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ATRIP Gene

protein-coding   GIFtS: 53
GCID: GC03P048488

ATR Interacting Protein

  See ATRIP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATR Interacting Protein1 2
ATM And Rad3-Related-Interacting Protein2 3
ATR-Interacting Protein2
AGS13

External Ids:    HGNC: 334991   Entrez Gene: 841262   Ensembl: ENSG000001640537   OMIM: 6066055   UniProtKB: Q8WXE13   

Export aliases for ATRIP gene to outside databases

Previous GC identifers: GC03U900864 GC03P048464 GC03P048465


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATRIP Gene:
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to
single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia
and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug
2012)

GeneCards Summary for ATRIP Gene:
ATRIP (ATR interacting protein) is a protein-coding gene. Diseases associated with ATRIP include prion disease, and sporadic breast cancer.

UniProtKB/Swiss-Prot: ATRIP_HUMAN, Q8WXE1
Function: Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing
the protein




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ATRIP gene promoter:
         CREB   SRF   NF-1   p53   deltaCREB   SRF (504 AA)   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ATRIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATRIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p24.3-p22.1

ATRIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATRIP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P048488:  view genomic region     (about GC identifiers)

Start:
48,488,114 bp from pter      End:
48,507,115 bp from pter
Size:
19,002 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ATRIP_HUMAN, Q8WXE1 (See protein sequence)
Recommended Name: ATR-interacting protein  
Size: 791 amino acids; 85838 Da
Subunit: Interacts with ATR (By similarity). Heterodimer with ATR. The heterodimer binds the RPA complex and is
then recruited to single-stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP
Caution: The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that
encode ATRIP also encode TREX1 in another reading frame
Sequence caution: Sequence=BAB14029.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14029.1; Type=Frameshift; Positions=650; Sequence=BAF84257.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ATRIP:
4IGK (3D)    
Secondary accessions: A8K6A3 A8K714 B2RCE7 B4DU92 B5MEB7 Q69YK9 Q8NHQ2 Q8WUG7 Q96CL3 Q9HA30
Alternative splicing: 4 isoforms:  Q8WXE1-1   Q8WXE1-2   Q8WXE1-3   Q8WXE1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATRIP: NX_Q8WXE1

Explore proteomics data for ATRIP at MOPED

Post-translational modifications: 

  • Phosphorylated by ATR1
  • Ubiquitination2 at Lys96
  • Modification sites at PhosphoSitePlus

  • See ATRIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001257951.1  NP_001257952.1  NP_115542.2  NP_569055.1  

    ENSEMBL proteins: 
     ENSP00000406664   ENSP00000402340   ENSP00000323099   ENSP00000302338   ENSP00000401761  
     ENSP00000400930   ENSP00000349620  
    Reactome Protein details: Q8WXE1

    ATRIP Human Recombinant Protein Products:

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    Novus Biologicals ATRIP Lysate
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    Cloud-Clone Corp. Proteins for ATRIP

     
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    antibodies-online proteins for ATRIP (2 products) 

     
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    ATRIP Antibody Products:

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    antibodies-online antibodies for ATRIP (108 products) 

    ATRIP Assay Products:

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    antibodies-online kits for ATRIP (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8WXE1

    UniProtKB/Swiss-Prot: ATRIP_HUMAN, Q8WXE1
    Domain: The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to
    sites of DNA damage
    Similarity: Belongs to the ATRIP family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATRIP_HUMAN, Q8WXE1
    Function: Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing
    the protein

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14657349
         
    Find genes that share ontologies with ATRIP           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Atrip (no phenotypes)

    Find genes that share phenotypes with ATRIP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ATRIP

    miRNA
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    miRTarBase miRNAs that target ATRIP:
    hsa-mir-124-3p (MIRT022640)

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    2 qRT-PCR Assays for microRNAs that regulate ATRIP:
    hsa-miR-34a* hsa-miR-1227
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    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATRIP

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    eBioscience FlowRNA Probe Sets ( VA6-13770) for ATRIP 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATRIP_HUMAN, Q8WXE1: Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0015630microtubule cytoskeleton IDA--

    Find genes that share ontologies with ATRIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATRIP About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1G2/M Checkpoints
    G2/M Checkpoints0.84
    G2/M DNA damage checkpoint0.00
    Activation of ATR in response to replication stress0.84
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    3Cell Cycle, Mitotic
    Cell Cycle0.90
    4CDK-mediated phosphorylation and removal of Cdc6
    Cell Cycle Checkpoints0.58
    5p53 signaling pathway
    DNA damage response0.41


    Find genes that share SuperPaths with ATRIP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ATRIP
        DNA Repair Mechanisms

    2 Cell Signaling Technology (CST) Pathways for ATRIP
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for ATRIP
        DNA damage ATM/ATR regulation of G1/S checkpoint

    2 BioSystems Pathways for ATRIP
        DNA damage response
    miRNA Regulation of DNA Damage Response

    2 Reactome Pathways for ATRIP
        Activation of ATR in response to replication stress
    G2/M DNA damage checkpoint


    1 Kegg Pathway  (Kegg details for ATRIP):
        Fanconi anemia pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including ATRIP: 
              DNA Damage Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ATRIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATRIP (Q8WXE11, 2, 3 ENSP000003230994) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK9P507501, 2, 3, ENSP000003623614EBI-747353,EBI-1383449 MINT-8058032 MINT-8058048 MINT-8058001 I2D: score=1 STRING: ENSP00000362361
    ATRQ135352, 3, ENSP000003437414MINT-8058048 MINT-8058001 I2D: score=3 STRING: ENSP00000343741
    IKBKGQ9Y6K92, 3, ENSP000003586224MINT-6978719 I2D: score=1 STRING: ENSP00000358622
    CHEK1O147572, 3, ENSP000002789164MINT-8043584 I2D: score=1 STRING: ENSP00000278916
    CLSPNQ9HAW42, ENSP000003129954MINT-8058048 MINT-8058001 STRING: ENSP00000312995
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint TAS14657349
    GO:0006260DNA replication TAS--
    GO:0006281DNA repair IEA--

    Find genes that share ontologies with ATRIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATRIP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATRIP gene (4 alternative transcripts): 
    NM_001271022.1  NM_001271023.1  NM_032166.3  NM_130384.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421175 ENST00000454733 ENST00000320211(uc003ctf.1) ENST00000346691(uc003ctg.1)
    ENST00000424906 ENST00000412052 ENST00000491468 ENST00000357105(uc011bbj.1)

    miRNA
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    hsa-miR-34a* hsa-miR-1227
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    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ATRIP
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    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-13770) for ATRIP 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATRIP (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
    SP1:        -                                               -                             -                                                                     
    SP2:        -                                               -                       -     -                                                                     
    SP3:                                                        -                       -     -                                                                     
    SP4:        -                                               -                       -     -                 -                                                   
    SP5:                                                        -                       -     -                                                                     


    ECgene alternative splicing isoforms for ATRIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATRIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCACCAG
    ATRIP Expression
    About this image


    ATRIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    ATRIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATRIP Protein Expression

    UniProtKB/Swiss-Prot: ATRIP_HUMAN, Q8WXE1
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including ATRIP: 
              DNA Damage Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATRIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ATRIP gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atrip1 , 5 ATR interacting protein1, 5 81.46(n)1
    75.45(a)1
      9 (59.63 cM)5
    2356101  NM_172774.31  NP_766362.21 
     1090579335 
    chicken
    (Gallus gallus)
    Aves ATRIP1 ATR interacting protein 57.3(n)
    48.06(a)
      415949  NM_001256151.1  NP_001243080.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATRIP6
    ATR interacting protein
    42(a)
    1 ↔ 1
    2(155927561-155954229)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atrip1 ATR interacting protein 53.58(n)
    44.69(a)
      100101245  NM_001015895.3  NP_001015895.2 
    zebrafish
    (Danio rerio)
    Actinopterygii atrip1 ATR interacting protein 49.51(n)
    40.24(a)
      558534  NM_001044867.2  NP_001038332.1 


    ENSEMBL Gene Tree for ATRIP (if available)
    TreeFam Gene Tree for ATRIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATRIP gene

    Find genes that share paralogs with ATRIP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ATRIP
    PGOHUM00000259849


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATRIP (see all 354)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764949401,2
    C,F--48486187(+) GTTGCT/CAGCAG 3 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1495934511,2
    C--48486206(+) CCATGC/TGCACC 3 -- us2k10--------
    rs1835284471,2
    --48486364(+) CCTACC/TGCTTG 3 -- us2k10--------
    rs106632631,2
    C--48486591(+) AAATT-/AATT  
            
    CAGAA
    4 -- us2k1 trp30--------
    rs674384591,2
    C--48486592(+) AAAAA-/AATT  
            
    ATTCA
    4 -- us2k10--------
    rs1893419501,2
    C--48486763(+) TACTAA/GATATT 4 -- us2k10--------
    rs18704441,2
    C,F,A,H--48486773(+) TAACGG/CGGGAG 4 -- us2k1 tfbs3 trp39Minor allele frequency- C:0.41NA WA CSA EA 369
    rs1822323761,2
    --48487032(+) ATGCAA/GCACTT 4 -- us2k10--------
    rs7305661,2
    C,F,H--48487048(-) CGTCAG/TATAGC 4 -- us2k137Minor allele frequency- T:0.32NA EA MN NS WA 4675
    rs1483198811,2
    --48487058(+) GGAGAA/CTACCA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATRIP (48488114 - 48507115 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ATRIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508917CNV Insertion20534489
    nsv876761CNV Loss21882294
    nsv834683CNV Gain17160897
    nsv834684CNV Gain17160897

    Human Gene Mutation Database (HGMD): ATRIP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATRIP
    DNA2.0 Custom Variant and Variant Library Synthesis for ATRIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606605    OMIM disorders: --

    6 diseases for ATRIP:    
    About MalaCards
    prion disease    sporadic breast cancer    seckel syndrome type 8    seckel syndrome
    ataxia telangiectasia    primary autosomal recessive microcephalies and seckel syndrome spectrum disorders


    Find genes that share disorders with ATRIP           About GenesLikeMe

    Genetic Association Database (GAD): ATRIP
    Human Genome Epidemiology (HuGE) Navigator: ATRIP (6 documents)

    Export disorders for ATRIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATRIP gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with ATRIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ATR and ATRIP: partners in checkpoint signaling. (PubMed id 11721054)1, 2, 3 Cortez D.... Elledge S.J. (Science 2001)
    2. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PubMed id 22210626)1, 4 Mead S....Collinge J. (Hum. Mol. Genet. 2012)
    3. Joint influence of small-effect genetic variants on human longevity. (PubMed id 20834067)1, 4 Yashin A.I....Ukraintseva S.V. (Aging (Albany NY) 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    6. Functional genomic screens identify CINP as a genome maintenance protein. (PubMed id 19889979)1, 2 Lovejoy C.A.... Cortez D. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    7. Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. (PubMed id 18283122)1, 2 Sivasubramaniam S.... Lee E.Y. (Genes Dev. 2008)
    8. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1, 2 Vasilescu J.... Figeys D. (J. Proteome Res. 2007)
    9. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. (PubMed id 15758953)1, 2 Falck J.... Jackson S.P. (Nature 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84126 HGNC: 33499 Ensembl:ENSG00000164053 euGenes: HUgn84126 ECgene: ATRIP Kegg: 84126
    H-InvDB: ATRIP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ATRIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ATRIP gene:
    Search GeneIP for patents involving ATRIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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