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Aliases for ATRN Gene

Aliases for ATRN Gene

  • Attractin 2 3
  • MGCA 3 4 6
  • Mahogany Protein 2 3
  • Mahogany Homolog 3 4
  • DPPT-L 3 4
  • Attractin-2 3
  • KIAA0548 4

External Ids for ATRN Gene

Previous GeneCards Identifiers for ATRN Gene

  • GC20P003439
  • GC20P003446
  • GC20P003399

Summaries for ATRN Gene

Entrez Gene Summary for ATRN Gene

  • Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other two isoforms are secreted proteins involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. [provided by RefSeq, May 2011]

GeneCards Summary for ATRN Gene

ATRN (Attractin) is a Protein Coding gene. Diseases associated with ATRN include radioulnar synostosis and obesity. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is MEGF8.

UniProtKB/Swiss-Prot for ATRN Gene

  • Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).

Gene Wiki entry for ATRN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATRN Gene

Genomics for ATRN Gene

Regulatory Elements for ATRN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATRN Gene

Start:
3,471,018 bp from pter
End:
3,651,122 bp from pter
Size:
180,105 bases
Orientation:
Plus strand

Genomic View for ATRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATRN Gene

Proteins for ATRN Gene

  • Protein details for ATRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75882-ATRN_HUMAN
    Recommended name:
    Attractin
    Protein Accession:
    O75882
    Secondary Accessions:
    • A8KAE5
    • O60295
    • O95414
    • Q3MIT3
    • Q5TDA2
    • Q5TDA4
    • Q5VYW3
    • Q9NTQ3
    • Q9NTQ4
    • Q9NU01
    • Q9NZ57
    • Q9NZ58
    • Q9UC75
    • Q9UDF5

    Protein attributes for ATRN Gene

    Size:
    1429 amino acids
    Molecular mass:
    158537 Da
    Quaternary structure:
    • Monomer and homotrimer.

    Alternative splice isoforms for ATRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATRN Gene

Proteomics data for ATRN Gene at MOPED

Post-translational modifications for ATRN Gene

  • Heavily glycosylated.
  • Glycosylation at Asn213, Asn237, Asn242, Asn253, Asn264, Asn300, Asn325, Asn362, Asn383, Asn416, Asn428, Asn575, Asn623, Asn731, Asn863, Asn914, Asn923, Asn986, Asn1043, Asn1054, Asn1073, Asn1082, Asn1198, Asn1206, Asn1250, and Asn1259
  • Modification sites at PhosphoSitePlus

Other Protein References for ATRN Gene

Antibody Products

No data available for DME Specific Peptides for ATRN Gene

Domains for ATRN Gene

Suggested Antigen Peptide Sequences for ATRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75882

UniProtKB/Swiss-Prot:

ATRN_HUMAN :
  • O75882
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 CUB domain.
  • Contains 1 EGF-like domain.
  • Contains 2 laminin EGF-like domains.
  • Contains 4 PSI domains.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with ATRN: view

No data available for Gene Families for ATRN Gene

Function for ATRN Gene

Molecular function for ATRN Gene

UniProtKB/Swiss-Prot Function:
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).
UniProtKB/Swiss-Prot Induction:
Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform

Gene Ontology (GO) - Molecular Function for ATRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ATRN: view
genes like me logo Genes that share phenotypes with ATRN: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATRN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATRN Gene

Localization for ATRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATRN Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATRN Gene COMPARTMENTS Subcellular localization image for ATRN gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ATRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane NAS 9736737
GO:0005887 integral component of plasma membrane TAS 10086356
GO:0016020 membrane --
genes like me logo Genes that share ontologies with ATRN: view

Pathways for ATRN Gene

SuperPathways for ATRN Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ATRN Gene

Gene Ontology (GO) - Biological Process for ATRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006979 response to oxidative stress IEA --
GO:0007275 multicellular organismal development --
GO:0021549 cerebellum development IEA --
GO:0040014 regulation of multicellular organism growth IEA --
genes like me logo Genes that share ontologies with ATRN: view

No data available for Pathways by source for ATRN Gene

Transcripts for ATRN Gene

Unigene Clusters for ATRN Gene

Attractin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATRN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATRN Gene

No ASD Table

Relevant External Links for ATRN Gene

GeneLoc Exon Structure for
ATRN
ECgene alternative splicing isoforms for
ATRN

Expression for ATRN Gene

mRNA expression in normal human tissues for ATRN Gene

Protein differential expression in normal tissues for ATRN Gene

This gene is overexpressed in Serum (24.5), Synovial fluid (16.4), and Plasma (14.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATRN Gene

SOURCE GeneReport for Unigene cluster for ATRN Gene Hs.276252

mRNA Expression by UniProt/SwissProt for ATRN Gene

O75882-ATRN_HUMAN
Tissue specificity: Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.
genes like me logo Genes that share expressions with ATRN: view

Expression partners for ATRN Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ATRN Gene

Orthologs for ATRN Gene

This gene was present in the common ancestor of animals.

Orthologs for ATRN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATRN 35
  • 92.79 (n)
  • 94.2 (a)
ATRN 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATRN 35
  • 93.06 (n)
  • 95.27 (a)
ATRN 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atrn 35
  • 90.63 (n)
  • 95.34 (a)
Atrn 16
Atrn 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATRN 35
  • 99.38 (n)
  • 99.57 (a)
ATRN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atrn 35
  • 90.16 (n)
  • 95.27 (a)
oppossum
(Monodelphis domestica)
Mammalia ATRN 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATRN 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATRN 35
  • 76.07 (n)
  • 82.79 (a)
ATRN 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATRN 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atrn 35
  • 73.38 (n)
  • 79.47 (a)
Str.15328 35
zebrafish
(Danio rerio)
Actinopterygii atrn 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dsd 37
  • 29 (a)
dsd 35
  • 49.84 (n)
  • 44.04 (a)
dsd 36
  • 39 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003506 35
  • 51.94 (n)
  • 45.42 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-53 35
  • 49.41 (n)
  • 39.93 (a)
tag-53 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5922 36
  • 32 (a)
OneToOne
Species with no ortholog for ATRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATRN Gene

ENSEMBL:
Gene Tree for ATRN (if available)
TreeFam:
Gene Tree for ATRN (if available)

Paralogs for ATRN Gene

Paralogs for ATRN Gene

Selected SIMAP similar genes for ATRN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATRN: view

Variants for ATRN Gene

Sequence variations from dbSNP and Humsavar for ATRN Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs12930 -- 3,650,034(+) AGCTA(A/C)CCCGG utr-variant-3-prime
rs64510 -- 3,519,764(-) CATCC(A/G)TTTCC intron-variant
rs149615 -- 3,556,271(-) ACTAT(A/G)AAATT intron-variant
rs151340 -- 3,581,884(-) AGACA(C/T)AGGAA intron-variant
rs151341 -- 3,570,047(-) attac(C/T)cagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATRN Gene

Variant ID Type Subtype PubMed ID
nsv3264 CNV Insertion 18451855
nsv525626 CNV Loss 19592680
esv2664121 CNV Deletion 23128226
esv2676231 CNV Deletion 23128226
nsv828672 CNV Loss 20364138

Relevant External Links for ATRN Gene

HapMap Linkage Disequilibrium report
ATRN
Human Gene Mutation Database (HGMD)
ATRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATRN Gene

Disorders for ATRN Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ATRN Gene in MalaCards »

(2) Diseases for ATRN Gene including...

(1) University of Copenhagen DISEASES for ATRN Gene

(3) Novoseek inferred disease relationships for ATRN Gene

Disease -log(P) Hits PubMed IDs
neurodegeneration 52.6 7
glioma 27.9 6
tumors 0 4

Relevant External Links for ATRN

Genetic Association Database (GAD)
ATRN
Human Genome Epidemiology (HuGE) Navigator
ATRN
genes like me logo Genes that share disorders with ATRN: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ATRN Gene

Publications for ATRN Gene

  1. Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions. (PMID: 9736737) Duke-Cohan J.S. … Schlossman S.F. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. Secreted and membrane attractin result from alternative splicing of the human ATRN gene. (PMID: 10811918) Tang W. … Duke-Cohan J.S. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  3. Does human attractin have DP4 activity? (PMID: 17261078) Friedrich D. … Demuth H.U. (Biol. Chem. 2007) 3 4 23
  4. Novel partners of SPAG11B isoform D in the human male reproductive tract. (PMID: 19535787) Radhakrishnan Y. … French F.S. (Biol. Reprod. 2009) 3 23
  5. Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells. (PMID: 8596018) Duke-Cohan J.S. … Schlossman S.F. (J. Immunol. 1996) 2 3

Products for ATRN Gene

Sources for ATRN Gene

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