP1 (Q9NWT81, 3 ENSP000003197784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKAO149651, 3, ENSP000002169114EBI-448665,EBI-448680 I2D: score=2 STRING: ENSP00000216911
    AJUBAQ96IF13, ENSP000002627134I2D: score=1 STRING: ENSP00000262713
    OAZ1ENSP000003148134STRING: ENSP00000314813
    HDAC1ENSP000003626494STRING: ENSP00000362649
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045839negative regulation of mitosis NAS12244051
    GO:0045862positive regulation of proteolysis IDA12244051

    AURKAIP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AURKAIP1 (AKIP)

    Search CenterWatch for drugs/clinical trials and news about AURKAIP1 / AKIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AURKAIP1 gene (3 alternative transcripts): 
    NM_001127229.1  NM_001127230.1  NM_017900.2  

    Unigene Cluster for AURKAIP1:

    Aurora kinase A interacting protein 1
    Hs.632515  [show with all ESTs]
    Unigene Representative Sequence: BM557781
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338370(uc001afb.1) ENST00000338338(uc001afc.2) ENST00000321751(uc009vkb.1)
    ENST00000378853(uc001afd.2) ENST00000489799 ENST00000496905
    miRNA
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    Additional mRNA sequence: 

    AK000615.1 BC022808.1 BC035595.1 BC046345.2 BC062333.1 

    23 DOTS entries:

    DT.92449601  DT.100059525  DT.100048317  DT.121375246  DT.92449606  DT.121375184  DT.121375175  DT.100796921 
    DT.121375086  DT.100796922  DT.95252455  DT.95252389  DT.95252439  DT.100059523  DT.100796920  DT.121375180 
    DT.121375171  DT.100796923  DT.121375096  DT.95252384  DT.95252438  DT.121375161  DT.121375235 

    24/187 AceView cDNA sequences (see all 187):

    AI201204 BQ882368 BG481188 AI203533 BM824236 CA390164 BE312488 BQ638980 
    AI818850 CB154281 AA335615 CA307137 BM504784 BU949807 AK000615 AA708784 
    BE222601 BE019565 CN484942 AI991037 AI183424 AI825659 BI763861 BQ879604 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AURKAIP1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                    -     -     -           -                                 
    SP2:                          -     -           -                                 
    SP3:                                -           -                                 
    SP4:                                -     -     -                                 
    SP5:                                            -                                 


    ECgene alternative splicing isoforms for AURKAIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AURKAIP1 expression in normal human tissues (normalized intensities)      AURKAIP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCTGGGGC
    AURKAIP1 Expression
    About this image


    AURKAIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             ganglion/cranial   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             Retina
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See AURKAIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AURKAIP1

    SOURCE GeneReport for Unigene cluster: Hs.632515

    UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8
    Tissue specificity: Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AURKAIP1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aurkaip11 , 5 aurora kinase A interacting protein 11, 5 74.04(n)1
    68.84(a)1
      4 (87.55 cM)5
    660771  NM_025338.41  NP_079614.11 
     1558312725 
    chicken
    (Gallus gallus)
    Aves AURKAIP11 aurora kinase A interacting protein 1 58.55(n)
    54.4(a)
      419415  NM_001030872.1  NP_001026043.1 
    lizard
    (Anolis carolinensis)
    Reptilia AURKAIP16
    Uncharacterized protein
    43(a)
    1 ↔ 1
    GL343701.1(42267-45004)
    zebrafish
    (Danio rerio)
    Actinopterygii aurkaip11 aurora kinase A interacting protein 1 56.85(n)
    58.91(a)
      100126015  NM_001105695.1  NP_001099165.1 


    ENSEMBL Gene Tree for AURKAIP1 (if available)
    TreeFam Gene Tree for AURKAIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AURKAIP1 gene

    AURKAIP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for AURKAIP1
    PGOHUM00000235511 PGOHUM00000235539


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/129 SNPs in AURKAIP1 are shown (see all 129)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24777751,2
    C--1308628(+) CGGAAG/AGCTTG 3 -- int18Minor allele frequency- A:0.00NA WA CSA 13
    rs1810447851,2
    --1308813(+) CTGTAC/GTTCTG 3 -- int10--------
    rs26495951,2
    C--1308871(-) ACAGAA/TCCCAC 3 -- int18Minor allele frequency- T:0.00NA WA CSA 15
    rs1138489691,2
    C,F--1308962(+) CAGCAT/CCCTCT 3 -- int12Minor allele frequency- C:0.33CSA 3
    rs27650151,2
    C,F,H--1308982(-) CTGGCC/TCTTGG 3 -- int118Minor allele frequency- T:0.05NS EA NA WA CSA 1890
    rs1510674701,2
    --1309095(+) TGGAGC/GTCCAG 3 -- int10--------
    rs1850760081,2
    --1309126(+) CCTCTA/GAGAAT 3 -- ut310--------
    rs1119336931,2
    C,F--1309185(+) CTCATT/CTGCCC 6 /K /R mis12Minor allele frequency- C:0.04WA NA 3982
    rs1455046611,2
    C,F--1309203(+) AGATCT/CTGGGG 6 /K /R mis11Minor allele frequency- C:0.00NA 4214
    rs1380141921,2
    F--1309209(+) TGGGGA/GTCTGC 6 T I mis11Minor allele frequency- C:0.00NA 4314

    HapMap Linkage Disequilibrium report for AURKAIP1 (1309110 - 1310875 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for AURKAIP1 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv25n71CNV Loss21882294
    dgv19n71CNV Loss21882294
    nsv470680CNV Loss18288195
    dgv34n71CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv33n71CNV Loss21882294
    dgv20n71CNV Loss21882294
    dgv38n71CNV Loss21882294
    dgv12n71CNV Loss21882294
    dgv31n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AURKAIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for AURKAIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609183    OMIM disorders: --

    2 diseases for AURKAIP1:    About MalaCards
    gastric cancer    


    AURKAIP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AURKAIP1
    Human Genome Epidemiology (HuGE) Navigator: AURKAIP1 (1 document)

    Export disorders for AURKAIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AURKAIP1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with AURKAIP1)
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    1. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. (PubMed id 12244051)1, 2, 3, 9 Kiat L.S.... Gopalan G. (2002)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. (PubMed id 17957726)1, 9 Katayama H....Sen S. (2007)
    7. Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A. (PubMed id 17452972)1, 9 Lim S.K. and Gopalan G. (2007)
    8. Iterative orthology prediction uncovers new mitochond rial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase. (PubMed id 22356826)1 Szklarczyk R....Huynen M.A. (2012)
    9. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    10. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54998 HGNC: 24114 AceView: CCNL2 Ensembl:ENSG00000175756 euGenes: HUgn54998
    ECgene: AURKAIP1 H-InvDB: AURKAIP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AURKAIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AURKAIP1 gene:
    Search GeneIP for patents involving AURKAIP1

    GeneCards and IP:
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