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Aliases for ATRNL1 Gene

Aliases for ATRNL1 Gene

  • Attractin Like 1 2 3 5
  • Attractin-Like Protein 1 3
  • Attractin-Like 1 2
  • BA338L11.1 3
  • BA454H24.1 3
  • KIAA0534 4
  • ALP 3

External Ids for ATRNL1 Gene

Previous GeneCards Identifiers for ATRNL1 Gene

  • GC10P116518
  • GC10P116843
  • GC10P110480

Summaries for ATRNL1 Gene

GeneCards Summary for ATRNL1 Gene

ATRNL1 (Attractin Like 1) is a Protein Coding gene. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is ATRN.

UniProtKB/Swiss-Prot for ATRNL1 Gene

  • May play a role in melanocortin signaling pathways that regulate energy homeostasis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATRNL1 Gene

Genomics for ATRNL1 Gene

Regulatory Elements for ATRNL1 Gene

Enhancers for ATRNL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ATRNL1 on UCSC Golden Path with GeneCards custom track

Promoters for ATRNL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATRNL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATRNL1 Gene

Chromosome:
10
Start:
115,093,365 bp from pter
End:
115,948,999 bp from pter
Size:
855,635 bases
Orientation:
Plus strand

Genomic View for ATRNL1 Gene

Genes around ATRNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATRNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATRNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATRNL1 Gene

Proteins for ATRNL1 Gene

  • Protein details for ATRNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VV63-ATRN1_HUMAN
    Recommended name:
    Attractin-like protein 1
    Protein Accession:
    Q5VV63
    Secondary Accessions:
    • O60283
    • Q5JSE8
    • Q5T5Y9
    • Q6T256
    • Q6ZSN4
    • Q86WX2

    Protein attributes for ATRNL1 Gene

    Size:
    1379 amino acids
    Molecular mass:
    152639 Da
    Quaternary structure:
    • Interacts with MC4R.
    SequenceCaution:
    • Sequence=BAC86914.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13482.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40416.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40793.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ATRNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATRNL1 Gene

Post-translational modifications for ATRNL1 Gene

  • Glycosylation at Asn 76, Asn 174, Asn 198, Asn 380, Asn 763, Asn 778, Asn 898, and Asn 1157
  • Modification sites at PhosphoSitePlus

Other Protein References for ATRNL1 Gene

No data available for DME Specific Peptides for ATRNL1 Gene

Domains & Families for ATRNL1 Gene

Gene Families for ATRNL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VV63

UniProtKB/Swiss-Prot:

ATRN1_HUMAN :
  • Contains 1 C-type lectin domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 CUB domain.
  • Contains 2 EGF-like domains.
  • Contains 2 laminin EGF-like domains.
  • Contains 5 PSI domains.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with ATRNL1: view

Function for ATRNL1 Gene

Molecular function for ATRNL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in melanocortin signaling pathways that regulate energy homeostasis.

Gene Ontology (GO) - Molecular Function for ATRNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ATRNL1: view
genes like me logo Genes that share phenotypes with ATRNL1: view

Animal Models for ATRNL1 Gene

MGI Knock Outs for ATRNL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ATRNL1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATRNL1 Gene

Localization for ATRNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATRNL1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATRNL1 Gene COMPARTMENTS Subcellular localization image for ATRNL1 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ATRNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATRNL1: view

Pathways & Interactions for ATRNL1 Gene

SuperPathways for ATRNL1 Gene

No Data Available

Interacting Proteins for ATRNL1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000347152%0d%0a9606.ENSP00000299766%0d%0a9606.ENSP00000435289%0d%0a9606.ENSP00000262890%0d%0a9606.ENSP00000287380%0d%0a9606.ENSP00000380378%0d%0a
Selected Interacting proteins: ENSP00000347152 Q5VV63-ATRN1_HUMAN for ATRNL1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ATRNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ATRNL1: view

No data available for Pathways by source and SIGNOR curated interactions for ATRNL1 Gene

Drugs & Compounds for ATRNL1 Gene

No Compound Related Data Available

Transcripts for ATRNL1 Gene

Unigene Clusters for ATRNL1 Gene

Attractin-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATRNL1 Gene

No ASD Table

Relevant External Links for ATRNL1 Gene

GeneLoc Exon Structure for
ATRNL1
ECgene alternative splicing isoforms for
ATRNL1

Expression for ATRNL1 Gene

mRNA expression in normal human tissues for ATRNL1 Gene

mRNA differential expression in normal tissues according to GTEx for ATRNL1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.0), Brain - Cortex (x7.6), and Brain - Anterior cingulate cortex (BA24) (x7.1).

Protein differential expression in normal tissues from HIPED for ATRNL1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ATRNL1 Gene



Protein tissue co-expression partners for ATRNL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATRNL1 Gene:

ATRNL1

SOURCE GeneReport for Unigene cluster for ATRNL1 Gene:

Hs.501127
genes like me logo Genes that share expression patterns with ATRNL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATRNL1 Gene

Orthologs for ATRNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATRNL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATRNL1 34
  • 92.06 (n)
  • 95.09 (a)
ATRNL1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATRNL1 34
  • 94.54 (n)
  • 97.46 (a)
ATRNL1 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atrnl1 34
  • 87.97 (n)
  • 96.15 (a)
Atrnl1 16
Atrnl1 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATRNL1 34
  • 99.66 (n)
  • 99.71 (a)
ATRNL1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atrnl1 34
  • 86.83 (n)
  • 95.69 (a)
oppossum
(Monodelphis domestica)
Mammalia ATRNL1 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATRNL1 34
  • 83.76 (n)
  • 91.49 (a)
ATRNL1 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATRNL1 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atrnl1 34
  • 72.43 (n)
  • 85.04 (a)
zebrafish
(Danio rerio)
Actinopterygii atrnl1b 34
  • 70.53 (n)
  • 76.27 (a)
atrnl1a 35
  • 69 (a)
ManyToMany
atrnl1b 35
  • 75 (a)
ManyToMany
Species where no ortholog for ATRNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATRNL1 Gene

ENSEMBL:
Gene Tree for ATRNL1 (if available)
TreeFam:
Gene Tree for ATRNL1 (if available)

Paralogs for ATRNL1 Gene

Paralogs for ATRNL1 Gene

(2) SIMAP similar genes for ATRNL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ATRNL1: view

Variants for ATRNL1 Gene

Sequence variations from dbSNP and Humsavar for ATRNL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1953758 - 115,315,665(+) CCACA(A/G)TGAGA nc-transcript-variant, reference, missense
rs382858 -- 115,288,734(+) ccagg(A/C)tggtc intron-variant
rs433358 -- 115,288,698(-) ctaaa(A/G)atata intron-variant
rs1908264 -- 115,291,711(-) tcctt(A/C/G/T)ttggt intron-variant
rs1927479 -- 115,617,424(-) CGCAA(C/T)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATRNL1 Gene

Variant ID Type Subtype PubMed ID
dgv1400n54 CNV loss 21841781
dgv1401n54 CNV loss 21841781
dgv977n100 CNV gain 25217958
esv2467201 CNV deletion 19546169
esv2519726 CNV insertion 19546169
esv2658582 CNV deletion 23128226
esv2659204 CNV deletion 23128226
esv2671147 CNV deletion 23128226
esv2675959 CNV deletion 23128226
esv2759783 CNV loss 17122850
esv2761634 CNV gain 21179565
esv3302921 CNV tandem duplication 20981092
esv3303163 CNV mobile element insertion 20981092
esv3397444 CNV insertion 20981092
esv3437617 CNV duplication 20981092
esv3577749 CNV gain 25503493
esv3579142 CNV loss 25503493
esv3624624 CNV gain 21293372
esv3624626 CNV gain 21293372
esv3624636 CNV loss 21293372
esv3624639 CNV loss 21293372
esv3624641 CNV loss 21293372
esv3624643 CNV loss 21293372
esv3624644 CNV loss 21293372
esv3624645 CNV gain 21293372
nsv1038050 CNV gain 25217958
nsv1044559 CNV loss 25217958
nsv1051747 CNV loss 25217958
nsv1069080 CNV deletion 25765185
nsv1110853 OTHER inversion 24896259
nsv1112597 CNV deletion 24896259
nsv1115962 CNV insertion 24896259
nsv1134058 CNV deletion 24896259
nsv1143520 CNV deletion 24896259
nsv25015 CNV deletion 16902084
nsv467458 CNV loss 19166990
nsv467459 CNV gain 19166990
nsv477011 CNV novel sequence insertion 20440878
nsv510235 OTHER sequence alteration 20534489
nsv516325 CNV loss 19592680
nsv517062 CNV loss 19592680
nsv519531 CNV gain 19592680
nsv552211 CNV gain 21841781
nsv7211 OTHER inversion 18451855
nsv819678 CNV loss 19587683
nsv825572 CNV loss 20364138
nsv831997 CNV gain 17160897
nsv831998 CNV loss 17160897
nsv831999 CNV loss 17160897
nsv8727 CNV gain 18304495
nsv951852 CNV deletion 24416366
nsv951853 CNV duplication 24416366

Variation tolerance for ATRNL1 Gene

Residual Variation Intolerance Score: 1.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATRNL1 Gene

Human Gene Mutation Database (HGMD)
ATRNL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATRNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATRNL1 Gene

Disorders for ATRNL1 Gene

Relevant External Links for ATRNL1

Genetic Association Database (GAD)
ATRNL1
Human Genome Epidemiology (HuGE) Navigator
ATRNL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATRNL1

No disorders were found for ATRNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATRNL1 Gene

Publications for ATRNL1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 65
  2. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 3 46 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 65
  5. Genetic and phenotypic studies of the dark-like mutant mouse. (PMID: 18821597) Cota C.D. … Gunn T.M. (Genesis 2008) 3 65

Products for ATRNL1 Gene

Sources for ATRNL1 Gene

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