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Aliases for AUNIP Gene

Aliases for AUNIP Gene

  • Aurora Kinase A And Ninein Interacting Protein 2 3 5
  • C1orf135 3 4
  • AIBP 3 4
  • Aurora Kinase A And Ninein-Interacting Protein 3
  • Chromosome 1 Open Reading Frame 135 2
  • Aurora A-Binding Protein 3

External Ids for AUNIP Gene

Previous HGNC Symbols for AUNIP Gene

  • C1orf135

Previous GeneCards Identifiers for AUNIP Gene

  • GC01M026159

Summaries for AUNIP Gene

GeneCards Summary for AUNIP Gene

AUNIP (Aurora Kinase A And Ninein Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AUNIP Gene

  • Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.

Additional gene information for AUNIP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AUNIP Gene

Genomics for AUNIP Gene

Regulatory Elements for AUNIP Gene

Enhancers for AUNIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H025903 1.4 ENCODE dbSUPER 11.9 -46.2 -46159 4.9 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS GPN2 MTFR1L ENSG00000261349 ENSG00000207302 ENSG00000261025 ENSG00000231953 RPL39P7 PIGV LOC101928324 ENSG00000236528
GH01H025835 0.5 dbSUPER 11.9 +24.0 23976 0.8 NFIC NFIA PRDM10 PAQR7 AUNIP ENSG00000236528 ENSG00000207302 ENSG00000252691 ENSG00000252190 EXTL1 RNU6-110P PIR62460
GH01H025834 0.4 dbSUPER 0.3 +24.7 24708 0.3 PRDM10 SELENON PAQR7 ENSG00000207302 EXTL1 PIR62460 AUNIP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AUNIP on UCSC Golden Path with GeneCards custom track

Promoters for AUNIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for AUNIP Gene

Genomic Locations for AUNIP Gene
27,546 bases
Minus strand

Genomic View for AUNIP Gene

Genes around AUNIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AUNIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AUNIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AUNIP Gene

Proteins for AUNIP Gene

  • Protein details for AUNIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Aurora kinase A and ninein-interacting protein
    Protein Accession:
    Secondary Accessions:
    • C9EI59
    • Q53F70

    Protein attributes for AUNIP Gene

    357 amino acids
    Molecular mass:
    40253 Da
    Quaternary structure:
    • Interacts (via C-terminus) with AURKA (via C-terminus). Interacts (via N-terminus) with NIN; this interaction blocks NIN phosphorylation by both AURKA and GSK3B. Identified in a complex with NIN and AURKA.

    Alternative splice isoforms for AUNIP Gene


neXtProt entry for AUNIP Gene

Post-translational modifications for AUNIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AUNIP Gene

No data available for DME Specific Peptides for AUNIP Gene

Domains & Families for AUNIP Gene

Gene Families for AUNIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AUNIP Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AUNIP: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for AUNIP Gene

Function for AUNIP Gene

Molecular function for AUNIP Gene

UniProtKB/Swiss-Prot Function:
Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
UniProtKB/Swiss-Prot Induction:
Overexpressed in brain tumors.

Gene Ontology (GO) - Molecular Function for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20596670
genes like me logo Genes that share ontologies with AUNIP: view

Phenotypes for AUNIP Gene

genes like me logo Genes that share phenotypes with AUNIP: view

Animal Model Products

CRISPR Products

miRNA for AUNIP Gene

miRTarBase miRNAs that target AUNIP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AUNIP Gene

Localization for AUNIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AUNIP Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the centrosome in interphase and to the spindle pole in metaphase.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AUNIP gene
Compartment Confidence
cytoskeleton 5
nucleus 3
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 20596670
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20596670
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with AUNIP: view

Pathways & Interactions for AUNIP Gene

SuperPathways for AUNIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007051 spindle organization IMP 20596670
genes like me logo Genes that share ontologies with AUNIP: view

No data available for Pathways by source and SIGNOR curated interactions for AUNIP Gene

Drugs & Compounds for AUNIP Gene

No Compound Related Data Available

Transcripts for AUNIP Gene

Unigene Clusters for AUNIP Gene

Aurora kinase A and ninein interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AUNIP Gene

No ASD Table

Relevant External Links for AUNIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AUNIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AUNIP Gene

mRNA differential expression in normal tissues according to GTEx for AUNIP Gene

This gene is overexpressed in Testis (x13.5).

NURSA nuclear receptor signaling pathways regulating expression of AUNIP Gene:


SOURCE GeneReport for Unigene cluster for AUNIP Gene:


mRNA Expression by UniProt/SwissProt for AUNIP Gene:

Tissue specificity: Expressed in heart, skeletal muscles, placenta and testis.

Evidence on tissue expression from TISSUES for AUNIP Gene

  • Kidney(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with AUNIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AUNIP Gene

Orthologs for AUNIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for AUNIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AUNIP 33 34
  • 99.53 (n)
(Canis familiaris)
Mammalia AUNIP 33 34
  • 83.43 (n)
(Bos Taurus)
Mammalia AUNIP 33 34
  • 81.87 (n)
(Rattus norvegicus)
Mammalia Aunip 33
  • 76.14 (n)
(Mus musculus)
Mammalia Clhc1 33
  • 74.95 (n)
Aunip 16 34
  • 59 (a)
(Monodelphis domestica)
Mammalia AUNIP 34
  • 42 (a)
Species where no ortholog for AUNIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AUNIP Gene

Gene Tree for AUNIP (if available)
Gene Tree for AUNIP (if available)

Paralogs for AUNIP Gene

No data available for Paralogs for AUNIP Gene

Variants for AUNIP Gene

Sequence variations from dbSNP and Humsavar for AUNIP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000034638 -- 25,838,657(+) TCAGG(C/T)GCTTT intron-variant
rs1000106488 -- 25,854,076(+) CATAG(A/T)GGTGC intron-variant, upstream-variant-2KB
rs1000317190 -- 25,859,621(+) CTGAT(C/T)CGCTC upstream-variant-2KB
rs1000335090 -- 25,851,848(+) TCCTG(C/T)CTCAG intron-variant
rs1000474336 -- 25,833,703(+) GAACC(A/G)TGTTC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for AUNIP Gene

Variant ID Type Subtype PubMed ID
nsv834502 CNV gain 17160897
nsv834491 CNV loss 17160897
nsv822165 CNV loss 20364138
nsv7490 CNV deletion 18451855
nsv545883 CNV loss 21841781
nsv460884 CNV loss 19166990

Variation tolerance for AUNIP Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AUNIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AUNIP Gene

Disorders for AUNIP Gene

Relevant External Links for AUNIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AUNIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AUNIP Gene

Publications for AUNIP Gene

  1. Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. (PMID: 20596670) Lieu AS … Hong YR (International journal of oncology 2010) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for AUNIP Gene

Sources for AUNIP Gene

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