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AURKA Gene

protein-coding   GIFtS: 73
GCID: GC20M054944

Aurora Kinase A

(Previous names: serine/threonine kinase 15, serine/threonine kinase 6)
(Previous symbols: STK15, STK6)
  See AURKA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aurora Kinase A1 2     hARK12 3
STK151 2 3 5     AURORA22 5
STK61 2 3 5     Protein Phosphatase 11
AIK2 3 5     Regulatory Subunit 471
ARK12 3 5     Serine/Threonine Kinase 151
BTAK2 3 5     PPP1R472
Serine/Threonine Kinase 61 2     STK72
Aurora-A Kinase1 2     Aurora/IPL1-Like Kinase2
Aurora 22 3     Breast-Tumor-Amplified Kinase2
Aurora-Related Kinase 12 3     IPL1-Related Kinase2
Aurora/IPL1-Related Kinase 12 3     Protein Phosphatase 1, Regulatory Subunit 472
Breast Tumor-Amplified Kinase2 3     Serine/Threonine Protein Kinase 152
Serine/Threonine-Protein Kinase 152 3     AIRK13
Serine/Threonine-Protein Kinase 62 3     AYK13
Serine/Threonine-Protein Kinase Aurora-A2 3     EC 2.7.11.13
ARK-12 3     IAK13
AURA2 3     

External Ids:    HGNC: 113931   Entrez Gene: 67902   Ensembl: ENSG000000875867   OMIM: 6030725   UniProtKB: O149653   

Export aliases for AURKA gene to outside databases

Previous GC identifers: GC20U900062 GC20M055629 GC20M054377 GC20M051729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AURKA Gene:
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule
formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at
the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor
development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an
unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein
have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for AURKA Gene:
AURKA (aurora kinase A) is a protein-coding gene. Diseases associated with AURKA include colon cancer, and atypical teratoid rhabdoid tumor. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is STK36.

UniProtKB/Swiss-Prot: AURKA_HUMAN, O14965
Function: Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression.
Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various
mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as
well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial
activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1,
CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A
tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during
neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory
component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic
transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the
protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly
prior to mitosis

summary for AURKA Gene:
Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in
regulating many of the processes that are pivotal to mitosis. Each isoform, Aurora A, Aurora B and Aurora C,
has a different function in the control of mitosis. Aurora A is involved in regulating many of the early
mitotic events, including entry into mitosis. Aurora A levels rise during the G2 phase and peak early in
mitosis. One target of aurora A is cdc25b, a direct regulator of the cyclin B1-Cdk1 complex, which provides
the basis for the role this enzyme plays in regulating entry into mitosis. Aurora A regulates centrosome
maturation by moderating the recruitment of proteins, such as TPX-2, Ajuba, Bora and Lats, which are
themselves essential for accumulating microtubule spindle components, such as gamma-tubulin. Aurora A is
also associated with separation of centrosomes, through phosphorylation of the kinesin motor protein, Eg5.
In addition, this enzyme regulates the microtubule network that forms mitotic spindles, through regulation
of the EXTAH multiprotein complex. Since their discovery in the 1990s, Aurora kinases have been strongly
linked to the progression of human cancers. Aurora A maps to human chromosome 20q13 and Aurora B to human
chromosome 17q13.1, which are loci altered frequently in human cancers. Overexpression of Aurora A and B is
seen in many cancers, but these enzymes are not oncoproteins, as concomitant oncogenic mutations are
required to promote tumor progression. Aurora kinase inhibitors are an intense area of research for the
development of anticancer therapies.

Gene Wiki entry for AURKA (Aurora A kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AURKA gene promoter:
         NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAURKA promoter sequence
   Search Chromatin IP Primers for AURKA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AURKA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.2   HGNC cytogenetic band: 20q13

AURKA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AURKA gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M054944:  view genomic region     (about GC identifiers)

Start:
54,944,445 bp from pter      End:
54,967,393 bp from pter
Size:
22,949 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AURKA_HUMAN, O14965 (See protein sequence)
Recommended Name: Aurora kinase A  
Size: 403 amino acids; 45809 Da
Subunit: Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the
protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2,
BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with
PIFO. Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via
C-terminus). Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates
AURKA-mediated PLK1 phosphorylation
Miscellaneous: Centrosome amplification can occur when the cycles are uncoupled, and this amplification is
associated with cancer and with an increase in the levels of chromosomal instability
Caution: Authors initially considered AURKA/STK6 and STK15 as 2 different proteins (PubMed:9771714). It is clear
that they are the same protein
Sequence caution: Sequence=BAA23592.1; Type=Frameshift; Positions=105, 125, 129, 235, 241;
Selected PDB 3D structures from and Proteopedia for AURKA (see all 70):
1MQ4 (3D)        1MUO (3D)        1OL5 (3D)        1OL6 (3D)        1OL7 (3D)        2BMC (3D)    
Secondary accessions: E1P5F9 O60445 O75873 Q9BQD6 Q9UPG5

Explore the universe of human proteins at neXtProt for AURKA: NX_O14965

Explore proteomics data for AURKA at MOPED

Post-translational modifications: 

  • Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment.
    Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at
    Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein
    phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis.
    Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51
    at the end of mitosis1
  • Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by
    the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity).
    Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome1
  • Ubiquitination2 at Lys143
  • Modification sites at PhosphoSitePlus

  • See AURKA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_003591.2  NP_940835.1  NP_940836.1  NP_940837.1  NP_940838.1  NP_940839.1  

    ENSEMBL proteins: 
     ENSP00000360407   ENSP00000216911   ENSP00000379247   ENSP00000321591   ENSP00000379251  
     ENSP00000379249   ENSP00000379243   ENSP00000393452   ENSP00000388073   ENSP00000405042  
     ENSP00000405170   ENSP00000401358   ENSP00000379245   ENSP00000379250  
    Reactome Protein details: O14965

    AURKA Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for AURKA
    Cloud-Clone Corp. Proteins for AURKA

     
    Search eBioscience for Proteins for AURKA 

     
    antibodies-online proteins for AURKA (24 products) 

     
    antibodies-online peptides for AURKA

    AURKA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AURKA
    R&D Systems Antibodies for AURKA (Aurora A)
    Cell Signaling Technology (CST) Antibodies for AURKA  (AurA)
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    Abcam antibodies for AURKA (Q96GD4, O14965)
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    ThermoFisher Antibody for AURKA
    antibodies-online antibodies for AURKA (184 products) 

    AURKA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
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    antibodies-online kits for AURKA (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    IUPHAR Guide to PHARMACOLOGY protein family classification: aurora kinase A
    Aurora kinase (Aur) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O14965

    ProtoNet protein and cluster: O14965

    UniProtKB/Swiss-Prot: AURKA_HUMAN, O14965
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with AURKA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AURKA_HUMAN, O14965
    Function: Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression.
    Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various
    mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as
    well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial
    activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1,
    CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A
    tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during
    neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory
    component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic
    transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the
    protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly
    prior to mitosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase
    inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and
    p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and
    selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO
    Induction: Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA14580337
    GO:0004674protein serine/threonine kinase activity EXP--
    GO:0004712protein serine/threonine/tyrosine kinase activity TAS19774610
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12244051
         
    Find genes that share ontologies with AURKA           About GenesLikeMe


    Phenotypes:
         11 GenomeRNAi human phenotypes for AURKA:
     Cell division defect  Decreased Salmonella enterica   Decreased cell number, increas  Decreased substrate adherent c 
     Increased cell death in HCT116  Increased cell death in breast  Increased colony dispersion (i  Increased gamma-H2AX phosphory 
     Increased number of cells in m  Increased number of mitotic ce  Synthetic lethal with paclitax 

         6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Aurka):
     cellular  embryogenesis  growth/size/body  mortality/aging  no phenotypic analysis 
     tumorigenesis 

    Find genes that share phenotypes with AURKA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for AURKA: Aurkatm1.2Sbsn Aurkatm1.2Tvd

       genOway: Develop your customized and physiologically relevant rodent model for AURKA

    miRNA
    Products:
        
    miRTarBase miRNAs that target AURKA:
    hsa-mir-193a-3p (MIRT044891), hsa-mir-124-3p (MIRT022391), hsa-let-7b-5p (MIRT005051), hsa-mir-155-5p (MIRT020589)

    Block miRNA regulation of human, mouse, rat AURKA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AURKA (see all 9):
    hsa-miR-222* hsa-miR-137 hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-363 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidAURKA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AURKA

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AURKA_HUMAN, O14965: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
    spindle pole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the
    centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from
    prophase to anaphase. Moves to the midbody during both telophase and cytokinesis. Associates with both the
    pericentriolar material (PCM) and centrioles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005813centrosome TAS19774610
    GO:0005819spindle TAS19774610
    GO:0005829cytosol TAS--
    GO:0005876spindle microtubule IDA19801554

    Find genes that share ontologies with AURKA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AURKA About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G10.93
    Regulation of mitotic cell cycle0.94
    2Regulation of PLK1 Activity at G2/M Transition
    Regulation of PLK1 Activity at G2/M Transition0.77
    Mitotic G2-G2/M phases0.69
    G2/M Transition0.70
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Aurora B signaling
    Aurora B signaling
    Signaling by Aurora kinases0.00
    5Oocyte meiosis
    Oocyte meiosis0.35


    Find genes that share SuperPaths with AURKA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AURKA
        Molecular Mechanisms of Cancer
    Sperm Motility

    1 Cell Signaling Technology (CST) Pathway for AURKA
        Cell Cycle / Checkpoint Control

    4 GeneGo (Thomson Reuters) Pathways for AURKA
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Chromosome condensation in prometaphase
    Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling RalA regulation pathway

    Selected BioSystems Pathways for AURKA (see all 6)
        Integrated Breast Cancer Pathway
    Gastric cancer network 1
    Aurora A signaling
    PLK1 signaling events
    Aurora B signaling


    2 Reactome Pathways for AURKA
        Regulation of PLK1 Activity at G2/M Transition
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1


    1 Kegg Pathway  (Kegg details for AURKA):
        Oocyte meiosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AURKA: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AURKA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AURKA (O149651, 2, 3 ENSP000002169114) via UniProtKB, MINT, STRING, and/or I2D (see all 837)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPKP619781, 2, 3, ENSP000003654394EBI-448680,EBI-304185 MINT-7945693 MINT-8200625 MINT-8200636 MINT-8201404 I2D: score=1 STRING: ENSP00000365439
    MBD3O959832, 3, ENSP000001568254MINT-7945693 I2D: score=3 STRING: ENSP00000156825
    UBE2NP610882, 3, ENSP000003161764MINT-7945693 I2D: score=3 STRING: ENSP00000316176
    AURKAIP1Q9NWT81, 3, ENSP000003197784EBI-448680,EBI-448665 I2D: score=2 STRING: ENSP00000319778
    MYCNP041981, 3, ENSP000002810434EBI-448680,EBI-878369 I2D: score=2 STRING: ENSP00000281043
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006468protein phosphorylation IDA--
    GO:0007049cell cycle NAS15504738
    GO:0007051spindle organization NAS15504738

    Find genes that share ontologies with AURKA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for AURKA (see all 28)     About this table
    CompoundAction CAS #
    AMG-900potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C[945595-80-2]
    Anacardic acidselectively activate Aurora kinase A-mediated phosphorylation of histone H3[16611-84-0]
    AT9283novel inhibitor of aurora kinase[896466-04-9]
    Aurora A Inhibitor Inovel, potent, and selective inhibitor of Aurora A[1158838-45-9]
    AZD1152selective Aurora B kinase inhibitor[722543-31-9]
    Barasertib (AZD1152-HQPA)potent aurora kinase inhibitor[722544-51-6]
    CCT129202ATP-competitively inhibits Aurora A, Aurora B and Aurora C[942947-93-5]
    CCT137690highly selective inhibitor of Aurora A, Aurora B and Aurora C[1095382-05-0]
    CYC116potent inhibitor of Aurora A/B[693228-63-6]
    Danusertib (PHA-739358)potent small-molecule inhibitor of aurora B kinase[827318-97-8]

    Compounds for AURKA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Anacardic acidNoncompetitive PCAF/p300 HAT inhibitor[16611-84-0]
    SNS 314 mesylatePotent pan-Aurora kinase inhibitor[1146618-41-8]
    TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor [1245907-03-2]
    CCT 137690Potent pan-Aurora kinase inhibitor[1095382-05-0]
    Hesperadin hydrochloridePotent Aurora kinase B inhibitor[422513-13-1]

    2 HMDB Compounds for AURKA    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected DrugBank Compounds for AURKA (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Phosphonothreonine-- --target--17139284 17016423
    1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea-- --target--10592235
    1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea-- --target--10592235
    1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea-- --target--10592235
    2-(1H-pyrazol-3-yl)-1H-benzimidazole-- --target--10592235
    4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE-- --target--10592235
    8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4',3':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one-- --target--10592235
    N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE-- --target--10592235
    N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide-- --target--10592235

    6 Novoseek inferred chemical compound relationships for AURKA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 74.2 30 17219423 (1), 17898866 (1), 19669217 (1), 12591738 (1) (see all 27)
    serine 64.1 30 17219423 (1), 17898866 (1), 19669217 (1), 12591738 (1) (see all 27)
    taxane 50.5 4 17634533 (2)
    paclitaxel 15.5 2 17634533 (1), 19107951 (1)
    estrogen 0 5 15601761 (2), 15598762 (1), 18497064 (1)
    aspartate 0 1 12208850 (1)



    Find genes that share compounds with AURKA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for AURKA gene (6 alternative transcripts): 
    NM_003600.2  NM_198433.1  NM_198434.1  NM_198435.1  NM_198436.1  NM_198437.1  

    Unigene Cluster for AURKA:

    Aurora kinase A
    Hs.250822  [show with all ESTs]
    Unigene Representative Sequence: NM_198433
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371356 ENST00000347343 ENST00000395911 ENST00000312783 ENST00000395915
    ENST00000395913 ENST00000395907 ENST00000441357 ENST00000420474 ENST00000422322
    ENST00000456249 ENST00000451915 ENST00000395909(uc002xxd.1 uc002xxi.1 uc002xxj.1)
    ENST00000395914(uc002xxe.1 uc002xxf.1 uc002xxg.1 uc002xxh.1 uc010zzd.1)

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    hsa-miR-222* hsa-miR-137 hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-363 hsa-miR-92b
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      QuantiFast Probe-based Assays in human, mouse, rat AURKA

    Additional mRNA sequence: 

    AF008551.1 AF011468.1 AK301769.1 AK312776.1 BC001280.1 BC002499.2 BC006423.1 BC027464.1 

    12 DOTS entries:

    DT.100685783  DT.101984387  DT.453145  DT.95311156  DT.97845478  DT.97845474  DT.100791978  DT.100029011 
    DT.100759768  DT.102838438  DT.92439587  DT.120832467 

    Selected AceView cDNA sequences (see all 258):

    NM_198437 AV702128 NM_198434 CR621289 AI038260 BM834359 Z39943 AA375986 
    BC006423 NM_198435 NM_198433 AI738674 NM_198436 AF011468 AI266728 AF008551 
    CB159790 AU124236 BQ277355 BQ435059 BM790362 AI638439 BC027464 W80533 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AURKA (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14
    SP1:                                -     -     -     -     -                                                                                                   
    SP2:                          -     -                 -     -                                                                                                   
    SP3:                          -     -     -     -     -     -                                                                                                   
    SP4:                                -     -     -           -                                                                                                   
    SP5:                                -                 -     -                                                                                                   


    ECgene alternative splicing isoforms for AURKA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    AURKA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTAAACT
    AURKA Expression
    About this image


    AURKA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
    AURKA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AURKA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250822

    UniProtKB/Swiss-Prot: AURKA_HUMAN, O14965
    Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly
    expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AURKA: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AURKA gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aurka1 , 5 aurora kinase A1, 5 78.76(n)1
    84.26(a)1
      2 (94.84 cM)5
    208781  NM_011497.31  NP_035627.11 
     1723561905 
    chicken
    (Gallus gallus)
    Aves AURKA1 aurora kinase A 70.94(n)
    75.38(a)
      428167  XM_425725.4  XP_425725.1 
    lizard
    (Anolis carolinensis)
    Reptilia AURKA6
    aurora kinase A
    57(a)
    1 ↔ 1
    GL343217.1(2066971-2081521)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979252 p46Eg265 75.97(n)    Z17207.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aurka1 aurora kinase A 60.95(n)
    63.32(a)
      445246  NM_001003640.2  NP_001003640.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta aur1 aurora 54.29(n)
    53.14(a)
      41446  NM_057401.4  NP_476749.1 
    worm
    (Caenorhabditis elegans)
    Secernentea air-21 air-2 57.11(n)
    62.13(a)
      172268  NM_059313.5  NP_491714.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IPL16
    Aurora kinase subunit of the conserved chromosomal...
    38(a)
    1 → many
    XVI(156490-157593) YPL209C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AUR21 AUR2 62.41(n)
    66.17(a)
      817129  NM_128148.3  NP_180159.2 
    rice
    (Oryza sativa)
    Liliopsida Os.6132 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.41(n)    AK061360.1 


    ENSEMBL Gene Tree for AURKA (if available)
    TreeFam Gene Tree for AURKA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AURKA gene
    STK362  AURKC2  AURKB2  
    Selected SIMAP similar genes for AURKA using alignment to 7 protein entries:     AURKA_HUMAN (see all proteins) (see all similar genes):
    AURKC    AURKB    MARK4    RPS6KA2    PLK4    Par1b
    RPS6KB2    SNRK    STK36    ULK3    MARK2    RPS6KA3
    NUAK1    PRKACG    MARK1    PRKACA    KIN27    RPS6KB1

    Find genes that share paralogs with AURKA           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for AURKA
    PGOHUM00000238628 PGOHUM00000244426 PGOHUM00000233556


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AURKA (see all 596)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0411294
    A metastatic melanoma sample4--see VAR_0411292 V M mis40--------
    VAR_0411284
    A colorectal adenocarcinoma sample4--see VAR_0411282 S R mis40--------
    rs22735351,2,,4
    C,F,Hother154931178(+) AGGAAA/TTTGCT 12 I F mis127Minor allele frequency- T:0.21NS EA NA MN WA CSA EU 7429
    rs746566581,2
    C,F--54913605(+) AACTAT/CAGCTT 6 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1875596811,2
    C--54913646(+) GTCAAA/GGTCAG 6 -- ds50010--------
    rs60248361,2
    C,F,A,H--54913705(+) TGGCAA/GCTGCA 6 -- ds500121Minor allele frequency- G:0.44NS EA NA WA CSA 2346
    rs169798231,2
    C,F--54913851(+) CACTTC/ATACTT 6 -- ds50017Minor allele frequency- A:0.02NA WA 266
    rs1421652391,2
    --54913902(+) GGACAC/GATGAC 6 -- ds50010--------
    rs1512308701,2
    --54914021(+) CAGCCC/TCTGCT 6 -- ds50010--------
    rs351065071,2
    C,F--54914050(-) ACCATC/GTGTTC 6 -- ds50018Minor allele frequency- G:0.08MN NA WA 512

    HapMap Linkage Disequilibrium report for AURKA (54944445 - 54967393 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for AURKA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv179472CNV Insertion16902084
    esv1411689CNV Insertion17803354
    esv990423CNV Insertion20482838
    nsv179276CNV Insertion16902084
    esv1000250CNV Insertion20482838
    nsv834013CNV Gain17160897
    esv259662OTHER Complex20981092

    Human Gene Mutation Database (HGMD): AURKA
    Site Specific Mutation Identification with PCR Assays
    3 Copy Number PCR Panels containing AURKA:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing AURKA
    DNA2.0 Custom Variant and Variant Library Synthesis for AURKA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603072   
    OMIM disorders: 114500  
    8 diseases for AURKA:    
    About MalaCards
    colon cancer    atypical teratoid rhabdoid tumor    laryngeal carcinoma    laryngeal squamous cell carcinoma
    neuroblastoma, susceptibility    colorectal cancer    neuroblastoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for AURKA:
    Measles

    Find genes that share disorders with AURKA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AURKA gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    laryngeal squamous cell carcinoma 60.4 12 12812651 (3), 16767676 (2), 17974987 (1), 12693093 (1) (see all 6)
    cancer 52.6 55 17895985 (4), 17634533 (2), 16737620 (2), 18667445 (2) (see all 34)
    tumors 48.6 83 12208897 (5), 14692019 (4), 19232520 (4), 17465238 (4) (see all 36)
    solid tumor 37.3 2 20124450 (1), 9606188 (1)
    chromosomal aberrations 33 4 18931650 (2), 16377583 (1)
    laryngeal carcinoma 31.6 12 12693093 (4), 15192826 (4), 16377583 (2)
    ovarian cancer 31.3 14 15839305 (4), 15466974 (3), 17895985 (1), 15880741 (1) (see all 6)
    bladder cancer 28 28 18812553 (5), 17786310 (4), 12208897 (3), 18361427 (1) (see all 5)
    colorectal cancer 25 7 16737620 (3), 9606188 (1), 17003782 (1), 19412426 (1) (see all 5)
    primary tumor 24.1 3 11190269 (1), 12631597 (1)

    Genetic Association Database (GAD): AURKA
    Human Genome Epidemiology (HuGE) Navigator: AURKA (53 documents)

    Export disorders for AURKA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AURKA gene, integrated from 10 sources (see all 521):
    (articles sorted by number of sources associating them with AURKA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese. (PubMed id 16011022)1, 2, 4, 9 Chen L.... Zhang X. (Yi Chuan Xue Bao 2005)
    2. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. (PubMed id 9771714)1, 2, 3, 9 Zhou H.... Sen S. (Nat. Genet. 1998)
    3. Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk. (PubMed id 15867347)1, 2, 4, 9 Kimura M.T....Nagase H. (Cancer Res. 2005)
    4. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. (PubMed id 14702041)1, 2, 9 Katayama H.... Sen S. (Nat. Genet. 2004)
    5. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. (PubMed id 9153231)1, 2, 9 Kimura M....Okano Y. (J. Biol. Chem. 1997)
    6. Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. (PubMed id 11551964)1, 2, 9 Katayama H.... Sen S. (J. Biol. Chem. 2001)
    7. Functional polymorphism 57Val&gt;Ile of aurora kinase A associated with increased risk of gastric cancer progression. (PubMed id 16412566)1, 4, 9 Ju H....Kang C. (Cancer Lett. 2006)
    8. Synergistic effects of STK15 gene polymorphisms and endogenous estrogen exposure in the risk of breast cancer. (PubMed id 15598762)1, 4, 9 Dai Q....Zheng W. (amp 2004)
    9. STK15 polymorphism and breast cancer risk in a population-based study. (PubMed id 15271853)1, 4, 9 Egan K.M....Nagase H. (Carcinogenesis 2004)
    10. STK15 polymorphisms and association with risk of invasive ovarian cancer. (PubMed id 15466974)1, 4, 9 Dicioccio R.A....Kruger-Kjaer S. (amp 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6790 HGNC: 11393 AceView: STK6 Ensembl:ENSG00000087586 euGenes: HUgn6790
    ECgene: AURKA Kegg: 6790 H-InvDB: AURKA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AURKA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AURKA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AURKA gene:
    Search GeneIP for patents involving AURKA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Block miRNA regulation of human, mouse, rat AURKA using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AURKA
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     PCR Arrays including human, mouse, rat AURKA Search Chromatin IP Primers for AURKA
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AURKA  GeneGlobe Interaction Network for AURKA
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     Antibodies & Assays for AURKA  (AurA)

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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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      Search eBioscience for proteins for AURKA
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     genOway: Develop your customized and physiologically relevant rodent model for AURKA
     antibodies-online antibodies for AURKA (184 products)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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