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Aliases for ATPAF1 Gene

Aliases for ATPAF1 Gene

  • ATP Synthase Mitochondrial F1 Complex Assembly Factor 1 2 3
  • ATP11 3 4
  • Homolog Of Yeast ATP11 3
  • ATP11 Homolog 4
  • ATP11p 3

External Ids for ATPAF1 Gene

Previous GeneCards Identifiers for ATPAF1 Gene

  • GC01M046794
  • GC01M046055
  • GC01M046487
  • GC01M046470
  • GC01M046812
  • GC01M046870
  • GC01M047098
  • GC01M045213

Summaries for ATPAF1 Gene

Entrez Gene Summary for ATPAF1 Gene

  • This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 beta subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for ATPAF1 Gene

ATPAF1 (ATP Synthase Mitochondrial F1 Complex Assembly Factor 1) is a Protein Coding gene. Diseases associated with ATPAF1 include isolated atp synthase deficiency.

UniProtKB/Swiss-Prot for ATPAF1 Gene

  • May play an essential role for the assembly of the mitochondrial F1-F0 complex.

Gene Wiki entry for ATPAF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATPAF1 Gene

Genomics for ATPAF1 Gene

Regulatory Elements for ATPAF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATPAF1 Gene

Start:
46,632,737 bp from pter
End:
46,673,867 bp from pter
Size:
41,131 bases
Orientation:
Minus strand

Genomic View for ATPAF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATPAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATPAF1 Gene

Proteins for ATPAF1 Gene

  • Protein details for ATPAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TC12-ATPF1_HUMAN
    Recommended name:
    ATP synthase mitochondrial F1 complex assembly factor 1
    Protein Accession:
    Q5TC12
    Secondary Accessions:
    • B1AQW7
    • B7Z7D6
    • B7Z7I6
    • Q9H6E3

    Protein attributes for ATPAF1 Gene

    Size:
    328 amino acids
    Molecular mass:
    36437 Da
    Quaternary structure:
    • Interacts with ATP5B.

    Alternative splice isoforms for ATPAF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATPAF1 Gene

Proteomics data for ATPAF1 Gene at MOPED

Post-translational modifications for ATPAF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATPAF1 Gene

Domains for ATPAF1 Gene

Gene Families for ATPAF1 Gene

HGNC:
  • MITOAF :Mitochondrial respiratory chain complex assembly factors

Protein Domains for ATPAF1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5TC12

UniProtKB/Swiss-Prot:

ATPF1_HUMAN :
  • Q5TC12
Family:
  • Belongs to the ATP11 family.
genes like me logo Genes that share domains with ATPAF1: view

Function for ATPAF1 Gene

Molecular function for ATPAF1 Gene

UniProtKB/Swiss-Prot Function: May play an essential role for the assembly of the mitochondrial F1-F0 complex.

Gene Ontology (GO) - Molecular Function for ATPAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11410595
genes like me logo Genes that share ontologies with ATPAF1: view

Animal Model Products

CRISPR Products

miRNA for ATPAF1 Gene

miRTarBase miRNAs that target ATPAF1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATPAF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATPAF1 Gene

Localization for ATPAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATPAF1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATPAF1 Gene COMPARTMENTS Subcellular localization image for ATPAF1 gene
Compartment Confidence
mitochondrion 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ATPAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ATPAF1: view

Pathways for ATPAF1 Gene

SuperPathways for ATPAF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATPAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly IEA --
genes like me logo Genes that share ontologies with ATPAF1: view

No data available for Pathways by source for ATPAF1 Gene

Transcripts for ATPAF1 Gene

Unigene Clusters for ATPAF1 Gene

ATP synthase mitochondrial F1 complex assembly factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATPAF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATPAF1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - - - -
SP3: -
SP4: - - - - - -
SP5:

Relevant External Links for ATPAF1 Gene

GeneLoc Exon Structure for
ATPAF1
ECgene alternative splicing isoforms for
ATPAF1

Expression for ATPAF1 Gene

mRNA expression in normal human tissues for ATPAF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATPAF1 Gene

SOURCE GeneReport for Unigene cluster for ATPAF1 Gene Hs.100874

mRNA Expression by UniProt/SwissProt for ATPAF1 Gene

Q5TC12-ATPF1_HUMAN
Tissue specificity: Weakly expressed in muscle.
genes like me logo Genes that share expressions with ATPAF1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ATPAF1 Gene

Orthologs for ATPAF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATPAF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATPAF1 35
  • 99.86 (n)
  • 99.58 (a)
cow
(Bos Taurus)
Mammalia ATPAF1 35
  • 92.1 (n)
  • 92.49 (a)
ATPAF1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATPAF1 35
  • 92.31 (n)
  • 92.63 (a)
ATPAF1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atpaf1 35
  • 88.7 (n)
  • 89.08 (a)
Atpaf1 16
Atpaf1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATPAF1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATPAF1 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atpaf1 35
  • 88.41 (n)
  • 87.64 (a)
chicken
(Gallus gallus)
Aves ATPAF1 35
  • 69.86 (n)
  • 69.52 (a)
ATPAF1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATPAF1 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atpaf1 35
  • 65.75 (n)
  • 62.07 (a)
Str.13192 35
zebrafish
(Danio rerio)
Actinopterygii atpaf1 35
  • 64.66 (n)
  • 60.99 (a)
atpaf1 36
  • 55 (a)
OneToOne
idibd1136 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004641 35
  • 50.07 (n)
  • 37.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10340 35
  • 47.46 (n)
  • 35.17 (a)
CG10340 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP11 36
  • 20 (a)
OneToOne
ATP11 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2656 36
  • 31 (a)
OneToOne
Species with no ortholog for ATPAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATPAF1 Gene

ENSEMBL:
Gene Tree for ATPAF1 (if available)
TreeFam:
Gene Tree for ATPAF1 (if available)

Paralogs for ATPAF1 Gene

Selected SIMAP similar genes for ATPAF1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ATPAF1: view

No data available for Paralogs for ATPAF1 Gene

Variants for ATPAF1 Gene

Sequence variations from dbSNP and Humsavar for ATPAF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs582269 -- 46,664,645(-) ACCCA(C/T)CCCCA intron-variant
rs582323 -- 46,656,924(+) TCTGG(A/C)ACAGA intron-variant
rs582760 -- 46,664,776(-) GCCAT(C/T)ATAGT intron-variant
rs583649 -- 46,657,184(+) ATGCA(C/T)ATGAA intron-variant
rs594118 -- 46,665,201(-) CTCCT(C/T)ACCCT intron-variant

Relevant External Links for ATPAF1 Gene

HapMap Linkage Disequilibrium report
ATPAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATPAF1 Gene

Disorders for ATPAF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ATPAF1 Gene including...

Search for ATPAF1 Gene in MalaCards »

Relevant External Links for ATPAF1

Genetic Association Database (GAD)
ATPAF1
Human Genome Epidemiology (HuGE) Navigator
ATPAF1
genes like me logo Genes that share disorders with ATPAF1: view

No data available for UniProtKB/Swiss-Prot for ATPAF1 Gene

Publications for ATPAF1 Gene

  1. Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria. (PMID: 11410595) Wang Z.-G. … Ackerman S.H. (J. Biol. Chem. 2001) 2 3 4
  2. Differential expression of ATPAF1 and ATPAF2 genes encoding F(1)- ATPase assembly proteins in mouse tissues. (PMID: 12965202) Pickova A. … Houstek J. (FEBS Lett. 2003) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling. (PMID: 20579638) Saito K. … Matsushita M. (FEBS Lett. 2010) 3

Products for ATPAF1 Gene

Sources for ATPAF1 Gene

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