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ATRAID Gene

protein-coding   GIFtS: 46
GCID: GC02P027435

All-Trans Retinoic Acid-Induced Differentiation Factor

(Previous name: chromosome 2 open reading frame 28)
(Previous symbol: C2orf28)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
All-Trans Retinoic Acid-Induced Differentiation Factor1 2     Chromosome 2 Open Reading Frame 281
C2orf281 2 3     APR--32
Apoptosis-Related Protein 31 2 3     PRO2402
APR-32 3     Apoptosis Related Protein 32
APR32 3     Apoptosis Related Protein APR-32
p182 3     

External Ids:    HGNC: 240901   Entrez Gene: 513742   Ensembl: ENSG000001380857   UniProtKB: Q6UW563   

Export aliases for ATRAID gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATRAID Gene:
This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and
differentiation. The use of alternative splice sites and promotors result in multiple transcript variants
encoding different isoforms.(provided by RefSeq, Dec 2009)

GeneCards Summary for ATRAID Gene:
ATRAID (all-trans retinoic acid-induced differentiation factor) is a protein-coding gene. Diseases associated with ATRAID include cervical squamous cell carcinoma, and hiv-1.

UniProtKB/Swiss-Prot: ARAID_HUMAN, Q6UW56
Function: Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell
cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway

Gene Wiki entry for ATRAID (C2orf28) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ATRAID
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATRAID promoter sequence
   Search Chromatin IP Primers for ATRAID

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATRAID


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

ATRAID Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATRAID gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027435:  view genomic region     (about GC identifiers)

Start:
27,434,895 bp from pter      End:
27,440,046 bp from pter
Size:
5,152 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARAID_HUMAN, Q6UW56 (See protein sequence)
Recommended Name: All-trans retinoic acid-induced differentiation factor precursor  
Size: 229 amino acids; 24747 Da
Subunit: Interacts with NELL1; the interaction promotes osteoblastic differentiation and mineralization
Sequence caution: Sequence=AAD27770.1; Type=Frameshift; Positions=19; Sequence=AAD31317.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=AAD31317.2; Type=Frameshift; Positions=189;
Sequence=AAH02846.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH11006.3;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH35850.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAX93173.1; Type=Erroneous gene model prediction;
Secondary accessions: A8C1S2 A8K779 Q96FF6 Q96RT2 Q9Y2R7 Q9Y5L7
Alternative promoter usage, Alternative splicing: 3 isoforms:  Q6UW56-1   Q6UW56-2   Q6UW56-3   (Produced by alternative promoter usage)

Explore the universe of human proteins at neXtProt for ATRAID: NX_Q6UW56

Explore proteomics data for ATRAID at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn44, Asn79, Asn157, Asn168
  • Modification sites at PhosphoSitePlus

  • See ATRAID Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001164266.1  NP_057169.2  NP_542159.3  

    ENSEMBL proteins: 
     ENSP00000369518   ENSP00000476080   ENSP00000384033   ENSP00000397319  

    ATRAID Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ATRAID
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    Novus Biologicals ATRAID Protein
    Novus Biologicals ATRAID Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ATRAID Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ATRAID Antibodies
    Search for Antibodies for ATRAID at Abcam
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    ThermoFisher Antibodies for ATRAID
    LSBio Antibodies in human, mouse, rat for ATRAID

    ATRAID Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q6UW56

    ProtoNet protein and cluster: Q6UW56

    UniProtKB/Swiss-Prot: ARAID_HUMAN, Q6UW56
    Similarity: Contains 1 EGF-like domain


    ATRAID for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARAID_HUMAN, Q6UW56
    Function: Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell
    cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway
    Induction: Up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI18388313
         
    ATRAID for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ATRAID:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Atraid):
     vision/eye 

    ATRAID for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATRAID
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATRAID

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATRAID
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATRAID

    miRNA
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    miRTarBase miRNAs that target ATRAID:
    hsa-mir-328-3p (MIRT043815)

    Block miRNA regulation of human, mouse, rat ATRAID using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ATRAID
    SwitchGear 3'UTR luciferase reporter plasmidATRAID 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ATRAID

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATRAID

    Clone
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    OriGene ORF clones in mouse, rat for ATRAID
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for ATRAID
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATRAID
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATRAID

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ATRAID
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATRAID 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATRAID


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARAID_HUMAN, Q6UW56: Nucleus envelope. Cell membrane; Single-pass membrane protein. Note=Colocalizes with NELL1
    on the nuclear envelope and the perinuclear region

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0048471perinuclear region of cytoplasm IDA--

    ATRAID for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATRAID About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    2Lymphocyte Signaling
    Lymphocyte Signaling
    3Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for ATRAID
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Lymphocyte Signaling



    ATRAID for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATRAID
    Interactions:

        Search GeneGlobe Interaction Network for ATRAID

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ATRAID (Q6UW561, 2, 3 ENSP000003695184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNX9Q9Y5X11, 2, 3, ENSP000003760244EBI-723802,EBI-77848 MINT-7302079 MINT-7302104 I2D: score=1 STRING: ENSP00000376024
    NELL1Q928321, 2, 3, ENSP000002989254EBI-723802,EBI-947754 MINT-8187819 MINT-8187643 MINT-8187782 MINT-8187801 I2D: score=1 STRING: ENSP00000298925
    LPPQ930522, 3, ENSP000003180894MINT-64677 I2D: score=3 STRING: ENSP00000318089
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010468regulation of gene expression IDA--
    GO:0030154cell differentiation IEA--
    GO:0030501positive regulation of bone mineralization IDA--
    GO:0033689negative regulation of osteoblast proliferation IDA--
    GO:0045669positive regulation of osteoblast differentiation IDA--

    ATRAID for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATRAID (ARAID)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATRAID gene (3 alternative transcripts): 
    NM_001170795.1  NM_016085.4  NM_080592.3  

    Unigene Cluster for ATRAID:

    All-trans retinoic acid-induced differentiation factor
    Hs.9527  [show with all ESTs]
    Unigene Representative Sequence: CD513016
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380171(uc002rjf.3) ENST00000484646 ENST00000606999 ENST00000405489(uc002rjg.3)
    ENST00000419744 ENST00000491220 ENST00000472515
    miRNA
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    Block miRNA regulation of human, mouse, rat ATRAID using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidATRAID 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ATRAID
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    GenScript Custom all cDNA clones Services for ATRAID
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATRAID
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATRAID
    Primer
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    OriGene qPCR primer pairs and template standards for ATRAID
    OriGene qSTAR qPCR primer pairs in human, mouse for ATRAID
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ATRAID
      QuantiTect SYBR Green Assays in human, mouse, rat ATRAID
      QuantiFast Probe-based Assays in human, mouse, rat ATRAID

    Additional mRNA sequence: 

    AB009017.1 AF077037.1 AF144055.2 AF275744.1 AK291894.1 AY358968.1 BC002846.1 BC011006.1 
    BC021237.2 BC035850.1 

    16 DOTS entries:

    DT.95222292  DT.101985101  DT.218168  DT.92445187  DT.95222294  DT.100890850  DT.100890886  DT.120996029 
    DT.95328518  DT.100890880  DT.91919621  DT.95222300  DT.100770201  DT.92445191  DT.95099860  DT.95195645 

    Selected AceView cDNA sequences (see all 500):

    BU579992 BG196385 BQ478534 BQ581855 H02975 BU071448 BM565101 BQ268274 
    AI753240 AW021005 CR591565 BU736803 NM_016085 BU947261 CR596120 CA450289 
    BQ636752 BU734481 BU948353 BM818165 BM707676 BM857713 AA487802 BU951624 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ATRAID    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:              -     -                                   -                           
    SP2:                    -                                   -                           
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for ATRAID

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATRAID expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ATRAID Expression
    About this image


    ATRAID expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    ATRAID Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATRAID Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9527

    UniProtKB/Swiss-Prot: ARAID_HUMAN, Q6UW56
    Tissue specificity: Weakly expressed in hematopoietic cell lines

        Custom PCR Arrays for ATRAID
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    QuantiFast Probe-based Assays in human, mouse, rat ATRAID
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATRAID

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ATRAID gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atraid1 , 5 RIKEN cDNA 0610007C21 gene5
    all-trans retinoic acid induced differentiation factor1
    83.9(n)1
    81.95(a)1
      5 (16.94 cM)5
    3816291  NM_027855.41  NP_082131.21 
     310483125 
    chicken
    (Gallus gallus)
    Aves ATRAID6
    all-trans retinoic acid-induced differentiation fa...
    48(a)
    1 ↔ 1
    AADN03014497.1(21-1754)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atraid1 all-trans retinoic acid-induced differentiation factor 55.21(n)
    48.47(a)
      496775  NM_001011316.1  NP_001011316.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atraid1 all-trans retinoic acid-induced differentiation factor 51.37(n)
    44.85(a)
      553468  NM_001044773.1  NP_001038238.1 


    ENSEMBL Gene Tree for ATRAID (if available)
    TreeFam Gene Tree for ATRAID (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATRAID gene
    1 SIMAP similar gene for ATRAID using alignment to 2 protein entries:     ARAID_HUMAN (see all proteins):
    C2orf28

    ATRAID for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATRAID (see all 37)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512988531,2
    --27437221(+) AATGTA/CCAGCA 3 -- int10--------
    rs58300391,2
    C--27437283(+) TGTGA-/CTTG  
            
    CTTTT
    3 -- int1 trp30--------
    rs2008096571,2
    C--27437286(+) GACTT-/GCT/
     CTT
    /TGC
    TTTTT
    9 -- int1 cds11NA 2
    rs1885076091,2
    C--27437287(+) GACTTG/TTTTTT 3 -- int10--------
    rs97120361,2
    C--27437288(+) ACTTTC/TTTTTT 3 -- int1 trp30--------
    rs1893616811,2
    C--27437457(+) TGGCTC/TATGCC 3 -- int10--------
    rs1416860571,2
    C--27437485(+) GGGAGG/TCCCAG 3 -- int10--------
    rs12755351,2
    C,F,A,H--27437496(+) atgggT/Cggatc 3 -- int17Minor allele frequency- C:0.19NA WA 16
    rs1819349251,2
    C--27437669(+) GAGCCA/GAGATC 3 -- int10--------
    rs1868157091,2
    C--27437683(+) CCACTC/GCACTC 3 -- int10--------

    HapMap Linkage Disequilibrium report for ATRAID (27434895 - 27440046 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ATRAID: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATRAID
    DNA2.0 Custom Variant and Variant Library Synthesis for ATRAID

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for ATRAID:    
    About MalaCards
    cervical squamous cell carcinoma    hiv-1    cervicitis    squamous cell carcinoma


    ATRAID for disorders           About GeneDecksing


    Export disorders for ATRAID gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATRAID gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ATRAID)
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    1. Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1. (PubMed id 17524364)1, 2, 3, 9 Yu F.... Lu Z. (Biochem. Biophys. Res. Commun. 2007)
    2. NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation. (PubMed id 21723284)1, 2, 3 Zou X.... Zhang X. (FEBS Lett. 2011)
    3. Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB. (PubMed id 17387583)1, 2, 9 Yang G....Lu Z. (Mol. Cell. Biochem. 2007)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    9. Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes. (PubMed id 10948432)1, 2 Zhu F.... Wang C.J. (BioTechniques 2000)
    10. Increased expression of apoptosis-related protein 3 is highly associated with tumorigenesis and progression of cervical squamous cell carcinoma. (PubMed id 23036366)1 Zhang Y....Yan W. (Hum. Pathol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51374 HGNC: 24090 AceView: C2orf28 Ensembl:ENSG00000138085 euGenes: HUgn51374
    ECgene: ATRAID H-InvDB: ATRAID

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATRAID Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATRAID gene:
    Search GeneIP for patents involving ATRAID

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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