Aliases for AUH Gene
External Ids for AUH Gene
Previous GeneCards Identifiers for AUH Gene
The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form. [provided by RefSeq, May 2010]
GeneCards Summary for AUH Gene
AUH (AU RNA Binding Protein/Enoyl-CoA Hydratase) is a Protein Coding gene. Diseases associated with AUH include 3-methylglutaconic aciduria, type i and leigh-like syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include mRNA 3-UTR binding and enoyl-CoA hydratase activity. An important paralog of this gene is CDY1B.
UniProtKB/Swiss-Prot for AUH Gene
Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5-AUUUA-3 motifs.