Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AURKAIP1 Gene

protein-coding   GIFtS: 52
GCID: GC01M001298

Aurora Kinase A Interacting Protein 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Aurora Kinase A Interacting Protein 11 2     AURKA-Interacting Protein2 3
AIP2 3 5     Aurora Kinase A-Interacting Protein2
AKIP2 3 5     Aurora-A Kinase Interacting Protein2
28S Ribosomal Protein S38, Mitochondrial2 3     MRPS383
MRP-S382 3     

External Ids:    HGNC: 241141   Entrez Gene: 549982   Ensembl: ENSG000001757567   OMIM: 6091835   UniProtKB: Q9NWT83   

Export aliases for AURKAIP1 gene to outside databases

Previous GC identifers: GC01M001350 GC01M000581


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for AURKAIP1 Gene:
AURKAIP1 (aurora kinase A interacting protein 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8
Function: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent
degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the AURKAIP1 gene promoter:
         C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAURKAIP1 promoter sequence
   Search Chromatin IP Primers for AURKAIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AURKAIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

AURKAIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AURKAIP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001298:  view genomic region     (about GC identifiers)

Start:
1,309,110 bp from pter      End:
1,310,875 bp from pter
Size:
1,766 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8 (See protein sequence)
Recommended Name: Aurora kinase A-interacting protein  
Size: 199 amino acids; 22354 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins. Interacts with Aurora-A
Sequence caution: Sequence=AAH22808.1; Type=Erroneous initiation;
Secondary accessions: Q5TA36 Q8TBD3

Explore the universe of human proteins at neXtProt for AURKAIP1: NX_Q9NWT8

Explore proteomics data for AURKAIP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys193
  • Modification sites at PhosphoSitePlus

  • See AURKAIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001120701.1  NP_001120702.1  NP_060370.1  

    ENSEMBL proteins: 
     ENSP00000342676   ENSP00000340656   ENSP00000319778   ENSP00000368130  

    AURKAIP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AURKAIP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AURKAIP1
    GenScript Custom Purified and Recombinant Proteins Services for AURKAIP1
    Novus Biologicals AURKAIP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AURKAIP1

     
    Search eBioscience for Proteins for AURKAIP1 

     
    antibodies-online proteins for AURKAIP1 (2 products) 

     
    antibodies-online peptides for AURKAIP1

    AURKAIP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AURKAIP1
    Novus Biologicals AURKAIP1 Antibodies
    Abcam antibodies for AURKAIP1
    Cloud-Clone Corp. Antibodies for AURKAIP1
    ThermoFisher Antibodies for AURKAIP1
    antibodies-online antibodies for AURKAIP1 (16 products) 

    AURKAIP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AURKAIP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AURKAIP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AURKAIP1
    Cloud-Clone Corp. CLIAs for AURKAIP1
    Search eBioscience for ELISAs for AURKAIP1 
    antibodies-online kits for AURKAIP1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR013177 DUF1713_mit

    Graphical View of Domain Structure for InterPro Entry Q9NWT8

    ProtoNet protein and cluster: Q9NWT8


    Find genes that share domains with AURKAIP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKIP_HUMAN, Q9NWT8
    Function: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent
    degradation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12244051
         
    Find genes that share ontologies with AURKAIP1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for AURKAIP1:
     Gemcitabine induced cell-death  Increased apoptosis 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AURKAIP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AURKAIP1:
    hsa-mir-331-3p (MIRT043432), hsa-mir-26a-5p (MIRT050107)

    Block miRNA regulation of human, mouse, rat AURKAIP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AURKAIP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AURKAIP1
    Predesigned siRNA for gene silencing in human, mouse, rat AURKAIP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AURKAIP1

    Clone
    Products:
         
    OriGene clones in human, mouse for AURKAIP1 (see all 17)
    OriGene ORF clones in mouse, rat for AURKAIP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AURKAIP1 (NM_001127230)
    Sino Biological Human cDNA Clone for AURKAIP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AURKAIP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AURKAIP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AURKAIP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for AURKAIP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AURKAIP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AKIP_HUMAN, Q9NWT8: Mitochondrion. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with AURKAIP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AURKAIP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Aurora A signaling
    Aurora A signaling

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AURKAIP1
        AHR Pathway

    1 BioSystems Pathway for AURKAIP1
        Aurora A signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AURKAIP1
    Interactions:

        GeneGlobe Interaction Network for AURKAIP1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for AURKAIP1 (Q9NWT81, 3 ENSP000003197784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKAO149651, 3, ENSP000002169114EBI-448665,EBI-448680 I2D: score=2 STRING: ENSP00000216911
    AJUBAQ96IF13, ENSP000002627134I2D: score=1 STRING: ENSP00000262713
    OAZ1ENSP000003148134STRING: ENSP00000314813
    HDAC1ENSP000003626494STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045839negative regulation of mitosis NAS12244051
    GO:0045862positive regulation of proteolysis IDA12244051

    Find genes that share ontologies with AURKAIP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AURKAIP1 (AKIP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AURKAIP1 gene (3 alternative transcripts): 
    NM_001127229.1  NM_001127230.1  NM_017900.2  

    Unigene Cluster for AURKAIP1:

    Aurora kinase A interacting protein 1
    Hs.632515  [show with all ESTs]
    Unigene Representative Sequence: BM557781
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338370(uc001afb.1) ENST00000338338(uc001afc.2) ENST00000321751(uc009vkb.1)
    ENST00000378853(uc001afd.2) ENST00000489799 ENST00000496905
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AURKAIP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AURKAIP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AURKAIP1
    Predesigned siRNA for gene silencing in human, mouse, rat AURKAIP1
    Clone
    Products:
         
    OriGene clones in human, mouse for AURKAIP1 (see all 17)
    OriGene ORF clones in mouse, rat for AURKAIP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AURKAIP1 (NM_001127230)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AURKAIP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AURKAIP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AURKAIP1
    OriGene qSTAR qPCR primer pairs in human, mouse for AURKAIP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AURKAIP1
      QuantiTect SYBR Green Assays in human, mouse, rat AURKAIP1
      QuantiFast Probe-based Assays in human, mouse, rat AURKAIP1

    Additional mRNA sequence: 

    AK000615.1 BC022808.1 BC035595.1 BC046345.2 BC062333.1 

    23 DOTS entries:

    DT.92449601  DT.100059525  DT.100048317  DT.121375246  DT.92449606  DT.121375184  DT.121375175  DT.100796921 
    DT.121375086  DT.100796922  DT.95252455  DT.95252389  DT.95252439  DT.100059523  DT.100796920  DT.121375180 
    DT.121375171  DT.100796923  DT.121375096  DT.95252384  DT.95252438  DT.121375161  DT.121375235 

    Selected AceView cDNA sequences (see all 187):

    AA708784 AI739169 BC062333 BU682875 AW162041 BM695908 BM761974 AI092925 
    BM551191 AI523882 AI568921 BF685762 AW160424 BQ882368 AW063916 BF223129 
    BQ638980 BU628734 AK000615 CD513071 Z42901 AI082366 AI700009 BU682874 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AURKAIP1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                    -     -     -           -                                 
    SP2:                          -     -           -                                 
    SP3:                                -           -                                 
    SP4:                                -     -     -                                 
    SP5:                                            -                                 


    ECgene alternative splicing isoforms for AURKAIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AURKAIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCTGGGGC
    AURKAIP1 Expression
    About this image


    AURKAIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Colon (Gastrointestinal Tract)
     
     Testis (Reproductive System)
     
     Adipose (Muscoskeletal System)
    AURKAIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AURKAIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632515

    UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8
    Tissue specificity: Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis

        Custom PCR Arrays for AURKAIP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AURKAIP1
    OriGene qSTAR qPCR primer pairs in human, mouse for AURKAIP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AURKAIP1
    QuantiTect SYBR Green Assays in human, mouse, rat AURKAIP1
    QuantiFast Probe-based Assays in human, mouse, rat AURKAIP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AURKAIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for AURKAIP1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aurkaip11 , 5 aurora kinase A interacting protein 11, 5 74.04(n)1
    68.84(a)1
      4 (87.55 cM)5
    660771  NM_025338.41  NP_079614.11 
     1558312725 
    chicken
    (Gallus gallus)
    Aves AURKAIP11 aurora kinase A interacting protein 1 58.25(n)
    54.12(a)
      419415  NM_001030872.2  NP_001026043.1 
    lizard
    (Anolis carolinensis)
    Reptilia AURKAIP16
    aurora kinase A interacting protein 1
    42(a)
    1 ↔ 1
    GL343701.1(42267-45004)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC5497201 uncharacterized LOC549720 53.3(n)
    45.31(a)
      549720  NM_001016966.1  NP_001016966.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aurkaip11 aurora kinase A interacting protein 1 56.33(n)
    58.91(a)
      100126015  NM_001105695.1  NP_001099165.1 


    ENSEMBL Gene Tree for AURKAIP1 (if available)
    TreeFam Gene Tree for AURKAIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AURKAIP1 gene

    Find genes that share paralogs with AURKAIP1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for AURKAIP1
    PGOHUM00000235511 PGOHUM00000235539


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AURKAIP1 (see all 129)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24777751,2
    C--1308628(+) CGGAAG/AGCTTG 3 -- int18Minor allele frequency- A:0.00NA WA CSA 13
    rs1810447851,2
    --1308813(+) CTGTAC/GTTCTG 3 -- int10--------
    rs26495951,2
    C--1308871(-) ACAGAA/TCCCAC 3 -- int18Minor allele frequency- T:0.00NA WA CSA 15
    rs1138489691,2
    C,F--1308962(+) CAGCAT/CCCTCT 3 -- int12Minor allele frequency- C:0.33CSA 3
    rs27650151,2
    C,F,H--1308982(-) CTGGCC/TCTTGG 3 -- int118Minor allele frequency- T:0.05NS EA NA WA CSA 1890
    rs1510674701,2
    --1309095(+) TGGAGC/GTCCAG 3 -- int10--------
    rs1850760081,2
    --1309126(+) CCTCTA/GAGAAT 3 -- ut310--------
    rs1119336931,2
    C,F--1309185(+) CTCATT/CTGCCC 6 /K /R mis12Minor allele frequency- C:0.04WA NA 3982
    rs1455046611,2
    C,F--1309203(+) AGATCT/CTGGGG 6 /K /R mis11Minor allele frequency- C:0.00NA 4214
    rs1380141921,2
    F--1309209(+) TGGGGA/GTCTGC 6 T I mis11Minor allele frequency- C:0.00NA 4314

    HapMap Linkage Disequilibrium report for AURKAIP1 (1309110 - 1310875 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AURKAIP1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv25n71CNV Loss21882294
    dgv19n71CNV Loss21882294
    nsv470680CNV Loss18288195
    dgv34n71CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv33n71CNV Loss21882294
    dgv20n71CNV Loss21882294
    dgv38n71CNV Loss21882294
    dgv12n71CNV Loss21882294
    dgv31n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AURKAIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for AURKAIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609183    OMIM disorders: --


    Find genes that share disorders with AURKAIP1           About GenesLikeMe

    Genetic Association Database (GAD): AURKAIP1
    Human Genome Epidemiology (HuGE) Navigator: AURKAIP1 (1 document)

    Export disorders for AURKAIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AURKAIP1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with AURKAIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. (PubMed id 12244051)1, 2, 3, 9 Kiat L.S.... Gopalan G. (J. Biol. Chem. 2002)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. (PubMed id 17957726)1, 9 Katayama H....Sen S. (J. Cell. Biochem. 2007)
    7. Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A. (PubMed id 17452972)1, 9 Lim S.K. and Gopalan G. (Oncogene 2007)
    8. Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. (PubMed id 23908630)2 Koc E.C.... Koc H. (Front. Physiol. 2013)
    9. Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase. (PubMed id 22356826)1 Szklarczyk R.... Huynen M.A. (Genome Biol. 2012)
    10. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54998 HGNC: 24114 AceView: CCNL2 Ensembl:ENSG00000175756 euGenes: HUgn54998
    ECgene: AURKAIP1 H-InvDB: AURKAIP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AURKAIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AURKAIP1 gene:
    Search GeneIP for patents involving AURKAIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AURKAIP1  
     OriGene qPCR primer pairs and template standards for AURKAIP1   OriGene Protein Over-expression Lysate for AURKAIP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AURKAIP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for AURKAIP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AURKAIP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AURKAIP1   OriGene Custom Protein Services for AURKAIP1  

     
     
     Block miRNA regulation of human, mouse, rat AURKAIP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AURKAIP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AURKAIP1 Predesigned siRNA for gene silencing in human, mouse, rat AURKAIP1
     QuantiFast Probe-based Assays in human, mouse, rat AURKAIP1 QuantiTect SYBR Green Assays in human, mouse, rat AURKAIP1
     Custom PCR Arrays for AURKAIP1 Search Chromatin IP Primers for AURKAIP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AURKAIP1  GeneGlobe Interaction Network for AURKAIP1
     Regulatory tfbs in AURKAIP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for AURKAIP1 GenScript cDNA clones with any tag delivered in your preferred vector for AURKAIP1
     GenScript Custom Assay Services for AURKAIP1 GenScript Custom overexpressing Cell Line Services for AURKAIP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for AURKAIP1 (AKIP)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for AURKAIP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AURKAIP1 antibodies
     AURKAIP1 lysates
     Antibodies for AURKAIP1
     See all of Abcam's Antibodies, Kits and Proteins for AURKAIP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for AURKAIP1
     Antibodies for AURKAIP1
     ELISAs for AURKAIP1
     CLIAs for AURKAIP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for AURKAIP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AURKAIP1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for AURKAIP1
     SwitchGear Promoter luciferase reporter plasmids for AURKAIP1
     ThermoFisher Antibodies for AURKAIP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AURKAIP1
     Browse compounds at ApexBio
     Search Addgene for plasmids for AURKAIP1
      Search eBioscience for proteins for AURKAIP1
      Search eBioscience for elisas for AURKAIP1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for AURKAIP1
     antibodies-online antibodies for AURKAIP1 (16 products)
     antibodies-online kits for AURKAIP1 (4 products)
     antibodies-online peptides for AURKAIP1
     antibodies-online proteins for AURKAIP1 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AURKAIP1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4