AUNIP Gene
protein-coding GIFtS: 34
GCID: GC01M026159
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aurora kinase A and ninein interacting protein(Previous name: chromosome 1 open reading frame 135 )
(Previous symbol: C1orf135)
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Aliases
for AUNIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aurora Kinase A And Ninein Interacting Protein1 2 | | Chromosome 1 Open Reading Frame 1351 | | C1orf1351 2 3 | | AIBP2 | | AIBp1 3 | | Aurora A-Binding Protein2 | | MGC26031 | | Aurora Kinase A And Ninein-Interacting Protein2 |
Export aliases for AUNIP gene to outside databases |
Summaries
for AUNIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AUNIP_HUMAN, Q9H7T9Function: Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle
|
Genomic Views
for AUNIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for AUNIP
Other transcription factors
Search SABiosciences Chromatin IP Primers for AUNIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AUNIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11AUNIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M026159: view genomic region
(about GC identifiers)
Start:
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26,158,414 bp from pter |
End:
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26,185,903 bp from pter |
Size:
|
27,490 bases |
Orientation:
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minus strand |
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Proteins
for AUNIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AUNIP_HUMAN, Q9H7T9 (See
protein sequence)Recommended Name: Aurora kinase A and ninein-interacting protein Size: 357 amino acids; 40253 Da
Subunit: Interacts (via C-terminus) with AURKA (via C-terminus). Interacts (via N-terminus) with NIN; this interactionblocks NIN phosphorylation by both AURKA and GSK3B. Identified in a complex with NIN and AURKA
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to thecentrosome in interphase and to the spindle pole in metaphase
Secondary accessions: C9EI59 Q53F70Alternative splicing: 2 isoforms: Q9H7T9-1 Q9H7T9-2 Explore the universe of human proteins at neXtProt for AUNIP: NX_Q9H7T9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H7T9
AUNIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076942.1
ENSEMBL proteins: ENSP00000363416 ENSP00000443647
Human Recombinant Protein Products for AUNIP:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
AUNIP for ontologies About GeneDecksing
AUNIP Antibody Products:
Assay Products for AUNIP: |
Protein
Domains /
Families
for AUNIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9H7T9 |
Function
for AUNIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: AUNIP_HUMAN, Q9H7T9Function: Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycleInduction: Overexpressed in brain tumors Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
AUNIP for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AUNIP
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AUNIP (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for AUNIP | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AUNIP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AUNIP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AUNIP |
|
Pathways & Interactions
for AUNIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AUNIP
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for AUNIP (ENSP000003634164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007051 | spindle organization |
IMP | -- |
AUNIP for ontologies About GeneDecksing
|
Drugs & Compounds
for AUNIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AUNIP
Search CenterWatch for drugs/clinical trials and news about AUNIP
|
Transcripts
for AUNIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AUNIP gene: NM_024037.1 Unigene Cluster for AUNIP: Aurora kinase A and ninein interacting protein Hs.725400 [show with all ESTs]Unigene Representative Sequence: AK0243263 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000481602 ENST00000374298(uc001bkw.1) ENST00000538789
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AUNIP
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AUNIP (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for AUNIP | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AUNIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AUNIP |
Additional cDNA sequence: AK024326.1 AK223419.1 BC000209.1 GQ844687.1 10 DOTS entries: DT.428960 DT.95159917 DT.101984770 DT.95304959 DT.100765548 DT.455925 DT.121357557 DT.100742374 DT.100879180 DT.92442381 24/44 AceView cDNA sequences (see all 44): BU620058 AW003447 BX105434 AI623292 AI655878 BC000209 BX427280 BE257955 AI198661 BM875612 BU176298 BI860225 AK024326 AA165018 BF924332 BE045367 AI700639 BG718541 BQ924010 BI333408 BG196541 AA159804 NM_024037 AA833888
GeneLoc Exon Structure
|
Expression
for AUNIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See AUNIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AUNIP
SOURCE GeneReport for Unigene cluster: Hs.725400
UniProtKB/Swiss-Prot: AUNIP_HUMAN, Q9H7T9Tissue specificity: Expressed in heart, skeletal muscles, placenta and testis
SABiosciences Custom PCR Arrays for AUNIP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AUNIP
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat AUNIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AUNIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AUNIP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AUNIP |
Orthologs
for AUNIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for AUNIP gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Aunip5
Clhc11 |
RIKEN cDNA 2610002D18 gene5
clathrin heavy chain linker domain containing 11 |
74.95(n)1
60.95(a)1 |
|
4 (66.82 cM)5
698851 NM_001081099.11 NP_001074568.11
1345109995 |
ENSEMBL Gene Tree for AUNIP (if available)
TreeFam Gene Tree for AUNIP (if available) |
Paralogs
for AUNIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for AUNIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AUNIP (26158414 - 26185903 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AUNIP: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AUNIP |
|
Disorders
/ Diseases
for AUNIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for AUNIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AUNIP gene integrated from 9 sources:
(articles sorted by number of sources associating them with AUNIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. (PubMed id 20596670)1, 2, 3 Lieu A.S....Hong Y.R. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for AUNIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing AUNIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AUNIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AUNIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AUNIP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AUNIP gene:
Search GeneIP for patents involving AUNIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AUNIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AUNIP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AUNIP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AUNIP | | | OriGene Protein Over-expression Lysate for AUNIP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AUNIP | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AUNIP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AUNIP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for AUNIP | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AUNIP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AUNIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AUNIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AUNIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AUNIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AUNIP |
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 | | | AUNIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AUNIP |
|  |  |  |  | | | | Search ThermoFisher Antibodies for AUNIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AUNIP |
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