Aliases for ATRIP Gene
External Ids for ATRIP Gene
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for ATRIP Gene
ATRIP (ATR Interacting Protein) is a Protein Coding gene. Diseases associated with ATRIP include prion disease and sporadic breast cancer. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle / Checkpoint Control.
UniProtKB/Swiss-Prot for ATRIP Gene
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.