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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AURKAIP1 Gene

protein-coding   GIFtS: 50
GCID: GC01M001298

aurora kinase A interacting protein 1

 Explore 2 diseases affiliated with
AURKAIP1 via our new
 Human Malady Compendium 
Biological research products
for AURKAIP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Aurora Kinase A Interacting Protein 11 2     FLJ206081
AIP1 2 3 5     Aurora Kinase A-Interacting Protein2
AKIP1 2 3 5     Aurora-A Kinase Interacting Protein2
AURKA-Interacting Protein2 3     

External Ids:    HGNC: 241141   Entrez Gene: 549982   Ensembl: ENSG000001757567   OMIM: 6091835   UniProtKB: Q9NWT83   

Export aliases for AURKAIP1 gene to outside databases

Previous GC identifers: GC01M001350 GC01M000581


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8
Function: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent
degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AURKAIP1 gene promoter:
         C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAURKAIP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AURKAIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AURKAIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

AURKAIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AURKAIP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001298:  view genomic region     (about GC identifiers)

Start:
1,309,110 bp from pter      End:
1,310,875 bp from pter
Size:
1,766 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8 (See protein sequence)
Recommended Name: Aurora kinase A-interacting protein  
Size: 199 amino acids; 22354 Da
Subunit: Interacts with Aurora-A
Subcellular location: Nucleus
Sequence caution: Sequence=AAH22808.1; Type=Erroneous initiation;
Secondary accessions: Q5TA36 Q8TBD3

Explore the universe of human proteins at neXtProt for AURKAIP1: NX_Q9NWT8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NWT8

  • AURKAIP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001120701.1  NP_001120702.1  NP_060370.1  

    ENSEMBL proteins: 
     ENSP00000342676   ENSP00000340656   ENSP00000319778   ENSP00000368130  

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    Uscn Proteins for AURKAIP1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    AURKAIP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    AURKAIP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013177 DUF1713_mit

    Graphical View of Domain Structure for InterPro Entry Q9NWT8

    ProtoNet protein and cluster: Q9NWT8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8
    Function: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent
    degradation

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12244051


    AURKAIP1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for AURKAIP1:
     Gemcitabine induced cell-death  Increased apoptosis 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Aurora A signaling
    Aurora A signaling1.00


    1 BioSystems Pathway for AURKAIP1 
        Aurora A signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AURKAIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for AURKAIP1 (Q9NWT81, 3 ENSP000003197784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKAO149651, 3, ENSP000002169114EBI-448665,EBI-448680 I2D: score=2 STRING: ENSP00000216911
    AJUBAQ96IF13, ENSP000002627134I2D: score=1 STRING: ENSP00000262713
    OAZ1ENSP000003148134STRING: ENSP00000314813
    HDAC1ENSP000003626494STRING: ENSP00000362649
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045839negative regulation of mitosis NAS12244051
    GO:0045862positive regulation of proteolysis IDA12244051


    AURKAIP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AURKAIP1
    Search CenterWatch for drugs/clinical trials and news about AURKAIP1 / AKIP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AURKAIP1 gene (3 alternative transcripts): 
    NM_001127229.1  NM_001127230.1  NM_017900.2  

    Unigene Cluster for AURKAIP1:

    Aurora kinase A interacting protein 1
    Hs.632515  [show with all ESTs]
    Unigene Representative Sequence: BM557781
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338370(uc001afb.1) ENST00000338338(uc001afc.2) ENST00000321751(uc009vkb.1)
    ENST00000378853(uc001afd.2) ENST00000489799 ENST00000496905

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    Additional cDNA sequence: 

    AK000615.1 BC022808.1 BC035595.1 BC046345.2 BC062333.1 

    23 DOTS entries:

    DT.92449601  DT.100059525  DT.100048317  DT.121375246  DT.92449606  DT.121375184  DT.121375175  DT.100796921 
    DT.121375086  DT.100796922  DT.95252455  DT.95252389  DT.95252439  DT.100059523  DT.100796920  DT.121375180 
    DT.121375171  DT.100796923  DT.121375096  DT.95252384  DT.95252438  DT.121375161  DT.121375235 

    24/187 AceView cDNA sequences (see all 187):

    BG696267 BQ276253 AW162017 BQ927531 AI990518 AI201204 AI991037 AI312749 
    BQ072820 AW197199 CK822515 AW063916 AI825659 AA971276 BE463815 Z39028 
    AW007087 BE312488 Z42901 AI924512 AI363140 AI391702 AW162041 BE252968 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AURKAIP1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                    -     -     -           -                                 
    SP2:                          -     -           -                                 
    SP3:                                -           -                                 
    SP4:                                -     -     -                                 
    SP5:                                            -                                 


    ECgene alternative splicing isoforms for AURKAIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AURKAIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCCTGGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See AURKAIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AURKAIP1

    SOURCE GeneReport for Unigene cluster: Hs.632515

    UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8
    Tissue specificity: Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AURKAIP1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aurkaip11 , 5 aurora kinase A interacting protein 11, 5 74.04(n)1
    68.84(a)1
      4 (87.55 cM)5
    660771  NM_025338.41  NP_079614.11 
     1558312725 
    chicken
    (Gallus gallus)
    Aves AURKAIP11 aurora kinase A interacting protein 1 58.55(n)
    54.4(a)
      419415  NM_001030872.1  NP_001026043.1 
    lizard
    (Anolis carolinensis)
    Reptilia AURKAIP16
    --
    43(a)
    1 ↔ 1
    GL343701.1(42267-45004)
    zebrafish
    (Danio rerio)
    Actinopterygii aurkaip11 aurora kinase A interacting protein 1 56.85(n)
    58.91(a)
      100126015  NM_001105695.1  NP_001099165.1 


    ENSEMBL Gene Tree for AURKAIP1 (if available)
    TreeFam Gene Tree for AURKAIP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AURKAIP1 gene

    AURKAIP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for AURKAIP1
    PGOHUM00000235511 PGOHUM00000235539


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/93 NCBI SNPs in AURKAIP1 are shown (see all 93    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24777751,2
    C,--1308628(+) CGGAAG/AGCTTG 3 -- int18Minor allele frequency- A:0.00NA WA CSA 13
    rs1810447851,2
    --1308813(+) CTGTAC/GTTCTG 3 -- int10--------
    rs26495951,2
    C,--1308871(-) ACAGAA/TCCCAC 3 -- int18Minor allele frequency- T:0.00NA WA CSA 15
    rs1138489691,2
    --1308962(+) CAGCAT/CCCTCT 3 -- int12Minor allele frequency- C:0.33CSA 3
    rs27650151,2
    C,F,H,--1308982(-) CTGGCC/TCTTGG 3 -- int118Minor allele frequency- T:0.05NS EA NA WA CSA 1890
    rs1510674701,2
    --1309095(+) TGGAGC/GTCCAG 3 -- int10--------
    rs1850760081,2
    --1309126(+) CCTCTA/GAGAAT 3 -- ut310--------
    rs1119336931,2
    C,F,--1309185(+) CTCATT/CTGCCC 6 /K /R mis12Minor allele frequency- C:0.04WA NA 3982
    rs1455046611,2
    C,F--1309203(+) AGATCT/CTGGGG 6 /K /R mis11Minor allele frequency- C:0.00NA 4214
    rs1380141921,2
    F--1309209(+) TGGGGG/CTCTGC 6 /T /S mis11Minor allele frequency- C:0.00NA 4314

    HapMap Linkage Disequilibrium report for AURKAIP1 (1309110 - 1310875 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for AURKAIP1
         2 CNVs: 3275 30362

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    AURKAIP1 for disorders           About GeneDecksing

    OMIM gene information: 609183    OMIM disorders: --

    2 diseases for AURKAIP1:    About MalaCards
    breast carcinoma    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: AURKAIP1 (1 document)

    Export disorders for AURKAIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AURKAIP1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with AURKAIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. (PubMed id 12244051)1, 2, 3, 9 Kiat L.S.... Gopalan G. (2002)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. (PubMed id 17957726)1, 9 Katayama H....Sen S. (2007)
    6. Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A. (PubMed id 17452972)1, 9 Lim S.K. and Gopalan G. (2007)
    7. Iterative orthology prediction uncovers new mitochond rial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase. (PubMed id 22356826)1 Szklarczyk R....Huynen M.A. (2012)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    10. Capsaicin induces apoptosis of cisplatin-resistant st omach cancer cells by causing degradation of cisplatin-inducible Aurora-A prote in. (PubMed id 21932983)1 Huh H.C....Han I.S. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54998 HGNC: 24114 AceView: CCNL2 Ensembl:ENSG00000175756 euGenes: HUgn54998
    ECgene: AURKAIP1 H-InvDB: AURKAIP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AURKAIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AURKAIP1 gene:
    Search GeneIP for patents involving AURKAIP1

    GeneCards and IP:
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