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Aliases for ATP8B4 Gene

Aliases for ATP8B4 Gene

  • ATPase, Class I, Type 8B, Member 4 2 3
  • P4-ATPase Flippase Complex Alpha Subunit ATP8B4 3 4
  • EC 3.6.3.1 4 63
  • Potential Phospholipid-Transporting ATPase IM 3
  • Probable Phospholipid-Transporting ATPase IM 3
  • ATPase Class I Type 8B Member 4 4
  • KIAA1939 4
  • EC 3.6.3 63
  • ATPIM 3

External Ids for ATP8B4 Gene

Summaries for ATP8B4 Gene

Entrez Gene Summary for ATP8B4 Gene

  • This gene encodes a member of the cation transport ATPase (P-type) family and type IV subfamily. The encoded protein is involved in phospholipid transport in the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for ATP8B4 Gene

ATP8B4 (ATPase, Class I, Type 8B, Member 4) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include magnesium ion binding and phospholipid-translocating ATPase activity. An important paralog of this gene is ATP11C.

UniProtKB/Swiss-Prot for ATP8B4 Gene

  • Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP8B4 Gene

Genomics for ATP8B4 Gene

Genomic Location for ATP8B4 Gene

Start:
49,858,238 bp from pter
End:
50,182,817 bp from pter
Size:
324,580 bases
Orientation:
Minus strand

Genomic View for ATP8B4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP8B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP8B4 Gene

Regulatory Elements for ATP8B4 Gene

Proteins for ATP8B4 Gene

  • Protein details for ATP8B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF62-AT8B4_HUMAN
    Recommended name:
    Probable phospholipid-transporting ATPase IM
    Protein Accession:
    Q8TF62
    Secondary Accessions:
    • Q9H727

    Protein attributes for ATP8B4 Gene

    Size:
    1192 amino acids
    Molecular mass:
    135868 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunits TMEM30A and TMEM30B.
    SequenceCaution:
    • Sequence=BAB15072.1; Type=Frameshift; Positions=997; Evidence={ECO:0000305}; Sequence=BAB85525.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin inserted in the coding sequence.; Evidence={ECO:0000305};

neXtProt entry for ATP8B4 Gene

Proteomics data for ATP8B4 Gene at MOPED

Post-translational modifications for ATP8B4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP8B4 Gene

Domains for ATP8B4 Gene

Gene Families for ATP8B4 Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

Suggested Antigen Peptide Sequences for ATP8B4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF62

UniProtKB/Swiss-Prot:

AT8B4_HUMAN
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.:
    • Q8TF62
genes like me logo Genes that share domains with ATP8B4: view

Function for ATP8B4 Gene

Molecular function for ATP8B4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
UniProtKB/Swiss-Prot Function: Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

Enzyme Numbers (IUBMB) for ATP8B4 Gene

Gene Ontology (GO) - Molecular Function for ATP8B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity IBA --
GO:0005524 ATP binding IEA --
GO:0019829 cation-transporting ATPase activity --
genes like me logo Genes that share ontologies with ATP8B4: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATP8B4 Gene

Localization for ATP8B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP8B4 Gene

Cell membrane; Multi-pass membrane protein. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP8B4 Gene COMPARTMENTS Subcellular localization image for ATP8B4 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ATP8B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 20947505
GO:0005886 plasma membrane IDA 20947505
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP8B4: view

Pathways for ATP8B4 Gene

genes like me logo Genes that share pathways with ATP8B4: view

Pathways by source for ATP8B4 Gene

Interacting Proteins for ATP8B4 Gene

Gene Ontology (GO) - Biological Process for ATP8B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IBA --
GO:0008152 metabolic process IEA --
GO:0015914 phospholipid transport --
GO:0045332 phospholipid translocation IBA --
GO:0098655 cation transmembrane transport --
genes like me logo Genes that share ontologies with ATP8B4: view

Compounds for ATP8B4 Gene

(2605) HMDB Compounds for ATP8B4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
genes like me logo Genes that share compounds with ATP8B4: view

Transcripts for ATP8B4 Gene

Unigene Clusters for ATP8B4 Gene

ATPase, class I, type 8B, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP8B4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^
SP1: -
SP2:
SP3: -
SP4:

ExUns: 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for ATP8B4 Gene

GeneLoc Exon Structure for
ATP8B4
ECgene alternative splicing isoforms for
ATP8B4

Expression for ATP8B4 Gene

mRNA expression in normal human tissues for ATP8B4 Gene

mRNA differential expression in normal tissues according to GTEx for ATP8B4 Gene

This gene is overexpressed in Fallopian Tube (4.5) and Whole Blood (4.4).

SOURCE GeneReport for Unigene cluster for ATP8B4 Gene Hs.511311

mRNA Expression by UniProt/SwissProt for ATP8B4 Gene

Q8TF62-AT8B4_HUMAN
Tissue specificity: Ubiquitously expressed at moderate levels
genes like me logo Genes that share expressions with ATP8B4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for ATP8B4 Gene

Orthologs for ATP8B4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP8B4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP8B4 35
  • 99.58 (n)
  • 99.5 (a)
ATP8B4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP8B4 36
  • 93 (a)
OneToOne
LOC100137953 35
  • 91.33 (n)
  • 93.12 (a)
dog
(Canis familiaris)
Mammalia ATP8B4 35
  • 91.32 (n)
  • 91.77 (a)
ATP8B4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp8b4 35
  • 85.74 (n)
  • 86.41 (a)
Atp8b4 16
Atp8b4 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP8B4 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP8B4 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp8b4 35
  • 85.96 (n)
  • 88.09 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 64 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp8b4 35
  • 73.79 (n)
  • 77.95 (a)
Str.1062 35
zebrafish
(Danio rerio)
Actinopterygii ATP8B4 36
  • 70 (a)
OneToOne
si:ch211-167m1.4 35
  • 67.88 (n)
  • 72.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14741 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tat-2 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DNF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G72700 35
  • 50.56 (n)
  • 43.94 (a)
rice
(Oryza sativa)
Liliopsida Os.8958 35
Species with no ortholog for ATP8B4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP8B4 Gene

ENSEMBL:
Gene Tree for ATP8B4 (if available)
TreeFam:
Gene Tree for ATP8B4 (if available)

Paralogs for ATP8B4 Gene

Paralogs for ATP8B4 Gene

Pseudogenes.org Pseudogenes for ATP8B4 Gene

genes like me logo Genes that share paralogs with ATP8B4: view

Variants for ATP8B4 Gene

Sequence variations from dbSNP and Humsavar for ATP8B4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs725530 -- 50,116,159(+) ATGCC(C/T)GTAAT intron-variant
rs935195 -- 49,935,943(+) GATGA(C/G)GTTAT intron-variant
rs935196 -- 50,017,275(+) CCACC(A/G)ACTAT intron-variant
rs935197 -- 50,024,242(+) TATGA(C/T)AGAGG intron-variant
rs935198 -- 50,024,289(+) AGAAA(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP8B4 Gene

Variant ID Type Subtype PubMed ID
nsv833003 CNV Loss 17160897
esv2196763 CNV Deletion 18987734
esv2749673 CNV Deletion 23290073
nsv1529 CNV Insertion 18451855
nsv517014 CNV Loss 19592680
dgv2382n71 CNV Loss 21882294
nsv904206 CNV Loss 21882294
nsv457133 CNV Loss 19166990
nsv904207 CNV Gain 21882294
nsv1530 CNV Loss 18451855
nsv483038 CNV Gain 15286789
nsv529006 CNV Gain 19592680

Relevant External Links for ATP8B4 Gene

HapMap Linkage Disequilibrium report
ATP8B4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP8B4 Gene

Disorders for ATP8B4 Gene

Relevant External Links for ATP8B4

Genetic Association Database (GAD)
ATP8B4
Human Genome Epidemiology (HuGE) Navigator
ATP8B4
genes like me logo Genes that share disorders with ATP8B4: view

No data available for UniProtKB/Swiss-Prot for ATP8B4 Gene

Publications for ATP8B4 Gene

  1. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck M.S. … Schlegel R.A. (Physiol. Genomics 1999) 2 3
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  5. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. (PMID: 17998437) Li H. … Roses A.D. (Arch. Neurol. 2008) 3 48

Products for ATP8B4 Gene

Sources for ATP8B4 Gene

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