Aliases for ATP6V1G3 Gene
- ATPase H+ Transporting V1 Subunit G3 2 3 5
- ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G3 2 3
- Vacuolar Proton Pump Subunit G 3 3 4
- V-ATPase 13 KDa Subunit 3 3 4
- V-ATPase Subunit G 3 3 4
- ATP6G3 3 4
- ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) Subunit G3 3
- ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G Isoform 3 2
- ATPase, H+ Transporting, Lysosomal 13kD, V1 Subunit G Isoform 3 2
External Ids for ATP6V1G3 Gene
Previous GeneCards Identifiers for ATP6V1G3 Gene
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP6V1G3 Gene
ATP6V1G3 (ATPase H+ Transporting V1 Subunit G3) is a Protein Coding gene. Among its related pathways are Rheumatoid arthritis and mTOR signaling pathway (KEGG). GO annotations related to this gene include ATPase binding and hydrogen-exporting ATPase activity, phosphorylative mechanism. An important paralog of this gene is ATP6V1G2.
UniProtKB/Swiss-Prot for ATP6V1G3 Gene
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.