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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP8B2 Gene

protein-coding   GIFtS: 55
GCID: GC01P154298

ATPase, Aminophospholipid Transporter, Class I, Type 8B,...

(Previous names: ATPase, class I, type 8B, member 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATPase, Aminophospholipid Transporter, Class I, Type 8B, Member 21 2     Probable Phospholipid-Transporting ATPase ID2
ATPID2 3 5     KIAA11373
ATPase, Class I, Type 8B, Member 21 2     ATPase Class I Type 8B Member 23
EC 3.6.3.13 8     EC 3.6.38
Phospholipid-Transporting ATPase ID2     

External Ids:    HGNC: 135341   Entrez Gene: 571982   Ensembl: ENSG000001435157   OMIM: 6058675   UniProtKB: P981983   

Export aliases for ATP8B2 gene to outside databases

Previous GC identifers: GC01P152118 GC01P150032 GC01P151076 GC01P151518 GC01P151517 GC01P151113 GC01P152564 GC01P125661


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATP8B2 Gene:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of
aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and
phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants
encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for ATP8B2 Gene: 
ATP8B2 (ATPase, aminophospholipid transporter, class I, type 8B, member 2) is a protein-coding gene. Diseases associated with ATP8B2 include intrahepatic cholestasis, and cholestasis, and among its related super-pathways are Ion channel transport and SLC-mediated transmembrane transport. GO annotations related to this gene include magnesium ion binding and ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism. An important paralog of this gene is ATP11A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP8B2 gene promoter:
         Spz1   POU2F1   Pbx1a   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ATP8B2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP8B2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP8B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

ATP8B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP8B2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154298:  view genomic region     (about GC identifiers)

Start:
154,298,029 bp from pter      End:
154,323,783 bp from pter
Size:
25,755 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AT8B2_HUMAN, P98198 (See protein sequence)
Recommended Name: Probable phospholipid-transporting ATPase ID  
Size: 1209 amino acids; 137440 Da
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAH30288.1; Type=Erroneous initiation; Sequence=BAB70822.1; Type=Frameshift;
Positions=364; Sequence=BAG65556.1; Type=Erroneous initiation;
Secondary accessions: B4E3P4 Q6NT69 Q7Z486 Q96I43 Q96NQ7
Alternative splicing: 4 isoforms:  P98198-1   P98198-2   P98198-3   P98198-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP8B2: NX_P98198

Explore proteomics data for ATP8B2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P98198

  • 4/20 DME Specific Peptides for ATP8B2 (P98198) (see all 20)
     LAIGDGA  TLAIGDG  RNFGFVF  WVLTGDK 

    ATP8B2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATP8B2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005855.1  NP_065185.1  

    ENSEMBL proteins: 
     ENSP00000357472   ENSP00000357475   ENSP00000340448  
    Reactome Protein details: P98198
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane RCA12880872

    ATP8B2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PATP: ATPases / P-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: ATP8B2 
    Phospholipid-transporting ATPase

    5/6 InterPro protein domains (see all 6):
     IPR023299 ATPase_P-typ_cyto_domN
     IPR008250 ATPase_P-typ_transduc_dom_A
     IPR023214 HAD-like_dom
     IPR006539 ATPase_P-typ_Plipid-transp
     IPR001757 Cation_transp_P_typ_ATPase

    Graphical View of Domain Structure for InterPro Entry P98198

    ProtoNet protein and cluster: P98198

    1 Blocks protein domain: IPB001757 ATPase

    UniProtKB/Swiss-Prot: AT8B2_HUMAN, P98198
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily


    ATP8B2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AT8B2_HUMAN, P98198
    Catalytic activity: ATP + H(2)O + phospholipid(side 1) = ADP + phosphate + phospholipid(side 2)

         Enzyme Numbers (IUBMB): EC 3.6.3.11 2 EC 3.6.32

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0000287magnesium ion binding IEA--
    GO:0004012phospholipid-translocating ATPase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity RCA12880872
         
    ATP8B2 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ATP8B2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ATP8B2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.49
    Ion transport by P-type ATPases0.32
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ATP8B2
        Transmembrane transport of small molecules
    Ion channel transport
    Ion transport by P-type ATPases



    ATP8B2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP8B2

    1 Interacting protein for ATP8B2 (P981983) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAJC2Q995433I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process RCA12880872
    GO:0006812cation transport ----
    GO:0015914phospholipid transport ----
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    ATP8B2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATP8B2 (AT8B2)

    10/2605 HMDB Compounds for ATP8B2 (see all 2605)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----

    Search CenterWatch for drugs/clinical trials and news about ATP8B2 / AT8B2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATP8B2 gene (2 alternative transcripts): 
    NM_001005855.1  NM_020452.3  

    Unigene Cluster for ATP8B2:

    ATPase, aminophospholipid transporter, class I, type 8B, member 2
    Hs.435700  [show with all ESTs]
    Unigene Representative Sequence: NM_020452
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368487(uc001few.3) ENST00000368490 ENST00000368489(uc001fex.3)
    ENST00000426445 ENST00000514107 ENST00000505882 ENST00000341822(uc001fey.1)

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    Additional mRNA sequence: 

    AB032963.1 AK304806.1 AL137537.1 AY302537.1 BC007837.2 BC030288.1 BC041573.1 BC063858.1 
    BC069264.1 X58235.1 

    3 DOTS entries:

    DT.95157507  DT.75149140  DT.95204116 

    24/81 AceView cDNA sequences (see all 81):

    BC030288 BX441200 BX101039 AL137537 NM_020452 AB032963 BI861069 BQ228487 
    BC069264 CA393751 BM712635 AY302537 BU145253 CR621246 AW295101 BC041573 
    BC063858 BC007837 AF150357 AI800649 AW003610 BQ940106 AK054886 BU615851 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP8B2 expression in normal human tissues (normalized intensities)      ATP8B2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTCTGTG
    ATP8B2 Expression
    About this image


    ATP8B2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Endochondral Facial Bones
             skeleton/pectoral girdle and thoracic body wall/sternum   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             sensory organ/nose/nasal septum   
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Pelvic Girdle
             limb/hindlimb/hind-paw   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 4 entries
             skeleton/cranium/chondrocranium   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon

    See ATP8B2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP8B2

    SOURCE GeneReport for Unigene cluster: Hs.435700

    UniProtKB/Swiss-Prot: AT8B2_HUMAN, P98198
    Tissue specificity: Isoform 3 is ubiquitous, with highest expression in aorta, cerebellum and uterus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATP8B2 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp8b21 , 5 ATPase, class I, type 8B, member 21, 5 90.7(n)1
    97.14(a)1
      3 (39.19 cM)5
    546671  NM_001081182.21  NP_001074651.21 
     899394815 
    chicken
    (Gallus gallus)
    Aves ATP8B21 ATPase, class I, type 8B, member 2 83.98(n)
    92.61(a)
      770035  XM_001233349.2  XP_001233350.2 
    lizard
    (Anolis carolinensis)
    Reptilia ATP8B26
    ATPase, aminophospholipid transporter, class I, ty...
    86(a)
    1 ↔ 1
    GL343805.1(152765-191822)
    zebrafish
    (Danio rerio)
    Actinopterygii 570461752   -- 80.09(n)    57046175 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG147411 , 3 P-type ATPase3
    CG147411
    54(a)3
    61.03(n)1
    59.32(a)1
      87A73
    414691  NM_169450.31  NP_731669.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T24H7.5b3
    tat-21
    ATPase3
    Protein TAT-21
    35(a)
    (best of 2)3
    56.92(n)1
    58.01(a)1
      II(6234538-6244184)3
    1772561  NM_001028081.11  NP_001023252.11 
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AGR120C1 AGR120Cp 48.17(n)
    39.26(a)
      4623088  NM_211848.1  NP_986786.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.199832 Triticum aestivum transcribed sequence with moderate more 76.92(n)    CD894847.1 


    ENSEMBL Gene Tree for ATP8B2 (if available)
    TreeFam Gene Tree for ATP8B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP8B2 gene
    ATP11A2  ATP8A12  ATP11C2  ATP11B2  ATP8A22  ATP8B42  
    12 SIMAP similar genes for ATP8B2 using alignment to 2 protein entries:     AT8B2_HUMAN (see all proteins):
    ATP8B4    ATP8B1    ATP8A1    ATP8B3    ATP8A2    ATP11A
    ATP11C    ATP11B    ATP10A    ATP10B    ATP10D    ATP9A

    ATP8B2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ATP8B2
    PGOHUM00000243365 PGOHUM00000236448


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/655 SNPs in ATP8B2 are shown (see all 655)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1415980971,2
    Cuntested1154321014(+) GACACG/AGTGAG 2 /T syn11Minor allele frequency- A:0.00NA 4548
    rs12055911,2
    C--154298374(+) CGGGTG/TCCCGG 2 -- int1 us2k111Minor allele frequency- T:0.19MN NA WA CSA EA 554
    rs74160101,2
    C,A,H--154298461(+) GGCGCG/AAGTGC 2 -- int1 us2k16Minor allele frequency- A:0.00NS EA NA 416
    rs284968191,2
    C,F,H--154298499(+) AGGGGA/GGACCC 2 -- int1 us2k12Minor allele frequency- G:0.23NS NA 286
    rs741157391,2
    C,F--154298924(+) CGAGAG/AGGGGC 2 -- int1 us2k12Minor allele frequency- A:0.08WA 120
    rs1446858251,2
    --154299009(+) TAAGAA/TGGAAA 2 -- int1 us2k10--------
    rs120831701,2
    C,F,H--154299045(+) GTCTCT/CCCTCT 2 -- int1 us2k1 trp34Minor allele frequency- C:0.05NS 790
    rs1416779911,2
    --154299287(+) GAACTC/TGTGAT 2 -- int1 us2k10--------
    rs1470881591,2
    --154299302(+) ACTCTG/TGCATC 2 -- int1 us2k10--------
    rs1919616681,2
    --154299457(+) CATAGC/TTGGAG 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for ATP8B2 (154298029 - 154323783 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ATP8B2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523934CNV Loss19592680
    nsv521887CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605867    OMIM disorders: --

    3 diseases for ATP8B2:    About MalaCards
    intrahepatic cholestasis    cholestasis    liver disease


    ATP8B2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATP8B2
    Human Genome Epidemiology (HuGE) Navigator: ATP8B2 (3 documents)

    Export disorders for ATP8B2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP8B2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ATP8B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (1999)
    2. FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. (PubMed id 12880872)1, 2, 9 Harris M.J. and Arias I.M. (2003)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Differential expression of putative transbilayer amphipath transporters. (PubMed id 11015572)1, 3 Halleck M.S.... Schlegel R.A. (1999)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57198 HGNC: 13534 AceView: ATP8B2 Ensembl:ENSG00000143515 euGenes: HUgn57198
    ECgene: ATP8B2 H-InvDB: ATP8B2

    (According to HUGE)
    About This Section
    HUGE: KIAA1137

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP8B2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATP8B2 gene:
    Search GeneIP for patents involving ATP8B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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