AURKAIP1 Gene
protein-coding GIFtS: 50
GCID: GC01M001298
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aurora kinase A interacting protein 1
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Aliases for AURKAIP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Aurora Kinase A Interacting Protein 11 2 | | FLJ206081 | | AIP1 2 3 5 | | Aurora Kinase A-Interacting Protein2 | | AKIP1 2 3 5 | | Aurora-A Kinase Interacting Protein2 | | AURKA-Interacting Protein2 3 | | |
Export aliases for AURKAIP1 gene to outside databasesPrevious GC identifers: GC01M001350 GC01M000581 |
Summaries for AURKAIP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8Function: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependentdegradation
|
Genomic Views for AURKAIP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AURKAIP1 gene promoter: C/EBPalpha Other transcription factors
Search SABiosciences Chromatin IP Primers for AURKAIP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AURKAIP1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33AURKAIP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M001298: view genomic region
(about GC identifiers)
Start:
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1,309,110 bp from pter |
End:
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1,310,875 bp from pter |
Size:
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1,766 bases |
Orientation:
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minus strand |
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Proteins for AURKAIP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8 (See
protein sequence)Recommended Name: Aurora kinase A-interacting protein Size: 199 amino acids; 22354 Da
Subunit: Interacts with Aurora-A
Subcellular location: Nucleus
Sequence caution: Sequence=AAH22808.1; Type=Erroneous initiation;
Secondary accessions: Q5TA36 Q8TBD3Explore the universe of human proteins at neXtProt for AURKAIP1: NX_Q9NWT8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWT8 AURKAIP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001120701.1 NP_001120702.1 NP_060370.1 ENSEMBL proteins: ENSP00000342676 ENSP00000340656 ENSP00000319778 ENSP00000368130 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
AURKAIP1 for ontologies About GeneDecksing
AURKAIP1 Antibody Products: Assay Products for AURKAIP1: |
Protein
Domains / Families for AURKAIP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AURKAIP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NWT8ProtoNet protein and cluster: Q9NWT8 |
Function for AURKAIP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8Function: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependentdegradation
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AURKAIP1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AURKAIP1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): AURKAIP1 (NM_001127230) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AURKAIP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AURKAIP1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AURKAIP1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
AURKAIP1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for AURKAIP1:
|
Pathways & Interactions for AURKAIP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Aurora A signaling | |
1 BioSystems Pathway for AURKAIP1 
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AURKAIP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
 5 Interacting proteins for AURKAIP1 (Q9NWT81, 3 ENSP000003197784) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
AURKAIP1 for ontologies About GeneDecksing
|
Drugs & Compounds for AURKAIP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for AURKAIP1 Search CenterWatch for drugs/clinical trials and news about AURKAIP1 / AKIP 
|
Transcripts for AURKAIP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for AURKAIP1 gene (3 alternative transcripts): NM_001127229.1 NM_001127230.1 NM_017900.2 Unigene Cluster for AURKAIP1: Aurora kinase A interacting protein 1 Hs.632515 [show with all ESTs]Unigene Representative Sequence: BM5577816 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338370(uc001afb.1) ENST00000338338(uc001afc.2) ENST00000321751(uc009vkb.1) ENST00000378853(uc001afd.2) ENST00000489799 ENST00000496905
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AURKAIP1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AURKAIP1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): AURKAIP1 (NM_001127230) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AURKAIP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AURKAIP1  |
Additional cDNA sequence: AK000615.1 BC022808.1 BC035595.1 BC046345.2 BC062333.1 23 DOTS entries: DT.92449601 DT.100059525 DT.100048317 DT.121375246 DT.92449606 DT.121375184 DT.121375175 DT.100796921 DT.121375086 DT.100796922 DT.95252455 DT.95252389 DT.95252439 DT.100059523 DT.100796920 DT.121375180 DT.121375171 DT.100796923 DT.121375096 DT.95252384 DT.95252438 DT.121375161 DT.121375235 24/187 AceView cDNA sequences (see all 187): BG696267 BQ276253 AW162017 BQ927531 AI990518 AI201204 AI991037 AI312749 BQ072820 AW197199 CK822515 AW063916 AI825659 AA971276 BE463815 Z39028 AW007087 BE312488 Z42901 AI924512 AI363140 AI391702 AW162041 BE252968 GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AURKAIP1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | |
| SP1: | |   | |   | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for AURKAIP1
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Expression for AURKAIP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AURKAIP1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CTCCTGGGGC
About this image See AURKAIP1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AURKAIP1
SOURCE GeneReport for Unigene cluster: Hs.632515 UniProtKB/Swiss-Prot: AKIP_HUMAN, Q9NWT8Tissue specificity: Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis SABiosciences Custom PCR Arrays for AURKAIP1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AURKAIP1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AURKAIP1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AURKAIP1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AURKAIP1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AURKAIP1 |
Orthologs for AURKAIP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for AURKAIP1 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for AURKAIP1 (if available) TreeFam Gene Tree for AURKAIP1 (if available)  |
Paralogs for AURKAIP1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for AURKAIP1 gene
AURKAIP1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for AURKAIP1 PGOHUM00000235511 PGOHUM00000235539
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Genomic Variants for AURKAIP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for AURKAIP1 (1309110 - 1310875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for AURKAIP1 2 CNVs: 3275 30362  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AURKAIP1 |
|
Disorders
/ Diseases for AURKAIP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AURKAIP1 for disorders About GeneDecksing
OMIM gene information: 609183
OMIM disorders: --
2 diseases for AURKAIP1: About MalaCardsbreast carcinoma carcinoma Human Genome Epidemiology (HuGE) Navigator: AURKAIP1 (1 document) Export disorders for AURKAIP1 gene to outside databases
|
Publications for AURKAIP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AURKAIP1 gene, integrated from 9 sources (see all 26): (articles sorted by number of sources associating them with AURKAIP1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. (PubMed id 12244051)1, 2, 3, 9 Kiat L.S.... Gopalan G. (2002)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. (PubMed id 17957726)1, 9 Katayama H....Sen S. (2007)
- Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A. (PubMed id 17452972)1, 9 Lim S.K. and Gopalan G. (2007)
- Iterative orthology prediction uncovers new mitochond rial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase. (PubMed id 22356826)1 Szklarczyk R....Huynen M.A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
- Capsaicin induces apoptosis of cisplatin-resistant st omach cancer cells by causing degradation of cisplatin-inducible Aurora-A prote in. (PubMed id 21932983)1 Huh H.C....Han I.S. (2011)
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External Searches for AURKAIP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AURKAIP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AURKAIP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AURKAIP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for AURKAIP1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for AURKAIP1 gene: Search GeneIP for patents involving AURKAIP1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for AURKAIP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for AURKAIP1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AURKAIP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AURKAIP1 | | OriGene Protein Over-expression Lysate for AURKAIP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for AURKAIP1 | | OriGene 3'-UTR Clone for AURKAIP1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AURKAIP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AURKAIP1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AURKAIP1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AURKAIP1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AURKAIP1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AURKAIP1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AURKAIP1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AURKAIP1 |
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 | | AURKAIP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AURKAIP1 |
|  |  |  | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AURKAIP1 |
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