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Aliases for ATRN Gene

Aliases for ATRN Gene

  • Attractin 2 3 5
  • Mahogany Protein 2 3
  • Mahogany Homolog 3 4
  • DPPT-L 3 4
  • MGCA 3 4
  • Attractin-2 3
  • KIAA0548 4

External Ids for ATRN Gene

Previous GeneCards Identifiers for ATRN Gene

  • GC20P003439
  • GC20P003446
  • GC20P003399

Summaries for ATRN Gene

Entrez Gene Summary for ATRN Gene

  • This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. [provided by RefSeq, Apr 2016]

GeneCards Summary for ATRN Gene

ATRN (Attractin) is a Protein Coding gene. Diseases associated with ATRN include shwartzman phenomenon and left ventricular noncompaction. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is MEGF8.

UniProtKB/Swiss-Prot for ATRN Gene

  • Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).

Gene Wiki entry for ATRN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATRN Gene

Genomics for ATRN Gene

Regulatory Elements for ATRN Gene

Promoters for ATRN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATRN on UCSC Golden Path with GeneCards custom track

Genomic Location for ATRN Gene

Chromosome:
20
Start:
3,471,018 bp from pter
End:
3,651,122 bp from pter
Size:
180,105 bases
Orientation:
Plus strand

Genomic View for ATRN Gene

Genes around ATRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATRN Gene

Proteins for ATRN Gene

  • Protein details for ATRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75882-ATRN_HUMAN
    Recommended name:
    Attractin
    Protein Accession:
    O75882
    Secondary Accessions:
    • A8KAE5
    • O60295
    • O95414
    • Q3MIT3
    • Q5TDA2
    • Q5TDA4
    • Q5VYW3
    • Q9NTQ3
    • Q9NTQ4
    • Q9NU01
    • Q9NZ57
    • Q9NZ58
    • Q9UC75
    • Q9UDF5

    Protein attributes for ATRN Gene

    Size:
    1429 amino acids
    Molecular mass:
    158537 Da
    Quaternary structure:
    • Monomer and homotrimer.

    Alternative splice isoforms for ATRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATRN Gene

Proteomics data for ATRN Gene at MOPED

Post-translational modifications for ATRN Gene

  • Heavily glycosylated.
  • Glycosylation at Asn 213, Asn 237, Asn 242, Asn 253, Asn 264, Asn 300, Asn 325, Asn 362, Asn 383, Asn 416, Asn 428, Asn 575, Asn 623, Asn 731, Asn 863, Asn 914, Asn 923, Asn 986, Asn 1043, Asn 1054, Asn 1073, Asn 1082, Asn 1198, Asn 1206, Asn 1250, and Asn 1259
  • Modification sites at PhosphoSitePlus

Other Protein References for ATRN Gene

Antibody Products

No data available for DME Specific Peptides for ATRN Gene

Domains & Families for ATRN Gene

Suggested Antigen Peptide Sequences for ATRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75882

UniProtKB/Swiss-Prot:

ATRN_HUMAN :
  • Contains 1 C-type lectin domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 CUB domain.
  • Contains 1 EGF-like domain.
  • Contains 2 laminin EGF-like domains.
  • Contains 4 PSI domains.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with ATRN: view

No data available for Gene Families for ATRN Gene

Function for ATRN Gene

Molecular function for ATRN Gene

UniProtKB/Swiss-Prot Function:
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).
UniProtKB/Swiss-Prot Induction:
Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.
genes like me logo Genes that share phenotypes with ATRN: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATRN Gene

Localization for ATRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATRN Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATRN Gene COMPARTMENTS Subcellular localization image for ATRN gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ATRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATRN: view

Pathways & Interactions for ATRN Gene

SuperPathways for ATRN Gene

No Data Available

Interacting Proteins for ATRN Gene

SIGNOR curated interactions for ATRN Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ATRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0042552 myelination IEA --
genes like me logo Genes that share ontologies with ATRN: view

No data available for Pathways by source for ATRN Gene

Drugs & Compounds for ATRN Gene

No Compound Related Data Available

Transcripts for ATRN Gene

Unigene Clusters for ATRN Gene

Attractin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATRN Gene

No ASD Table

Relevant External Links for ATRN Gene

GeneLoc Exon Structure for
ATRN
ECgene alternative splicing isoforms for
ATRN

Expression for ATRN Gene

mRNA expression in normal human tissues for ATRN Gene

Protein differential expression in normal tissues from HIPED for ATRN Gene

This gene is overexpressed in Serum (24.5), Synovial fluid (16.4), and Plasma (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATRN Gene



SOURCE GeneReport for Unigene cluster for ATRN Gene Hs.276252

mRNA Expression by UniProt/SwissProt for ATRN Gene

O75882-ATRN_HUMAN
Tissue specificity: Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with ATRN: view

Protein tissue co-expression partners for ATRN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ATRN Gene

Orthologs for ATRN Gene

This gene was present in the common ancestor of animals.

Orthologs for ATRN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATRN 35
  • 92.79 (n)
  • 94.2 (a)
ATRN 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATRN 35
  • 93.06 (n)
  • 95.27 (a)
ATRN 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atrn 35
  • 90.63 (n)
  • 95.34 (a)
Atrn 16
Atrn 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATRN 35
  • 99.38 (n)
  • 99.57 (a)
ATRN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atrn 35
  • 90.16 (n)
  • 95.27 (a)
oppossum
(Monodelphis domestica)
Mammalia ATRN 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATRN 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATRN 35
  • 76.07 (n)
  • 82.79 (a)
ATRN 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATRN 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atrn 35
  • 73.38 (n)
  • 79.47 (a)
Str.15328 35
zebrafish
(Danio rerio)
Actinopterygii atrn 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dsd 37
  • 29 (a)
dsd 35
  • 49.84 (n)
  • 44.04 (a)
dsd 36
  • 39 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003506 35
  • 51.94 (n)
  • 45.42 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-53 35
  • 49.41 (n)
  • 39.93 (a)
tag-53 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5922 36
  • 32 (a)
OneToOne
Species with no ortholog for ATRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATRN Gene

ENSEMBL:
Gene Tree for ATRN (if available)
TreeFam:
Gene Tree for ATRN (if available)

Paralogs for ATRN Gene

Paralogs for ATRN Gene

(1) SIMAP similar genes for ATRN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATRN: view

Variants for ATRN Gene

Sequence variations from dbSNP and Humsavar for ATRN Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6107308 - 3,547,454(+) AAGTG(A/C)TGTCA reference, missense
rs17782078 - 3,560,735(+) TCACA(C/T)TCATA reference, missense
rs3886999 - 3,596,415(-) TTCCT(C/T)TGAGA reference, missense
rs12329487 - 3,604,137(+) CTGTT(A/G)TTTCA reference, missense
rs12930 -- 3,650,034(+) AGCTA(A/C)CCCGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATRN Gene

Variant ID Type Subtype PubMed ID
nsv3264 CNV Insertion 18451855
nsv525626 CNV Loss 19592680
esv2664121 CNV Deletion 23128226
esv2676231 CNV Deletion 23128226
nsv828672 CNV Loss 20364138

Variation tolerance for ATRN Gene

Residual Variation Intolerance Score: 8.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.13; 92.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATRN Gene

HapMap Linkage Disequilibrium report
ATRN
Human Gene Mutation Database (HGMD)
ATRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATRN Gene

Disorders for ATRN Gene

MalaCards: The human disease database

(2) MalaCards diseases for ATRN Gene - From: DISEASES

Disorder Aliases PubMed IDs
shwartzman phenomenon
  • shwartzman reaction
left ventricular noncompaction
  • left ventricular hypertrabeculation
- elite association - COSMIC cancer census association via MalaCards
Search ATRN in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATRN

Genetic Association Database (GAD)
ATRN
Human Genome Epidemiology (HuGE) Navigator
ATRN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATRN
genes like me logo Genes that share disorders with ATRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATRN Gene

Publications for ATRN Gene

  1. Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions. (PMID: 9736737) Duke-Cohan J.S. … Schlossman S.F. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. Novel partners of SPAG11B isoform D in the human male reproductive tract. (PMID: 19535787) Radhakrishnan Y. … French F.S. (Biol. Reprod. 2009) 3 23
  3. Does human attractin have DP4 activity? (PMID: 17261078) Friedrich D. … Demuth H.U. (Biol. Chem. 2007) 3 23
  4. Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function. (PMID: 16835316) Wrenger S. … Reinhold D. (J. Leukoc. Biol. 2006) 3 23
  5. Isolation and characterization of attractin-2. (PMID: 12675230) Friedrich D. … Demuth H.U. (Adv. Exp. Med. Biol. 2003) 3 23

Products for ATRN Gene

Sources for ATRN Gene

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