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Aliases for ATP6V1G2-DDX39B Gene

Subcategory (RNA class) for ATP6V1G2-DDX39B Gene

ncRNA

Quality Score for this RNA gene is

13

Aliases for ATP6V1G2-DDX39B Gene

  • ATP6V1G2-DDX39B Readthrough (NMD Candidate) 2 3 5

External Ids for ATP6V1G2-DDX39B Gene

Previous GeneCards Identifiers for ATP6V1G2-DDX39B Gene

  • GC06U902172
  • GC06M031501
  • GC06M031523
  • GC06M031532
  • GC06M031545
  • GC06M031561
  • GC06M031576
  • GC06M031590
  • GC06M031827

Summaries for ATP6V1G2-DDX39B Gene

Entrez Gene Summary for ATP6V1G2-DDX39B Gene

  • This locus represents naturally occurring read-through transcription between the neighboring ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) and DDX39B (DEAD box polypeptide 39B) genes located in the major histocompatibility complex class III region of chromosome 6. The read-through transcript and is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]

GeneCards Summary for ATP6V1G2-DDX39B Gene

ATP6V1G2-DDX39B (ATP6V1G2-DDX39B Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. An important paralog of this gene is ATP6V1G2.

Additional gene information for ATP6V1G2-DDX39B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V1G2-DDX39B Gene

Genomics for ATP6V1G2-DDX39B Gene

Regulatory Elements for ATP6V1G2-DDX39B Gene


Promoters for ATP6V1G2-DDX39B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195556 -452 1401 MLX YBX1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D

Genomic Location for ATP6V1G2-DDX39B Gene

Chromosome:
6
Start:
31,530,219 bp from pter
End:
31,546,848 bp from pter
Size:
16,630 bases
Orientation:
Minus strand

Genomic View for ATP6V1G2-DDX39B Gene

Genes around ATP6V1G2-DDX39B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP6V1G2-DDX39B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP6V1G2-DDX39B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ATP6V1G2-DDX39B Gene

  • Protein details for ATP6V1G2-DDX39B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F2Z307
    Recommended name:
    V-type proton ATPase subunit G
    Protein Accession:
    F2Z307

    Protein attributes for ATP6V1G2-DDX39B Gene

    Size:
    99 amino acids
    Molecular mass:
    11355 Da
    Quaternary structure:
    • V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.

neXtProt entry for ATP6V1G2-DDX39B Gene

Post-translational modifications for ATP6V1G2-DDX39B Gene

No Post-translational modifications

Other Protein References for ATP6V1G2-DDX39B Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ATP6V1G2-DDX39B Gene

Domains & Families for ATP6V1G2-DDX39B Gene

Protein Domains for ATP6V1G2-DDX39B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ATP6V1G2-DDX39B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ATP6V1G2-DDX39B Gene

Function for ATP6V1G2-DDX39B Gene

Gene Ontology (GO) - Molecular Function for ATP6V1G2-DDX39B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ATP6V1G2-DDX39B: view

Phenotypes for ATP6V1G2-DDX39B Gene

genes like me logo Genes that share phenotypes with ATP6V1G2-DDX39B: view

Animal Model Products

CRISPR Products

miRNA for ATP6V1G2-DDX39B Gene

miRTarBase miRNAs that target ATP6V1G2-DDX39B

Clone Products

  • Applied Biological Materials Clones for ATP6V1G2-DDX39B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP6V1G2-DDX39B Gene

Localization for ATP6V1G2-DDX39B Gene

Gene Ontology (GO) - Cellular Components for ATP6V1G2-DDX39B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016471 vacuolar proton-transporting V-type ATPase complex IEA --
genes like me logo Genes that share ontologies with ATP6V1G2-DDX39B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ATP6V1G2-DDX39B Gene

Pathways & Interactions for ATP6V1G2-DDX39B Gene

SuperPathways for ATP6V1G2-DDX39B Gene

No Data Available

Interacting Proteins for ATP6V1G2-DDX39B Gene

Gene Ontology (GO) - Biological Process for ATP6V1G2-DDX39B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015992 proton transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with ATP6V1G2-DDX39B: view

No data available for Pathways by source and SIGNOR curated interactions for ATP6V1G2-DDX39B Gene

Drugs & Compounds for ATP6V1G2-DDX39B Gene

No Compound Related Data Available

Transcripts for ATP6V1G2-DDX39B Gene

mRNA/cDNA for ATP6V1G2-DDX39B Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for ATP6V1G2-DDX39B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V1G2-DDX39B Gene

No ASD Table

Relevant External Links for ATP6V1G2-DDX39B Gene

GeneLoc Exon Structure for
ATP6V1G2-DDX39B
ECgene alternative splicing isoforms for
ATP6V1G2-DDX39B

Expression for ATP6V1G2-DDX39B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP6V1G2-DDX39B Gene

genes like me logo Genes that share expression patterns with ATP6V1G2-DDX39B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP6V1G2-DDX39B Gene

Orthologs for ATP6V1G2-DDX39B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP6V1G2-DDX39B Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 57 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm5283 34
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Vha13 34
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vha-10 34
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA10 34
  • 25 (a)
OneToMany
SUB2 36
Species where no ortholog for ATP6V1G2-DDX39B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ATP6V1G2-DDX39B Gene

ENSEMBL:
Gene Tree for ATP6V1G2-DDX39B (if available)
TreeFam:
Gene Tree for ATP6V1G2-DDX39B (if available)

Paralogs for ATP6V1G2-DDX39B Gene

Paralogs for ATP6V1G2-DDX39B Gene

(3) SIMAP similar genes for ATP6V1G2-DDX39B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATP6V1G2-DDX39B: view

Variants for ATP6V1G2-DDX39B Gene

Sequence variations from dbSNP and Humsavar for ATP6V1G2-DDX39B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000206682 -- 31,543,039(+) TTTTC(C/T)TGAAT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000501115 -- 31,537,902(+) GCATG(A/G)TGGCA intron-variant, upstream-variant-2KB
rs1000639768 -- 31,530,616(+) CCACA(A/T)AAAGG intron-variant, downstream-variant-500B
rs1000684336 -- 31,530,463(+) GAAAA(C/T)GTAGC intron-variant, downstream-variant-500B
rs1000783743 -- 31,537,688(+) GGGGA(A/G)AAGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ATP6V1G2-DDX39B Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv213e55 CNV gain 17911159
dgv995e201 CNV deletion 23290073
esv2759414 CNV gain+loss 17122850
nsv1021578 CNV gain 25217958
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv470809 CNV loss 18288195
nsv830627 CNV loss 17160897

Relevant External Links for ATP6V1G2-DDX39B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP6V1G2-DDX39B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ATP6V1G2-DDX39B Gene

Disorders for ATP6V1G2-DDX39B Gene

Relevant External Links for ATP6V1G2-DDX39B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP6V1G2-DDX39B

No disorders were found for ATP6V1G2-DDX39B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP6V1G2-DDX39B Gene

Publications for ATP6V1G2-DDX39B Gene

  1. A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. (PMID: 21912425) Tohkin M … Japan Pharmacogenomics Data Science Consortium (The pharmacogenomics journal 2013) 3 60
  2. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. (PMID: 22197932) Paternoster L … EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (Nature genetics 2011) 3 60
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60
  4. The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy. (PMID: 16101831) Shichi D … Inoko H (Tissue antigens 2005) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for ATP6V1G2-DDX39B Gene

Sources for ATP6V1G2-DDX39B Gene

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