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Aliases for ATRAID Gene

Aliases for ATRAID Gene

  • All-Trans Retinoic Acid Induced Differentiation Factor 2 3 5
  • Apoptosis-Related Protein 3 2 3 4
  • C2orf28 3 4
  • APR-3 3 4
  • APR3 3 4
  • P18 3 4
  • Chromosome 2 Open Reading Frame 28 2
  • Apoptosis Related Protein APR-3 3
  • Apoptosis Related Protein 3 3
  • HSPC013 3
  • APR--3 3
  • PRO240 3

External Ids for ATRAID Gene

Previous HGNC Symbols for ATRAID Gene

  • C2orf28

Previous GeneCards Identifiers for ATRAID Gene

  • GC02P027435

Summaries for ATRAID Gene

Entrez Gene Summary for ATRAID Gene

  • This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2009]

GeneCards Summary for ATRAID Gene

ATRAID (All-Trans Retinoic Acid Induced Differentiation Factor) is a Protein Coding gene. Diseases associated with ATRAID include cervical squamous cell carcinoma.

UniProtKB/Swiss-Prot for ATRAID Gene

  • Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.

Gene Wiki entry for ATRAID Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATRAID Gene

Genomics for ATRAID Gene

Regulatory Elements for ATRAID Gene

Promoters for ATRAID Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATRAID on UCSC Golden Path with GeneCards custom track

Genomic Location for ATRAID Gene

Chromosome:
2
Start:
27,212,027 bp from pter
End:
27,217,178 bp from pter
Size:
5,152 bases
Orientation:
Plus strand

Genomic View for ATRAID Gene

Genes around ATRAID on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATRAID Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATRAID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATRAID Gene

Proteins for ATRAID Gene

  • Protein details for ATRAID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW56-ARAID_HUMAN
    Recommended name:
    All-trans retinoic acid-induced differentiation factor
    Protein Accession:
    Q6UW56
    Secondary Accessions:
    • A8C1S2
    • A8K779
    • Q96FF6
    • Q96RT2
    • Q9Y2R7
    • Q9Y5L7

    Protein attributes for ATRAID Gene

    Size:
    229 amino acids
    Molecular mass:
    24747 Da
    Quaternary structure:
    • Interacts with NELL1; the interaction promotes osteoblastic differentiation and mineralization.
    SequenceCaution:
    • Sequence=AAD27770.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305}; Sequence=AAD31317.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAD31317.2; Type=Frameshift; Positions=189; Evidence={ECO:0000305}; Sequence=AAH02846.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH11006.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH35850.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAX93173.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ATRAID Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATRAID Gene

Proteomics data for ATRAID Gene at MOPED

Post-translational modifications for ATRAID Gene

  • Glycosylation at Asn 44, Asn 79, Asn 157, and Asn 168
  • Modification sites at PhosphoSitePlus

Other Protein References for ATRAID Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ATRAID (3-Apr)
  • Santa Cruz Biotechnology (SCBT) Antibodies for ATRAID

No data available for DME Specific Peptides for ATRAID Gene

Domains & Families for ATRAID Gene

Protein Domains for ATRAID Gene

Suggested Antigen Peptide Sequences for ATRAID Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UW56

UniProtKB/Swiss-Prot:

ARAID_HUMAN :
  • Contains 1 EGF-like domain.
Domain:
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with ATRAID: view

No data available for Gene Families for ATRAID Gene

Function for ATRAID Gene

Molecular function for ATRAID Gene

UniProtKB/Swiss-Prot Function:
Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.
UniProtKB/Swiss-Prot Induction:
Up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines.

Gene Ontology (GO) - Molecular Function for ATRAID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ATRAID: view
genes like me logo Genes that share phenotypes with ATRAID: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATRAID Gene

Localization for ATRAID Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATRAID Gene

Nucleus envelope. Cell membrane; Single-pass membrane protein. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATRAID Gene COMPARTMENTS Subcellular localization image for ATRAID gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2
lysosome 2
vacuole 2

Gene Ontology (GO) - Cellular Components for ATRAID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 21723284
genes like me logo Genes that share ontologies with ATRAID: view

Pathways & Interactions for ATRAID Gene

SuperPathways for ATRAID Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATRAID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045669 positive regulation of osteoblast differentiation IDA 21723284
GO:2000599 negative regulation of cyclin catabolic process IDA 21723284
genes like me logo Genes that share ontologies with ATRAID: view

No data available for Pathways by source and SIGNOR curated interactions for ATRAID Gene

Drugs & Compounds for ATRAID Gene

No Compound Related Data Available

Transcripts for ATRAID Gene

Unigene Clusters for ATRAID Gene

All-trans retinoic acid-induced differentiation factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATRAID Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for ATRAID Gene

GeneLoc Exon Structure for
ATRAID
ECgene alternative splicing isoforms for
ATRAID

Expression for ATRAID Gene

mRNA expression in normal human tissues for ATRAID Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATRAID Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ATRAID Gene



SOURCE GeneReport for Unigene cluster for ATRAID Gene Hs.9527

mRNA Expression by UniProt/SwissProt for ATRAID Gene

Q6UW56-ARAID_HUMAN
Tissue specificity: Weakly expressed in hematopoietic cell lines.
genes like me logo Genes that share expression patterns with ATRAID: view

Protein tissue co-expression partners for ATRAID Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ATRAID Gene

Orthologs for ATRAID Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATRAID Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATRAID 36
  • 98 (a)
OneToOne
ATRAID 35
  • 99.18 (n)
  • 97.89 (a)
cow
(Bos Taurus)
Mammalia C11H2orf28 35
  • 86.61 (n)
  • 81.66 (a)
ATRAID 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATRAID 36
  • 81 (a)
OneToOne
ATRAID 35
  • 87.63 (n)
  • 80.79 (a)
mouse
(Mus musculus)
Mammalia Atraid 35
  • 83.9 (n)
  • 81.95 (a)
Atraid 16
Atraid 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATRAID 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atraid 35
  • 81.71 (n)
  • 77.88 (a)
chicken
(Gallus gallus)
Aves ATRAID 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atraid 35
  • 55.21 (n)
  • 48.47 (a)
zebrafish
(Danio rerio)
Actinopterygii atraid 35
  • 51.37 (n)
  • 44.85 (a)
atraid 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for ATRAID:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATRAID Gene

ENSEMBL:
Gene Tree for ATRAID (if available)
TreeFam:
Gene Tree for ATRAID (if available)

Paralogs for ATRAID Gene

(1) SIMAP similar genes for ATRAID Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATRAID: view

No data available for Paralogs for ATRAID Gene

Variants for ATRAID Gene

Sequence variations from dbSNP and Humsavar for ATRAID Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_057991 -
rs1275535 -- 27,214,628(+) atggg(C/T)ggatc intron-variant
rs34379579 -- 27,215,062(+) CTAAA(-/A)GTGCT intron-variant
rs36109859 -- 27,214,953(+) CTGAA(-/T)TTTTA intron-variant
rs115343750 -- 27,214,928(+) AAATA(C/T)GGCTA intron-variant

Variation tolerance for ATRAID Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.35; 70.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATRAID Gene

HapMap Linkage Disequilibrium report
ATRAID

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATRAID Gene

Disorders for ATRAID Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATRAID Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ATRAID

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATRAID
genes like me logo Genes that share disorders with ATRAID: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATRAID Gene

Publications for ATRAID Gene

  1. Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1. (PMID: 17524364) Yu F. … Lu Z. (Biochem. Biophys. Res. Commun. 2007) 2 3 4 23 67
  2. NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation. (PMID: 21723284) Zou X. … Zhang X. (FEBS Lett. 2011) 2 3
  3. Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB. (PMID: 17387583) Yang G. … Lu Z. (Mol. Cell. Biochem. 2007) 3 23
  4. Increased expression of apoptosis-related protein 3 is highly associated with tumorigenesis and progression of cervical squamous cell carcinoma. (PMID: 23036366) Zhang Y. … Yan W. (Hum. Pathol. 2013) 3
  5. Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. (PMID: 23284715) Kammula E.C. … Willbold D. (PLoS ONE 2012) 3

Products for ATRAID Gene

Sources for ATRAID Gene

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