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Aliases for ATXN7L3B Gene

Aliases for ATXN7L3B Gene

  • Ataxin 7-Like 3B 2 3
  • Putative Ataxin-7-Like Protein 3B 3
  • Lnc-SCA7 3

External Ids for ATXN7L3B Gene

Previous GeneCards Identifiers for ATXN7L3B Gene

  • GC12P074931
  • GC12P071980

Summaries for ATXN7L3B Gene

GeneCards Summary for ATXN7L3B Gene

ATXN7L3B (Ataxin 7-Like 3B) is a Protein Coding gene. An important paralog of this gene is ATXN7L3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATXN7L3B Gene

Genomics for ATXN7L3B Gene

Genomic Location for ATXN7L3B Gene

Start:
74,537,771 bp from pter
End:
74,545,430 bp from pter
Size:
7,660 bases
Orientation:
Plus strand

Genomic View for ATXN7L3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATXN7L3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATXN7L3B Gene

No data available for Regulatory Elements for ATXN7L3B Gene

Proteins for ATXN7L3B Gene

  • Protein details for ATXN7L3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GX2-A7L3B_HUMAN
    Recommended name:
    Putative ataxin-7-like protein 3B
    Protein Accession:
    Q96GX2
    Secondary Accessions:

    Protein attributes for ATXN7L3B Gene

    Size:
    97 amino acids
    Molecular mass:
    10771 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by an expressed retrotransposed copy of the ATXN7L3 locus that emerged prior to the speciation event separating primates and rodents
    SequenceCaution:
    • Sequence=AAH09111.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for ATXN7L3B Gene

Proteomics data for ATXN7L3B Gene at MOPED

Post-translational modifications for ATXN7L3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATXN7L3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATXN7L3B Gene

Domains for ATXN7L3B Gene

Protein Domains for ATXN7L3B Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ATXN7L3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GX2

UniProtKB/Swiss-Prot:

A7L3B_HUMAN :
  • Q96GX2
Family:
  • Belongs to the SGF11 family.
genes like me logo Genes that share domains with ATXN7L3B: view

No data available for Gene Families for ATXN7L3B Gene

Function for ATXN7L3B Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATXN7L3B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATXN7L3B Gene

Localization for ATXN7L3B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ATXN7L3B Gene

Pathways for ATXN7L3B Gene

SuperPathways for ATXN7L3B Gene

No Data Available

Interacting Proteins for ATXN7L3B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000430000%0d%0a9606.ENSP00000261497%0d%0a
Selected Interacting proteins: ENSP00000430000 Q96GX2-A7L3B_HUMAN for ATXN7L3B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ATXN7L3B Gene

None

No data available for Pathways by source for ATXN7L3B Gene

Transcripts for ATXN7L3B Gene

mRNA/cDNA for ATXN7L3B Gene

(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATXN7L3B Gene

Ataxin 7-like 3B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATXN7L3B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATXN7L3B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATXN7L3B Gene

No ASD Table

Relevant External Links for ATXN7L3B Gene

GeneLoc Exon Structure for
ATXN7L3B
ECgene alternative splicing isoforms for
ATXN7L3B

Expression for ATXN7L3B Gene

mRNA expression in normal human tissues for ATXN7L3B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATXN7L3B Gene

SOURCE GeneReport for Unigene cluster for ATXN7L3B Gene Hs.744849

genes like me logo Genes that share expressions with ATXN7L3B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATXN7L3B Gene

Orthologs for ATXN7L3B Gene

This gene was present in the common ancestor of animals.

Orthologs for ATXN7L3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATXN7L3B 35
  • 99.66 (n)
  • 98.97 (a)
ATXN7L3B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATXN7L3B 35
  • 94.85 (n)
  • 97.94 (a)
ATXN7L3B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATXN7L3B 35
  • 77.66 (n)
  • 79.38 (a)
ATXN7L3B 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atxn7l3b 35
  • 89.35 (n)
  • 93.81 (a)
Atxn7l3b 16
Atxn7l3b 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 13 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ATXN7L3B 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atxn7l3b 35
  • 92.78 (n)
  • 95.88 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 12 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii atxn7l3 36
  • 12 (a)
ManyToMany
si:dkeyp-118b1.2 36
  • 23 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Sgf11 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10247 36
  • 6 (a)
OneToMany
Species with no ortholog for ATXN7L3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATXN7L3B Gene

ENSEMBL:
Gene Tree for ATXN7L3B (if available)
TreeFam:
Gene Tree for ATXN7L3B (if available)

Paralogs for ATXN7L3B Gene

Paralogs for ATXN7L3B Gene

Selected SIMAP similar genes for ATXN7L3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATXN7L3B: view

Variants for ATXN7L3B Gene

Sequence variations from dbSNP and Humsavar for ATXN7L3B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8744 -- 74,540,963(+) CAGGT(G/T)CCCAG utr-variant-3-prime
rs588875 -- 74,541,769(+) TCAAT(A/G)TATCT downstream-variant-500B
rs590352 -- 74,538,379(+) CAGCT(C/G)CAGCG synonymous-codon, reference
rs647129 -- 74,541,872(+) TTCTC(A/C)ATACT downstream-variant-500B
rs694314 -- 74,537,551(+) TTTCC(A/C)CTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ATXN7L3B Gene

Variant ID Type Subtype PubMed ID
nsv899292 CNV Loss 21882294
dgv1456n71 CNV Loss 21882294
nsv470303 CNV Gain 18288195
nsv899296 CNV Loss 21882294

Relevant External Links for ATXN7L3B Gene

HapMap Linkage Disequilibrium report
ATXN7L3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATXN7L3B Gene

Disorders for ATXN7L3B Gene

Relevant External Links for ATXN7L3B

Genetic Association Database (GAD)
ATXN7L3B
genes like me logo Genes that share disorders with ATXN7L3B: view

No data available for UniProtKB/Swiss-Prot for ATXN7L3B Gene

Publications for ATXN7L3B Gene

  1. Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7. (PMID: 25306109) Tan J.Y. … Marques A.C. (Nat. Struct. Mol. Biol. 2014) 2 3
  2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 48
  3. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PMID: 17903306) Newton-Cheh C. … Larson M.G. (BMC Med. Genet. 2007) 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4

Products for ATXN7L3B Gene

Sources for ATXN7L3B Gene

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