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Aliases for AURKA Gene

Aliases for AURKA Gene

  • Aurora Kinase A 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 47 2 3
  • Serine/Threonine-Protein Kinase Aurora-A 3 4
  • Serine/Threonine-Protein Kinase 6 3 4
  • Breast Tumor-Amplified Kinase 3 4
  • Aurora/IPL1-Related Kinase 1 3 4
  • Aurora 2 3 4
  • STK15 3 4
  • STK6 3 4
  • ARK1 3 4
  • AURA 3 4
  • BTAK 3 4
  • AIK 3 4
  • Serine/Threonine Protein Kinase 15 3
  • Serine/Threonine-Protein Kinase 15 4
  • Serine/Threonine Kinase 15 2
  • Serine/Threonine Kinase 6 2
  • Aurora/IPL1-Like Kinase 3
  • Aurora-Related Kinase 1 4
  • Aurora-A Kinase 2
  • EC 2.7.11.1 4
  • PPP1R47 3
  • AIRK1 4
  • ARK-1 4
  • HARK1 4
  • STK7 3
  • AYK1 4
  • IAK1 4

External Ids for AURKA Gene

Previous HGNC Symbols for AURKA Gene

  • STK15
  • STK6

Previous GeneCards Identifiers for AURKA Gene

  • GC20U900062
  • GC20M055629
  • GC20M054377
  • GC20M054944
  • GC20M051729

Summaries for AURKA Gene

Entrez Gene Summary for AURKA Gene

  • The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CIViC summary for AURKA Gene

GeneCards Summary for AURKA Gene

AURKA (Aurora Kinase A) is a Protein Coding gene. Diseases associated with AURKA include Colorectal Cancer and Colorectal Adenocarcinoma. Among its related pathways are Regulation of TP53 Activity and PLK1 signaling events. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKB.

UniProtKB/Swiss-Prot for AURKA Gene

  • Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

Tocris Summary for AURKA Gene

  • Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.

Gene Wiki entry for AURKA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKA Gene

Genomics for AURKA Gene

Regulatory Elements for AURKA Gene

Enhancers for AURKA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G056358 1.6 FANTOM5 ENCODE dbSUPER 13.7 +31.0 30966 6.0 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A YBX1 ZNF2 YY1 FAM210B AURKA CSTF1 GC20P056367
GH20G056483 1 Ensembl ENCODE dbSUPER 10.7 -91.6 -91596 1.3 CTCF RAD51 ZBTB40 FAM209A RPL39P AURKA CSTF1 FAM210B LOC105372681 RTFDC1
GH20G056447 0.7 dbSUPER 11.2 -55.7 -55680 1.9 HDGF PKNOX1 TAL1 JUN ZIC2 FOSL1 TCF12 POLR2A NCOR1 SMARCE1 RTFDC1 AURKA CSTF1 RPL39P CASS4
GH20G056368 0.6 dbSUPER 12.3 +23.3 23327 0.6 POLR2H RAD51 POLR2A AGO1 USF2 SUPT5H FAM210B AURKA CSTF1 GC20P056367
GH20G056385 0.6 dbSUPER 6.9 +6.1 6127 1.1 FOXA2 MAFG BACH1 ZNF316 ZKSCAN8 NFE2L1 NFE2 EMSY MAFK NFE2L2 FAM210B RTFDC1 AURKA GC20P056367
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AURKA on UCSC Golden Path with GeneCards custom track

Promoters for AURKA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139095 -63 2401 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21

Genomic Location for AURKA Gene

Chromosome:
20
Start:
56,369,389 bp from pter
End:
56,392,337 bp from pter
Size:
22,949 bases
Orientation:
Minus strand

Genomic View for AURKA Gene

Genes around AURKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AURKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AURKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKA Gene

Proteins for AURKA Gene

  • Protein details for AURKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14965-AURKA_HUMAN
    Recommended name:
    Aurora kinase A
    Protein Accession:
    O14965
    Secondary Accessions:
    • E1P5F9
    • O60445
    • O75873
    • Q9BQD6
    • Q9UPG5

    Protein attributes for AURKA Gene

    Size:
    403 amino acids
    Molecular mass:
    45809 Da
    Quaternary structure:
    • Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with PIFO. Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via C-terminus). Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with SIRT2.
    Miscellaneous:
    • Centrosome amplification can occur when the cycles are uncoupled, and this amplification is associated with cancer and with an increase in the levels of chromosomal instability.
    SequenceCaution:
    • Sequence=BAA23592.1; Type=Frameshift; Positions=105, 125, 129, 235, 241; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AURKA Gene

neXtProt entry for AURKA Gene

Post-translational modifications for AURKA Gene

  • Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis.
  • Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AURKA Gene

Domains & Families for AURKA Gene

Gene Families for AURKA Gene

Suggested Antigen Peptide Sequences for AURKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14965

UniProtKB/Swiss-Prot:

AURKA_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
genes like me logo Genes that share domains with AURKA: view

Function for AURKA Gene

Molecular function for AURKA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO.
UniProtKB/Swiss-Prot Function:
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
UniProtKB/Swiss-Prot Induction:
Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.

Enzyme Numbers (IUBMB) for AURKA Gene

Gene Ontology (GO) - Molecular Function for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IDA 14580337
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 19774610
GO:0005515 protein binding IPI 12244051
genes like me logo Genes that share ontologies with AURKA: view

Phenotypes for AURKA Gene

MGI mutant phenotypes for AURKA:
inferred from 6 alleles
GenomeRNAi human phenotypes for AURKA:
genes like me logo Genes that share phenotypes with AURKA: view

Animal Models for AURKA Gene

MGI Knock Outs for AURKA:

Animal Model Products

  • Taconic Biosciences Mouse Models for AURKA

CRISPR Products

miRNA for AURKA Gene

miRTarBase miRNAs that target AURKA

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AURKA Gene

Localization for AURKA Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKA Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). {ECO:0000250 UniProtKB:P97477, ECO:0000269 PubMed:17229885, ECO:0000269 PubMed:17726514, ECO:0000269 PubMed:21225229, ECO:0000269 PubMed:22014574, ECO:0000269 PubMed:9606188}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AURKA gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000780 condensed nuclear chromosome, centromeric region IBA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IDA,TAS 20531406
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with AURKA: view

Pathways & Interactions for AURKA Gene

genes like me logo Genes that share pathways with AURKA: view

SIGNOR curated interactions for AURKA Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000212 meiotic spindle organization IEA --
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0000278 mitotic cell cycle IEA,TAS 9153231
GO:0006468 protein phosphorylation IDA,TAS 21600873
genes like me logo Genes that share ontologies with AURKA: view

Drugs & Compounds for AURKA Gene

(67) Drugs for AURKA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea Experimental Pharma Target 0
1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea Experimental Pharma Target 0
1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea Experimental Pharma Target 0
2-(1H-pyrazol-3-yl)-1H-benzimidazole Experimental Pharma Target 0

(5) Additional Compounds for AURKA Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Hesperadin hydrochloride
422513-13-1
PF 03814735
942487-16-3
TC-S 7010
1158838-45-9

(5) Tocris Compounds for AURKA Gene

Compound Action Cas Number
Anacardic acid Noncompetitive PCAF/p300 inhibitor 16611-84-0
Hesperadin hydrochloride Potent Aurora kinase B inhibitor 422513-13-1
PF 03814735 Aurora kinase A and B inhibitor 942487-16-3
TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor 1245907-03-2
TC-S 7010 Potent and selective Aurora kinase A inhibitor 1158838-45-9

(30) ApexBio Compounds for AURKA Gene

Compound Action Cas Number
AMG-900 Aurora kinase inhibitor 945595-80-2
Anacardic acid HAT inhibitor 16611-84-0
AT9283 Aurora kinase/JAK inhibitor 896466-04-9
Aurora A Inhibitor I Aurora A inhibitor 1158838-45-9
Bendamustine HCl Cytostatic agent for non-Hodgkin lymphomas 3543-75-7
BI-847325 dual inhibitor of MEK and Aurora kinases 1207293-36-4
CCT129202 Aurora kinase inhibitor,ATP-competitive and potent 942947-93-5
CCT137690 Aurora A/B/C inhibitor 1095382-05-0
CYC116 Potent Aurora A/B inhibitor 693228-63-6
Danusertib (PHA-739358) Pan-aurora kinase inhibitor 827318-97-8
ENMD-2076 Selective Aurora A/Flt3 inhibitor 934353-76-1
ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor 1291074-87-7
GSK1070916 Aurora B/C inhibitor 942918-07-2
Hesperadin Aurora B kinase inhibitor 422513-13-1
JNJ-7706621 Potent CDK/Aurora kinase inhibitor 443797-96-4
KW 2449 Multikinase inhibitor 1000669-72-6
MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective 1010085-13-8
MK-8745 Aurora A inhibitor,potent and selective 885325-71-3
MLN8054 Aurora A inhibitor 869363-13-3
MLN8237 (Alisertib) Aurora A Kinase inhibitor, Potent and selective 1028486-01-2
PF-03814735 Aurora A/B inhibitor 942487-16-3
PHA-680632 Aurora kinase inhibitor,novel and potent 398493-79-3
Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor 656820-32-5
SCH-1473759 Aurora A/B inhibitor 1094069-99-4
SNS-314 Mesylate Aurora A/B/C kinases inhibitor, potent and selective 1146618-41-8
TAK-901 Novel Aurora A/B inhibitor 934541-31-8
TC-A 2317 hydrochloride Aurora kinase A inhibitor,potent and selective 1245907-03-2
VX-680 (MK-0457,Tozasertib) Aurora kinase inhibitor 639089-54-6
XL228 IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor 898280-07-4
ZM 447439 Aurora Kinase inhibitor,potent and selective 331771-20-1
genes like me logo Genes that share compounds with AURKA: view

Drug Products

Transcripts for AURKA Gene

Unigene Clusters for AURKA Gene

Aurora kinase A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AURKA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11: - -
SP12: - - -
SP13:
SP14: - - -
SP15: -
SP16: - -
SP17: - - - -
SP18: - - -

Relevant External Links for AURKA Gene

GeneLoc Exon Structure for
AURKA
ECgene alternative splicing isoforms for
AURKA

Expression for AURKA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AURKA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AURKA Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for AURKA Gene

This gene is overexpressed in Lung (49.6) and Breast (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AURKA Gene



Protein tissue co-expression partners for AURKA Gene

NURSA nuclear receptor signaling pathways regulating expression of AURKA Gene:

AURKA

SOURCE GeneReport for Unigene cluster for AURKA Gene:

Hs.250822

mRNA Expression by UniProt/SwissProt for AURKA Gene:

O14965-AURKA_HUMAN
Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.

Evidence on tissue expression from TISSUES for AURKA Gene

  • Intestine(4.5)
  • Blood(4.4)
  • Kidney(4.3)
  • Muscle(4.3)
  • Nervous system(2.6)
  • Liver(2.4)
genes like me logo Genes that share expression patterns with AURKA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AURKA Gene

Orthologs for AURKA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AURKA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AURKA 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia AURKA 34 35
  • 89.83 (n)
cow
(Bos Taurus)
Mammalia AURKA 34 35
  • 86.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AURKA 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aurka 34
  • 80.05 (n)
mouse
(Mus musculus)
Mammalia Aurka 34 16 35
  • 78.76 (n)
oppossum
(Monodelphis domestica)
Mammalia AURKA 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves AURKA 34 35
  • 70.94 (n)
lizard
(Anolis carolinensis)
Reptilia AURKA 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aurka 34
  • 63.41 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397925 34
zebrafish
(Danio rerio)
Actinopterygii aurka 34 35
  • 60.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta aur 34 35
  • 54.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001793 34
  • 53.39 (n)
worm
(Caenorhabditis elegans)
Secernentea air-2 34 35
  • 57.11 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPL1 35
  • 38 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AUR2 34
  • 62.41 (n)
rice
(Oryza sativa)
Liliopsida Os01g0191800 34
  • 59.36 (n)
Os.613 34
wheat
(Triticum aestivum)
Liliopsida Ta.7757 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4656 35
  • 65 (a)
OneToMany
Species where no ortholog for AURKA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AURKA Gene

ENSEMBL:
Gene Tree for AURKA (if available)
TreeFam:
Gene Tree for AURKA (if available)

Paralogs for AURKA Gene

Variants for AURKA Gene

Sequence variations from dbSNP and Humsavar for AURKA Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_041128 A colorectal adenocarcinoma sample
VAR_041129 A metastatic melanoma sample
rs2273535 other 56,386,485(+) AGGAA(A/T)TTGCT reference, missense
rs1000100584 -- 56,377,189(+) GGAGG(A/C)TCACT intron-variant
rs1000209810 -- 56,393,513(+) AACTG(A/G)ACATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AURKA Gene

Variant ID Type Subtype PubMed ID
esv1000250 CNV insertion 20482838
esv1411689 CNV insertion 17803354
esv3302688 CNV tandem duplication 20981092
esv3351171 CNV insertion 20981092
esv3402144 CNV insertion 20981092
esv990423 CNV insertion 20482838
nsv1117286 CNV tandem duplication 24896259
nsv179276 CNV insertion 16902084
nsv179472 CNV insertion 16902084
nsv834013 CNV gain 17160897
nsv964411 CNV duplication 23825009
nsv979444 CNV duplication 23825009

Variation tolerance for AURKA Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AURKA Gene

Human Gene Mutation Database (HGMD)
AURKA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AURKA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKA Gene

Disorders for AURKA Gene

MalaCards: The human disease database

(10) MalaCards diseases for AURKA Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
colorectal adenocarcinoma
  • adenocarcinoma of large intestine
postsurgical hypothyroidism
  • post-surgical hypothyroidism
prostate small cell carcinoma
  • prostate oat cell carcinoma
retinitis pigmentosa 62
  • rp62
- elite association - COSMIC cancer census association via MalaCards
Search AURKA in MalaCards View complete list of genes associated with diseases

Relevant External Links for AURKA

Genetic Association Database (GAD)
AURKA
Human Genome Epidemiology (HuGE) Navigator
AURKA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AURKA
genes like me logo Genes that share disorders with AURKA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AURKA Gene

Publications for AURKA Gene

  1. Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk. (PMID: 15867347) Kimura M.T. … Nagase H. (Cancer Res. 2005) 3 4 22 46 64
  2. Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese. (PMID: 16011022) Chen L. … Zhang X. (Yi Chuan Xue Bao 2005) 3 4 22 46 64
  3. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. (PMID: 9771714) Zhou H. … Sen S. (Nat. Genet. 1998) 2 3 4 22 64
  4. Aurora A, centrosome structure, and the centrosome cycle. (PMID: 19774610) Lukasiewicz K.B. … Lingle W.L. (Environ. Mol. Mutagen. 2009) 3 4 22 64
  5. Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. (PMID: 19551141) Ricketts C. … Maher E.R. (PLoS ONE 2009) 3 22 46 64

Products for AURKA Gene

  • Addgene plasmids for AURKA

Sources for AURKA Gene

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