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Aliases for AUP1 Gene

Aliases for AUP1 Gene

  • Ancient Ubiquitous Protein 1 2 3 5

External Ids for AUP1 Gene

Previous GeneCards Identifiers for AUP1 Gene

  • GC02M074891
  • GC02M074966
  • GC02M074711
  • GC02M074728
  • GC02M074665
  • GC02M074607
  • GC02M074753
  • GC02M074490

Summaries for AUP1 Gene

Entrez Gene Summary for AUP1 Gene

  • The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for AUP1 Gene

AUP1 (Ancient Ubiquitous Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AUP1 Gene

  • May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.

Gene Wiki entry for AUP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AUP1 Gene

Genomics for AUP1 Gene

Regulatory Elements for AUP1 Gene

Enhancers for AUP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AUP1 on UCSC Golden Path with GeneCards custom track

Promoters for AUP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AUP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AUP1 Gene

74,526,645 bp from pter
74,529,939 bp from pter
3,295 bases
Minus strand

Genomic View for AUP1 Gene

Genes around AUP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AUP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AUP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AUP1 Gene

Proteins for AUP1 Gene

  • Protein details for AUP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ancient ubiquitous protein 1
    Protein Accession:
    Secondary Accessions:
    • C0H5W8
    • Q9H866
    • Q9UNQ6
    • Q9Y685

    Protein attributes for AUP1 Gene

    476 amino acids
    Molecular mass:
    53028 Da
    Quaternary structure:
    • Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM.
    • Sequence=AAH33646.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AUP1 Gene

    Alternative splice isoforms for AUP1 Gene


neXtProt entry for AUP1 Gene

Proteomics data for AUP1 Gene at MOPED

Post-translational modifications for AUP1 Gene

  • Ubiquitination at Lys 209, Lys 316, Lys 330, Lys 335, and Lys 443
  • Modification sites at PhosphoSitePlus

Other Protein References for AUP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AUP1 (AUP1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for AUP1

No data available for DME Specific Peptides for AUP1 Gene

Domains & Families for AUP1 Gene

Protein Domains for AUP1 Gene

Suggested Antigen Peptide Sequences for AUP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUE domain.
  • Belongs to the AUP1 family.
  • Contains 1 CUE domain.
  • Belongs to the AUP1 family.
genes like me logo Genes that share domains with AUP1: view

No data available for Gene Families for AUP1 Gene

Function for AUP1 Gene

Molecular function for AUP1 Gene

GENATLAS Biochemistry:
ancient ubiquitous protein 1,43kDa,homolog to mouse Aup1 and C elegans hypothetical protein F44b9.5
UniProtKB/Swiss-Prot Function:
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.
genes like me logo Genes that share phenotypes with AUP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AUP1 Gene

Localization for AUP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AUP1 Gene

Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for AUP1 Gene COMPARTMENTS Subcellular localization image for AUP1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for AUP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with AUP1: view

Pathways & Interactions for AUP1 Gene

SuperPathways for AUP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AUP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with AUP1: view

No data available for Pathways by source and SIGNOR curated interactions for AUP1 Gene

Drugs & Compounds for AUP1 Gene

No Compound Related Data Available

Transcripts for AUP1 Gene

Unigene Clusters for AUP1 Gene

Ancient ubiquitous protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AUP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - - - - - - - - -
SP10: -
SP11: -

Relevant External Links for AUP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AUP1 Gene

mRNA expression in normal human tissues for AUP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AUP1 Gene

This gene is overexpressed in Breast (39.4) and Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AUP1 Gene

SOURCE GeneReport for Unigene cluster for AUP1 Gene Hs.411480

mRNA Expression by UniProt/SwissProt for AUP1 Gene

Tissue specificity: Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
genes like me logo Genes that share expression patterns with AUP1: view

Protein tissue co-expression partners for AUP1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for AUP1 Gene

Orthologs for AUP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AUP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AUP1 35
  • 91.22 (n)
  • 94.63 (a)
AUP1 36
  • 95 (a)
(Canis familiaris)
Mammalia AUP1 35
  • 92.72 (n)
  • 96.28 (a)
AUP1 36
  • 95 (a)
(Mus musculus)
Mammalia Aup1 35
  • 89.67 (n)
  • 90.24 (a)
Aup1 16
Aup1 36
  • 84 (a)
(Pan troglodytes)
Mammalia AUP1 35
  • 99.76 (n)
  • 99.76 (a)
AUP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Aup1 35
  • 90.41 (n)
  • 91.46 (a)
(Gallus gallus)
Aves AUP1 35
  • 64.73 (n)
  • 62.32 (a)
AUP1 36
  • 37 (a)
(Anolis carolinensis)
Reptilia AUP1 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aup1 35
  • 59.96 (n)
  • 54.89 (a)
(Danio rerio)
Actinopterygii aup1 35
  • 58.44 (n)
  • 55.92 (a)
wufc37d06 35
aup1 36
  • 53 (a)
(Caenorhabditis elegans)
Secernentea F44B9.5 35
  • 41.64 (n)
  • 35.78 (a)
F44B9.5 36
  • 34 (a)
Species with no ortholog for AUP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AUP1 Gene

Gene Tree for AUP1 (if available)
Gene Tree for AUP1 (if available)

Paralogs for AUP1 Gene

(1) SIMAP similar genes for AUP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AUP1: view

No data available for Paralogs for AUP1 Gene

Variants for AUP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for AUP1 Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Variation tolerance for AUP1 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AUP1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for AUP1 Gene

Disorders for AUP1 Gene

Relevant External Links for AUP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AUP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AUP1 Gene

Publications for AUP1 Gene

  1. Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3. (PMID: 12042322) Kato A. … Oshimi K. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13. (PMID: 8812468) Jang W. … Meisler M.H. (Genomics 1996) 2 3
  3. Identification of ERAD components essential for dislocation of the null Hong Kong variant of I+-1-antitrypsin (NHK). (PMID: 25660456) Zhong Y. … Fang S. (Biochem. Biophys. Res. Commun. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for AUP1 Gene

Sources for AUP1 Gene