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Aliases for ATRIP Gene

Aliases for ATRIP Gene

  • ATR Interacting Protein 2 3
  • ATM And Rad3-Related-Interacting Protein 4
  • AGS1 4

External Ids for ATRIP Gene

Summaries for ATRIP Gene

Entrez Gene Summary for ATRIP Gene

  • This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for ATRIP Gene

ATRIP (ATR Interacting Protein) is a Protein Coding gene. Diseases associated with ATRIP include prion disease and sporadic breast cancer. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle / Checkpoint Control.

UniProtKB/Swiss-Prot for ATRIP Gene

  • Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATRIP Gene

Genomics for ATRIP Gene

Genomic Location for ATRIP Gene

Start:
48,446,710 bp from pter
End:
48,467,644 bp from pter
Size:
20,935 bases
Orientation:
Plus strand

Genomic View for ATRIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATRIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATRIP Gene

Regulatory Elements for ATRIP Gene

Proteins for ATRIP Gene

  • Protein details for ATRIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXE1-ATRIP_HUMAN
    Recommended name:
    ATR-interacting protein
    Protein Accession:
    Q8WXE1
    Secondary Accessions:
    • A8K6A3
    • A8K714
    • B2RCE7
    • B4DU92
    • B5MEB7
    • Q69YK9
    • Q8NHQ2
    • Q8WUG7
    • Q96CL3
    • Q9HA30

    Protein attributes for ATRIP Gene

    Size:
    791 amino acids
    Molecular mass:
    85838 Da
    Quaternary structure:
    • Interacts with ATR (By similarity). Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single-stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.
    SequenceCaution:
    • Sequence=BAB14029.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14029.1; Type=Frameshift; Positions=650; Evidence={ECO:0000305}; Sequence=BAF84257.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATRIP Gene

    Alternative splice isoforms for ATRIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATRIP Gene

Proteomics data for ATRIP Gene at MOPED

Post-translational modifications for ATRIP Gene

No data available for DME Specific Peptides for ATRIP Gene

Domains for ATRIP Gene

Protein Domains for ATRIP Gene

ProtoNet:

UniProtKB/Swiss-Prot:

ATRIP_HUMAN
Domain:
  • The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.:
    • Q8WXE1
Family:
  • Belongs to the ATRIP family.:
    • Q8WXE1
genes like me logo Genes that share domains with ATRIP: view

No data available for Gene Families for ATRIP Gene

Function for ATRIP Gene

Molecular function for ATRIP Gene

UniProtKB/Swiss-Prot Function: Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.

Gene Ontology (GO) - Molecular Function for ATRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004527 exonuclease activity --
GO:0005515 protein binding IPI 14657349
GO:0070530 K63-linked polyubiquitin binding IDA 24332808
genes like me logo Genes that share ontologies with ATRIP: view

miRNA for ATRIP Gene

miRTarBase miRNAs that target ATRIP

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATRIP Gene

Localization for ATRIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATRIP Gene

Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATRIP Gene COMPARTMENTS Subcellular localization image for ATRIP gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ATRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0015630 microtubule cytoskeleton --
genes like me logo Genes that share ontologies with ATRIP: view

Pathways for ATRIP Gene

genes like me logo Genes that share pathways with ATRIP: view

Pathways by source for ATRIP Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for ATRIP Gene
1 Qiagen pathway for ATRIP Gene
2 Cell Signaling Technology pathways for ATRIP Gene

Gene Ontology (GO) - Biological Process for ATRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint TAS 14657349
GO:0006260 DNA replication TAS --
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with ATRIP: view

Transcripts for ATRIP Gene

mRNA/cDNA for ATRIP Gene

(4) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATRIP Gene

ATR interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATRIP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9: -
SP10: - -

Relevant External Links for ATRIP Gene

GeneLoc Exon Structure for
ATRIP
ECgene alternative splicing isoforms for
ATRIP

Expression for ATRIP Gene

mRNA expression in normal human tissues for ATRIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATRIP Gene

This gene is overexpressed in Testis (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATRIP Gene

SOURCE GeneReport for Unigene cluster for ATRIP Gene Hs.694840

mRNA Expression by UniProt/SwissProt for ATRIP Gene

Q8WXE1-ATRIP_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with ATRIP: view

Orthologs for ATRIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATRIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATRIP 36
  • 99.71 (n)
  • 99.49 (a)
ATRIP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATRIP 36
  • 86.64 (n)
  • 83.08 (a)
ATRIP 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATRIP 36
  • 87.58 (n)
  • 84.66 (a)
ATRIP 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atrip 36
  • 81.46 (n)
  • 75.45 (a)
Atrip 16
Atrip 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATRIP 37
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATRIP 37
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atrip 36
  • 81.71 (n)
  • 74.87 (a)
chicken
(Gallus gallus)
Aves ATRIP 36
  • 57.3 (n)
  • 48.06 (a)
ATRIP 37
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATRIP 37
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atrip 36
  • 53.58 (n)
  • 44.69 (a)
zebrafish
(Danio rerio)
Actinopterygii atrip 36
  • 49.51 (n)
  • 40.24 (a)
atrip 37
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 19 (a)
OneToOne
Species with no ortholog for ATRIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATRIP Gene

ENSEMBL:
Gene Tree for ATRIP (if available)
TreeFam:
Gene Tree for ATRIP (if available)

Paralogs for ATRIP Gene

Pseudogenes.org Pseudogenes for ATRIP Gene

genes like me logo Genes that share paralogs with ATRIP: view

No data available for Paralogs for ATRIP Gene

Variants for ATRIP Gene

Sequence variations from dbSNP and Humsavar for ATRIP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs730566 -- 48,445,644(-) CGTCA(G/T)ATAGC upstream-variant-2KB
rs744087 -- 48,459,874(+) TTCTG(A/C)GTCTC reference, missense
rs747654 -- 48,461,207(-) AGCCC(A/G)TGGGC intron-variant
rs922075 -- 48,447,994(+) ctacc(A/G)gctgc intron-variant
rs1824363 -- 48,449,203(+) GAGGC(C/G)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATRIP Gene

Variant ID Type Subtype PubMed ID
nsv834683 CNV Gain 17160897
nsv834684 CNV Gain 17160897
nsv508917 CNV Insertion 20534489
nsv876761 CNV Loss 21882294

Relevant External Links for ATRIP Gene

HapMap Linkage Disequilibrium report
ATRIP
Human Gene Mutation Database (HGMD)
ATRIP

Disorders for ATRIP Gene

Relevant External Links for ATRIP

Genetic Association Database (GAD)
ATRIP
Human Genome Epidemiology (HuGE) Navigator
ATRIP
genes like me logo Genes that share disorders with ATRIP: view

No data available for UniProtKB/Swiss-Prot for ATRIP Gene

Publications for ATRIP Gene

  1. ATR and ATRIP: partners in checkpoint signaling. (PMID: 11721054) Cortez D. … Elledge S.J. (Science 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. (PMID: 15758953) Falck J. … Jackson S.P. (Nature 2005) 3 4
  4. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PMID: 17203973) Vasilescu J. … Figeys D. (J. Proteome Res. 2007) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ATRIP Gene

  • antibodies-online proteins for ATRIP
  • antibodies-online antibodies for ATRIP
  • antibodies-online kits for ATRIP

Sources for ATRIP Gene

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