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Aliases for ATRNL1 Gene

Aliases for ATRNL1 Gene

  • Attractin Like 1 2 3 5
  • Attractin-Like Protein 1 3
  • Attractin-Like 1 2
  • BA338L11.1 3
  • BA454H24.1 3
  • KIAA0534 4
  • ALP 3

External Ids for ATRNL1 Gene

Previous GeneCards Identifiers for ATRNL1 Gene

  • GC10P116518
  • GC10P116843
  • GC10P110480

Summaries for ATRNL1 Gene

GeneCards Summary for ATRNL1 Gene

ATRNL1 (Attractin Like 1) is a Protein Coding gene. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is ATRN.

UniProtKB/Swiss-Prot for ATRNL1 Gene

  • May play a role in melanocortin signaling pathways that regulate energy homeostasis.

Additional gene information for ATRNL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATRNL1 Gene

Genomics for ATRNL1 Gene

Regulatory Elements for ATRNL1 Gene

Enhancers for ATRNL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H114937 1.1 ENCODE 31.1 -154.7 -154692 2 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SP3 ATRNL1 FAM160B1 TRUB1 RNU6-1121P
GH10H114879 1.1 Ensembl ENCODE 22.1 -212.4 -212410 3 PKNOX1 ZSCAN4 INSM2 ZNF76 FEZF1 ZNF2 RAD21 GTF3C2 SCRT2 ZNF143 FAM160B1 ATRNL1 CCDC186 UBE2V1P5 RPL15P13
GH10H115001 0.8 Ensembl ENCODE 25.1 -91.5 -91534 1 ELF3 POLR2A SAP130 MLX SMAD4 RUNX3 TEAD3 ATRNL1 LOC102724589 GC10P115026
GH10H114876 1 Ensembl ENCODE 16.4 -216.2 -216171 0 CTCF ARID4B CEBPG ZSCAN9 RAD21 ZKSCAN1 TEAD3 ZFHX2 GATAD1 SMC3 ATRNL1 RPL15P13 FAM160B1
GH10H114820 1.5 FANTOM5 ENCODE dbSUPER 10 -269.2 -269214 6 PKNOX1 FOXA2 ARNT SIN3A YY1 GLIS2 ZNF143 ZNF207 FOS ATF7 FAM160B1 ATRNL1 TRUB1 RPL15P13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATRNL1 on UCSC Golden Path with GeneCards custom track

Promoters for ATRNL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000033867 35 2000 FEZF1 GLIS2 SP3 REST ZEB2 ZFP69B PRDM6 ZNF610 KLF16 ZNF341

Genomic Location for ATRNL1 Gene

115,093,365 bp from pter
115,948,999 bp from pter
855,635 bases
Plus strand

Genomic View for ATRNL1 Gene

Genes around ATRNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATRNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATRNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATRNL1 Gene

Proteins for ATRNL1 Gene

  • Protein details for ATRNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Attractin-like protein 1
    Protein Accession:
    Secondary Accessions:
    • O60283
    • Q5JSE8
    • Q5T5Y9
    • Q6T256
    • Q6ZSN4
    • Q86WX2

    Protein attributes for ATRNL1 Gene

    1379 amino acids
    Molecular mass:
    152639 Da
    Quaternary structure:
    • Interacts with MC4R.
    • Sequence=BAC86914.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13482.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40416.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40793.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ATRNL1 Gene


neXtProt entry for ATRNL1 Gene

Post-translational modifications for ATRNL1 Gene

  • Glycosylation at Asn76, posLast=174174, Asn198, posLast=380380, posLast=763763, Asn778, Asn898, and posLast=11571157
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ATRNL1 Gene

Domains & Families for ATRNL1 Gene

Gene Families for ATRNL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ATRNL1: view

No data available for UniProtKB/Swiss-Prot for ATRNL1 Gene

Function for ATRNL1 Gene

Molecular function for ATRNL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in melanocortin signaling pathways that regulate energy homeostasis.

Phenotypes From GWAS Catalog for ATRNL1 Gene

Gene Ontology (GO) - Molecular Function for ATRNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ATRNL1: view
genes like me logo Genes that share phenotypes with ATRNL1: view

Animal Models for ATRNL1 Gene

MGI Knock Outs for ATRNL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ATRNL1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ATRNL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATRNL1 Gene

Localization for ATRNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATRNL1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATRNL1 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATRNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATRNL1: view

Pathways & Interactions for ATRNL1 Gene

SuperPathways for ATRNL1 Gene

No Data Available

Interacting Proteins for ATRNL1 Gene

Gene Ontology (GO) - Biological Process for ATRNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ATRNL1: view

No data available for Pathways by source and SIGNOR curated interactions for ATRNL1 Gene

Drugs & Compounds for ATRNL1 Gene

No Compound Related Data Available

Transcripts for ATRNL1 Gene

Unigene Clusters for ATRNL1 Gene

Attractin-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ATRNL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ATRNL1 Gene

No ASD Table

Relevant External Links for ATRNL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATRNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATRNL1 Gene

mRNA differential expression in normal tissues according to GTEx for ATRNL1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.0), Brain - Cortex (x7.6), and Brain - Anterior cingulate cortex (BA24) (x7.1).

Protein differential expression in normal tissues from HIPED for ATRNL1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATRNL1 Gene

Protein tissue co-expression partners for ATRNL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATRNL1 Gene:


SOURCE GeneReport for Unigene cluster for ATRNL1 Gene:


Evidence on tissue expression from TISSUES for ATRNL1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ATRNL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATRNL1 Gene

Orthologs for ATRNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATRNL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATRNL1 33 34
  • 99.66 (n)
(Canis familiaris)
Mammalia ATRNL1 34 33
  • 94.54 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 94 (a)
-- 34
  • 89 (a)
(Monodelphis domestica)
Mammalia ATRNL1 34
  • 93 (a)
(Bos Taurus)
Mammalia ATRNL1 33 34
  • 92.06 (n)
(Mus musculus)
Mammalia Atrnl1 16 34 33
  • 87.97 (n)
(Rattus norvegicus)
Mammalia Atrnl1 33
  • 86.83 (n)
(Gallus gallus)
Aves ATRNL1 34 33
  • 83.76 (n)
(Anolis carolinensis)
Reptilia ATRNL1 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atrnl1 33
  • 72.43 (n)
(Danio rerio)
Actinopterygii atrnl1b 34 33
  • 70.53 (n)
atrnl1a 34
  • 69 (a)
Species where no ortholog for ATRNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATRNL1 Gene

Gene Tree for ATRNL1 (if available)
Gene Tree for ATRNL1 (if available)

Paralogs for ATRNL1 Gene

Paralogs for ATRNL1 Gene

(2) SIMAP similar genes for ATRNL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ATRNL1: view

Variants for ATRNL1 Gene

Sequence variations from dbSNP and Humsavar for ATRNL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000003588 -- 115,263,847(+) ATTAT(A/G)TGAAA intron-variant
rs1000010329 -- 115,306,001(+) TAGGG(A/G)AAAAC intron-variant
rs1000014958 -- 115,771,380(+) CGCCC(A/G)CCACC intron-variant
rs1000015281 -- 115,890,567(+) CCAAG(G/T)GCATT intron-variant
rs1000018477 -- 115,848,254(+) GTTCC(C/T)ATTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATRNL1 Gene

Variant ID Type Subtype PubMed ID
dgv1400n54 CNV loss 21841781
dgv1401n54 CNV loss 21841781
dgv977n100 CNV gain 25217958
esv2467201 CNV deletion 19546169
esv2519726 CNV insertion 19546169
esv2658582 CNV deletion 23128226
esv2659204 CNV deletion 23128226
esv2671147 CNV deletion 23128226
esv2675959 CNV deletion 23128226
esv2759783 CNV loss 17122850
esv2761634 CNV gain 21179565
esv3302921 CNV tandem duplication 20981092
esv3303163 CNV mobile element insertion 20981092
esv3397444 CNV insertion 20981092
esv3437617 CNV duplication 20981092
esv3577749 CNV gain 25503493
esv3579142 CNV loss 25503493
esv3624624 CNV gain 21293372
esv3624626 CNV gain 21293372
esv3624636 CNV loss 21293372
esv3624639 CNV loss 21293372
esv3624641 CNV loss 21293372
esv3624643 CNV loss 21293372
esv3624644 CNV loss 21293372
esv3624645 CNV gain 21293372
nsv1038050 CNV gain 25217958
nsv1044559 CNV loss 25217958
nsv1051747 CNV loss 25217958
nsv1069080 CNV deletion 25765185
nsv1110853 OTHER inversion 24896259
nsv1112597 CNV deletion 24896259
nsv1115962 CNV insertion 24896259
nsv1134058 CNV deletion 24896259
nsv1143520 CNV deletion 24896259
nsv25015 CNV deletion 16902084
nsv467458 CNV loss 19166990
nsv467459 CNV gain 19166990
nsv477011 CNV novel sequence insertion 20440878
nsv510235 OTHER sequence alteration 20534489
nsv516325 CNV loss 19592680
nsv517062 CNV loss 19592680
nsv519531 CNV gain 19592680
nsv552211 CNV gain 21841781
nsv7211 OTHER inversion 18451855
nsv819678 CNV loss 19587683
nsv825572 CNV loss 20364138
nsv831997 CNV gain 17160897
nsv831998 CNV loss 17160897
nsv831999 CNV loss 17160897
nsv8727 CNV gain 18304495
nsv951852 CNV deletion 24416366
nsv951853 CNV duplication 24416366

Variation tolerance for ATRNL1 Gene

Residual Variation Intolerance Score: 1.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATRNL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATRNL1 Gene

Disorders for ATRNL1 Gene

Relevant External Links for ATRNL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ATRNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATRNL1 Gene

Publications for ATRNL1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  2. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M … Deary IJ (Biological psychology 2011) 3 45 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60
  5. Genetic and phenotypic studies of the dark-like mutant mouse. (PMID: 18821597) Cota CD … Gunn TM (Genesis (New York, N.Y. : 2000) 2008) 3 60

Products for ATRNL1 Gene

Sources for ATRNL1 Gene

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