Aliases for AURKA Gene
Aliases for AURKA Gene
- Aurora Kinase A 2 3 5
- Protein Phosphatase 1, Regulatory Subunit 47 2 3
- Serine/Threonine-Protein Kinase Aurora-A 3 4
- Serine/Threonine-Protein Kinase 6 3 4
- Breast Tumor-Amplified Kinase 3 4
- Aurora/IPL1-Related Kinase 1 3 4
- Aurora 2 3 4
- STK15 3 4
- STK6 3 4
- ARK1 3 4
- AURA 3 4
- BTAK 3 4
- AIK 3 4
- Serine/Threonine Protein Kinase 15 3
- Serine/Threonine-Protein Kinase 15 4
External Ids for AURKA Gene
- HGNC: 11393
- Entrez Gene: 6790
- Ensembl: ENSG00000087586
- OMIM: 603072
- UniProtKB: O14965
Previous HGNC Symbols for AURKA Gene
- STK15
- STK6
Previous GeneCards Identifiers for AURKA Gene
- GC20U900062
- GC20M055629
- GC20M054377
- GC20M054944
- GC20M051729
Summaries for AURKA Gene
-
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for AURKA Gene
AURKA (Aurora Kinase A) is a Protein Coding gene. Diseases associated with AURKA include Colorectal Cancer and Colorectal Adenocarcinoma. Among its related pathways are Regulation of TP53 Activity and PLK1 signaling events. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKB.
UniProtKB/Swiss-Prot for AURKA Gene
-
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
-
Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKA Gene
Genomics for AURKA Gene
Regulatory Elements for AURKA Gene
Enhancers for AURKA Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH20G056358 | 1.6 | FANTOM5 ENCODE dbSUPER | 13.7 | +31.0 | 30966 | 6.0 | HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A YBX1 ZNF2 YY1 | FAM210B AURKA CSTF1 GC20P056367 |
| GH20G056483 | 1 | Ensembl ENCODE dbSUPER | 10.7 | -91.6 | -91596 | 1.3 | CTCF RAD51 ZBTB40 | FAM209A RPL39P CSTF1 AURKA FAM210B LOC105372681 RTFDC1 |
| GH20G056448 | 0.7 | dbSUPER | 11.2 | -55.7 | -55740 | 1.8 | HDGF PKNOX1 TAL1 JUN ZIC2 FOSL1 TCF12 POLR2A NCOR1 SMARCE1 | RTFDC1 AURKA CSTF1 RPL39P CASS4 |
| GH20G056368 | 0.6 | dbSUPER | 12.3 | +23.3 | 23327 | 0.6 | POLR2H RAD51 POLR2A AGO1 USF2 SUPT5H | FAM210B AURKA CSTF1 GC20P056367 |
| GH20G056447 | 0.6 | dbSUPER | 11.2 | -55.2 | -55195 | 1.0 | ARID1B HDGF SP1 PKNOX1 NCOR1 ZBTB33 DPF2 ZIC2 ZNF592 | RTFDC1 AURKA CSTF1 RPL39P CASS4 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around AURKA on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the AURKA gene promoter:
Regulatory Element Products
Genomic Location for AURKA Gene
- Chromosome:
- 20
- Start:
- 56,369,389 bp from pter
- End:
- 56,392,337 bp from pter
- Size:
- 22,949 bases
- Orientation:
- Minus strand
Genomic View for AURKA Gene
Genes around AURKA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.2 by Ensembl
- 20q13.2 by Entrez Gene
- 20q13.2 by HGNC
AURKA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AURKA Gene
Proteins for AURKA Gene
-
Protein details for AURKA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14965-AURKA_HUMAN
- Recommended name:
- Aurora kinase A
- Protein Accession:
- O14965
- E1P5F9
- O60445
- O75873
- Q9BQD6
- Q9UPG5
Protein attributes for AURKA Gene
- Size:
- 403 amino acids
- Molecular mass:
- 45809 Da
- Quaternary structure:
-
- Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with PIFO. Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via C-terminus). Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with SIRT2.
- Miscellaneous:
-
- Centrosome amplification can occur when the cycles are uncoupled, and this amplification is associated with cancer and with an increase in the levels of chromosomal instability.
- SequenceCaution:
-
- Sequence=BAA23592.1; Type=Frameshift; Positions=105, 125, 129, 235, 241; Evidence={ECO:0000305};
Protein Expression for AURKA Gene
Post-translational modifications for AURKA Gene
- Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis.
- Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for AURKA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for AURKA
- R&D Systems Antibodies for AURKA (Aurora A)
- Cell Signaling Technology (CST) Antibodies for AURKA (AurA)
-
Custom Antibody ServicesOriGene Antibodies for AURKA
- AM06572SU-N
- AM06573SU-N
- AM20207PU-N
- AM20208PU-N
- TA353585
- TA352608
- TA352403
- TA347975
- TA346888
- TA336917
- TA336807
- TA335339
- TA333165
- TA329186
- TA328061
- TA328060
- TA327283
- TA325248
- TA325247
- TA302646
- SP2058P
- SM2084P
- SM2084B
- AP20206PU-N
- AP15874PU-T
- AP14756PU-N
- AP08036PU-S
- AP08036PU-N
- AP07516PU-N
- AP07481PU-N
- AP06626PU-N
- AM33229PU-S
- AM33229PU-N
- AM33229PU-M
- AM20483PU-N
- Novus Biologicals Antibodies for AURKA
-
Abcam antibodies for AURKA
- Invitrogen Antibodies for AURKA
- antibodies-online Antibodies for AURKA: See all 251
- GeneTex AURKA antibody for AURKA
-
Santa Cruz Biotechnology (SCBT) Antibodies for AURKA
Protein Products
- EMD Millipore Purified and/or Recombinant AURKA Protein
- Enzo Life Sciences proteins for AURKA
- Search Origene for MassSpec and Protein Over-expression Lysates for AURKA
- Origene Custom Protein Services for AURKA
- ProSpec Recombinant Proteins for AURKA
- antibodies-online Proteins for AURKA: See all 28
- Search antibodies-online for peptides
- Search GeneTex for Proteins for AURKA
-
Abcam proteins for AURKA
Assay Products
- antibodies-online Kits for AURKA: See all 1
No data available for DME Specific Peptides for AURKA Gene
Domains & Families for AURKA Gene
Gene Families for AURKA Gene
- HGNC:
- IUPHAR :
Protein Domains for AURKA Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AURKA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14965UniProtKB/Swiss-Prot:
AURKA_HUMAN :- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Function for AURKA Gene
Molecular function for AURKA Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO.
- UniProtKB/Swiss-Prot Function:
- Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
- UniProtKB/Swiss-Prot Induction:
- Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.
Enzyme Numbers (IUBMB) for AURKA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IDA | 14580337 |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | TAS | 19774610 |
| GO:0005515 | protein binding | IPI | 12244051 |
Phenotypes for AURKA Gene
- MGI mutant phenotypes for AURKA:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for AURKA:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability in esophageal squamous lineage
- Dynamic nuclei (hole, folded or small irregular)
- FOXO1 nuclear localization
- Increased G1 DNA content
- G0/1 arrest
- Transferrin accumulation in the perinuclear area
- Effect on mitosis
- Decreased viability
- Decreased substrate adherent cell growth
- Increased number of mitotic cells
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased Salmonella enterica Typhimurium invasion
- Decreased cell migration
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death HMECs cells
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased Nanog expression
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased cell proliferation
- Increased cell migration
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Synthetic lethal with paclitaxel
- Synthetic lethal with gemcitabine
- Decreased viability with SS1P at EC30
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Models for AURKA Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for AURKA
- Cyagen custom Knockout/knockin (KOKI) mouse models for AURKA
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AURKA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AURKA gene
- Search ViGene Biosciences for AURKA
CRISPR Products
-
OriGene CRISPR knockouts for AURKA
-
Santa Cruz Biotechnology (SCBT) CRISPR for AURKA
- GenScript: Design CRISPR guide RNA sequences for AURKA
miRNA for AURKA Gene
- miRTarBase miRNAs that target AURKA
-
- hsa-let-7b-5p (MIRT005051)
- hsa-mir-155-5p (MIRT020589)
- hsa-mir-124-3p (MIRT022391)
- hsa-mir-193a-3p (MIRT044891)
- hsa-mir-3918 (MIRT296432)
- hsa-mir-3127-5p (MIRT541456)
- hsa-mir-137 (MIRT541457)
- hsa-mir-4448 (MIRT541458)
- hsa-mir-6736-3p (MIRT541459)
- hsa-mir-154-5p (MIRT541460)
- hsa-mir-7843-5p (MIRT541461)
- hsa-mir-6735-5p (MIRT541462)
- hsa-mir-6879-5p (MIRT541463)
- hsa-mir-4632-5p (MIRT541464)
- hsa-mir-4436b-3p (MIRT541465)
- hsa-mir-6876-5p (MIRT541466)
- hsa-mir-4476 (MIRT541467)
- hsa-mir-367-3p (MIRT541468)
- hsa-mir-363-3p (MIRT541469)
- hsa-mir-92b-3p (MIRT541470)
- hsa-mir-25-3p (MIRT541471)
- hsa-mir-32-5p (MIRT541472)
- hsa-mir-92a-3p (MIRT541473)
- hsa-mir-7152-5p (MIRT559278)
- hsa-mir-4326 (MIRT559279)
- hsa-mir-24-3p (MIRT559280)
- hsa-mir-4284 (MIRT559281)
- hsa-mir-885-3p (MIRT559282)
- hsa-mir-149-5p (MIRT559283)
- hsa-mir-5699-3p (MIRT559284)
- hsa-mir-4421 (MIRT559285)
- hsa-mir-6748-3p (MIRT559286)
- hsa-mir-183-5p (MIRT559287)
- hsa-mir-8076 (MIRT559288)
- hsa-mir-6779-3p (MIRT559289)
- hsa-mir-578 (MIRT568349)
- hsa-mir-6734-5p (MIRT568350)
- hsa-mir-1226-5p (MIRT568351)
- hsa-mir-6834-5p (MIRT568352)
- hsa-mir-4777-5p (MIRT568353)
- hsa-mir-526a (MIRT568354)
- hsa-mir-523-5p (MIRT568355)
- hsa-mir-522-5p (MIRT568356)
- hsa-mir-520c-5p (MIRT568357)
- hsa-mir-519c-5p (MIRT568358)
- hsa-mir-519b-5p (MIRT568359)
- hsa-mir-519a-5p (MIRT568360)
- hsa-mir-518f-5p (MIRT568361)
- hsa-mir-518e-5p (MIRT568362)
- hsa-mir-518d-5p (MIRT568363)
- hsa-mir-4721 (MIRT568364)
- hsa-mir-3616-3p (MIRT568365)
- hsa-mir-581 (MIRT568366)
miRNA Products
- Search ViGene Biosciences for AURKA
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AURKA
- Browse OriGene Inhibitory RNA Products For AURKA
-
ViGene Biosciences ready-to-package AAV shRNAs for AURKA gene
Clone Products
-
OriGene ORF clones in human for AURKA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AURKA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for AURKA
- VectorBuilder custom plasmid, inducible vectors for AURKA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AURKA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for AURKA gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AURKA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AURKA gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AURKA Gene
Localization for AURKA Gene
Subcellular locations from UniProtKB/Swiss-Prot for AURKA Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). {ECO:0000250 UniProtKB:P97477, ECO:0000269 PubMed:17229885, ECO:0000269 PubMed:17726514, ECO:0000269 PubMed:21225229, ECO:0000269 PubMed:22014574, ECO:0000269 PubMed:9606188}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000780 | condensed nuclear chromosome, centromeric region | IBA | -- |
| GO:0000922 | spindle pole | IEA | -- |
| GO:0005634 | nucleus | IDA,TAS | 20531406 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for AURKA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 3 | Regulation of TP53 Activity | ||
| 4 | Cell Cycle, Mitotic |
.83
|
|
| 5 | Gene Expression |
.48
|
|
Pathways by source for AURKA Gene
1 GeneTex pathway for AURKA Gene
1 Cell Signaling Technology pathway for AURKA Gene
7 BioSystems pathways for AURKA Gene
1 KEGG pathway for AURKA Gene
4 GeneGo (Thomson Reuters) pathways for AURKA Gene
2 Qiagen pathways for AURKA Gene
Interacting Proteins for AURKA Gene
Selected Interacting proteins:
ENSP00000216911
O14965-AURKA_HUMAN
for AURKA Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for AURKA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0000212 | meiotic spindle organization | IEA | -- |
| GO:0000226 | microtubule cytoskeleton organization | IEA | -- |
| GO:0000278 | mitotic cell cycle | IEA,TAS | 9153231 |
| GO:0006468 | protein phosphorylation | IDA,TAS | 21600873 |
Drugs & Compounds for AURKA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| 1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea | Experimental | Pharma | Target | 0 | ||
| 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea | Experimental | Pharma | Target | 0 | ||
| 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea | Experimental | Pharma | Target | 0 | ||
| 2-(1H-pyrazol-3-yl)-1H-benzimidazole | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| Hesperadin hydrochloride |
|
422513-13-1 |
|
|
||
| PF 03814735 |
|
942487-16-3 |
|
|
||
| TC-S 7010 |
|
1158838-45-9 |
|
|
(5) Tocris Compounds for AURKA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Anacardic acid | Noncompetitive PCAF/p300 inhibitor | 16611-84-0 |
| Hesperadin hydrochloride | Potent Aurora kinase B inhibitor | 422513-13-1 |
| PF 03814735 | Aurora kinase A and B inhibitor | 942487-16-3 |
| TC-A 2317 hydrochloride | Potent, selective Aurora kinase A inhibitor | 1245907-03-2 |
| TC-S 7010 | Potent and selective Aurora kinase A inhibitor | 1158838-45-9 |
(30) ApexBio Compounds for AURKA Gene
| Compound | Action | Cas Number |
|---|---|---|
| AMG-900 | Aurora kinase inhibitor | 945595-80-2 |
| Anacardic acid | HAT inhibitor | 16611-84-0 |
| AT9283 | Aurora kinase/JAK inhibitor | 896466-04-9 |
| Aurora A Inhibitor I | Aurora A inhibitor | 1158838-45-9 |
| Bendamustine HCl | Cytostatic agent for non-Hodgkin lymphomas | 3543-75-7 |
| BI-847325 | dual inhibitor of MEK and Aurora kinases | 1207293-36-4 |
| CCT129202 | Aurora kinase inhibitor,ATP-competitive and potent | 942947-93-5 |
| CCT137690 | Aurora A/B/C inhibitor | 1095382-05-0 |
| CYC116 | Potent Aurora A/B inhibitor | 693228-63-6 |
| Danusertib (PHA-739358) | Pan-aurora kinase inhibitor | 827318-97-8 |
| ENMD-2076 | Selective Aurora A/Flt3 inhibitor | 934353-76-1 |
| ENMD-2076 L-(+)-Tartaric acid | Aurora kinases inhibitor | 1291074-87-7 |
| GSK1070916 | Aurora B/C inhibitor | 942918-07-2 |
| Hesperadin | Aurora B kinase inhibitor | 422513-13-1 |
| JNJ-7706621 | Potent CDK/Aurora kinase inhibitor | 443797-96-4 |
| KW 2449 | Multikinase inhibitor | 1000669-72-6 |
| MK-5108 (VX-689) | Aurora-A kinase inhibitor,highly selective | 1010085-13-8 |
| MK-8745 | Aurora A inhibitor,potent and selective | 885325-71-3 |
| MLN8054 | Aurora A inhibitor | 869363-13-3 |
| MLN8237 (Alisertib) | Aurora A Kinase inhibitor, Potent and selective | 1028486-01-2 |
| PF-03814735 | Aurora A/B inhibitor | 942487-16-3 |
| PHA-680632 | Aurora kinase inhibitor,novel and potent | 398493-79-3 |
| Reversine | A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor | 656820-32-5 |
| SCH-1473759 | Aurora A/B inhibitor | 1094069-99-4 |
| SNS-314 Mesylate | Aurora A/B/C kinases inhibitor, potent and selective | 1146618-41-8 |
| TAK-901 | Novel Aurora A/B inhibitor | 934541-31-8 |
| TC-A 2317 hydrochloride | Aurora kinase A inhibitor,potent and selective | 1245907-03-2 |
| VX-680 (MK-0457,Tozasertib) | Aurora kinase inhibitor | 639089-54-6 |
| XL228 | IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor | 898280-07-4 |
| ZM 447439 | Aurora Kinase inhibitor,potent and selective | 331771-20-1 |
Transcripts for AURKA Gene
mRNA/cDNA for AURKA Gene
- (11) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (258) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for AURKA
-
Santa Cruz Biotechnology (SCBT) CRISPR for AURKA
- GenScript: Design CRISPR guide RNA sequences for AURKA
miRNA Products
- Search ViGene Biosciences for AURKA
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AURKA
- Browse OriGene Inhibitory RNA Products For AURKA
-
ViGene Biosciences ready-to-package AAV shRNAs for AURKA gene
Clone Products
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OriGene ORF clones in human for AURKA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AURKA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for AURKA
- VectorBuilder custom plasmid, inducible vectors for AURKA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AURKA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP18: | - | - | - |
Expression for AURKA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for AURKA Gene
This gene is overexpressed in Testis (x5.8).
This gene is overexpressed in Lung (49.6) and Breast (18.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AURKA Gene
NURSA nuclear receptor signaling pathways regulating expression of AURKA Gene:
AURKASOURCE GeneReport for Unigene cluster for AURKA Gene:
Hs.250822mRNA Expression by UniProt/SwissProt for AURKA Gene:
O14965-AURKA_HUMAN
Tissue specificity:
Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Evidence on tissue expression from TISSUES for AURKA Gene
- Intestine(4.5)
- Blood(4.4)
- Kidney(4.3)
- Muscle(4.3)
- Nervous system(2.6)
- Liver(2.4)
Primer Products
-
OriGene qPCR primer pairs for AURKA
-
OriGene qPCR primer pairs and template standards for AURKA
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AURKA Gene
Orthologs for AURKA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AURKA 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | AURKA 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | AURKA 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | AURKA 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Aurka 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Aurka 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AURKA 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AURKA 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | AURKA 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | aurka 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397925 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | aurka 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | aur 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001793 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | air-2 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IPL1 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AUR2 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0191800 34 |
|
||
| Os.613 34 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.7757 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4656 35 |
|
OneToMany |
- Species where no ortholog for AURKA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for AURKA Gene
(49) SIMAP similar genes for AURKA Gene using alignment to 7 proteins:
- AURKC
- AURKB
- MARK4
- RPS6KA2
- PLK4
- Par1b
- ULK3
- STK36
- SNRK
- RPS6KB2
- MARK2
- RPS6KA3
- NUAK1
- PRKACG
- PRKACA
- MARK1
- KIN27
- RPS6KB1
- SIK3
- PRKACB
- SGK2
- RPS6KA6
- STK11
- CAMK1
- MARK3
- KIAA0999
- PNCK
- DKFZp564L2416
- RPS6KA1
- TSSK6
- TSSK3
- PRKAA1
- CDK4
- CAMK1D
- PDPK1
- TSSK4
- PDPK2
- MGC45428
- DCLK2
- PRKX
- DCLK3
- PRKY
- PRKCQ
- CDK5
- PkB-like 1
- AKT2
- NEK7
- NEK6
- CDK1
Pseudogenes.org Pseudogenes for AURKA Gene
Variants for AURKA Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_041128 | A colorectal adenocarcinoma sample | ||||
| VAR_041129 | A metastatic melanoma sample | ||||
| rs2273535 | other | 56,386,485(+) | AGGAA(A/T)TTGCT | reference, missense | |
| rs1000100584 | -- | 56,377,189(+) | GGAGG(A/C)TCACT | intron-variant | |
| rs1000209810 | -- | 56,393,513(+) | AACTG(A/G)ACATT | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1000250 | CNV | insertion | 20482838 |
| esv1411689 | CNV | insertion | 17803354 |
| esv3302688 | CNV | tandem duplication | 20981092 |
| esv3351171 | CNV | insertion | 20981092 |
| esv3402144 | CNV | insertion | 20981092 |
| esv990423 | CNV | insertion | 20482838 |
| nsv1117286 | CNV | tandem duplication | 24896259 |
| nsv179276 | CNV | insertion | 16902084 |
| nsv179472 | CNV | insertion | 16902084 |
| nsv834013 | CNV | gain | 17160897 |
| nsv964411 | CNV | duplication | 23825009 |
| nsv979444 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.77;
33.46% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for AURKA Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKA Gene
Disorders for AURKA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer |
|
|
| colorectal adenocarcinoma |
|
|
| postsurgical hypothyroidism |
|
|
| prostate small cell carcinoma |
|
|
| retinitis pigmentosa 62 |
|
|
Search AURKA in MalaCards
View complete list of genes associated with diseases
Relevant External Links for AURKA
No data available for UniProtKB/Swiss-Prot and Genatlas for AURKA Gene
Publications for AURKA Gene
- Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk. (PMID: 15867347) Kimura M.T. … Nagase H. (Cancer Res. 2005) 3 4 22 46 64
- Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese. (PMID: 16011022) Chen L. … Zhang X. (Yi Chuan Xue Bao 2005) 3 4 22 46 64
- Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. (PMID: 9771714) Zhou H. … Sen S. (Nat. Genet. 1998) 2 3 4 22 64
- Aurora A, centrosome structure, and the centrosome cycle. (PMID: 19774610) Lukasiewicz K.B. … Lingle W.L. (Environ. Mol. Mutagen. 2009) 3 4 22 64
- Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. (PMID: 19551141) Ricketts C. … Maher E.R. (PLoS ONE 2009) 3 22 46 64
Products for AURKA Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for AURKA
- EMD Millipore Purified and/or Recombinant AURKA Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for AURKA (Aurora A)
- Browse R&D Systems for Human Recombinant Proteins
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- Custom Antibody ServicesOriGene Antibodies for AURKA
- AM06572SU-N
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- AM33229PU-S
- AP06626PU-N
- AP07481PU-N
- AP07516PU-N
- AP08036PU-N
- AP08036PU-S
- AP14756PU-N
- AP15874PU-T
- AP20206PU-N
- SM2084B
- SM2084P
- SP2058P
- TA302646
- TA325247
- TA325248
- TA327283
- TA328060
- TA328061
- TA329186
- TA333165
- TA335339
- TA336807
- TA336917
- TA346888
- TA347975
- TA352403
- TA352608
- TA353585
- Browse OriGene ELISA Kits
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- Browse OriGene Inhibitory RNA Products For AURKA
- OriGene qPCR primer pairs and template standards for AURKA
- OriGene qPCR primer pairs for AURKA
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for AURKA in any vector
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- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for AURKA
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- Enzo Life Sciences proteins for AURKA
- Browse Enzo Life Sciences for kits & assays
- Enzo Life Sciences drugs & compounds for AURKA
- Search Enzo Life Sciences for proteins, assays, substrates, inhibitors & antibodies
- Novus Biologicals Antibodies for AURKA
- Novus Biologicals proteins and lysates for AURKA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for AURKA
- Abcam proteins for AURKA
- Search for Assays for AURKA at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for AURKA
- Taconic Biosciences Mouse Models for AURKA
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for AURKA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- Addgene plasmids for AURKA
- antibodies-online Antibodies for AURKA: See all 251
- antibodies-online Kits for AURKA: See all 1
- antibodies-online Proteins for AURKA: See all 28
- Search antibodies-online for peptides
- GeneTex AURKA antibody for AURKA
- Search GeneTex for Proteins for AURKA
- ViGene Biosciences adenoviral particle packaged cDNA for AURKA gene
- ViGene Biosciences lentiviral particle packaged cDNA for AURKA gene
- ViGene Biosciences ready-to-package AAV shRNAs for AURKA gene
- Search ViGene Biosciences for AURKA
- Santa Cruz Biotechnology (SCBT) Antibodies for AURKA
- Search Santa Cruz Biotechnology (SCBT) for AURKA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AURKA
- Cyagen custom Knockout/knockin (KOKI) mouse models for AURKA
- VectorBuilder custom plasmid, inducible vectors for AURKA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AURKA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AURKA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer