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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATPIF1 Gene

protein-coding   GIFtS: 52
GCID: GC01P028562

ATPase inhibitory factor 1

 Explore 2 diseases affiliated with
ATPIF1 via our new
 Human Malady Compendium 
Biological research products
for ATPIF1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ATPase Inhibitory Factor 11 2     IF12 3
ATPI1 2 3     MGC11671
ATPIP1 2     MGC88981
IP1 2     ATP Synthase Inhibitor Protein2
Inhibitor Of F(1)F(O)-ATPase2 3     ATPase Inhibitor Protein2
IF(1)2 3     ATPase Inhibitor, Mitochondrial2

External Ids:    HGNC: 8711   Entrez Gene: 939742   Ensembl: ENSG000001307707   OMIM: 6149815   UniProtKB: Q9UII23   

Export aliases for ATPIF1 gene to outside databases

Previous GC identifers: GC00U991040 GC01P027573 GC01P027795 GC01P028167 GC01P028246 GC01P028435 GC01P026819


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATPIF1:
This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript
variants encoding distinct isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATIF1_HUMAN, Q9UII2
Function: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls
below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial
matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP
hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by
modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron
into protoporphyrin IX to produce heme

Gene Wiki entry for ATPIF1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATPIF1 gene promoter:
         TBP   STAT1   STAT1beta   STAT1alpha   RORalpha1   deltaCREB   HSF2   c-Myb   ZID   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATPIF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATPIF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATPIF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

ATPIF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATPIF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028562:  view genomic region     (about GC identifiers)

Start:
28,562,611 bp from pter      End:
28,573,417 bp from pter
Size:
10,807 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATIF1_HUMAN, Q9UII2 (See protein sequence)
Recommended Name: ATPase inhibitor, mitochondrial precursor  
Size: 106 amino acids; 12249 Da
Subunit: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the
inactive form and is present at a pH value above 7.0 (By similarity)
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAH04955.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5JXL8 Q6IAQ7 Q9BSL9
Alternative splicing: 3 isoforms:  Q9UII2-1   Q9UII2-2   Q9UII2-3   

Explore the universe of human proteins at neXtProt for ATPIF1: NX_Q9UII2

Post-translational modifications:

  • Exhibits variability in chain length, mitochondria have distinct pools of protein cleaved after the 24th, 25th, and
  • 26th amino acid1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UII2

  • ATPIF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_057395.1  NP_835497.1  NP_835498.1  

    ENSEMBL proteins: 
     ENSP00000435579   ENSP00000409232   ENSP00000335203   ENSP00000435341   ENSP00000437337  

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    Novus Biologicals ATPIF1 Proteins
    Novus Biologicals ATPIF1 Lysates
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    ProSpec Recombinant Protein for ATPIF1
    Uscn Proteins for ATPIF1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005753colocalizes with mitochondrial proton-transporting ATP synthase complex IDA12110673
    GO:0009986cell surface IDA15528193


    ATPIF1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ATPIF1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007648 ATPase_inhibitor_IATP_mt

    Graphical View of Domain Structure for InterPro Entry Q9UII2

    ProtoNet protein and cluster: Q9UII2

    1 Blocks protein family: IPB007648 Mitochondrial ATPase inhibitor

    UniProtKB/Swiss-Prot: ATIF1_HUMAN, Q9UII2
    Domain: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil composed of
    residues 74-106, leaving each N-terminal inhibitory region (residues 26-52) accessible for interaction with an F1
    catalytic domain. The inhibitory N-terminal region (residues 26-52) binds the alpha(ADP-bound)-beta(ADP-bound)
    (ATP5A1-ATP5B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5C1). This dimeric state is
    favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the
    inhibitory region is occluded, masking its inhibitory activity (By similarity)
    Similarity: Belongs to the ATPase inhibitor family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ATIF1_HUMAN, Q9UII2
    Function: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls
    below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial
    matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP
    hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by
    modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron
    into protoporphyrin IX to produce heme

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ATPIF1:
    hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidATPIF1 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity TAS10664857
    GO:0005515protein binding ----
    GO:0005516calmodulin binding ISS--
    GO:0042030ATPase inhibitor activity ISS--
    GO:0042803protein homodimerization activity ISS--


    ATPIF1 for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atpif1):
     behavior/neurological  homeostasis/metabolism 

    ATPIF1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucose / Energy Metabolism
    Glucose / Energy Metabolism1.00
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Electron Transport Chain0.76

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ATPIF1
        Glucose / Energy Metabolism

    1 BioSystems Pathway for ATPIF1 
        Electron Transport Chain



    ATPIF1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATPIF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/24 Interacting proteins for ATPIF1 (Q9UII22, 3 ENSP000003352034) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-65749 I2D: score=5 
    GSK3BP498412, 3MINT-8256888 I2D: score=2 
    UBQLN4Q9NRR53, ENSP000003572924I2D: score=3 STRING: ENSP00000357292
    PIK3CAP423363, ENSP000002639674I2D: score=2 STRING: ENSP00000263967
    ATP5A1ENSP000002820504STRING: ENSP00000282050
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS15528193
    GO:0001937negative regulation of endothelial cell proliferation IDA15528193
    GO:0006091generation of precursor metabolites and energy TAS10664857
    GO:0006783heme biosynthetic process IMP--
    GO:0030218erythrocyte differentiation IMP--


    ATPIF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATPIF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATPIF1
    1 Novoseek chemical compound relationship for ATPIF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 44.7 5 1833193 (3)

    Search CenterWatch for drugs/clinical trials and news about ATPIF1 / ATIF1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATPIF1 gene (3 alternative transcripts): 
    NM_016311.4  NM_178190.2  NM_178191.2  

    Unigene Cluster for ATPIF1:

    ATPase inhibitory factor 1
    Hs.590908  [show with all ESTs]
    Unigene Representative Sequence: NM_178191
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497986(uc001bpq.3 uc001bpp.3) ENST00000417632 ENST00000335514
    ENST00000468425 ENST00000465645(uc001bpr.3)

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ATPIF1:
    hsa-miR-877*
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB029042.1 AF114836.1 AK000934.1 AK316600.1 AL050386.1 BC004955.1 BC009677.1 BC017562.2 
    BT009849.1 CR457097.1 

    19 DOTS entries:

    DT.121422470  DT.87017920  DT.99953392  DT.100825302  DT.100825303  DT.121422436  DT.80101170  DT.100714322 
    DT.121422503  DT.121422345  DT.91847615  DT.121422469  DT.91742055  DT.95157370  DT.95157425  DT.100825306 
    DT.121422386  DT.100657872  DT.100825304 

    24/433 AceView cDNA sequences (see all 433):

    BC017562 AA443703 BG337348 BU557395 AW162531 BP376352 AI146343 AB029042 
    BG026493 CB162326 BE253195 BF684523 BE279835 CR621184 BU854961 BX339117 
    BP352058 BU163117 AA252800 BU500942 BQ651029 BM662569 CR457097 AA147873 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ATPIF1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
    SP1:                                -     -     -         
    SP2:                                -     -               
    SP3:                          -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for ATPIF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATPIF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTCTGGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ATPIF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATPIF1

    SOURCE GeneReport for Unigene cluster: Hs.590908
        SABiosciences Custom PCR Arrays for ATPIF1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATPIF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ATPIF1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atpif11 , 5 ATPase inhibitory factor 11, 5 76.19(n)1
    68.57(a)1
      4 (65.51 cM)5
    119831  NM_007512.31  NP_031538.21 
     1325305555 
    chicken
    (Gallus gallus)
    Aves ATPIF16
    Uncharacterized protein
    79(a)
    1 ↔ 1
    23(1508031-1508174)
    lizard
    (Anolis carolinensis)
    Reptilia ATPIF16
    --
    71(a)
    1 ↔ 1
    GL343743.1(176182-178408)
    zebrafish
    (Danio rerio)
    Actinopterygii atpif11 ATPase inhibitory factor 1 66.2(n)
    77.46(a)
      100037369  NM_001089521.1  NP_001082990.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG135516
    CG344236
    --
    33(a)
    31(a)
    many → 1
    many → 1
    2R(19265383-19270944)
    2R(19246206-19246727)
    worm
    (Caenorhabditis elegans)
    Secernentea mai-16
    mai-26
    ATPase inhibitor mai-2, mitochondrial
    34(a)
    33(a)
    many → 1
    many → 1
    X(3114672-3116528)
    IV(3385635-3386904)


    ENSEMBL Gene Tree for ATPIF1 (if available)
    TreeFam Gene Tree for ATPIF1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/86 NCBI SNPs in ATPIF1 are shown (see all 86    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476617091,2
    --28561849(+) GTTTT-/CTTTTT 3 -- us2k10--------
    rs5739951,2
    C,F,A,H,--28561856(+) TTTTTG/TTTTTT 3 -- us2k1 trp38Minor allele frequency- T:0.50NA WA CSA 16
    rs5370951,2
    C,F,A,H,--28561860(+) TTTTTT/GTTTGT 3 -- us2k1 trp311Minor allele frequency- G:0.31NA WA CSA EA 374
    rs1914153991,2
    --28561861(+) TTTTTG/TTTGTT 3 -- us2k10--------
    rs1836432201,2
    --28561882(+) GTCTCC/GCTTTG 3 -- us2k10--------
    rs125629471,2
    H--28561890(+) ttgtcA/Cccagg 3 -- us2k10--------
    rs1886910561,2
    --28561909(+) CAGTTC/GCGCAA 3 -- us2k10--------
    rs4822491,2
    C,F,A,H,--28562006(+) CCACCG/ACACCC 3 -- us2k18Minor allele frequency- A:0.47NA WA CSA 17
    rs1131201131,2
    C,--28562095(+) ATCCAC/TCCACT 3 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1402002121,2
    --28562156(+) AGAACA/GCTGAC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATPIF1 (28562611 - 28573417 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ATPIF1
         1 CNV: 58383

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ATPIF1 for disorders           About GeneDecksing

    OMIM gene information: 614981    OMIM disorders: --

    2 diseases for ATPIF1:    About MalaCards
    seizures    ataxia

    Human Genome Epidemiology (HuGE) Navigator: ATPIF1 (2 documents)

    Export disorders for ATPIF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATPIF1 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with ATPIF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IF(1): setting the pace of the F(1)F(o)-ATP synthase. (PubMed id 19559621)1, 2, 3 Campanella M.... Duchen M.R. (2009)
    2. Nucleotide sequence of cDNA coding the mitochondrial precursor protein of the ATPase inhibitor from humans. (PubMed id 10664857)1, 2, 3 Ichikawa N.... Masazumi Y. (1999)
    3. Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. (PubMed id 23135403)1, 2 Shah D.I.... Paw B.H. (2012)
    4. An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface. (PubMed id 15528193)1, 2 Burwick N.R....Pizzo S.V. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies. (PubMed id 12110673)1, 2 Aggeler R....Marusich M.F. (2002)
    8. The inhibitor protein of the F1F0-ATP synthase is associated to the external surface of endothelial cells. (PubMed id 15809073)1, 9 Cortes-Hernandez P....Garcia J.J. (2005)
    9. The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response. (PubMed id 22342343)1 Formentini L....Cuezva J.M. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93974 HGNC: 871 AceView: ATPIF1 Ensembl:ENSG00000130770 euGenes: HUgn93974
    ECgene: ATPIF1 H-InvDB: ATPIF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATPIF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATPIF1 gene:
    Search GeneIP for patents involving ATPIF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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