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Aliases for AUNIP Gene

Aliases for AUNIP Gene

  • Aurora Kinase A And Ninein Interacting Protein 2 3 5
  • C1orf135 3 4
  • AIBP 3 4
  • Aurora Kinase A And Ninein-Interacting Protein 3
  • Chromosome 1 Open Reading Frame 135 2
  • Aurora A-Binding Protein 3

External Ids for AUNIP Gene

Previous HGNC Symbols for AUNIP Gene

  • C1orf135

Previous GeneCards Identifiers for AUNIP Gene

  • GC01M026159

Summaries for AUNIP Gene

GeneCards Summary for AUNIP Gene

AUNIP (Aurora Kinase A And Ninein Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AUNIP Gene

  • Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AUNIP Gene

Genomics for AUNIP Gene

Regulatory Elements for AUNIP Gene

Enhancers for AUNIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F025903 1.1 ENCODE 11.9 -46.2 -46159 4.9 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 MTFR1L ENSG00000207302 ENSG00000261025 ENSG00000231953 RPL39P7 PIGV ZNF593 LIN28A AUNIP ENSG00000236528
GH01F025848 0.9 Ensembl 0.4 +10.6 10558 0.2 ADNP PRDM10 NR2C2 TRIM28 SELENON ENSG00000207302 PAQR7 EXTL1 TRIM63 FAM110D AUNIP PIR62460
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around AUNIP on UCSC Golden Path with GeneCards custom track

Promoters for AUNIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000280503 -42 1801 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF416 ZNF143

Genomic Location for AUNIP Gene

Chromosome:
1
Start:
25,831,913 bp from pter
End:
25,859,458 bp from pter
Size:
27,546 bases
Orientation:
Minus strand

Genomic View for AUNIP Gene

Genes around AUNIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AUNIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AUNIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AUNIP Gene

Proteins for AUNIP Gene

  • Protein details for AUNIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7T9-AUNIP_HUMAN
    Recommended name:
    Aurora kinase A and ninein-interacting protein
    Protein Accession:
    Q9H7T9
    Secondary Accessions:
    • C9EI59
    • Q53F70

    Protein attributes for AUNIP Gene

    Size:
    357 amino acids
    Molecular mass:
    40253 Da
    Quaternary structure:
    • Interacts (via C-terminus) with AURKA (via C-terminus). Interacts (via N-terminus) with NIN; this interaction blocks NIN phosphorylation by both AURKA and GSK3B. Identified in a complex with NIN and AURKA.

    Alternative splice isoforms for AUNIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AUNIP Gene

Post-translational modifications for AUNIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AUNIP Gene

No data available for DME Specific Peptides for AUNIP Gene

Domains & Families for AUNIP Gene

Protein Domains for AUNIP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AUNIP: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for AUNIP Gene

Function for AUNIP Gene

Molecular function for AUNIP Gene

UniProtKB/Swiss-Prot Function:
Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
UniProtKB/Swiss-Prot Induction:
Overexpressed in brain tumors.

Gene Ontology (GO) - Molecular Function for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20596670
genes like me logo Genes that share ontologies with AUNIP: view

Phenotypes for AUNIP Gene

genes like me logo Genes that share phenotypes with AUNIP: view

Animal Model Products

miRNA for AUNIP Gene

miRTarBase miRNAs that target AUNIP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AUNIP Gene

Localization for AUNIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AUNIP Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the centrosome in interphase and to the spindle pole in metaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AUNIP Gene COMPARTMENTS Subcellular localization image for AUNIP gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 20596670
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20596670
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with AUNIP: view

Pathways & Interactions for AUNIP Gene

SuperPathways for AUNIP Gene

No Data Available

Interacting Proteins for AUNIP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363416%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000363416 Q9H7T9-AUNIP_HUMAN for AUNIP Gene via STRING IID

Gene Ontology (GO) - Biological Process for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007051 spindle organization IMP 20596670
genes like me logo Genes that share ontologies with AUNIP: view

No data available for Pathways by source and SIGNOR curated interactions for AUNIP Gene

Transcripts for AUNIP Gene

Unigene Clusters for AUNIP Gene

Aurora kinase A and ninein interacting protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AUNIP Gene

No ASD Table

Relevant External Links for AUNIP Gene

GeneLoc Exon Structure for
AUNIP
ECgene alternative splicing isoforms for
AUNIP

Expression for AUNIP Gene

mRNA expression in normal human tissues for AUNIP Gene

mRNA differential expression in normal tissues according to GTEx for AUNIP Gene

This gene is overexpressed in Testis (x13.5).

NURSA nuclear receptor signaling pathways regulating expression of AUNIP Gene:

AUNIP

SOURCE GeneReport for Unigene cluster for AUNIP Gene:

Hs.725400

mRNA Expression by UniProt/SwissProt for AUNIP Gene:

Q9H7T9-AUNIP_HUMAN
Tissue specificity: Expressed in heart, skeletal muscles, placenta and testis.
genes like me logo Genes that share expression patterns with AUNIP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for AUNIP Gene

Orthologs for AUNIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for AUNIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AUNIP 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia AUNIP 34 35
  • 83.43 (n)
cow
(Bos Taurus)
Mammalia AUNIP 34 35
  • 81.87 (n)
rat
(Rattus norvegicus)
Mammalia Aunip 34
  • 76.14 (n)
mouse
(Mus musculus)
Mammalia Clhc1 34
  • 74.95 (n)
Aunip 16 35
  • 59 (a)
oppossum
(Monodelphis domestica)
Mammalia AUNIP 35
  • 42 (a)
OneToOne
Species where no ortholog for AUNIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AUNIP Gene

ENSEMBL:
Gene Tree for AUNIP (if available)
TreeFam:
Gene Tree for AUNIP (if available)

Paralogs for AUNIP Gene

No data available for Paralogs for AUNIP Gene

Variants for AUNIP Gene

Sequence variations from dbSNP and Humsavar for AUNIP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1044488 -- 25,832,743(+) GGAAA(A/G)AGAGA intron-variant, utr-variant-3-prime
rs1044494 -- 25,832,745(+) AAAGA(A/G)AGAGG intron-variant, utr-variant-3-prime
rs1044496 -- 25,832,747(+) AGAGA(A/G)AGGAG intron-variant, utr-variant-3-prime
rs1044508 -- 25,832,778(+) TCTTT(C/T)TTCCA intron-variant, utr-variant-3-prime
rs1044518 -- 25,832,831(+) ACCAC(A/C)CCATG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AUNIP Gene

Variant ID Type Subtype PubMed ID
nsv460884 CNV loss 19166990
nsv545883 CNV loss 21841781
nsv7490 CNV deletion 18451855
nsv822165 CNV loss 20364138
nsv834491 CNV loss 17160897
nsv834502 CNV gain 17160897

Variation tolerance for AUNIP Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AUNIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AUNIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AUNIP Gene

Disorders for AUNIP Gene

Relevant External Links for AUNIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AUNIP

No disorders were found for AUNIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AUNIP Gene

Publications for AUNIP Gene

  1. Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. (PMID: 20596670) Lieu A.S. … Hong Y.R. (Int. J. Oncol. 2010) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64

Products for AUNIP Gene

Sources for AUNIP Gene

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