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ATPIF1 Gene

protein-coding   GIFtS: 52
GCID: GC01P028562

ATPase Inhibitory Factor 1

  Search for ATPIF1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATPase Inhibitory Factor 11 2     IF(1)2 3
IF12 3 5     ATPIP2
ATP Synthase Inhibitor Protein1 2     IP2
ATPase Inhibitor Protein1 2     ATPase Inhibitor, Mitochondrial2
Inhibitor Of F(1)F(O)-ATPase2 3     ATP1F15
ATPI2 3     

External Ids:    HGNC: 8711   Entrez Gene: 939742   Ensembl: ENSG000001307707   OMIM: 6149815   UniProtKB: Q9UII23   

Export aliases for ATPIF1 gene to outside databases

Previous GC identifers: GC00U991040 GC01P027573 GC01P027795 GC01P028167 GC01P028246 GC01P028435 GC01P026819


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATPIF1 Gene:
This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript
variants encoding distinct isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for ATPIF1 Gene:
ATPIF1 (ATPase inhibitory factor 1) is a protein-coding gene. GO annotations related to this gene include enzyme inhibitor activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: ATIF1_HUMAN, Q9UII2
Function: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential
falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the
mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme
acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme
synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the
incorporation of iron into protoporphyrin IX to produce heme

Gene Wiki entry for ATPIF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ATPIF1 gene promoter:
         TBP   STAT1   STAT1beta   STAT1alpha   RORalpha1   deltaCREB   HSF2   c-Myb   ZID   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATPIF1 promoter sequence
   Search Chromatin IP Primers for ATPIF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATPIF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

ATPIF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATPIF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028562:  view genomic region     (about GC identifiers)

Start:
28,562,602 bp from pter      End:
28,573,417 bp from pter
Size:
10,816 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATIF1_HUMAN, Q9UII2 (See protein sequence)
Recommended Name: ATPase inhibitor, mitochondrial precursor  
Size: 106 amino acids; 12249 Da
Subunit: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents
the inactive form and is present at a pH value above 7.0 (By similarity)
Sequence caution: Sequence=AAH04955.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5JXL8 Q6IAQ7 Q9BSL9
Alternative splicing: 3 isoforms:  Q9UII2-1   Q9UII2-2   Q9UII2-3   

Explore the universe of human proteins at neXtProt for ATPIF1: NX_Q9UII2

Explore proteomics data for ATPIF1 at MOPED

Post-translational modifications: 

  • Exhibits variability in chain length, mitochondria have distinct pools of protein cleaved after the 24th, 25th,
    and 26th amino acid1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ATPIF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_057395.1  NP_835497.1  NP_835498.1  

    ENSEMBL proteins: 
     ENSP00000435579   ENSP00000335203   ENSP00000435341   ENSP00000437337  

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    Cloud-Clone Corp. Proteins for ATPIF1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FATP: Mitochondrial respiratory chain complex / Complex V

    1 InterPro protein domain:
     IPR007648 ATPase_inhibitor_IATP_mt

    Graphical View of Domain Structure for InterPro Entry Q9UII2

    ProtoNet protein and cluster: Q9UII2

    1 Blocks protein domain: IPB007648 Mitochondrial ATPase inhibitor

    UniProtKB/Swiss-Prot: ATIF1_HUMAN, Q9UII2
    Domain: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil
    composed of residues 74-106, leaving each N-terminal inhibitory region (residues 26-52) accessible for
    interaction with an F1 catalytic domain. The inhibitory N-terminal region (residues 26-52) binds the
    alpha(ADP-bound)-beta(ADP-bound) (ATP5A1-ATP5B) interface of F1-ATPase, and also contact the central gamma
    subunit (ATP5C1). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate
    to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity (By
    similarity)
    Similarity: Belongs to the ATPase inhibitor family


    Find genes that share domains with ATPIF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATIF1_HUMAN, Q9UII2
    Function: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential
    falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the
    mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme
    acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme
    synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the
    incorporation of iron into protoporphyrin IX to produce heme

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity TAS10664857
    GO:0005515protein binding ----
    GO:0005516calmodulin binding ISS--
    GO:0042030ATPase inhibitor activity ISS--
    GO:0042803protein homodimerization activity ISS--
         
    Find genes that share ontologies with ATPIF1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atpif1):
     behavior/neurological  homeostasis/metabolism 

    Find genes that share phenotypes with ATPIF1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATPIF1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATPIF1
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    miRNA
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    miRTarBase miRNAs that target ATPIF1:
    hsa-mir-615-3p (MIRT040414), hsa-mir-324-3p (MIRT042994)

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    1 qRT-PCR Assays for microRNA that regulate ATPIF1:
    hsa-miR-877*
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATIF1_HUMAN, Q9UII2: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast1
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005753colocalizes with mitochondrial proton-transporting ATP synthase complex IDA12110673
    GO:0009986cell surface IDA15528193

    Find genes that share ontologies with ATPIF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATPIF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Electron Transport Chain0.75
    2Glucose / Energy Metabolism
    Glucose / Energy Metabolism


    Find genes that share SuperPaths with ATPIF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ATPIF1
        Glucose / Energy Metabolism

    1 BioSystems Pathway for ATPIF1
        Electron Transport Chain



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATPIF1
    Interactions:

        Search GeneGlobe Interaction Network for ATPIF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATPIF1 (Q9UII22, 3 ENSP000003352034) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-65749 I2D: score=5 
    GSK3BP498412, 3MINT-8256888 I2D: score=2 
    UBQLN4Q9NRR53, ENSP000003572924I2D: score=3 STRING: ENSP00000357292
    PIK3CAP423363, ENSP000002639674I2D: score=2 STRING: ENSP00000263967
    ACOT7ENSP000003670864STRING: ENSP00000367086
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS15528193
    GO:0001937negative regulation of endothelial cell proliferation IDA15528193
    GO:0006091generation of precursor metabolites and energy TAS10664857
    GO:0006783heme biosynthetic process IMP--
    GO:0030218erythrocyte differentiation IMP--

    Find genes that share ontologies with ATPIF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATPIF1 (ATIF1)

    1 Novoseek inferred chemical compound relationship for ATPIF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 44.7 5 1833193 (3)



    Find genes that share compounds with ATPIF1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATPIF1 gene (3 alternative transcripts): 
    NM_016311.4  NM_178190.2  NM_178191.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497986(uc001bpq.3 uc001bpp.3) ENST00000335514 ENST00000468425
    ENST00000465645(uc001bpr.3)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ATPIF1:
    hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidATPIF1 3' UTR sequence
    Inhib. RNA
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    Selected AceView cDNA sequences (see all 433):

    AI146343 CK824020 BU163117 BM924260 NM_178191 AA315596 F26198 AW954001 
    BU948912 BQ007789 BG026493 BM976899 AW268818 CR621184 AU117578 CB156216 
    AI217899 CR592071 BU557395 AB029042 BQ651029 AA365906 BX339117 BP376352 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ATPIF1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
    SP1:                                -     -     -         
    SP2:                                -     -               
    SP3:                          -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for ATPIF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATPIF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCTGGTTT
    ATPIF1 Expression
    About this image


    ATPIF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    ATPIF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATPIF1 Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ATPIF1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atpif11 , 5 ATPase inhibitory factor 11, 5 76.19(n)1
    68.57(a)1
      4 (65.51 cM)5
    119831  NM_007512.31  NP_031538.21 
     1325305555 
    lizard
    (Anolis carolinensis)
    Reptilia ATPIF16
    ATPase inhibitory factor 1
    52(a)
    1 ↔ 1
    GL343743.1(175914-181386)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atpif11 ATPase inhibitory factor 1 61.59(n)
    67.39(a)
      100216112  NM_001142093.1  NP_001135565.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atpif1a1 ATPase inhibitory factor 1a 66.2(n)
    77.46(a)
      100037369  NM_001089521.1  NP_001082990.1 


    ENSEMBL Gene Tree for ATPIF1 (if available)
    TreeFam Gene Tree for ATPIF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATPIF1 (see all 107)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476617091,2
    --28561849(+) GTTTT-/CTTTTT 3 -- us2k10--------
    rs5739951,2
    C,F,A,H--28561856(+) tttttG/Tttttt 3 -- us2k1 trp38Minor allele frequency- T:0.50NA WA CSA 16
    rs5370951,2
    C,F,A,H--28561860(+) tttttT/Gtttgt 3 -- us2k1 trp311Minor allele frequency- G:0.31NA WA CSA EA 374
    rs1914153991,2
    --28561861(+) TTTTTG/TTTGTT 3 -- us2k10--------
    rs1836432201,2
    --28561882(+) GTCTCC/GCTTTG 3 -- us2k10--------
    rs125629471,2
    H--28561890(+) ttgtcA/Cccagg 3 -- us2k10--------
    rs1886910561,2
    --28561909(+) CAGTTC/GCGCAA 3 -- us2k10--------
    rs4822491,2
    C,F,A,H--28562006(+) ccaccG/Acaccc 3 -- us2k18Minor allele frequency- A:0.47NA WA CSA 17
    rs1131201131,2
    C,F--28562095(+) ATCCAC/TCCACT 3 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1402002121,2
    --28562156(+) AGAACA/GCTGAC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATPIF1 (28562602 - 28573417 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ATPIF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819729CNV Loss19587683
    dgv208n71CNV Gain21882294
    nsv871151CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614981    OMIM disorders: --


    Find genes that share disorders with ATPIF1           About GenesLikeMe

    Genetic Association Database (GAD): ATPIF1
    Human Genome Epidemiology (HuGE) Navigator: ATPIF1 (2 documents)

    Export disorders for ATPIF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATPIF1 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with ATPIF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IF(1): setting the pace of the F(1)F(o)-ATP synthase. (PubMed id 19559621)1, 2, 3 Campanella M.... Duchen M.R. (Trends Biochem. Sci. 2009)
    2. Nucleotide sequence of cDNA coding the mitochondrial precursor protein of the ATPase inhibitor from humans. (PubMed id 10664857)1, 2, 3 Ichikawa N.... Masazumi Y. (Biosci. Biotechnol. Biochem. 1999)
    3. Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. (PubMed id 23135403)1, 2 Shah D.I.... Paw B.H. (Nature 2012)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface. (PubMed id 15528193)1, 2 Burwick N.R.... Pizzo S.V. (J. Biol. Chem. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies. (PubMed id 12110673)1, 2 Aggeler R.... Marusich M.F. (J. Biol. Chem. 2002)
    10. The inhibitor protein of the F1F0-ATP synthase is associated to the external surface of endothelial cells. (PubMed id 15809073)1, 9 CortAcs-HernA!ndez P....GarcA-a J.J. (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93974 HGNC: 871 AceView: ATPIF1 Ensembl:ENSG00000130770 euGenes: HUgn93974
    ECgene: ATPIF1 H-InvDB: ATPIF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATPIF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATPIF1 gene:
    Search GeneIP for patents involving ATPIF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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