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Aliases for ATRNL1 Gene

Aliases for ATRNL1 Gene

  • Attractin-Like 1 2 3
  • KIAA0534 4 6
  • ALP 3 6
  • Attractin-Like Protein 1 3
  • BA338L11.1 3
  • BA454H24.1 3

External Ids for ATRNL1 Gene

Previous GeneCards Identifiers for ATRNL1 Gene

  • GC10P116518
  • GC10P116843
  • GC10P110480

Summaries for ATRNL1 Gene

GeneCards Summary for ATRNL1 Gene

ATRNL1 (Attractin-Like 1) is a Protein Coding gene. Diseases associated with ATRNL1 include radioulnar synostosis. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is ATRN.

UniProtKB/Swiss-Prot for ATRNL1 Gene

  • May play a role in melanocortin signaling pathways that regulate energy homeostasis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATRNL1 Gene

Genomics for ATRNL1 Gene

Regulatory Elements for ATRNL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATRNL1 Gene

Start:
115,093,365 bp from pter
End:
115,948,992 bp from pter
Size:
855,628 bases
Orientation:
Plus strand

Genomic View for ATRNL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATRNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATRNL1 Gene

Proteins for ATRNL1 Gene

  • Protein details for ATRNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VV63-ATRN1_HUMAN
    Recommended name:
    Attractin-like protein 1
    Protein Accession:
    Q5VV63
    Secondary Accessions:
    • O60283
    • Q5JSE8
    • Q5T5Y9
    • Q6T256
    • Q6ZSN4
    • Q86WX2

    Protein attributes for ATRNL1 Gene

    Size:
    1379 amino acids
    Molecular mass:
    152639 Da
    Quaternary structure:
    • Interacts with MC4R.
    SequenceCaution:
    • Sequence=BAC86914.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13482.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40416.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40793.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ATRNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATRNL1 Gene

Proteomics data for ATRNL1 Gene at MOPED

Post-translational modifications for ATRNL1 Gene

  • Glycosylation at Asn76, Asn174, Asn198, Asn380, Asn763, Asn778, Asn898, and Asn1157
  • Modification sites at PhosphoSitePlus

Other Protein References for ATRNL1 Gene

Antibody Products

No data available for DME Specific Peptides for ATRNL1 Gene

Domains for ATRNL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VV63

UniProtKB/Swiss-Prot:

ATRN1_HUMAN :
  • Q5VV63
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 CUB domain.
  • Contains 2 EGF-like domains.
  • Contains 2 laminin EGF-like domains.
  • Contains 5 PSI domains.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with ATRNL1: view

No data available for Gene Families for ATRNL1 Gene

Function for ATRNL1 Gene

Molecular function for ATRNL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in melanocortin signaling pathways that regulate energy homeostasis.

Gene Ontology (GO) - Molecular Function for ATRNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ATRNL1: view
genes like me logo Genes that share phenotypes with ATRNL1: view

Animal Model Products

miRNA for ATRNL1 Gene

miRTarBase miRNAs that target ATRNL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATRNL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATRNL1 Gene

Localization for ATRNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATRNL1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATRNL1 Gene COMPARTMENTS Subcellular localization image for ATRNL1 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATRNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATRNL1: view

Pathways for ATRNL1 Gene

SuperPathways for ATRNL1 Gene

No Data Available

Interacting Proteins for ATRNL1 Gene

Gene Ontology (GO) - Biological Process for ATRNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with ATRNL1: view

No data available for Pathways by source for ATRNL1 Gene

Transcripts for ATRNL1 Gene

Unigene Clusters for ATRNL1 Gene

Attractin-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATRNL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATRNL1 Gene

No ASD Table

Relevant External Links for ATRNL1 Gene

GeneLoc Exon Structure for
ATRNL1
ECgene alternative splicing isoforms for
ATRNL1

Expression for ATRNL1 Gene

mRNA expression in normal human tissues for ATRNL1 Gene

mRNA differential expression in normal tissues according to GTEx for ATRNL1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (9.0), Brain - Cortex (7.6), and Brain - Anterior cingulate cortex (BA24) (7.1).

Protein differential expression in normal tissues for ATRNL1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATRNL1 Gene

SOURCE GeneReport for Unigene cluster for ATRNL1 Gene Hs.501127

genes like me logo Genes that share expressions with ATRNL1: view

Expression partners for ATRNL1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATRNL1 Gene

Orthologs for ATRNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATRNL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATRNL1 35
  • 92.06 (n)
  • 95.09 (a)
ATRNL1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATRNL1 35
  • 94.54 (n)
  • 97.46 (a)
ATRNL1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atrnl1 35
  • 87.97 (n)
  • 96.15 (a)
Atrnl1 16
Atrnl1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATRNL1 35
  • 99.66 (n)
  • 99.71 (a)
ATRNL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atrnl1 35
  • 86.83 (n)
  • 95.69 (a)
oppossum
(Monodelphis domestica)
Mammalia ATRNL1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATRNL1 35
  • 83.76 (n)
  • 91.49 (a)
ATRNL1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATRNL1 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atrnl1 35
  • 72.43 (n)
  • 85.04 (a)
zebrafish
(Danio rerio)
Actinopterygii atrnl1b 35
  • 70.53 (n)
  • 76.27 (a)
atrnl1a 36
  • 69 (a)
ManyToMany
atrnl1b 36
  • 75 (a)
ManyToMany
Species with no ortholog for ATRNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATRNL1 Gene

ENSEMBL:
Gene Tree for ATRNL1 (if available)
TreeFam:
Gene Tree for ATRNL1 (if available)

Paralogs for ATRNL1 Gene

Paralogs for ATRNL1 Gene

Selected SIMAP similar genes for ATRNL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ATRNL1: view

Variants for ATRNL1 Gene

Sequence variations from dbSNP and Humsavar for ATRNL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8416 -- 115,946,427(+) CTTAT(A/G)TAAGA utr-variant-3-prime
rs382858 -- 115,288,734(+) ccagg(A/C)tggtc intron-variant
rs433358 -- 115,288,698(-) ctaaa(A/G)atata intron-variant
rs581518 -- 115,392,540(-) CTAGG(C/T)TAAGA intron-variant
rs582686 -- 115,378,966(-) TGTTC(A/C)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATRNL1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831997 CNV Gain 17160897
nsv831998 CNV Loss 17160897
nsv831999 CNV Loss 17160897
esv2519726 CNV Insertion 19546169
esv268380 CNV Insertion 20981092
esv272873 CNV Insertion 20981092
nsv517062 CNV Loss 19592680
esv2467201 CNV Deletion 19546169
nsv896037 CNV Loss 21882294
nsv510235 CNV Loss 20534489
nsv516325 CNV Loss 19592680
nsv825572 CNV Loss 20364138
esv2658582 CNV Deletion 23128226
essv8563 CNV CNV 17122850
esv2675959 CNV Deletion 23128226
nsv467458 CNV Loss 19166990
nsv8727 CNV Gain 18304495
nsv25015 CNV Loss 16902084
esv2659204 CNV Deletion 23128226
nsv819678 CNV Loss 19587683
nsv467459 CNV Gain 19166990
nsv519531 CNV Gain 19592680
esv259895 OTHER Complex 20981092
esv2671147 CNV Deletion 23128226
esv274054 CNV Insertion 20981092
esv267443 CNV Insertion 20981092

Relevant External Links for ATRNL1 Gene

HapMap Linkage Disequilibrium report
ATRNL1
Human Gene Mutation Database (HGMD)
ATRNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATRNL1 Gene

Disorders for ATRNL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ATRNL1 Gene in MalaCards »

(1) Diseases for ATRNL1 Gene including...

(1) University of Copenhagen DISEASES for ATRNL1 Gene

Relevant External Links for ATRNL1

Genetic Association Database (GAD)
ATRNL1
Human Genome Epidemiology (HuGE) Navigator
ATRNL1
genes like me logo Genes that share disorders with ATRNL1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ATRNL1 Gene

Publications for ATRNL1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 3 48
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48

Products for ATRNL1 Gene

Sources for ATRNL1 Gene

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