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Aliases for AURKA Gene

Aliases for AURKA Gene

  • Aurora Kinase A 2 3 5
  • Serine/Threonine-Protein Kinase Aurora-A 3 4
  • Serine/Threonine-Protein Kinase 6 3 4
  • Breast Tumor-Amplified Kinase 3 4
  • Aurora/IPL1-Related Kinase 1 3 4
  • Aurora 2 3 4
  • STK15 3 4
  • STK6 3 4
  • ARK1 3 4
  • AURA 3 4
  • BTAK 3 4
  • AIK 3 4
  • Protein Phosphatase 1, Regulatory Subunit 47 3
  • Serine/Threonine Protein Kinase 15 3
  • Serine/Threonine-Protein Kinase 15 4
  • Serine/Threonine Kinase 15 2
  • Serine/Threonine Kinase 6 2
  • Aurora/IPL1-Like Kinase 3
  • Aurora-Related Kinase 1 4
  • Protein Phosphatase 1 2
  • Regulatory Subunit 47 2
  • Aurora-A Kinase 2
  • EC 2.7.11.1 4
  • PPP1R47 3
  • AIRK1 4
  • ARK-1 4
  • HARK1 4
  • STK7 3
  • AYK1 4
  • IAK1 4

External Ids for AURKA Gene

Previous HGNC Symbols for AURKA Gene

  • STK15
  • STK6

Previous GeneCards Identifiers for AURKA Gene

  • GC20U900062
  • GC20M055629
  • GC20M054377
  • GC20M054944
  • GC20M051729

Summaries for AURKA Gene

Entrez Gene Summary for AURKA Gene

  • The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AURKA Gene

AURKA (Aurora Kinase A) is a Protein Coding gene. Diseases associated with AURKA include colorectal cancer and postsurgical hypothyroidism. Among its related pathways are Oocyte meiosis and DNA Damage. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKC.

UniProtKB/Swiss-Prot for AURKA Gene

  • Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

Tocris Summary for AURKA Gene

  • Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.

Gene Wiki entry for AURKA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKA Gene

Genomics for AURKA Gene

Regulatory Elements for AURKA Gene

Enhancers for AURKA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AURKA on UCSC Golden Path with GeneCards custom track

Promoters for AURKA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AURKA on UCSC Golden Path with GeneCards custom track

Genomic Location for AURKA Gene

Chromosome:
20
Start:
56,369,389 bp from pter
End:
56,392,337 bp from pter
Size:
22,949 bases
Orientation:
Minus strand

Genomic View for AURKA Gene

Genes around AURKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AURKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AURKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKA Gene

Proteins for AURKA Gene

  • Protein details for AURKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14965-AURKA_HUMAN
    Recommended name:
    Aurora kinase A
    Protein Accession:
    O14965
    Secondary Accessions:
    • E1P5F9
    • O60445
    • O75873
    • Q9BQD6
    • Q9UPG5

    Protein attributes for AURKA Gene

    Size:
    403 amino acids
    Molecular mass:
    45809 Da
    Quaternary structure:
    • Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with PIFO. Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via C-terminus). Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with SIRT2.
    Miscellaneous:
    • Centrosome amplification can occur when the cycles are uncoupled, and this amplification is associated with cancer and with an increase in the levels of chromosomal instability.
    SequenceCaution:
    • Sequence=BAA23592.1; Type=Frameshift; Positions=105, 125, 129, 235, 241; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AURKA Gene

neXtProt entry for AURKA Gene

Proteomics data for AURKA Gene at MOPED

Post-translational modifications for AURKA Gene

  • Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis.
  • Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AURKA (AurA)

No data available for DME Specific Peptides for AURKA Gene

Domains & Families for AURKA Gene

Gene Families for AURKA Gene

Suggested Antigen Peptide Sequences for AURKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14965

UniProtKB/Swiss-Prot:

AURKA_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
genes like me logo Genes that share domains with AURKA: view

Function for AURKA Gene

Molecular function for AURKA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO.
UniProtKB/Swiss-Prot Function:
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
UniProtKB/Swiss-Prot Induction:
Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.

Enzyme Numbers (IUBMB) for AURKA Gene

genes like me logo Genes that share phenotypes with AURKA: view

Animal Models for AURKA Gene

MGI Knock Outs for AURKA:

Animal Model Products

  • Taconic Biosciences Mouse Models for AURKA

miRNA for AURKA Gene

miRTarBase miRNAs that target AURKA

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AURKA Gene

Localization for AURKA Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKA Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). {ECO:0000250 UniProtKB:P97477, ECO:0000269 PubMed:17229885, ECO:0000269 PubMed:17726514, ECO:0000269 PubMed:21225229, ECO:0000269 PubMed:22014574, ECO:0000269 PubMed:9606188}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AURKA Gene COMPARTMENTS Subcellular localization image for AURKA gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20531406
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle TAS 19774610
GO:0005829 cytosol TAS --
GO:0005876 colocalizes_with spindle microtubule IDA 19801554
genes like me logo Genes that share ontologies with AURKA: view

Pathways & Interactions for AURKA Gene

genes like me logo Genes that share pathways with AURKA: view

SIGNOR curated interactions for AURKA Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000212 meiotic spindle organization IEA --
GO:0006468 protein phosphorylation IEA,IDA 21600873
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0007051 spindle organization IMP 21820309
genes like me logo Genes that share ontologies with AURKA: view

Drugs & Compounds for AURKA Gene

(62) Drugs for AURKA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea Experimental Pharma Target 0
1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea Experimental Pharma Target 0
1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea Experimental Pharma Target 0
2-(1H-pyrazol-3-yl)-1H-benzimidazole Experimental Pharma Target 0

(4) Additional Compounds for AURKA Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Hesperadin hydrochloride
422513-13-1
TC-A 2317 hydrochloride
1245907-03-2

(5) Tocris Compounds for AURKA Gene

Compound Action Cas Number
Anacardic acid Noncompetitive PCAF/p300 inhibitor 16611-84-0
CCT 137690 Potent pan-Aurora kinase inhibitor 1095382-05-0
Hesperadin hydrochloride Potent Aurora kinase B inhibitor 422513-13-1
TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor 1245907-03-2
ZM 447439 Inhibits Aurora kinase B 331771-20-1

(24) ApexBio Compounds for AURKA Gene

Compound Action Cas Number
AMG-900 Aurora kinase inhibitor 945595-80-2
Anacardic acid HAT inhibitor 16611-84-0
AT9283 Aurora kinase/JAK inhibitor 896466-04-9
Aurora A Inhibitor I Aurora A inhibitor 1158838-45-9
Bendamustine HCl Cytostatic agent for non-Hodgkin lymphomas 3543-75-7
CCT129202 Aurora kinase inhibitor,ATP-competitive and potent 942947-93-5
CCT137690 Aurora A/B/C inhibitor 1095382-05-0
CYC116 Potent Aurora A/B inhibitor 693228-63-6
Danusertib (PHA-739358) Pan-aurora kinase inhibitor 827318-97-8
ENMD-2076 Selective Aurora A/Flt3 inhibitor 934353-76-1
ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor 1291074-87-7
GSK1070916 Aurora B/C inhibitor 942918-07-2
Hesperadin Aurora B kinase inhibitor 422513-13-1
JNJ-7706621 Potent CDK/Aurora kinase inhibitor 443797-96-4
MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective 1010085-13-8
MK-8745 Aurora A inhibitor,potent and selective 885325-71-3
MLN8054 Aurora A inhibitor 869363-13-3
MLN8237 (Alisertib) Aurora A Kinase inhibitor, Potent and selective 1028486-01-2
PF-03814735 Aurora A/B inhibitor 942487-16-3
PHA-680632 Aurora kinase inhibitor,novel and potent 398493-79-3
SNS-314 Mesylate Aurora A/B/C kinases inhibitor, potent and selective 1146618-41-8
TAK-901 Novel Aurora A/B inhibitor 934541-31-8
VX-680 (MK-0457,Tozasertib) Aurora kinase inhibitor 639089-54-6
ZM 447439 Aurora Kinase inhibitor,potent and selective 331771-20-1
genes like me logo Genes that share compounds with AURKA: view

Drug Products

Transcripts for AURKA Gene

Unigene Clusters for AURKA Gene

Aurora kinase A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AURKA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11: - -
SP12: - - -
SP13:
SP14: - - -
SP15: -
SP16: - -
SP17: - - - -
SP18: - - -

Relevant External Links for AURKA Gene

GeneLoc Exon Structure for
AURKA
ECgene alternative splicing isoforms for
AURKA

Expression for AURKA Gene

mRNA expression in normal human tissues for AURKA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AURKA Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for AURKA Gene

This gene is overexpressed in Lung (49.6) and Breast (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AURKA Gene



SOURCE GeneReport for Unigene cluster for AURKA Gene Hs.250822

mRNA Expression by UniProt/SwissProt for AURKA Gene

O14965-AURKA_HUMAN
Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
genes like me logo Genes that share expression patterns with AURKA: view

Protein tissue co-expression partners for AURKA Gene

In Situ Assay Products

Orthologs for AURKA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AURKA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AURKA 35
  • 86.4 (n)
  • 89.05 (a)
AURKA 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AURKA 35
  • 89.83 (n)
  • 90.07 (a)
AURKA 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aurka 35
  • 78.76 (n)
  • 84.26 (a)
Aurka 16
Aurka 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AURKA 35
  • 99.34 (n)
  • 99.75 (a)
AURKA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aurka 35
  • 80.05 (n)
  • 85.1 (a)
oppossum
(Monodelphis domestica)
Mammalia AURKA 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AURKA 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves AURKA 35
  • 70.94 (n)
  • 75.38 (a)
AURKA 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AURKA 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aurka 35
  • 63.41 (n)
  • 67.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397925 35
zebrafish
(Danio rerio)
Actinopterygii aurka 35
  • 60.95 (n)
  • 63.32 (a)
aurka 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001793 35
  • 53.39 (n)
  • 56.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta aur 35
  • 54.29 (n)
  • 53.14 (a)
aur 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea air-2 35
  • 57.11 (n)
  • 62.13 (a)
air-2 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPL1 36
  • 38 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AUR2 35
  • 62.41 (n)
  • 66.17 (a)
rice
(Oryza sativa)
Liliopsida Os.613 35
Os01g0191800 35
  • 59.36 (n)
  • 65.02 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7757 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4656 36
  • 65 (a)
OneToMany
Species with no ortholog for AURKA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AURKA Gene

ENSEMBL:
Gene Tree for AURKA (if available)
TreeFam:
Gene Tree for AURKA (if available)

Paralogs for AURKA Gene

Paralogs for AURKA Gene

Pseudogenes.org Pseudogenes for AURKA Gene

genes like me logo Genes that share paralogs with AURKA: view

Variants for AURKA Gene

Sequence variations from dbSNP and Humsavar for AURKA Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6069717 - 56,388,167(-) AGGTC(A/C/G/T)TGAAA reference, missense
rs2273535 - 56,386,485(+) AGGAA(A/T)TTGCT reference, missense
rs1047972 - 56,386,407(-) AGCGC(A/G)TTCCT reference, missense
rs34572020 - 56,386,427(+) TTGAA(A/G)GACAC reference, missense
VAR_041128 A colorectal adenocarcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for AURKA Gene

Variant ID Type Subtype PubMed ID
nsv834013 CNV Gain 17160897
esv259662 OTHER Complex 20981092
esv1000250 CNV Insertion 20482838
nsv179276 CNV Insertion 16902084
esv990423 CNV Insertion 20482838
esv1411689 CNV Insertion 17803354
nsv179472 CNV Insertion 16902084

Variation tolerance for AURKA Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AURKA Gene

HapMap Linkage Disequilibrium report
AURKA
Human Gene Mutation Database (HGMD)
AURKA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKA Gene

Disorders for AURKA Gene

MalaCards: The human disease database

(10) MalaCards diseases for AURKA Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
postsurgical hypothyroidism
  • post-surgical hypothyroidism
colorectal adenocarcinoma
  • adenocarcinoma of large intestine
atypical teratoid rhabdoid tumor
  • at/rt
squamous cell papilloma
  • epidermoid papilloma
- elite association - COSMIC cancer census association via MalaCards
Search AURKA in MalaCards View complete list of genes associated with diseases

Relevant External Links for AURKA

Genetic Association Database (GAD)
AURKA
Human Genome Epidemiology (HuGE) Navigator
AURKA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AURKA
genes like me logo Genes that share disorders with AURKA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AURKA Gene

Publications for AURKA Gene

  1. Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese. (PMID: 16011022) Chen L. … Zhang X. (Yi Chuan Xue Bao 2005) 3 4 23 48 67
  2. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. (PMID: 9771714) Zhou H. … Sen S. (Nat. Genet. 1998) 2 3 23
  3. Characterization of human CD4 helper T cell responses against Aurora kinase A. (PMID: 20182874) Kobayashi H. … Celis E. (Cancer Immunol. Immunother. 2010) 3 23
  4. Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. (PMID: 19551141) Ricketts C. … Maher E.R. (PLoS ONE 2009) 3 23
  5. Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression. (PMID: 19652203) Dutta-Simmons J. … Carrasco D.R. (Blood 2009) 3 23

Products for AURKA Gene

Sources for AURKA Gene

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