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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AURKA Gene

protein-coding GIFtS: 71
GCID: GC20M054944

aurora kinase A

(Previous names: serine/threonine kinase 15, serine/threonine kinase 6...)
(Previous symbols: STK15, STK6)

Explore 78 diseases affiliated with
AURKA via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aurora Kinase A¹ ²		ARK-1² ³
AIK¹ ² ³ ⁵		AURA² ³
ARK1¹ ² ³ ⁵		HARK1¹
BTAK¹ ² ³ ⁵		AURORA2² ⁵
STK15¹ ² ³ ⁵		AurA¹
STK6¹ ² ³ ⁵		Serine/Threonine Kinase 15¹
PPP1R47¹ ²		Aurora-A Kinase²
STK7¹ ²		Aurora/IPL1-Like Kinase²
Serine/Threonine Kinase 6¹ ²		Breast-Tumor-Amplified Kinase²
Aurora 2² ³		IPL1-Related Kinase²
Aurora-Related Kinase 1² ³		Protein Phosphatase 1, Regulatory Subunit 47²
Aurora/IPL1-Related Kinase 1² ³		Serine/Threonine Protein Kinase 15²
Breast Tumor-Amplified Kinase² ³		AIRK1³
Serine/Threonine-Protein Kinase 15² ³		AYK1³
Serine/Threonine-Protein Kinase 6² ³		EC 2.7.11.1³
Serine/Threonine-Protein Kinase Aurora-A² ³		IAK1³

External Ids:	HGNC: 11393¹	Entrez Gene: 6790²	Ensembl: ENSG00000087586⁷	OMIM: 603072⁵	UniProtKB: O14965³

Export aliases for AURKA gene to outside databases

Previous GC identifers: GC20U900062 GC20M055629 GC20M054377 GC20M051729

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AURKA:

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation

and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome

in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and

progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has

been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AURKA_HUMAN, O14965

Function: Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates

with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events

including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation,

chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at

centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A,

LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity.

Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for

microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and

particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and

stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit

their activity. Necessary for proper cilia disassembly prior to mitosis

summary for AURKA:

Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in

regulating many of the processes that are pivotal to mitosis. Each isoform, Aurora A, Aurora B and Aurora C,

has a different function in the control of mitosis. Aurora A is involved in regulating many of the early

mitotic events, including entry into mitosis. Aurora A levels rise during the G2 phase and peak early in

mitosis. One target of aurora A is cdc25b, a direct regulator of the cyclin B1-Cdk1 complex, which provides

the basis for the role this enzyme plays in regulating entry into mitosis. Aurora A regulates centrosome

maturation by moderating the recruitment of proteins, such as TPX-2, Ajuba, Bora and Lats, which are

themselves essential for accumulating microtubule spindle components, such as gamma-tubulin. Aurora A is

also associated with separation of centrosomes, through phosphorylation of the kinesin motor protein, Eg5.

In addition, this enzyme regulates the microtubule network that forms mitotic spindles, through regulation

of the EXTAH multiprotein complex. Since their discovery in the 1990s, Aurora kinases have been strongly

linked to the progression of human cancers. Aurora A maps to human chromosome 20q13 and Aurora B to human

chromosome 17q13.1, which are loci altered frequently in human cancers. Overexpression of Aurora A and B is

seen in many cancers, but these enzymes are not oncoproteins, as concomitant oncogenic mutations are

required to promote tumor progression. Aurora kinase inhibitors are an intense area of research for the

development of anticancer therapies.

Gene Wiki entry for AURKA (Aurora A kinase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AURKA gene promoter:
NF-kappaB1 NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AURKA promoter sequence

Search SABiosciences Chromatin IP Primers for AURKA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AURKA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13 Ensembl cytogenetic band: 20q13.2 HGNC cytogenetic band: 20q13

AURKA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AURKA gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M054944: view genomic region (about GC identifiers)

Start:	54,944,445 bp from pter	End:	54,967,393 bp from pter
Size:	22,949 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AURKA_HUMAN, O14965 (See protein sequence)

Recommended Name: Aurora kinase A

Size: 403 amino acids; 45809 Da

Subunit: Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the

protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA,

BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with PIFO.

Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via C-terminus).

Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates AURKA-mediated PLK1

phosphorylation

Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the

neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early

prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase. Moves to the midbody

during both telophase and cytokinesis. Associates with both the pericentriolar material (PCM) and centrioles

Miscellaneous: Centrosome amplification can occur when the cycles are uncoupled, and this amplification is associated

with cancer and with an increase in the levels of chromosomal instability

Caution: Authors initially considered AURKA/STK6 and STK15 as 2 different proteins (PubMed:9771714). It is clear that

they are the same protein

Sequence caution: Sequence=BAA23592.1; Type=Frameshift; Positions=105, 125, 129, 235, 241;

6/62 PDB 3D structures from and Proteopedia for AURKA (see all 62):

1MQ4 (3D)

1MUO (3D)

1OL5 (3D)

1OL6 (3D)

1OL7 (3D)

2BMC (3D)

Secondary accessions: E1P5F9 O60445 O75873 Q9BQD6 Q9UPG5

Explore the universe of human proteins at neXtProt for AURKA: NX_O14965

Post-translational modifications:

Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment.

Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288

upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1

(PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342

decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis¹

Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the

proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the

anaphase-promoting complex (APC), leading to its degradation by the proteasome¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14965

AURKA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_003591.2 NP_940835.1 NP_940836.1 NP_940837.1 NP_940838.1 NP_940839.1

ENSEMBL proteins:

ENSP00000216911 ENSP00000379251 ENSP00000321591 ENSP00000360407 ENSP00000379249

ENSP00000379247 ENSP00000379243 ENSP00000393452 ENSP00000388073 ENSP00000405042

ENSP00000405170 ENSP00000401358 ENSP00000379245 ENSP00000379250

Reactome Protein details: O14965
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant AURKA Protein
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for AURKA
	OriGene Purified Proteins (see all 4): AURKA OriGene Protein Over-expression Lysate (see all 9): AURKA OriGene Custom Protein Services for AURKA
	GenScript Custom Purified and Recombinant Proteins Services for AURKA
	Novus Biologicals AURKA Proteins Novus Biologicals AURKA Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for AURKA
	Uscn Proteins for AURKA

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005813	centrosome	TAS	19774610
GO:0005819	spindle	TAS	19774610
GO:0005829	cytosol	TAS	--
GO:0005876	spindle microtubule	IDA	19801554

AURKA for ontologies About GeneDecksing

AURKA Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of AURKA
	R&D Systems Antibodies for AURKA (Aurora A)
	Cell Signaling Technology (CST) Antibodies for AURKA (AurA)
	OriGene Antibodies (see all 2): AURKA OriGene Custom Antibody Services for AURKA
	GenScript Custom Superior Antibodies Services for AURKA
	Novus Biologicals AURKA Antibodies
	Abcam antibodies for AURKA
	Uscn Antibodies for AURKA
	ThermoFisher Antibody for AURKA

Assay Products for AURKA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript AURKA-Activity-based Kinase Assay for Compound Screening
	Cell Signaling Technology (CST) Sandwich ELISA Kits for AURKA (AurA)
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AURKA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AURKA for domains About GeneDecksing

5 InterPro domains/families:

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry O14965

ProtoNet protein and cluster: O14965

UniProtKB/Swiss-Prot: AURKA_HUMAN, O14965

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: