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ATP8B3 Gene

protein-coding   GIFtS: 59
GCID: GC19M001783

ATPase, Aminophospholipid Transporter, Class I, Type 8B,...

(Previous names: ATPase, Class I, type 8B, member 3, ATPase, class I, type...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATPase, Aminophospholipid Transporter, Class I, Type 8B, Member 31 2     Probable Phospholipid-Transporting ATPase IK2
ATPase, Class I, Type 8B, Member 31 2     ATP1K3
Aminophospholipid Translocase ATP8B31 2     FOS37502_23
Potential Phospholipid-Transporting ATPase IK1 2     ATPase Class I Type 8B Member 33
EC 3.6.3.13 8     EC 3.6.38
ATPIK2 5     

External Ids:    HGNC: 135351   Entrez Gene: 1482292   Ensembl: ENSG000001302707   OMIM: 6058665   UniProtKB: O604233   

Export aliases for ATP8B3 gene to outside databases

Previous GC identifers: GC19U990228 GC19M001722 GC19M001733 GC19M001553


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATP8B3 Gene:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of
aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and
phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of
phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and
18. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Apr 2012)

GeneCards Summary for ATP8B3 Gene:
ATP8B3 (ATPase, aminophospholipid transporter, class I, type 8B, member 3) is a protein-coding gene. GO annotations related to this gene include magnesium ion binding and cation-transporting ATPase activity. An important paralog of this gene is ATP11A.

Gene Wiki entry for ATP8B3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP8B3 gene promoter:
         GR   Max1   AhR   p53   E47   Arnt   CREB   deltaCREB   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP8B3 promoter sequence
   Search Chromatin IP Primers for ATP8B3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP8B3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ATP8B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP8B3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001783:  view genomic region     (about GC identifiers)

Start:
1,782,074 bp from pter      End:
1,812,275 bp from pter
Size:
30,202 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AT8B3_HUMAN, O60423 (See protein sequence)
Recommended Name: Probable phospholipid-transporting ATPase IK  
Size: 1300 amino acids; 146752 Da
Sequence caution: Sequence=AAC17601.1; Type=Erroneous gene model prediction; Sequence=BAB71492.1; Type=Erroneous
initiation;
Secondary accessions: Q7Z485 Q8IVB8 Q8N4Y8 Q96M22
Alternative splicing: 3 isoforms:  O60423-2   O60423-1   O60423-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP8B3: NX_O60423

Explore proteomics data for ATP8B3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys108, Lys296, Lys326, Lys496, Lys509
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ATP8B3 (O60423) (see all 11)
     LAIGDGA  TLAIGDG  DKTGTLT  WVLTGDK 


    See ATP8B3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171473.1  NP_620168.1  

    ENSEMBL proteins: 
     ENSP00000311336   ENSP00000444334   ENSP00000437115   ENSP00000439993   ENSP00000445204  
     ENSP00000445883   ENSP00000465027   ENSP00000443574  
    Reactome Protein details: O60423

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PATP: ATPases / P-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: ATP8B3
    Phospholipid-transporting ATPase

    Selected InterPro protein domains (see all 6):
     IPR008250 ATPase_P-typ_transduc_dom_A
     IPR023214 HAD-like_dom
     IPR006539 ATPase_P-typ_Plipid-transp
     IPR001757 Cation_transp_P_typ_ATPase
     IPR018303 ATPase_P-typ_P_site

    Graphical View of Domain Structure for InterPro Entry O60423

    ProtoNet protein and cluster: O60423

    1 Blocks protein domain: IPB001757 ATPase

    UniProtKB/Swiss-Prot: AT8B3_HUMAN, O60423
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily


    Find genes that share domains with ATP8B3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AT8B3_HUMAN, O60423
    Catalytic activity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)

         Enzyme Numbers (IUBMB): EC 3.6.3.11 2 EC 3.6.32

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0000287magnesium ion binding IEA--
    GO:0004012phospholipid-translocating ATPase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity RCA12880872
         
    Find genes that share ontologies with ATP8B3           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Atp8b3):
     reproductive system 

    Find genes that share phenotypes with ATP8B3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Atp8b3tm1Gar for ATP8B3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AT8B3_HUMAN, O60423: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0016021integral component of membrane RCA12880872

    Find genes that share ontologies with ATP8B3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATP8B3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Ion transport by P-type ATPases
    Ion transport by P-type ATPases


    Find genes that share SuperPaths with ATP8B3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ATP8B3
        Ion transport by P-type ATPases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATP8B3
    Interactions:

        Search GeneGlobe Interaction Network for ATP8B3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ATP8B3 (ENSP000003113364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    TMEM30BENSP000003479304STRING: ENSP00000347930
    MON2ENSP000003772524STRING: ENSP00000377252
    GBF1ENSP000003590004STRING: ENSP00000359000
    NEK11ENSP000003728574STRING: ENSP00000372857
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process RCA12880872
    GO:0006812cation transport ----
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0015914phospholipid transport ----
    GO:0045332phospholipid translocation ----

    Find genes that share ontologies with ATP8B3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ATP8B3 (AT8B3)

    Selected HMDB Compounds for ATP8B3 (see all 2605)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATP8B3 gene (2 alternative transcripts): 
    NM_001178002.2  NM_138813.3  

    Unigene Cluster for ATP8B3:

    ATPase, aminophospholipid transporter, class I, type 8B, member 3
    Hs.306212  [show with all ESTs]
    Unigene Representative Sequence: NR_047593
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310127(uc002ltw.3) ENST00000531925(uc002ltx.3) ENST00000525591
    ENST00000526847 ENST00000533107(uc002lty.1) ENST00000526092(uc002ltz.1)
    ENST00000533993 ENST00000587160 ENST00000539485(uc002ltv.3)
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    Additional mRNA sequence: 

    AK057452.1 AK058189.1 AK125225.1 AK125969.1 AY302538.1 BC035162.2 NR_047593.1 

    5 DOTS entries:

    DT.308925  DT.101978600  DT.101978599  DT.100748796  DT.95259665 

    Selected AceView cDNA sequences (see all 41):

    NM_138813 BM563416 AI638803 BX109561 AA383337 CF780661 BC035162 CD365734 
    BQ017039 CB068829 AW444739 BX494377 AK125225 BG395886 AY302538 BX327580 
    BU542181 AA758015 BQ937660 AA905217 BC033179 BU543228 AK125969 BX280503 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATP8B3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:        -                                                                                                                           
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ATP8B3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATP8B3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCACCATA
    ATP8B3 Expression
    About this image


    ATP8B3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             hIPS1
     
     Testis (Reproductive System)
    ATP8B3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATP8B3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306212

    UniProtKB/Swiss-Prot: AT8B3_HUMAN, O60423
    Tissue specificity: Isoform 3 was only detected in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ATP8B3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp8b31 , 5 ATPase, class I, type 8B, member 31, 5 74.61(n)1
    70.87(a)1
      10 (39.72 cM)5
    673311  NM_026094.31  NP_080370.21 
     805195855 
    chicken
    (Gallus gallus)
    Aves ATP8B31 ATPase, aminophospholipid transporter, class I, type more 66.44(n)
    58.44(a)
      428328  XM_425888.4  XP_425888.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atp8b31 ATPase, aminophospholipid transporter, class I, type more 56.29(n)
    53.74(a)
      100490666  XM_002938818.2  XP_002938864.2 
    zebrafish
    (Danio rerio)
    Actinopterygii atp8b36
    ATPase, aminophospholipid transporter, class I, ty...
    42(a)
    1 ↔ 1
    22(20793575-20835693) ENSDARG00000042285
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DRS26
    Aminophospholipid translocase (flippase) that main...
    31(a)
    1 → many
    I(95630-99697) YAL026C


    ENSEMBL Gene Tree for ATP8B3 (if available)
    TreeFam Gene Tree for ATP8B3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATP8B3 gene
    ATP11A2  ATP8B12  ATP11B2  ATP8A12  ATP11C2  ATP8B42  ATP8A22  ATP8B22  
    16 SIMAP similar genes for ATP8B3 using alignment to 6 protein entries:     AT8B3_HUMAN (see all proteins):
    CIR1    ECD    SUN3    C12orf23    DKFZp779H1459    ATP8B1
    ATP8B4    ATP8B2    ATP8A2    DKFZp686H2093    ATP8A1    ATP10A
    ATP11A    ATP10D    ATP11B    ATP11C

    Find genes that share paralogs with ATP8B3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATP8B3 (see all 989)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104121241,2
    C,F,A,H--1781576(+) TGGGCA/GACAGA 3 -- int15Minor allele frequency- G:0.33NA WA 12
    rs30514721,2
    C--1781596(-) TTTTT-/TT/TTTTT
    TT
    /TTTTTTTT
    TTTTT
    3 -- int10--------
    rs1839422391,2
    --1781631(+) GAAAAA/GCTTGG 3 -- int10--------
    rs124620971,2
    C,H--1781644(+) CCTTAA/GAAGGA 3 -- int10--------
    rs49945681,2
    C--1781708(+) CCTGCT/CTCTGT 3 -- int12Minor allele frequency- C:0.27WA 120
    rs1398026741,2
    --1781753(+) TGAACA/GGAGGC 3 -- int10--------
    rs1876569561,2
    --1781815(+) AGGAAA/GAAGCT 3 -- int10--------
    rs1925741011,2
    --1781855(+) TTTCTG/TGGGAG 3 -- int10--------
    rs1497937971,2
    C--1781867(+) GGCCAC/GCTGTC 3 -- int10--------
    rs110849081,2
    C,F,A,H--1781879(+) GGCAGT/CGGGGG 3 -- int128Minor allele frequency- C:0.14NS EA NA WA CSA 2678

    HapMap Linkage Disequilibrium report for ATP8B3 (1782074 - 1812275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ATP8B3 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717852CNV Deletion23290073
    nsv470107CNV Loss18288195
    dgv3614n71CNV Loss21882294
    nsv910499CNV Loss21882294
    dgv3609n71CNV Loss21882294
    dgv3613n71CNV Loss21882294
    dgv3615n71CNV Loss21882294
    dgv3617n71CNV Loss21882294
    nsv521005CNV Loss19592680
    dgv3612n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATP8B3
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP8B3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605866    OMIM disorders: --


    Find genes that share disorders with ATP8B3           About GenesLikeMe

    Genetic Association Database (GAD): ATP8B3
    Human Genome Epidemiology (HuGE) Navigator: ATP8B3 (1 document)

    Export disorders for ATP8B3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATP8B3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ATP8B3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. (PubMed id 12880872)1, 2, 9 Harris M.J. and Arias I.M. (Biochim. Biophys. Acta 2003)
    2. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. (PubMed id 19416921)1, 4 Scott L.J....Boehnke M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Differential expression of putative transbilayer amphipath transporters. (PubMed id 11015572)1, 3 Halleck M.S.... Schlegel R.A. (Physiol. Genomics 1999)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 148229 HGNC: 13535 AceView: ATP8B3 Ensembl:ENSG00000130270 euGenes: HUgn148229
    ECgene: ATP8B3 H-InvDB: ATP8B3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATP8B3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATP8B3 gene:
    Search GeneIP for patents involving ATP8B3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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