ATRN Gene
protein-coding GIFtS: 54
GCID: GC20P003451
|
|
attractin
| |
Aliases
for ATRN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Attractin1 | | Attractin-21 | | MGCA1 2 3 5 | | Mahogany Protein2 | | DPPT-L1 2 3 | | KIAA05483 | | Mahogany Homolog2 3 | | |
Export aliases for ATRN gene to outside databasesPrevious GC identifers: GC20P003439 GC20P003446 GC20P003399 |
Summaries
for ATRN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ATRN:
Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-boundprotein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The othertwo isoforms are secreted proteins involved in the initial immune cell clustering during inflammatory responses thatmay regulate the chemotactic activity of chemokines. (provided by RefSeq, May 2011)
UniProtKB/Swiss-Prot: ATRN_HUMAN, O75882Function: Involved in the initial immune cell clustering during inflammatory response and may regulate chemotacticactivity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and haircolor. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the centralnervous system (By similarity)
Gene Wiki entry for ATRN
|
Genomic Views
for ATRN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATRN gene promoter:
E2F-3a E2F-4 NF-1/L NF-1 E2F-5 E2F-2 YY1 E2F-1 E2F c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATRN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATRN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13ATRN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P003451: view genomic region
(about GC identifiers)
Start:
|
3,451,665 bp from pter |
End:
|
3,631,769 bp from pter |
Size:
|
180,105 bases |
Orientation:
|
plus strand |
|
Proteins
for ATRN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATRN_HUMAN, O75882 (See
protein sequence)Recommended Name: Attractin precursor Size: 1429 amino acids; 158537 Da
Subunit: Monomer and homotrimer
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Subcellular location: Isoform 3: Secreted
Caution: Was originally (PubMed:7539799 and PubMed:9736737) thought to have dipeptidase activity but it was shown laterto lack that activity (PubMed:17261078)
Secondary accessions: A8KAE5 O60295 O95414 Q3MIT3 Q5TDA2 Q5TDA4 Q5VYW3 Q9NTQ3 Q9NTQ4 Q9NU01 Q9NZ57Q9NZ58 Q9UC75 Q9UDF5Alternative splicing: 3 isoforms: O75882-1 O75882-2 O75882-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ATRN: NX_O75882
Post-translational modifications:
Heavily glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75882
ATRN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001193976.1 NP_647537.1 NP_647538.1
ENSEMBL proteins: ENSP00000262919 ENSP00000416587
Human Recombinant Protein Products for ATRN:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ATRN for ontologies About GeneDecksing
ATRN Antibody Products:
Assay Products for ATRN: |
Protein
Domains /
Families
for ATRN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATRN for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry O75882ProtoNet protein and cluster: O75882 2 Blocks protein families: IPB000859 CUB domain IPB002049 Laminin-type EGF-like domain
UniProtKB/Swiss-Prot: ATRN_HUMAN, O75882Similarity: Contains 1 C-type lectin domainSimilarity: Contains 1 CUB domainSimilarity: Contains 1 EGF-like domainSimilarity: Contains 6 Kelch repeatsSimilarity: Contains 2 laminin EGF-like domainsSimilarity: Contains 4 PSI domains |
Function
for ATRN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ATRN_HUMAN, O75882Function: Involved in the initial immune cell clustering during inflammatory response and may regulate chemotacticactivity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and haircolor. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the centralnervous system (By similarity)Induction: Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membraneisoform followed by the release of the secreted isoform Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ATRN for ontologies About GeneDecksing
Phenotypes:
10 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Atrn):
ATRN for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATRN (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATRN (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ATRN (NM_139321) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATRN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATRN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATRN |
|
Pathways & Interactions
for ATRN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATRN
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for ATRN (O758823 ENSP000002629194) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006954 | inflammatory response |
IEA | -- | | GO:0006979 | response to oxidative stress |
IEA | -- | | GO:0040014 | regulation of multicellular organism growth |
IEA | -- |
ATRN for ontologies About GeneDecksing
|
Drugs & Compounds
for ATRN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ATRN
Search CenterWatch for drugs/clinical trials and news about ATRN
|
Transcripts
for ATRN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATRN gene (4 alternative transcripts): NM_001207047.1 NM_139321.2 NM_139322.2 NM_012070.2 Unigene Cluster for ATRN: Attractin Hs.276252 [show with all ESTs]Unigene Representative Sequence: NM_1393212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262919(uc002wim.2) ENST00000446916(uc002wil.2 uc021vzz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATRN (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATRN (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ATRN (NM_139321) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATRN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATRN |
Additional cDNA sequence: AB011120.1 AF106861.1 AK000356.1 AK293010.1 AK302730.1 BC009724.1 BC101705.1 6 DOTS entries: DT.447089 DT.95269461 DT.91709761 DT.40111160 DT.101978504 DT.95210500 24/193 AceView cDNA sequences (see all 193): NM_139321 CD644584 NM_139322 AA345684 BE671400 AA771958 CA306924 AI083581 AL134717 AI648497 BU726574 BQ183626 CB242644 CA425093 NM_012070 BP341675 CA415219 BX644402 CA502816 AA628635 AW630543 CB269066 AI253184 BV178807
GeneLoc Exon Structure
|
Expression
for ATRN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATRN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATATGGA
About this image
See ATRN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATRN
SOURCE GeneReport for Unigene cluster: Hs.276252
UniProtKB/Swiss-Prot: ATRN_HUMAN, O75882Tissue specificity: Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activatedT-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bonemarrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral bloodleukocytes
SABiosciences Expression via Pathway-Focused PCR Array including ATRN:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATRN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATRN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATRN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATRN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATRN |
Orthologs
for ATRN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ATRN gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for ATRN (if available)
TreeFam Gene Tree for ATRN (if available) |
Paralogs
for ATRN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATRN gene
- MEGF82 ATRNL12
1 SIMAP similar gene for ATRN using alignment to 1 protein entry: ATRN_HUMAN:ATRNL1
ATRN for paralogs About GeneDecksing
|
Genomic Variants
for ATRN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATRN (3451665 - 3631769 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATRN: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATRN |
|
Disorders
/ Diseases
for ATRN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATRN for disorders About GeneDecksing
OMIM gene information: 603130
OMIM disorders: --
16  diseases for ATRN: About MalaCardsspinal cord injury radioulnar synostosis obesity common variable immunodeficiency
synostosis hypercalcemia tremor neurodegeneration
tonsillitis skin cancer vaccinia osteoporosis
immunodeficiency astrocytoma melanoma neuronitis
1 disease from the University of Copenhagen DISEASES database for ATRN:Radioulnar synostosis 3 Novoseek disease relationships for ATRN gene About this table
Human Genome Epidemiology (HuGE) Navigator: ATRN (4 documents)
Export disorders for ATRN gene to outside databases
|
Publications
for ATRN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATRN gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with ATRN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions. (PubMed id 9736737)1, 2, 3, 9 Duke-Cohan J.S....Schlossman S.F. (1998)
- Does human attractin have DP4 activity? (PubMed id 17261078)1, 2, 9 Friedrich D....Demuth H.U. (2007)
- Secreted and membrane attractin result from alternative splicing of the human ATRN gene. (PubMed id 10811918)1, 2, 9 Tang W....Duke-Cohan J.S. (2000)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
- Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells. (PubMed id 8596018)1, 3 Duke-Cohan J.S....Schlossman S.F. (1996)
- Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function. (PubMed id 16835316)1, 9 Wrenger S....Reinhold D. (2006)
|
External Searches for ATRN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ATRN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATRN gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ATRN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ATRN | Pharmacogenomics, SNPs, Pathways | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_206 |
|
| | |
About This Section
| Patent Information for ATRN gene:
Search GeneIP for patents involving ATRN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ATRN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATRN |
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