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Aliases for ATRN Gene

Aliases for ATRN Gene

  • Attractin 2 3 3 5
  • Mahogany Protein 2 3
  • Mahogany Homolog 3 4
  • DPPT-L 3 4
  • MGCA 3 4
  • Attractin-2 3
  • KIAA0548 4

External Ids for ATRN Gene

Previous GeneCards Identifiers for ATRN Gene

  • GC20P003439
  • GC20P003446
  • GC20P003399

Summaries for ATRN Gene

Entrez Gene Summary for ATRN Gene

  • This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. [provided by RefSeq, Apr 2016]

GeneCards Summary for ATRN Gene

ATRN (Attractin) is a Protein Coding gene. Diseases associated with ATRN include Shwartzman Phenomenon and Kidney Cortex Necrosis. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is ATRNL1.

UniProtKB/Swiss-Prot for ATRN Gene

  • Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).

Gene Wiki entry for ATRN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATRN Gene

Genomics for ATRN Gene

Regulatory Elements for ATRN Gene

Enhancers for ATRN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G003419 1.2 Ensembl ENCODE 12.1 -50.5 -50489 1.2 PKNOX1 WRNIP1 YY1 ZNF766 CBX5 RELB ETV6 IKZF2 CREM CBFB ITPA ENSG00000225116 ATRN ENSG00000201346 UBE2V1P1 RNU6-1019P LOC105372509 LOC105372508
GH20G003470 1.1 ENCODE 8.3 +1.0 964 3.8 PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ATRN SF3A3P1
GH20G003413 0.8 FANTOM5 11.3 -57.3 -57265 0.4 SAP130 NR2F1 ARID4B MAX ZNF384 RARA NR2F2 NCOR1 HNF4A NR2F6 ENSG00000225116 ATRN RNU6-1019P UBE2V1P1 AVP OXT LOC105372509 LOC105372508
GH20G003541 1 ENCODE 6.2 +72.8 72799 5.1 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 SP5 MXD4 HSPA12B ATRN ITPA SF3A3P1 GC20M003527
GH20G003461 0.5 ENCODE 4.8 -9.4 -9355 1.2 PKNOX1 ZIC2 ATF2 EP300 ATRN PIR61960 LOC105372508
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATRN on UCSC Golden Path with GeneCards custom track

Promoters for ATRN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133777 282 1801 PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9

Genomic Location for ATRN Gene

Chromosome:
20
Start:
3,471,018 bp from pter
End:
3,651,122 bp from pter
Size:
180,105 bases
Orientation:
Plus strand

Genomic View for ATRN Gene

Genes around ATRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATRN Gene

Proteins for ATRN Gene

  • Protein details for ATRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75882-ATRN_HUMAN
    Recommended name:
    Attractin
    Protein Accession:
    O75882
    Secondary Accessions:
    • A8KAE5
    • O60295
    • O95414
    • Q3MIT3
    • Q5TDA2
    • Q5TDA4
    • Q5VYW3
    • Q9NTQ3
    • Q9NTQ4
    • Q9NU01
    • Q9NZ57
    • Q9NZ58
    • Q9UC75
    • Q9UDF5

    Protein attributes for ATRN Gene

    Size:
    1429 amino acids
    Molecular mass:
    158537 Da
    Quaternary structure:
    • Monomer and homotrimer.

    Alternative splice isoforms for ATRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATRN Gene

Post-translational modifications for ATRN Gene

  • Heavily glycosylated.
  • Glycosylation at Asn213, Asn237, posLast=242242, posLast=253253, Asn264, Asn300, posLast=325325, posLast=362362, Asn383, Asn416, posLast=428428, Asn575, Asn623, posLast=731731, posLast=863863, posLast=914914, Asn923, posLast=986986, Asn1043, Asn1054, posLast=10731073, posLast=10821082, posLast=11981198, posLast=12061206, posLast=12501250, and posLast=12591259
  • Modification sites at PhosphoSitePlus

Other Protein References for ATRN Gene

Antibody Products

Assay Products

  • Cloud-Clone Corp. Assay Kits for ATRN

No data available for DME Specific Peptides for ATRN Gene

Domains & Families for ATRN Gene

Gene Families for ATRN Gene

Suggested Antigen Peptide Sequences for ATRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ATRN: view

No data available for UniProtKB/Swiss-Prot for ATRN Gene

Function for ATRN Gene

Molecular function for ATRN Gene

UniProtKB/Swiss-Prot Function:
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).
UniProtKB/Swiss-Prot Induction:
Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.

Gene Ontology (GO) - Molecular Function for ATRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ATRN: view
genes like me logo Genes that share phenotypes with ATRN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATRN Gene

Localization for ATRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATRN Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATRN gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ATRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,TAS 17261078
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane NAS 9736737
GO:0005887 integral component of plasma membrane TAS 10086356
genes like me logo Genes that share ontologies with ATRN: view

Pathways & Interactions for ATRN Gene

No Data Available

Interacting Proteins for ATRN Gene

SIGNOR curated interactions for ATRN Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ATRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006979 response to oxidative stress IEA --
GO:0021549 cerebellum development IEA --
GO:0040014 regulation of multicellular organism growth IEA --
GO:0042552 myelination IEA --
genes like me logo Genes that share ontologies with ATRN: view

No data available for Pathways by source for ATRN Gene

Drugs & Compounds for ATRN Gene

No Compound Related Data Available

Transcripts for ATRN Gene

Unigene Clusters for ATRN Gene

Attractin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATRN Gene

No ASD Table

Relevant External Links for ATRN Gene

GeneLoc Exon Structure for
ATRN
ECgene alternative splicing isoforms for
ATRN

Expression for ATRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATRN Gene

Protein differential expression in normal tissues from HIPED for ATRN Gene

This gene is overexpressed in Serum (24.5), Synovial fluid (16.4), and Plasma (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATRN Gene



Protein tissue co-expression partners for ATRN Gene

NURSA nuclear receptor signaling pathways regulating expression of ATRN Gene:

ATRN

SOURCE GeneReport for Unigene cluster for ATRN Gene:

Hs.276252

mRNA Expression by UniProt/SwissProt for ATRN Gene:

O75882-ATRN_HUMAN
Tissue specificity: Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ATRN Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Lung(4.3)
  • Bone marrow(4.1)
  • Bone(4)
  • Intestine(3.8)
  • Skin(3.8)
  • Blood(3.7)
  • Kidney(3.5)
  • Muscle(3.2)
  • Pancreas(2.9)
  • Eye(2.2)
  • Heart(2.2)
  • Stomach(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with ATRN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATRN Gene

Orthologs for ATRN Gene

This gene was present in the common ancestor of animals.

Orthologs for ATRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATRN 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia ATRN 34 35
  • 93.06 (n)
cow
(Bos Taurus)
Mammalia ATRN 34 35
  • 92.79 (n)
mouse
(Mus musculus)
Mammalia Atrn 34 16 35
  • 90.63 (n)
rat
(Rattus norvegicus)
Mammalia Atrn 34
  • 90.16 (n)
oppossum
(Monodelphis domestica)
Mammalia ATRN 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATRN 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATRN 34 35
  • 76.07 (n)
lizard
(Anolis carolinensis)
Reptilia ATRN 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atrn 34
  • 73.38 (n)
Str.15328 34
zebrafish
(Danio rerio)
Actinopterygii atrn 35
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003506 34
  • 51.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta dsd 36 34 35
  • 49.84 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-53 34 35
  • 49.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5922 35
  • 32 (a)
OneToOne
Species where no ortholog for ATRN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATRN Gene

ENSEMBL:
Gene Tree for ATRN (if available)
TreeFam:
Gene Tree for ATRN (if available)

Paralogs for ATRN Gene

Paralogs for ATRN Gene

(1) SIMAP similar genes for ATRN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATRN: view

Variants for ATRN Gene

Sequence variations from dbSNP and Humsavar for ATRN Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000019966 -- 3,603,554(+) GCGCA(A/G)TCTTG intron-variant
rs1000030956 -- 3,554,573(+) TCGTG(A/G)TCTGC intron-variant
rs1000091321 -- 3,602,217(+) CCCAG(C/T)TACTC intron-variant
rs1000109581 -- 3,576,012(+) TTATA(G/T)TGTAT intron-variant
rs1000111244 -- 3,550,294(+) TGAAG(C/T)CTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATRN Gene

Variant ID Type Subtype PubMed ID
dgv772e214 CNV loss 21293372
esv2664121 CNV deletion 23128226
esv2676231 CNV deletion 23128226
esv3575354 CNV gain 25503493
esv3645043 CNV gain 21293372
esv3645044 CNV loss 21293372
nsv1125392 OTHER inversion 24896259
nsv3264 CNV insertion 18451855
nsv525626 CNV loss 19592680
nsv828672 CNV loss 20364138
nsv965846 CNV duplication 23825009

Variation tolerance for ATRN Gene

Residual Variation Intolerance Score: 8.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.13; 92.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATRN Gene

Human Gene Mutation Database (HGMD)
ATRN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATRN Gene

Disorders for ATRN Gene

MalaCards: The human disease database

(5) MalaCards diseases for ATRN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
shwartzman phenomenon
  • shwartzman reaction
kidney cortex necrosis
  • renal cortical necrosis
3-methylglutaconic aciduria, type iv
  • 3-methylglutaconic aciduria type 4
obesity
  • obesity, association with
left ventricular noncompaction
  • left ventricular hypertrabeculation
- elite association - COSMIC cancer census association via MalaCards
Search ATRN in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATRN

Genetic Association Database (GAD)
ATRN
Human Genome Epidemiology (HuGE) Navigator
ATRN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATRN
genes like me logo Genes that share disorders with ATRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATRN Gene

Publications for ATRN Gene

  1. Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions. (PMID: 9736737) Duke-Cohan J.S. … Schlossman S.F. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 22 64
  2. Does human attractin have DP4 activity? (PMID: 17261078) Friedrich D. … Demuth H.U. (Biol. Chem. 2007) 3 4 22 64
  3. Secreted and membrane attractin result from alternative splicing of the human ATRN gene. (PMID: 10811918) Tang W. … Duke-Cohan J.S. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Novel partners of SPAG11B isoform D in the human male reproductive tract. (PMID: 19535787) Radhakrishnan Y. … French F.S. (Biol. Reprod. 2009) 3 22 64

Products for ATRN Gene

Sources for ATRN Gene

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