External Ids for ATXN7L3 Gene
Previous GeneCards Identifiers for ATXN7L3 Gene
GeneCards Summary for ATXN7L3 Gene
ATXN7L3 (Ataxin 7-Like 3) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include transcription coactivator activity and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is ATXN7L3B.
UniProtKB/Swiss-Prot for ATXN7L3 Gene
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.