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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP8B4 Gene

protein-coding   GIFtS: 52
GCID: GC15M050150

ATPase, class I, type 8B, member 4

(Previous names: ATPase, Class I, type 8B, member 4 )
 Explore 5 diseases affiliated with
ATP8B4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATP8B4    

Aliases
for ATP8B4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATPase, Class I, Type 8B, Member 41 2     Potential Phospholipid-Transporting ATPase IM2
ATPIM1 2     Probable Phospholipid-Transporting ATPase IM2
KIAA19391 3     ATPase Class I Type 8B Member 43
EC 3.6.3.13 8     EC 3.6.38

External Ids:    HGNC: 135361   Entrez Gene: 798952   Ensembl: ENSG000001040437   OMIM: 6091235   UniProtKB: Q8TF623   

Export aliases for ATP8B4 gene to outside databases

Previous GC identifers: GC00U990808 GC15M047729 GC15M047866 GC15M047937 GC15M026981


Summaries
for ATP8B4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ATP8B4:
This gene encodes a member of the cation transport ATPase (P-type) family and type IV subfamily. The encoded protein is
involved in phospholipid transport in the cell membrane. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jan 2013)




Genomic Views
for ATP8B4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP8B4 gene promoter:
         HOXA9   HOXA9B   GATA-3   AML1a   GATA-2   GATA-1   Meis-1b   HEN1   Ik-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATP8B4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP8B4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP8B4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

ATP8B4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP8B4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M050150:  view genomic region     (about GC identifiers)

Start:
 50,150,435 bp from pter      End:
 50,475,014 bp from pter
Size:
 324,580 bases      Orientation:
 minus strand

Proteins
for ATP8B4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AT8B4_HUMAN, Q8TF62 (See protein sequence)
Recommended Name: Probable phospholipid-transporting ATPase IM  
Size: 1192 amino acids; 135868 Da
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAB15072.1; Type=Frameshift; Positions=997; Sequence=BAB85525.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Sequence of unknown origin inserted in the coding sequence;
Secondary accessions: Q9H727

Explore the universe of human proteins at neXtProt for ATP8B4: NX_Q8TF62

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TF62

    • 4/19 DME Specific Peptides for ATP8B4 (Q8TF62) (see all 19)
     LAIGDGA  TLAIGDG  WVLTGDK  DGETNLK 

    ATP8B4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079113.2  
    ENSEMBL proteins: 
     ENSP00000452663   ENSP00000453229   ENSP00000453169   ENSP00000453070   ENSP00000453690  
     ENSP00000452956   ENSP00000453482   ENSP00000453143   ENSP00000453539   ENSP00000284509  
    Reactome Protein details: Q8TF62
    Human Recombinant Protein Products: 
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    Novus Biologicals ATP8B4 Protein
    Novus Biologicals ATP8B4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ATP8B4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    ATP8B4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ATP8B4

    Protein Domains /
    Families
    for ATP8B4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATP8B4 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR023306 ATPase_cation_domN
     IPR023299 ATPase_P-typ_cyto_domN
     IPR008250 ATPase_P-typ_transduc_dom_A
     IPR023214 HAD-like_dom
     IPR006539 ATPase_P-typ_Plipid-transp

    Graphical View of Domain Structure for InterPro Entry Q8TF62

    ProtoNet protein and cluster: Q8TF62

    1 Blocks protein family: IPB001757 ATPase

    UniProtKB/Swiss-Prot: AT8B4_HUMAN, Q8TF62
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily


    Function
    for ATP8B4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AT8B4_HUMAN, Q8TF62
    Catalytic activity: ATP + H(2)O + phospholipid(side 1) = ADP + phosphate + phospholipid(side 2)

    Enzyme Numbers (IUBMB): EC 3.6.3.11 2 EC 3.6.32

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP8B4 (see all 23):
    hsa-miR-607 hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-346 hsa-miR-218 hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ATP8B4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004012phospholipid-translocating ATPase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism IEA--


    ATP8B4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ATP8B4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    		Ion transport by P-type ATPases0.32
    2SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ATP8B4
        Transmembrane transport of small molecules
    Ion channel transport
    Ion transport by P-type ATPases



    ATP8B4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP8B4

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport IEA--


    ATP8B4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATP8B4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATP8B4

    10/2605 HMDB Compounds for ATP8B4 (see all 2605)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----
    Search CenterWatch for drugs/clinical trials and news about ATP8B4 / AT8B4 

    Transcripts
    for ATP8B4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATP8B4 gene: 
    NM_024837.3  

    Unigene Cluster for ATP8B4:

    ATPase, class I, type 8B, member 4
    Hs.511311  [show with all ESTs]
    Unigene Representative Sequence: AB075819
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558498(uc001zxt.3) ENST00000559726(uc010ber.3) ENST00000559829
    ENST00000560479 ENST00000557955 ENST00000558906 ENST00000558203 ENST00000560354
    ENST00000560161 ENST00000561385(uc001zxv.1) ENST00000559998 ENST00000561104
    ENST00000558458 ENST00000558959 ENST00000560437 ENST00000558024 ENST00000558829
    ENST00000284509(uc001zxu.3 uc010ufd.2 uc010ufe.2)

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP8B4 (see all 23):
    hsa-miR-607 hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-346 hsa-miR-218 hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ATP8B4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP8B4 (see all 3)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB075819.1 AK025125.1 AK123747.1 AK128602.1 AL832039.1 BC057236.1 BC144297.1 BC144298.1 
    BX647496.1 

    14 DOTS entries:

    DT.121026407  DT.101974586  DT.425672  DT.75138857  DT.97822878  DT.121026391  DT.121026374  DT.121026384 
    DT.65286764  DT.91747926  DT.95294046  DT.95261575  DT.95261574  DT.95330538 

    24/48 AceView cDNA sequences (see all 48):

    BI258773 NM_024837 AB075819 BX110805 AK128602 AI638633 AW468493 AJ713631 
    BQ012502 BU754430 AL597024 BF446914 BX106818 AI760818 AL598105 BC057236 
    BX647496 BG413537 AL832039 BF904690 AK123747 BG570719 AA318526 BQ022087 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ATP8B4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^
    SP1:                                                                                                                          -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30
    SP1:        -     -                                 
    SP2:              -                                 
    SP3:                                                
    SP4:                                                


    ECgene alternative splicing isoforms for ATP8B4

    Expression
    for ATP8B4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP8B4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ATP8B4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ATP8B4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP8B4

    SOURCE GeneReport for Unigene cluster: Hs.511311

    UniProtKB/Swiss-Prot: AT8B4_HUMAN, Q8TF62
    Tissue specificity: Ubiquitously expressed at moderate levels

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    In Situ
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    Orthologs
    for ATP8B4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATP8B4 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.10622 Transcribed sequence with weak similarity to protein more 73.92(n)    BX735914.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BX005048.16
    		 --
    		 72(a)
    		 1 ↔ 1
    		 25(33384052-33427846)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG147416
    		 --
    		 37(a)
    		 1 → many
    		 3R(7894964-7916334)
    worm
    (Caenorhabditis elegans)    		 Secernentea tat-26
    		 Transbilayer Amphipath Transporters (subfamily IV ...
    		 47(a)
    		 1 → many
    		 IV(4827864-4841119)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G727001 phospholipid-translocating ATPase 50.7(n)
    43.98(a)    		   843602  NM_105929.4  NP_177414.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.89582 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.75(n)    NM_196468.1 


    ENSEMBL Gene Tree for ATP8B4 (if available)
    TreeFam Gene Tree for ATP8B4 (if available) 

    Paralogs
    for ATP8B4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP8B4 gene
    ATP11A2  ATP8A12  ATP8B12  ATP11C2  ATP11B2  ATP8A22  ATP8B32  ATP8B22  
    17 SIMAP similar genes for ATP8B4 using alignment to 9 protein entries:     AT8B4_HUMAN (see all proteins):
    ATP8B2    ATP8B1    ATP10A    DKFZp434P0831    DKFZp686H2093    ATP8A2
    ATP8B3    ATP8A1    DKFZp779H1459    ATP11A    ATP11C    ATP11B
    ATP9B    hMMR1    ATP10D    ATP10B    ATP9A

    ATP8B4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ATP8B4
    PGOHUM00000261989 PGOHUM00000261991


    Genomic Variants
    for ATP8B4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4291 NCBI SNPs in ATP8B4 are shown (see all 4291)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs359163001,2
    		C--27157672(+) CCTTGT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs284978681,2
    		--50150099(+) ATCCCC/TGGCGC 1 -- ds50010--------
    rs1406448381,2
    		--50150103(+) CTGGCA/GCTTGT 1 -- ds50010--------
    rs1445429231,2
    		--50150342(+) TTTCCC/TCAGCA 1 -- ds50010--------
    rs42757931,2
    		C,F,H,--50150400(+) CCCCAA/GTGAAT 1 -- ds500123Minor allele frequency- G:0.11NA NS EA 2562
    rs285640501,2
    		C,F,--50150525(+) ACAAAT/CTAGAC 1 -- ut313Minor allele frequency- C:0.04WA CSA 122
    rs1466291181,2
    		--50150711(+) CTATAA/GATATC 1 -- ut310--------
    rs1412640321,2
    		--50150718(+) TATCAC/TATTAG 1 -- ut310--------
    rs1858924531,2
    		--50150802(+) TAATAC/GGGACC 1 -- ut310--------
    rs1905586221,2
    		--50150807(+) GGGACC/TAGATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ATP8B4 (50150435 - 50400435 bp, first 250kb of ATP8B4)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ATP8B4
         1 CNV: 0188
         1 Indel: 49561

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ATP8B4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATP8B4 for disorders           About GeneDecksing

    OMIM gene information: 609123    OMIM disorders: --

    5 diseases for ATP8B4:    About MalaCards
    intrahepatic cholestasis    cholestasis    liver disease    alzheimer's disease
    pharyngitis

    Human Genome Epidemiology (HuGE) Navigator: ATP8B4 (3 documents)

    Export disorders for ATP8B4 gene to outside databases

    Publications
    for ATP8B4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP8B4 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ATP8B4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)
    4. Differential expression of putative transbilayer amphipath transporters. (PubMed id 11015572)1, 3 Halleck M.S.... Schlegel R.A. (1999)
    5. Translocation t(11;14) (q13;q32) and genomic imbalance s in multi-ethnic multiple myeloma patients: a Malaysian study. (PubMed id 23087808)1 Ni I.B....Zakaria Z. (2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. (PubMed id 17998437)1 Li H....Roses A.D. (2008)
    8. FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. (PubMed id 12880872)1 Harris M.J. and Arias I.M. (2003)
    9. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)6 Kurz M....Kramer W. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for ATP8B4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing ATP8B4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79895 HGNC: 13536 AceView: ATP8B4 Ensembl:ENSG00000104043 euGenes: HUgn79895
    ECgene: ATP8B4 H-InvDB: ATP8B4

    Other Databases showing ATP8B4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1939

    Specialized Databases showing ATP8B4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP8B4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATP8B4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATP8B4 gene:
    Search GeneIP for patents involving ATP8B4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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