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Aliases for AUNIP Gene

Aliases for AUNIP Gene

  • Aurora Kinase A And Ninein Interacting Protein 2 3
  • C1orf135 3 4
  • AIBP 3 4
  • Aurora Kinase A And Ninein-Interacting Protein 3
  • Chromosome 1 Open Reading Frame 135 2
  • Aurora A-Binding Protein 3

External Ids for AUNIP Gene

Previous Symbols for AUNIP Gene

  • C1orf135

Summaries for AUNIP Gene

GeneCards Summary for AUNIP Gene

AUNIP (Aurora Kinase A And Ninein Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AUNIP Gene

  • Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AUNIP Gene

Genomics for AUNIP Gene

Genomic Location for AUNIP Gene

Start:
25,831,913 bp from pter
End:
25,859,458 bp from pter
Size:
27,546 bases
Orientation:
Minus strand

Genomic View for AUNIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AUNIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AUNIP Gene

No data available for Regulatory Elements for AUNIP Gene

Proteins for AUNIP Gene

  • Protein details for AUNIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7T9-AUNIP_HUMAN
    Recommended name:
    Aurora kinase A and ninein-interacting protein
    Protein Accession:
    Q9H7T9
    Secondary Accessions:
    • C9EI59
    • Q53F70

    Protein attributes for AUNIP Gene

    Size:
    357 amino acids
    Molecular mass:
    40253 Da
    Quaternary structure:
    • Interacts (via C-terminus) with AURKA (via C-terminus). Interacts (via N-terminus) with NIN; this interaction blocks NIN phosphorylation by both AURKA and GSK3B. Identified in a complex with NIN and AURKA.

    Alternative splice isoforms for AUNIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AUNIP Gene

Proteomics data for AUNIP Gene at MOPED

Post-translational modifications for AUNIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AUNIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AUNIP Gene

Domains for AUNIP Gene

Protein Domains for AUNIP Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with AUNIP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AUNIP Gene

Function for AUNIP Gene

Molecular function for AUNIP Gene

UniProtKB/Swiss-Prot Function: Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
UniProtKB/Swiss-Prot Induction: Overexpressed in brain tumors.

Gene Ontology (GO) - Molecular Function for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20596670
genes like me logo Genes that share ontologies with AUNIP: view

miRNA for AUNIP Gene

miRTarBase miRNAs that target AUNIP

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AUNIP Gene

Localization for AUNIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AUNIP Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the centrosome in interphase and to the spindle pole in metaphase.

Gene Ontology (GO) - Cellular Components for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 20596670
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with AUNIP: view

Pathways for AUNIP Gene

SuperPathways for AUNIP Gene

No Data Available

Interacting Proteins for AUNIP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363416%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000363416 for AUNIP Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007051 spindle organization IMP 20596670
genes like me logo Genes that share ontologies with AUNIP: view

No data available for Pathways by source for AUNIP Gene

Transcripts for AUNIP Gene

mRNA/cDNA for AUNIP Gene

Unigene Clusters for AUNIP Gene

Aurora kinase A and ninein interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AUNIP Gene

No ASD Table

Relevant External Links for AUNIP Gene

GeneLoc Exon Structure for
AUNIP
ECgene alternative splicing isoforms for
AUNIP

Expression for AUNIP Gene

mRNA expression in normal human tissues for AUNIP Gene

mRNA differential expression in normal tissues according to GTEx for AUNIP Gene

This gene is overexpressed in Testis (13.5).

SOURCE GeneReport for Unigene cluster for AUNIP Gene Hs.725400

mRNA Expression by UniProt/SwissProt for AUNIP Gene

Q9H7T9-AUNIP_HUMAN
Tissue specificity: Expressed in heart, skeletal muscles, placenta and testis
genes like me logo Genes that share expressions with AUNIP: view

Orthologs for AUNIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for AUNIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AUNIP 36
  • 99.53 (n)
  • 99.16 (a)
AUNIP 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AUNIP 36
  • 81.87 (n)
  • 69.12 (a)
AUNIP 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AUNIP 36
  • 83.43 (n)
  • 71.19 (a)
AUNIP 37
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aunip 16
Aunip 37
  • 59 (a)
OneToOne
Clhc1 36
  • 74.95 (n)
  • 60.95 (a)
oppossum
(Monodelphis domestica)
Mammalia AUNIP 37
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aunip 36
  • 76.14 (n)
  • 62.32 (a)
Species with no ortholog for AUNIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AUNIP Gene

ENSEMBL:
Gene Tree for AUNIP (if available)
TreeFam:
Gene Tree for AUNIP (if available)

Paralogs for AUNIP Gene

No data available for Paralogs for AUNIP Gene

Variants for AUNIP Gene

Sequence variations from dbSNP and Humsavar for AUNIP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs169932 -- 25,844,137(+) gttgc(A/G)ctctt intron-variant
rs169933 -- 25,843,969(+) attga(A/G)aaagc intron-variant
rs169934 -- 25,843,660(+) taaca(C/T)gaata intron-variant
rs172498 -- 25,842,987(-) cccag(A/G)ctggt intron-variant
rs177258 -- 25,844,193(+) cctcc(A/G)cctcc intron-variant

Relevant External Links for AUNIP Gene

HapMap Linkage Disequilibrium report
AUNIP

No data available for Structural Variations from Database of Genomic Variants (DGV) for AUNIP Gene

Disorders for AUNIP Gene

No disorders were found for AUNIP Gene.

No data available for UniProtKB/Swiss-Prot for AUNIP Gene

Publications for AUNIP Gene

  1. Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. (PMID: 20596670) Lieu A.S. … Hong Y.R. (Int. J. Oncol. 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3

Products for AUNIP Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate AUNIP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for AUNIP
    • Block miRNA regulation of AUNIP using miScript Target Protectors

    Sources for AUNIP Gene

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