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AURKA Gene

protein-coding GIFtS: 65

GC20M054377

aurora kinase A
(Previous names: serine/threonine kinase 15, serine/threonine kinase 6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: STK15, STK6)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AIK ^², ³, ⁵
ARK1 ^², ³, ⁵
AURA ^², ³
AURORA2 ^², ⁵
AurA ^¹
Aurora-A ^³
BTAK ^¹, ², ³, ⁵
EC 2.7.11.1 ^³
MGC34538 ^²
OTTHUMP00000031340 ^²
OTTHUMP00000031342 ^²
OTTHUMP00000031343 ^²
OTTHUMP00000031344 ^²
OTTHUMP00000031345 ^²
OTTHUMP00000166071 ^²
STK15 ^², ³, ⁵
STK6 ^², ³, ⁵
STK7 ^¹, ²
hARK1 ^³

Descriptions
Aurora-related kinase 1 ^², ³
Aurora/IPL1-related kinase 1 ^³
Breast tumor-amplified kinase ^³
IPL1-related kinase ^²
Serine/threonine kinase 15 ^¹, ³
aurora kinase A ^², ³
aurora/IPL1-like kinase ^²
breast-tumor-amplified kinase ^²
serine/threonine kinase 6 ^¹, ²
serine/threonine protein kinase 15 ^²
serine/threonine protein kinase 6 ^²

External Ids
HGNC: 11393¹
Entrez Gene: 6790²
UniProtKB: O14965³
Ensembl: ENSG00000087586⁷

Search outside databases for aliases for AURKA gene

Previous GC identifers: GC20U900062 GC20M055629

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AURKA:

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in

microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The

encoded protein is found at the centrosome in interphase cells and at the spindle poles in

mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of

this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on

chromosome 10. Multiple transcript variants encoding the same protein have been found for this

gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: STK6_HUMAN, O14965

Function: May play a role in cell cycle regulation during anaphase and/or telophase, in relation to

the function of the centrosome/spindle pole region during chromosome segregation. May be involved

in microtubule formation and/or stabilization. Phosphorylates ARHGEF2 and BORA

Gene Wiki entry for AURKA (Aurora_A_kinase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AURKA gene

Entrez Gene cytogenetic band: 20q13.2-q13.3 Ensembl cytogenetic band: 20q13.31 HGNC cytogenetic band: 20q13

AURKA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M054377: (about GC identifiers)

Start:	54,377,852 bp from pter
End:	54,400,800 bp from pter
Size:	22,949 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: STK6_HUMAN, O14965 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase 6

Size: 403 amino acids; 45809 Da

Subunit: Interacts with TACC1 and CPEB1. Interacts with its substrates BORA and ARHGEF2

Subcellular location: Centrosome. Spindle. Note=Localizes on centrosomes in interphase cells and at

each spindle pole in mitosis

Caution: Although authors have considered STK6 and STK15 as two different proteins, it is clear

that they are the same protein

Sequence caution: Sequence=BAA23592.1; Type=Frameshift; Positions=105, 125, 129, 235, 241;

PDB structures from and Proteopedia :

1MQ4 (3D)

1MUO (3D)

1OL5 (3D)

1OL6 (3D)

1OL7 (3D)

2BMC (3D)

2C6D (3D)

2C6E (3D)

2DWB (3D)

2J4Z (3D)

2J50 (3D)

2NP8 (3D)

2W1C (3D)

2W1D (3D)

2W1E (3D)

2W1F (3D)

2W1G (3D)

3COH (3D)

3E5A (3D)

3EFW (3D)

Secondary accessions: O60445 O75873 Q9BQD6 Q9UPG5

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (6 alternative transcripts):

NP_003591.2 NP_940835.1 NP_940836.1 NP_940837.1 NP_940838.1 NP_940839.1

ENSEMBL proteins:

ENSP00000216911 ENSP00000379250 ENSP00000360407 ENSP00000379247 ENSP00000379249 ENSP00000321591

ENSP00000379251 ENSP00000379243 ENSP00000379245

Human Recombinant Proteins

	Invitrogen human recombinant proteins for AURKA
	Millipore Purified and/or Recombinant AURKA Protein
	Sigma-Aldrich Proteins and AQUA Peptides for AURKA
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for AURKA
	Recombinant Proteins from Abcam (ARK 1 + 2, Aurora A)
	Human Recombinant Proteins from Abnova (STK6)

OriGene Purified Recombinant Human Proteins (see all 2): AURKA

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	9153231
GO:0005813	centrosome	IEA	--
GO:0005819	spindle	TAS	9153231

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Antibodies for AURKA:

	Invitrogen Antibodies for AURKA
	Millipore Mono- and Polyclonal Antibodies for the study of AURKA
	Sigma-Aldrich Antibodies for AURKA
	R&D Systems Antibodies for AURKA (Aurora A)
	Cell Signaling Technology (CST) Antibodies for AURKA (Aurora A)
	Antibodies from Abcam (ARK 1 + 2, Aurora A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (STK6)
	Novus Biologicals Antibodies for AURKA

Assays for AURKA:

	Invitrogen Assays for AURKA
	Millipore Kits and Assays for the Analysis of AURKA
	Browse R&D Systems for biochemical assays
	Cell Signaling Technology (CST) Sandwich ELISA Kits for AURKA (Aurora A)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O14965

ProtoNet protein and cluster: O14965

UniProtKB/Swiss-Prot: STK6_HUMAN, O14965

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora

subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AURKA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (STK6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_003600

Applied Biosystems Silencer® siRNAs for AURKA

Sigma-Aldrich siRNA and siRNA Panels for AURKA

Sigma-Aldrich shRNA Panels and shRNA for AURKA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_003600
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_003600
untagged cDNA clones in CMV expression vector (see all 6): NM_003600

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_198435

UniProtKB/Swiss-Prot: STK6_HUMAN, O14965

Function: May play a role in cell cycle regulation during anaphase and/or telophase, in relation to

the function of the centrosome/spindle pole region during chromosome segregation. May be involved

in microtubule formation and/or stabilization. Phosphorylates ARHGEF2 and BORA

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Aurka):

cellular

embryogenesis

lethality-prenatal/perinatal

tumorigenesis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005515	protein binding	IPI	12244051 15987997
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for AURKA (Your Favorite Gene powered by Ingenuity)

Molecular Mechanisms of Cancer

GeneDecks AURKA for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for AURKA

5/101 Interacting proteins for AURKA (ENSP00000321591³ O14965¹) via UniProtKB, MINT, and/or STRING (see all 101 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AURKAIP1	Q9NWT8¹	STRING (score=.96) EBI-448680, EBI-448665
CDKN2A	P42771¹	EBI-448680, EBI-375053
FABP5	Q01469¹	EBI-448680, EBI-1054073
RAB10	P61026¹	EBI-448680, EBI-726075
SOD2	P04179¹	EBI-448680, EBI-716989

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000278	mitotic cell cycle	IEA	--
GO:0006468	protein amino acid phosphorylation	TAS	9153231
GO:0007051	spindle organization	NAS	15504738
GO:0007067	mitosis	TAS	9153231
GO:0031647	regulation of protein stability	IMP	15987997

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for AURKA available from Tocris Bioscience

Compound	Action	CAS number
Anti-Aurora A	Antibody recognizing Aurora A

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1 Novoseek chemical compound relationship for AURKA gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	71.14	25	17219423 (1), 17898866 (1), 12591738 (1), 15466974 (1) (see all 22)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AURKA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (STK6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_003600

Sigma-Aldrich siRNA and siRNA Panels for AURKA

Sigma-Aldrich shRNA Panels and shRNA for AURKA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003600 NM_198433 NM_198434 NM_198435 NM_198436 NM_198437

REFSEQ mRNAs for AURKA gene (6 alternative transcripts):

NM_003600.2 NM_198433.1 NM_198434.1 NM_198435.1 NM_198436.1 NM_198437.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003600 NM_198433 NM_198434 NM_198435 NM_198436 NM_198437

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_003600
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_003600
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_003600

Additional cDNA sequence:

AF008551.1 AF011468.1 AK301769.1 AK312776.1 BC001280.1 BC002499.2 BC006423.1 BC027464.1

CR611278.1 CR616247.1 CR621289.1

12 DOTS entries:

DT.100685783 DT.101984387 DT.453145 DT.95311156 DT.97845478 DT.97845474 DT.100791978 DT.100029011

DT.100759768 DT.102838438 DT.92439587 DT.120832467

24/258 AceView cDNA sequences (see all 258 ):

BC006423 BX482198 BQ277355 AI638439 BC001280 BC027464 AF011468 BM790362

CA455229 AI038260 CA417669 AU124236 BQ440632 CR611278 CA416232 NM_198436

Z39943 BM834359 BU542363 BU521208 NM_198437 AI738674 AF008551 AI500164

highest scoring ESTs for AURKA:

AF011468 AA305997 AA373999 AA375986 AL516768 AL518529 AL711075 AU120266 BC001280 BC006423

Unigene Cluster for AURKA:

Aurora kinase A

Hs.250822 [show with all ESTs]

Unigene Representative Sequence: NM_198433

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for AURKA (see all 18 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	^	13a	·	13b	^	14
SP1:											-		-		-		-		-
SP2:									-		-						-		-
SP3:									-		-		-		-		-		-
SP4:											-		-		-				-
SP5:											-						-		-

About this scheme

ECgene alternative splicing isoforms for AURKA

9 Ensembl transcripts including schematic representations:

ENST00000347343 ENST00000395914 ENST00000371356 ENST00000395911 ENST00000395913 ENST00000312783

ENST00000395915 ENST00000395907 ENST00000395909

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AURKA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AURKA

¹ / ² / ³

8 probe-sets matching AURKA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34852_g_at²^{, 3}	U95-A	2	1.00	0.94	0.97	0.86	AF011468	1.00	1.00	1.00	1
34851_at²^{, 3}	U95-A	2	1.00	0.94	0.96	1.15	AF011468	1.00	1.00	1.00	1
208080_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003158	0.20	1.00	0.72	1
208079_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003158	0.20	1.00	0.72	1
204092_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003600	0.60	1.00	0.82	1
208080_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208079_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204092_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AURKA for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTGTAAACT

SOURCE GeneReport for Unigene cluster: Hs.250822
UniProtKB/Swiss-Prot: STK6_HUMAN, O14965
Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.
Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell
lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases
rapidly after

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AURKA gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AURKA¹	--	aurora kinase A	89.83(n) 90.07(a)	485940 XM_543064.2 XP_543064.2
chimpanzee (Pan troglodytes)	AURKA¹	--	aurora kinase A	99.34(n) 99.75(a)	469980 XM_525364.2 XP_525364.2
cow (Bos taurus)	AURKA¹	--	aurora kinase A	86.4(n) 89.05(a)	504437 NM_001038028.1 NP_001033117.1
rat (Rattus norvegicus)	Aurka¹	--	aurora kinase A	80.05(n) 85.1(a)	261730 NM_153296.2 NP_695208.2
mouse (Mus musculus)	Aurka^{1, 5}	2 (100.00 cM)⁵	aurora kinase A^{1, 5}	78.76(n)¹ 84.26(a)¹	20878¹ NM_011497.3¹ NP_035627.1¹ AF007817⁵ AK077513⁵ (see all 19)

About this table Species with no ortholog for AURKA

ENSEMBL Gene Tree for AURKA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AURKA gene

PLK4² AURKC² AURKB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/144 NCBI SNPs in AURKA are shown (see all 144 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 100)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs8173^1,2	A,C,F,H	54378198(+)	`GGCTTG/CGCCAA`	6	--	ut3¹ ese³		14	MN NA EA WA CSAM	2800
--	rs1047972^1,2	C,F,H	54394870(-)	`AGCGCA/GTTCCT`	6	I/V	mis¹		26	MN EA NS EU WA NA CSAM	3362
	rs2273535^1,2	C,F,H	54394948(+)	`AGGAAA/TTTGCT`	6	F/I	mis¹		20	NS EU EA WA MN CSAM NA	1606
--	rs6099119^1,2	C,F,H	54378367(+)	`AGTCGA/GACCTT`	6	--	ut3¹		9	EU EA WA MN CSAM	784
--	rs33923703^1,2	C,F	54378716(-)	`GGCCAA/GTGCTC`	6	M/V	mis¹		5	MN CSAM EA	400
	rs34852291^1,2	F	54377995(-)	`AACACG/ATGCTC`	6	--	ut3¹		5	MN CSAM EA	404
	rs6069717^1,2	H	54396630(+)	`AGGTCC/TTGAAA`	6	G/R	mis¹ ese³		4	EU EA WA	406
--	rs35436934^1,2	F	54378616(-)	`GGAMTC/TGTGCA`	6	--	ut3¹		5	MN CSAM EA	400
--	rs6099118^1,2	H	54378336(+)	`CATGCC/TTAGCA`	6	--	ut3¹		4	EU EA WA	416
	rs35106507^1,2	F	54377820(-)	`ACCATC/GTGTTC`	6	--	ng5¹		5	MN CSAM EA	272

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HapMap Linkage Disequilibrium images for AURKA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603072 disorders: 114500

UniProtKB/Swiss-Prot: STK6_HUMAN, O14965

Defects in AURKA are responsible for numerical centrosome aberrations including aneuploidy

10/26 Novoseek disease relationships for AURKA gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
laryngeal squamous cell carcinoma	63.32	12	12812651 (3), 16767676 (2), 17974987 (1), 12693093 (1) (see all 6)
cancer	49.22	49	17895985 (4), 17634533 (2), 16737620 (2), 18667445 (2) (see all 28)
tumors	46.35	80	12208897 (5), 14692019 (4), 19232520 (4), 17465238 (4) (see all 33)
ovarian cancer	35.05	14	15839305 (4), 15466974 (3), 17895985 (1), 15880741 (1) (see all 6)
laryngeal carcinoma	34.98	12	12693093 (4), 15192826 (4), 16377583 (2)
chromosomal aberrations	29.46	4	18931650 (2), 16377583 (1)
primary tumor	27.75	3	11190269 (1), 12631597 (1)
bladder cancer	26.91	28	18812553 (5), 17786310 (4), 12208897 (3), 18361427 (1) (see all 5)
carcinoma squamous cell	24.26	11	16792546 (3), 19107951 (2), 15087379 (1), 16951231 (1) (see all 7)
breast cancer	23.10	17	15271853 (3), 15598762 (3), 11190269 (2), 16411056 (2) (see all 9)

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Human Gene Mutation Database: AURKA
Genetic Association Database: AURKA
Human Genome Epidemiology Navigator: AURKA (32 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/275 PubMed articles for AURKA gene (see all 275 ):

Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese. (PubMed id 16011022)^{1, 3, 4, 6} Chen L....Zhang X. (2005)
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. (PubMed id 9771714)^{1, 2, 3, 4} Zhou H....Sen S. (1998)
Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk. (PubMed id 15867347)^{1, 3, 4, 6} Kimura M.T....Nagase H. (2005)
Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. (PubMed id 9153231)^{1, 3, 4} Kimura M....Okano Y. (1997)
Synergistic effects of STK15 gene polymorphisms and endogenous estrogen exposure in the risk of breast cancer. (PubMed id 15598762)^{1, 3, 6} Dai Q....Zheng W. (2004)
STK15 polymorphism and breast cancer risk in a population-based study. (PubMed id 15271853)^{1, 3, 6} Egan K.M....Nagase H. (2004)
STK15 polymorphisms and association with risk of invasive ovarian cancer. (PubMed id 15466974)^{1, 3, 6} Dicioccio R.A....Kruger-Kjaer S. (2004)
Functional STK15 Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal squamous cell carcinoma. (PubMed id 15087379)^{1, 3, 6} Miao X....Lin D. (2004)
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. (PubMed id 17488622)^{3, 4} Birkenfeld J....Bokoch G.M. (2007)
Mitotic activation of the kinase Aurora-A requires its binding partner Bora. (PubMed id 16890155)^{3, 4} Hutterer A....Knoblich J.A. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6790	HGNC: 11393	AceView: STK6	Ensembl:ENSG00000087586	euGenes: HUgn6790
ECgene: AURKA	H-InvDB: AURKA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AURKA	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AURKA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AURKA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AURKA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AURKA		Antibodies for AURKA
	Explore super-pooled esiRNAs		Proteins for AURKA
	Lentivirus-delivered shRNAs for AURKA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (STK6)
	Antibodies (STK6)
	Chimera RNAi (STK6)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for AURKA (Aurora A)

	Recombinant Proteins (ARK 1 + 2, Aurora A)
	Antibodies (ARK 1 + 2, Aurora A)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for AURKA

	Proteins for AURKA
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AURKA

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
AURKA Gene at Home site.
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AURKA Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for AURKA

Summaries
for AURKA

Genomic Location
for AURKA

Proteins
for AURKA

Protein Domains/
Families
for AURKA

Gene Function
for AURKA

Pathways & Interactions
for AURKA

Drugs & Compounds
for AURKA

Transcripts
for AURKA

Expression
for AURKA

Orthologs
for AURKA

Paralogs
for AURKA

SNPs/Variants
for AURKA

Disorders & Mutations
for AURKA

Medical News
for AURKA

Publications
for AURKA

Search for AURKA

Genome Databases showing AURKA

Other Databases showing AURKA

Specialized Databases showing AURKA

Licensable Technologies
for AURKA

Services
for AURKA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AURKA (Gene Symbol)
AIK
ARK1
AURA
AURORA2
AurA
Aurora-A
BTAK
EC 2.7.11.1
MGC34538
OTTHUMP00000031340
OTTHUMP00000031342
OTTHUMP00000031343
OTTHUMP00000031344
OTTHUMP00000031345
OTTHUMP00000166071
STK15
STK6
STK7
hARK1
Aurora-related kinase 1
Aurora/IPL1-related kinase 1
Breast tumor-amplified kinase
IPL1-related kinase
Serine/threonine kinase 15
aurora kinase A
aurora/IPL1-like kinase
breast-tumor-amplified kinase
serine/threonine kinase 6
serine/threonine protein kinase 15
serine/threonine protein kinase 6

AURKA Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor AURKA

Summariesfor AURKA

Genomic Locationfor AURKA

Proteinsfor AURKA

Protein Domains/Familiesfor AURKA

Gene Functionfor AURKA

Pathways & Interactionsfor AURKA

Drugs & Compoundsfor AURKA

Transcriptsfor AURKA

Expression for AURKA

Orthologsfor AURKA

Paralogsfor AURKA

SNPs/Variantsfor AURKA

Disorders & Mutationsfor AURKA

Medical Newsfor AURKA

Publicationsfor AURKA

Search for AURKA

Genome Databases showing AURKA

Other Databases showing AURKA

Specialized Databases showing AURKA

Licensable Technologiesfor AURKA

Servicesfor AURKA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AURKA

Summaries
for AURKA

Genomic Location
for AURKA

Proteins
for AURKA

Protein Domains/
Families
for AURKA

Gene Function
for AURKA

Pathways & Interactions
for AURKA

Drugs & Compounds
for AURKA

Transcripts
for AURKA

Expression
for AURKA

Orthologs
for AURKA

Paralogs
for AURKA

SNPs/Variants
for AURKA

Disorders & Mutations
for AURKA

Medical News
for AURKA

Publications
for AURKA

Licensable Technologies
for AURKA

Services
for AURKA