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Aliases for ATP6V1G3 Gene

Aliases for ATP6V1G3 Gene

  • ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G3 2 3
  • Vacuolar Proton Pump Subunit G 3 3 4
  • V-ATPase 13 KDa Subunit 3 3 4
  • V-ATPase Subunit G 3 3 4
  • ATP6G3 3 4
  • ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) Subunit G3 3
  • ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G Isoform 3 2
  • ATPase, H+ Transporting, Lysosomal 13kD, V1 Subunit G Isoform 3 2
  • Vacuolar ATP Synthase Subunit G 3 3
  • V-Type Proton ATPase Subunit G 3 3
  • Vacuolar Proton Pump G Subunit 3 3
  • Vacuolar Proton Pump, Subunit G3 3
  • V-ATPase G Subunit 3 3
  • V-ATPase G3 Subunit 3
  • Vma10 3

External Ids for ATP6V1G3 Gene

Previous GeneCards Identifiers for ATP6V1G3 Gene

  • GC01M196219
  • GC01M193950
  • GC01M194958
  • GC01M195780
  • GC01M195224
  • GC01M196758
  • GC01M169660

Summaries for ATP6V1G3 Gene

Entrez Gene Summary for ATP6V1G3 Gene

  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP6V1G3 Gene

ATP6V1G3 (ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include ATPase binding and hydrogen-exporting ATPase activity, phosphorylative mechanism. An important paralog of this gene is ATP6V1G2.

UniProtKB/Swiss-Prot for ATP6V1G3 Gene

  • Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Tocris Summary for ATP6V1G3 Gene

  • H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains. The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation. There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of sperm motility and maturation.

Gene Wiki entry for ATP6V1G3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V1G3 Gene

Genomics for ATP6V1G3 Gene

Regulatory Elements for ATP6V1G3 Gene

Genomic Location for ATP6V1G3 Gene

198,523,222 bp from pter
198,540,945 bp from pter
17,724 bases
Minus strand

Genomic View for ATP6V1G3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP6V1G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP6V1G3 Gene

Proteins for ATP6V1G3 Gene

  • Protein details for ATP6V1G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-type proton ATPase subunit G 3
    Protein Accession:
    Secondary Accessions:
    • Q495K2
    • Q495K4
    • Q5T9L6

    Protein attributes for ATP6V1G3 Gene

    118 amino acids
    Molecular mass:
    13917 Da
    Quaternary structure:
    • V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c, c and d).

    Alternative splice isoforms for ATP6V1G3 Gene


neXtProt entry for ATP6V1G3 Gene

Proteomics data for ATP6V1G3 Gene at MOPED

Post-translational modifications for ATP6V1G3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP6V1G3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP6V1G3 Gene

Domains for ATP6V1G3 Gene

Gene Families for ATP6V1G3 Gene

  • VATP :ATPases / V-type

Protein Domains for ATP6V1G3 Gene


Suggested Antigen Peptide Sequences for ATP6V1G3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96LB4
  • Belongs to the V-ATPase G subunit family.
genes like me logo Genes that share domains with ATP6V1G3: view

Function for ATP6V1G3 Gene

Molecular function for ATP6V1G3 Gene

UniProtKB/Swiss-Prot Function: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Gene Ontology (GO) - Molecular Function for ATP6V1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism IEA --
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances --
GO:0051117 ATPase binding IPI 17360703
genes like me logo Genes that share ontologies with ATP6V1G3: view

Phenotypes for ATP6V1G3 Gene

GenomeRNAi human phenotypes for ATP6V1G3:
genes like me logo Genes that share phenotypes with ATP6V1G3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP6V1G3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATP6V1G3 Gene

Localization for ATP6V1G3 Gene

Subcellular locations from

Jensen Localization Image for ATP6V1G3 Gene COMPARTMENTS Subcellular localization image for ATP6V1G3 gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 2
vacuole 2

Gene Ontology (GO) - Cellular Components for ATP6V1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 17360703
GO:0016471 vacuolar proton-transporting V-type ATPase complex IEA --
genes like me logo Genes that share ontologies with ATP6V1G3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ATP6V1G3 Gene

Pathways for ATP6V1G3 Gene

genes like me logo Genes that share pathways with ATP6V1G3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ATP6V1G3 Gene

Gene Ontology (GO) - Biological Process for ATP6V1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006879 cellular iron ion homeostasis TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0015992 proton transport --
GO:0033572 transferrin transport TAS --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with ATP6V1G3: view

Compounds for ATP6V1G3 Gene

(3) Tocris Compounds for ATP6V1G3 Gene

Compound Action Cas Number
Bafilomycin A1 H+-ATPase (vacuolar) inhibitor [88899-55-2]
Concanamycin A H+-ATPase (vacuolar) inhibitor [80890-47-7]
Disulfiram Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities [97-77-8]

(4) HMDB Compounds for ATP6V1G3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • NFB Orthophosphate
  • Dihydrogen oxide
genes like me logo Genes that share compounds with ATP6V1G3: view

Transcripts for ATP6V1G3 Gene

Unigene Clusters for ATP6V1G3 Gene

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP6V1G3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATP6V1G3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V1G3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for ATP6V1G3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP6V1G3 Gene

mRNA expression in normal human tissues for ATP6V1G3 Gene

mRNA differential expression in normal tissues according to GTEx for ATP6V1G3 Gene

This gene is overexpressed in Kidney - Cortex (51.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATP6V1G3 Gene

SOURCE GeneReport for Unigene cluster for ATP6V1G3 Gene Hs.127743

mRNA Expression by UniProt/SwissProt for ATP6V1G3 Gene

Tissue specificity: Kidney.
genes like me logo Genes that share expressions with ATP6V1G3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ATP6V1G3 Gene

Orthologs for ATP6V1G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP6V1G3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP6V1G3 35
  • 99.72 (n)
  • 99.15 (a)
ATP6V1G3 36
  • 94 (a)
(Bos Taurus)
Mammalia ATP6V1G3 35
  • 83.76 (n)
  • 78.63 (a)
ATP6V1G3 36
  • 77 (a)
(Canis familiaris)
Mammalia ATP6V1G3 35
  • 88.14 (n)
  • 88.14 (a)
ATP6V1G3 36
  • 88 (a)
(Mus musculus)
Mammalia Atp6v1g3 35
  • 84.18 (n)
  • 83.9 (a)
Atp6v1g3 16
Atp6v1g3 36
  • 84 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
-- 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ATP6V1G3 36
  • 51 (a)
(Rattus norvegicus)
Mammalia Atp6v1g3 35
  • 82.2 (n)
  • 81.36 (a)
(Gallus gallus)
Aves ATP6V1G3 35
  • 71.3 (n)
  • 68.7 (a)
ATP6V1G3 36
  • 66 (a)
(Anolis carolinensis)
Reptilia ATP6V1G3 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp6v1g3 35
  • 68.42 (n)
  • 62.28 (a)
Str.15644 35
fruit fly
(Drosophila melanogaster)
Insecta Vha13 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea vha-10 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA10 36
  • 34 (a)
VMA10 38
Species with no ortholog for ATP6V1G3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ATP6V1G3 Gene

Gene Tree for ATP6V1G3 (if available)
Gene Tree for ATP6V1G3 (if available)

Paralogs for ATP6V1G3 Gene

Paralogs for ATP6V1G3 Gene

Selected SIMAP similar genes for ATP6V1G3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATP6V1G3: view

Variants for ATP6V1G3 Gene

Sequence variations from dbSNP and Humsavar for ATP6V1G3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs943132 -- 198,540,915(-) TTATA(C/T)CTCCT utr-variant-5-prime, upstream-variant-2KB
rs1055160 -- 198,523,324(-) TTCGT(A/G)TTTTT utr-variant-3-prime
rs1326283 -- 198,542,232(+) AAAAA(G/T)AAGTA upstream-variant-2KB
rs1536317 -- 198,523,965(+) TAAAC(C/T)CACTT intron-variant
rs1536318 -- 198,529,930(+) CGAAA(C/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP6V1G3 Gene

Variant ID Type Subtype PubMed ID
nsv832259 CNV Gain 17160897
nsv4043 CNV Insertion 18451855

Relevant External Links for ATP6V1G3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP6V1G3 Gene

Disorders for ATP6V1G3 Gene

(1) University of Copenhagen DISEASES for ATP6V1G3 Gene

Relevant External Links for ATP6V1G3

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ATP6V1G3: view

No data available for UniProtKB/Swiss-Prot for ATP6V1G3 Gene

Publications for ATP6V1G3 Gene

  1. Structure, function and regulation of the vacuolar (H+)-ATPase. (PMID: 9442887) Stevens T.H. … Forgac M. (Annu. Rev. Cell Dev. Biol. 1997) 2 3
  2. Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis. (PMID: 12384298) Smith A.N. … Karet F.E. (Gene 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 48

Products for ATP6V1G3 Gene

Sources for ATP6V1G3 Gene

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