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Aliases for ATP8B2 Gene

Aliases for ATP8B2 Gene

  • ATPase, Aminophospholipid Transporter, Class I, Type 8B, Member 2 2 3
  • ATPID 3 4 6
  • P4-ATPase Flippase Complex Alpha Subunit ATP8B2 3 4
  • ATPase, Class I, Type 8B, Member 2 2 3
  • EC 3.6.3.1 4 64
  • Probable Phospholipid-Transporting ATPase ID 3
  • Phospholipid-Transporting ATPase ID 3
  • ATPase Class I Type 8B Member 2 4
  • KIAA1137 4
  • EC 3.6.3 64

External Ids for ATP8B2 Gene

Summaries for ATP8B2 Gene

Entrez Gene Summary for ATP8B2 Gene

  • The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP8B2 Gene

ATP8B2 (ATPase, Aminophospholipid Transporter, Class I, Type 8B, Member 2) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include magnesium ion binding and cation-transporting ATPase activity. An important paralog of this gene is ATP8B4.

UniProtKB/Swiss-Prot for ATP8B2 Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP8B2 Gene

Genomics for ATP8B2 Gene

Genomic Location for ATP8B2 Gene

Start:
154,325,553 bp from pter
End:
154,351,307 bp from pter
Size:
25,755 bases
Orientation:
Plus strand

Genomic View for ATP8B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP8B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP8B2 Gene

Regulatory Elements for ATP8B2 Gene

Proteins for ATP8B2 Gene

  • Protein details for ATP8B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98198-AT8B2_HUMAN
    Recommended name:
    Phospholipid-transporting ATPase ID
    Protein Accession:
    P98198
    Secondary Accessions:
    • B4E3P4
    • Q6NT69
    • Q7Z486
    • Q96I43
    • Q96NQ7

    Protein attributes for ATP8B2 Gene

    Size:
    1209 amino acids
    Molecular mass:
    137440 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). The probable flippase ATP8B2:TMEM30A complex can form an intermediate phosphoenzyme in vitro. The interaction with TMEM30B is reported conflictingly.
    SequenceCaution:
    • Sequence=AAH30288.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB70822.1; Type=Frameshift; Positions=364; Evidence={ECO:0000305}; Sequence=BAG65556.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP8B2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP8B2 Gene

Proteomics data for ATP8B2 Gene at MOPED

Post-translational modifications for ATP8B2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys229

Other Protein References for ATP8B2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ATP8B2 Gene

Gene Families for ATP8B2 Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

UniProtKB/Swiss-Prot:

AT8B2_HUMAN
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.:
    • P98198
genes like me logo Genes that share domains with ATP8B2: view

Function for ATP8B2 Gene

Molecular function for ATP8B2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
UniProtKB/Swiss-Prot Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

Enzyme Numbers (IUBMB) for ATP8B2 Gene

Gene Ontology (GO) - Molecular Function for ATP8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity IBA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ATP8B2: view

Phenotypes for ATP8B2 Gene

MGI mutant phenotypes for ATP8B2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ATP8B2: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP8B2 Gene

Localization for ATP8B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP8B2 Gene

Membrane; Multi-pass membrane protein. Cell membrane. Note=TMEM30A, but not TMEM30B, is required for its export from ER to the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP8B2 Gene COMPARTMENTS Subcellular localization image for ATP8B2 gene
Compartment Confidence
plasma membrane 4
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 20947505
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP8B2: view

Pathways for ATP8B2 Gene

genes like me logo Genes that share pathways with ATP8B2: view

Pathways by source for ATP8B2 Gene

Interacting Proteins for ATP8B2 Gene

Gene Ontology (GO) - Biological Process for ATP8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IBA --
GO:0008152 metabolic process IEA --
GO:0015914 phospholipid transport --
GO:0034220 ion transmembrane transport TAS --
GO:0045332 phospholipid translocation IBA --
genes like me logo Genes that share ontologies with ATP8B2: view

Compounds for ATP8B2 Gene

(2605) HMDB Compounds for ATP8B2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
genes like me logo Genes that share compounds with ATP8B2: view

Transcripts for ATP8B2 Gene

Unigene Clusters for ATP8B2 Gene

ATPase, aminophospholipid transporter, class I, type 8B, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP8B2 Gene

No ASD Table

Relevant External Links for ATP8B2 Gene

GeneLoc Exon Structure for
ATP8B2
ECgene alternative splicing isoforms for
ATP8B2

Expression for ATP8B2 Gene

mRNA expression in normal human tissues for ATP8B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATP8B2 Gene

SOURCE GeneReport for Unigene cluster for ATP8B2 Gene Hs.435700

mRNA Expression by UniProt/SwissProt for ATP8B2 Gene

P98198-AT8B2_HUMAN
Tissue specificity: Isoform 3 is ubiquitous, with highest expression in aorta, cerebellum and uterus.
genes like me logo Genes that share expressions with ATP8B2: view

Orthologs for ATP8B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP8B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP8B2 36
  • 99.38 (n)
  • 99.66 (a)
ATP8B2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP8B2 36
  • 92.44 (n)
  • 98.49 (a)
ATP8B2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP8B2 36
  • 89.7 (n)
  • 95.11 (a)
ATP8B2 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp8b2 36
  • 90.7 (n)
  • 97.14 (a)
Atp8b2 16
Atp8b2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP8B2 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 81 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC685152 36
  • 90.36 (n)
  • 97.05 (a)
chicken
(Gallus gallus)
Aves ATP8B2 36
  • 83.84 (n)
  • 92.33 (a)
ATP8B2 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP8B2 37
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii atp8b2 37
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002644 36
  • 60.17 (n)
  • 60.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14741 36
  • 61.03 (n)
  • 59.26 (a)
CG14741 37
  • 39 (a)
OneToMany
CG14741 38
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea tat-2 36
  • 57.2 (n)
  • 58.3 (a)
tat-2 37
  • 49 (a)
OneToMany
T24H7.5a 38
  • 35 (a)
T24H7.5b 38
  • 35 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.19983 36
Species with no ortholog for ATP8B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for ATP8B2 Gene

ENSEMBL:
Gene Tree for ATP8B2 (if available)
TreeFam:
Gene Tree for ATP8B2 (if available)

Paralogs for ATP8B2 Gene

Paralogs for ATP8B2 Gene

Selected SIMAP similar genes for ATP8B2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ATP8B2 Gene

genes like me logo Genes that share paralogs with ATP8B2: view

Variants for ATP8B2 Gene

Sequence variations from dbSNP and Humsavar for ATP8B2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs749966 -- 154,341,932(-) GTTCC(A/G)CCTGG intron-variant
rs753034 -- 154,343,453(+) CATAG(G/T)GCGGA missense, reference, nc-transcript-variant
rs767804 -- 154,338,019(+) TGGAT(A/C)GGTCG downstream-variant-500B, intron-variant
rs1047610 -- 154,350,547(+) GGCCT(A/C)TCTGC utr-variant-3-prime
rs1194583 -- 154,347,720(-) caggt(A/G)atccg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP8B2 Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV Gain 19592680
nsv523934 CNV Loss 19592680

Relevant External Links for ATP8B2 Gene

HapMap Linkage Disequilibrium report
ATP8B2

Disorders for ATP8B2 Gene

Relevant External Links for ATP8B2

Genetic Association Database (GAD)
ATP8B2
Human Genome Epidemiology (HuGE) Navigator
ATP8B2
genes like me logo Genes that share disorders with ATP8B2: view

No data available for UniProtKB/Swiss-Prot for ATP8B2 Gene

Publications for ATP8B2 Gene

  1. FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. (PMID: 12880872) Harris M.J. … Arias I.M. (Biochim. Biophys. Acta 2003) 3 4 23
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  3. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck M.S. … Schlegel R.A. (Physiol. Genomics 1999) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ATP8B2 Gene

Sources for ATP8B2 Gene

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