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Aliases for ATP9A Gene

Aliases for ATP9A Gene

  • ATPase Phospholipid Transporting 9A (Putative) 2 3
  • ATPase, Class II, Type 9A 2 3 5
  • EC 4 63
  • ATPIIA 3 4
  • ATPase Type IV, Phospholipid-Transporting (P-Type),(Putative) 3
  • Phospholipid-Transporting ATPase IIA 3
  • ATPase Class II Type 9A 4
  • KIAA0611 4
  • EC 3.6.3 63

External Ids for ATP9A Gene

Previous GeneCards Identifiers for ATP9A Gene

  • GC20M049936
  • GC20M050851
  • GC20M050898
  • GC20M049646
  • GC20M050213
  • GC20M046960

Summaries for ATP9A Gene

GeneCards Summary for ATP9A Gene

ATP9A (ATPase Phospholipid Transporting 9A (Putative)) is a Protein Coding gene. Among its related pathways are Ion channel transport and Cardiac conduction. GO annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP9B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP9A Gene

Genomics for ATP9A Gene

Regulatory Elements for ATP9A Gene

Enhancers for ATP9A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATP9A on UCSC Golden Path with GeneCards custom track

Promoters for ATP9A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATP9A on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP9A Gene

51,596,514 bp from pter
51,768,634 bp from pter
172,121 bases
Minus strand

Genomic View for ATP9A Gene

Genes around ATP9A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP9A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP9A Gene

Proteins for ATP9A Gene

  • Protein details for ATP9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable phospholipid-transporting ATPase IIA
    Protein Accession:
    Secondary Accessions:
    • E1P5Y3
    • E1P5Y4
    • Q5TFW5
    • Q5TFW6
    • Q5TFW9
    • Q6ZMF3
    • Q9NQK6
    • Q9NQK7

    Protein attributes for ATP9A Gene

    1047 amino acids
    Molecular mass:
    118583 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18775.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI18889.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19203.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22924.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP9A Gene


neXtProt entry for ATP9A Gene

Proteomics data for ATP9A Gene at MOPED

Post-translational modifications for ATP9A Gene

  • Ubiquitination at Lys 48, Lys 765, and Lys 822
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP9A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ATP9A Gene

Gene Families for ATP9A Gene

Suggested Antigen Peptide Sequences for ATP9A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
genes like me logo Genes that share domains with ATP9A: view

Function for ATP9A Gene

Molecular function for ATP9A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Enzyme Numbers (IUBMB) for ATP9A Gene

Gene Ontology (GO) - Molecular Function for ATP9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ATP9A: view
genes like me logo Genes that share phenotypes with ATP9A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP9A

miRNA for ATP9A Gene

miRTarBase miRNAs that target ATP9A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP9A Gene

Localization for ATP9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP9A Gene

Early endosome membrane; Multi-pass membrane protein. Recycling endosome. Golgi apparatus, trans-Golgi network membrane. Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B.

Subcellular locations from

Jensen Localization Image for ATP9A Gene COMPARTMENTS Subcellular localization image for ATP9A gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ATP9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005802 trans-Golgi network IDA 21914794
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 21914794
genes like me logo Genes that share ontologies with ATP9A: view

Pathways & Interactions for ATP9A Gene

genes like me logo Genes that share pathways with ATP9A: view

Pathways by source for ATP9A Gene

Interacting Proteins for ATP9A Gene

Gene Ontology (GO) - Biological Process for ATP9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IBA --
genes like me logo Genes that share ontologies with ATP9A: view

No data available for SIGNOR curated interactions for ATP9A Gene

Drugs & Compounds for ATP9A Gene

(1) Drugs for ATP9A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(402) Additional Compounds for ATP9A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
genes like me logo Genes that share compounds with ATP9A: view

Transcripts for ATP9A Gene

Unigene Clusters for ATP9A Gene

ATPase, class II, type 9A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP9A Gene

No ASD Table

Relevant External Links for ATP9A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP9A Gene

mRNA expression in normal human tissues for ATP9A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATP9A Gene

This gene is overexpressed in Nasal epithelium (45.0) and Frontal cortex (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP9A Gene

SOURCE GeneReport for Unigene cluster for ATP9A Gene Hs.649234

genes like me logo Genes that share expression patterns with ATP9A: view

Protein tissue co-expression partners for ATP9A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP9A Gene

Orthologs for ATP9A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP9A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATP9A 35
  • 89.8 (n)
  • 97.95 (a)
ATP9A 36
  • 97 (a)
(Canis familiaris)
Mammalia ATP9A 35
  • 91.76 (n)
  • 99.22 (a)
ATP9A 36
  • 96 (a)
(Mus musculus)
Mammalia Atp9a 35
  • 88.54 (n)
  • 97.99 (a)
Atp9a 16
Atp9a 36
  • 98 (a)
(Pan troglodytes)
Mammalia ATP9A 35
  • 99.54 (n)
  • 100 (a)
ATP9A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Atp9a 35
  • 88.12 (n)
  • 97.87 (a)
(Monodelphis domestica)
Mammalia ATP9A 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia ATP9A 36
  • 97 (a)
(Gallus gallus)
Aves ATP9A 35
  • 83.04 (n)
  • 96.39 (a)
ATP9A 36
  • 95 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
-- 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp9a 35
  • 77.99 (n)
  • 92.54 (a)
MGC76068 35
(Danio rerio)
Actinopterygii Dr.15835 35
ATP9A 36
  • 88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31729 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F02C9.3 37
  • 55 (a)
tat-5 36
  • 55 (a)
tat-6 36
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NEO1 36
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for ATP9A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP9A Gene

Gene Tree for ATP9A (if available)
Gene Tree for ATP9A (if available)

Paralogs for ATP9A Gene

Paralogs for ATP9A Gene

genes like me logo Genes that share paralogs with ATP9A: view

Variants for ATP9A Gene

Sequence variations from dbSNP and Humsavar for ATP9A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs12632 -- 51,598,090(-) GCGTG(C/T)GCACA utr-variant-3-prime
rs13128 -- 51,597,183(-) GCCAC(A/G)GCATG utr-variant-3-prime
rs1009232 -- 51,640,313(-) tgttg(C/G)cgcgg intron-variant
rs1009233 -- 51,638,003(-) tggga(C/T)tgggg intron-variant
rs1009234 -- 51,637,621(-) CGGAG(A/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP9A Gene

Variant ID Type Subtype PubMed ID
esv2751917 CNV Gain 17911159
nsv834004 CNV Loss 17160897
esv2668584 CNV Deletion 23128226
dgv1334e1 CNV Complex 17122850
nsv527764 CNV Loss 19592680
esv274686 CNV Insertion 20981092
esv268229 CNV Insertion 20981092
esv2501264 CNV Insertion 19546169
nsv513549 CNV Insertion 21212237
esv1250125 CNV Insertion 17803354
dgv703n67 CNV Gain 20364138
nsv9816 CNV Gain 18304495

Variation tolerance for ATP9A Gene

Residual Variation Intolerance Score: 1.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATP9A Gene

Disorders for ATP9A Gene

Relevant External Links for ATP9A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ATP9A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP9A Gene

Publications for ATP9A Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck M.S. … Schlegel R.A. (Physiol. Genomics 1999) 2 3
  3. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. (PMID: 25158072) Yu D. … Pauls D.L. (Am J Psychiatry 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION. (PMID: 26240149) Ansari I.U. … MacDonald M.J. (J. Biol. Chem. 2015) 3

Products for ATP9A Gene

Sources for ATP9A Gene