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Aliases for ATP9A Gene

Aliases for ATP9A Gene

  • ATPase Phospholipid Transporting 9A (Putative) 2 3 5
  • ATPase, Class II, Type 9A 2 3
  • EC 3.6.3.1 4 61
  • ATPIIA 3 4
  • ATPase Type IV, Phospholipid-Transporting (P-Type),(Putative) 3
  • Probable Phospholipid-Transporting ATPase IIA 3
  • Phospholipid-Transporting ATPase IIA 3
  • ATPase Class II Type 9A 4
  • KIAA0611 4
  • EC 3.6.3 61

External Ids for ATP9A Gene

Previous GeneCards Identifiers for ATP9A Gene

  • GC20M049936
  • GC20M050851
  • GC20M050898
  • GC20M049646
  • GC20M050213
  • GC20M046960

Summaries for ATP9A Gene

GeneCards Summary for ATP9A Gene

ATP9A (ATPase Phospholipid Transporting 9A (Putative)) is a Protein Coding gene. Among its related pathways are Ion channel transport and Cardiac conduction. GO annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP9B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP9A Gene

Genomics for ATP9A Gene

Regulatory Elements for ATP9A Gene

Enhancers for ATP9A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F051765 1.1 FANTOM5 ENCODE 18.9 +1.5 1458 2.5 HDGF PKNOX1 ZFP64 ARID4B SIN3A YY1 ZNF766 ZNF143 ZNF207 FOS ATP9A PSMD10P1 LOC100419570
GH20F051749 1.3 FANTOM5 Ensembl ENCODE 10.6 +17.1 17105 5.0 HDGF PKNOX1 ARNT MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 PSMD10P1 DPM1 ATP9A MOCS3 ZFP64 LOC100419570
GH20F051741 1.2 Ensembl ENCODE 10.3 +25.2 25178 4.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 PSMD10P1 ATP9A SALL4 LOC100419570
GH20F051656 0.3 FANTOM5 10 +112.2 112218 0.4 SOX13 DMAP1 CEBPG RAD21 ZKSCAN1 TEAD3 ZNF664 POLR2A NR2F6 MAFK ATP9A GC20M051626 GC20M051714
GH20F051760 0.7 Ensembl ENCODE 9.6 +7.3 7320 1.9 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF121 ELK1 ZNF207 PSMD10P1 ATP9A LOC100419570
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ATP9A on UCSC Golden Path with GeneCards custom track

Promoters for ATP9A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000402920 634 2400 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YBX1 YY1 ZNF766 ZNF143

Genomic Location for ATP9A Gene

Chromosome:
20
Start:
51,596,514 bp from pter
End:
51,768,634 bp from pter
Size:
172,121 bases
Orientation:
Minus strand

Genomic View for ATP9A Gene

Genes around ATP9A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP9A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP9A Gene

Proteins for ATP9A Gene

  • Protein details for ATP9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75110-ATP9A_HUMAN
    Recommended name:
    Probable phospholipid-transporting ATPase IIA
    Protein Accession:
    O75110
    Secondary Accessions:
    • E1P5Y3
    • E1P5Y4
    • Q5TFW5
    • Q5TFW6
    • Q5TFW9
    • Q6ZMF3
    • Q9NQK6
    • Q9NQK7

    Protein attributes for ATP9A Gene

    Size:
    1047 amino acids
    Molecular mass:
    118583 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18775.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI18889.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19203.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22924.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP9A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP9A Gene

Selected DME Specific Peptides for ATP9A Gene

O75110:
  • WLEEECGN
  • WMLTGDK
  • PLGFVLAVT
  • SSPDEVALV
  • ELACQCPAVVCCRC
  • ISTMQAVFSSVFYFASVPLYQGFL
  • HGRNSYKRSA
  • ESVGLTL
  • GRLLMVHGR
  • GKEGKQASLAADFSITQF
  • NDVSMIQ
  • YQASSPDE
  • SKRMGIIVRDE
  • FLRTSEK
  • EITFYMKGADV
  • EEQYQDFE
  • DKTGTLT
  • EMELLCLTGVEDQLQADVRPTLE
  • ESLSIENTLWA
  • IIPISLRVNLDMGK

Post-translational modifications for ATP9A Gene

  • Ubiquitination at Lys 48, Lys 765, and Lys 822
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP9A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ATP9A Gene

Gene Families for ATP9A Gene

Suggested Antigen Peptide Sequences for ATP9A Gene

Graphical View of Domain Structure for InterPro Entry

O75110

UniProtKB/Swiss-Prot:

ATP9A_HUMAN :
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
genes like me logo Genes that share domains with ATP9A: view

Function for ATP9A Gene

Molecular function for ATP9A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Enzyme Numbers (IUBMB) for ATP9A Gene

Gene Ontology (GO) - Molecular Function for ATP9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity IEA,IBA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ATP9A: view
genes like me logo Genes that share phenotypes with ATP9A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP9A

miRNA for ATP9A Gene

miRTarBase miRNAs that target ATP9A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP9A Gene

Localization for ATP9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP9A Gene

Early endosome membrane; Multi-pass membrane protein. Recycling endosome. Golgi apparatus, trans-Golgi network membrane. Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP9A Gene COMPARTMENTS Subcellular localization image for ATP9A gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ATP9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005769 early endosome IDA 21914794
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IEA,IDA 21914794
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with ATP9A: view

Pathways & Interactions for ATP9A Gene

genes like me logo Genes that share pathways with ATP9A: view

Pathways by source for ATP9A Gene

Gene Ontology (GO) - Biological Process for ATP9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA --
GO:0006897 endocytosis IBA --
GO:0015914 phospholipid transport IEA --
GO:0045332 phospholipid translocation NAS 21914794
genes like me logo Genes that share ontologies with ATP9A: view

No data available for SIGNOR curated interactions for ATP9A Gene

Drugs & Compounds for ATP9A Gene

(2) Drugs for ATP9A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(401) Additional Compounds for ATP9A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
genes like me logo Genes that share compounds with ATP9A: view

Transcripts for ATP9A Gene

Unigene Clusters for ATP9A Gene

ATPase, class II, type 9A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP9A Gene

No ASD Table

Relevant External Links for ATP9A Gene

GeneLoc Exon Structure for
ATP9A
ECgene alternative splicing isoforms for
ATP9A

Expression for ATP9A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATP9A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATP9A Gene

This gene is overexpressed in Nasal epithelium (45.0) and Frontal cortex (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP9A Gene



Protein tissue co-expression partners for ATP9A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP9A Gene:

ATP9A

SOURCE GeneReport for Unigene cluster for ATP9A Gene:

Hs.649234
genes like me logo Genes that share expression patterns with ATP9A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP9A Gene

Orthologs for ATP9A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP9A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP9A 34 35
  • 99.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATP9A 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP9A 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP9A 34 35
  • 91.76 (n)
cow
(Bos Taurus)
Mammalia ATP9A 34 35
  • 89.8 (n)
mouse
(Mus musculus)
Mammalia Atp9a 34 16 35
  • 88.54 (n)
rat
(Rattus norvegicus)
Mammalia Atp9a 34
  • 88.12 (n)
chicken
(Gallus gallus)
Aves ATP9A 34 35
  • 83.04 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 99 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp9a 34
  • 77.99 (n)
MGC76068 34
zebrafish
(Danio rerio)
Actinopterygii ATP9A 35
  • 88 (a)
OneToOne
Dr.15835 34
fruit fly
(Drosophila melanogaster)
Insecta CG31729 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tat-5 35
  • 55 (a)
ManyToMany
F02C9.3 36
  • 55 (a)
tat-6 35
  • 52 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NEO1 35
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToMany
Species where no ortholog for ATP9A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP9A Gene

ENSEMBL:
Gene Tree for ATP9A (if available)
TreeFam:
Gene Tree for ATP9A (if available)

Paralogs for ATP9A Gene

Paralogs for ATP9A Gene

genes like me logo Genes that share paralogs with ATP9A: view

Variants for ATP9A Gene

Sequence variations from dbSNP and Humsavar for ATP9A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1009232 -- 51,640,313(-) tgttg(C/G)cgcgg intron-variant
rs1009233 -- 51,638,003(-) tggga(C/T)tgggg intron-variant
rs1009234 -- 51,637,621(-) CGGAG(A/T)ATTTT intron-variant
rs1009740 -- 51,637,415(-) TGTCT(C/T)CTGTG intron-variant
rs1009741 -- 51,637,257(-) CACAG(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP9A Gene

Variant ID Type Subtype PubMed ID
dgv703n67 CNV gain 20364138
esv1250125 CNV insertion 17803354
esv2501264 CNV insertion 19546169
esv2668584 CNV deletion 23128226
esv2751917 CNV gain 17911159
esv2758800 CNV loss 17122850
esv3395647 CNV insertion 20981092
esv3410408 CNV insertion 20981092
esv3425228 CNV insertion 20981092
esv3646065 CNV loss 21293372
esv3646067 CNV gain 21293372
esv3646068 CNV gain 21293372
esv3646069 CNV gain 21293372
esv3646070 CNV gain 21293372
nsv1114224 CNV deletion 24896259
nsv1114225 CNV deletion 24896259
nsv1123494 CNV deletion 24896259
nsv1136329 CNV deletion 24896259
nsv473453 CNV novel sequence insertion 20440878
nsv513549 CNV insertion 21212237
nsv527764 CNV loss 19592680
nsv834004 CNV loss 17160897
nsv9816 CNV gain 18304495

Variation tolerance for ATP9A Gene

Residual Variation Intolerance Score: 1.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP9A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP9A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP9A Gene

Disorders for ATP9A Gene

Relevant External Links for ATP9A

Genetic Association Database (GAD)
ATP9A
Human Genome Epidemiology (HuGE) Navigator
ATP9A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP9A

No disorders were found for ATP9A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP9A Gene

Publications for ATP9A Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PMID: 21914794) Takatsu H. … Shin H.W. (J. Biol. Chem. 2011) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ATP9A Gene

Sources for ATP9A Gene

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