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Aliases for ATP6V1G2 Gene

Aliases for ATP6V1G2 Gene

  • ATPase H+ Transporting V1 Subunit G2 2 3
  • ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G2 2 3 5
  • ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 2 3
  • V-ATPase 13 KDa Subunit 2 3 4
  • ATP6G2 3 4
  • ATP6G 3 4
  • NG38 3 4
  • ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G Isoform 2 2
  • H(+)-Transporting Two-Sector ATPase, Subunit G2 3
  • Vacuolar ATP Synthase Subunit G 2 3
  • Vacuolar Proton Pump G Subunit 2 3
  • Vacuolar Proton Pump Subunit G 2 4
  • V-ATPase Subunit G 2 4
  • Vma10 3

External Ids for ATP6V1G2 Gene

Previous HGNC Symbols for ATP6V1G2 Gene

  • ATP6G
  • ATP6G2

Previous GeneCards Identifiers for ATP6V1G2 Gene

  • GC06M031567
  • GC06M031552
  • GC06M031282
  • GC06M031604
  • GC06M031616
  • GC06M031606
  • GC06M031621
  • GC06M031609
  • GC06M031624
  • GC06M031498
  • GC06M031299
  • GC06M031512
  • GC06M031569
  • GC06M031586

Summaries for ATP6V1G2 Gene

Entrez Gene Summary for ATP6V1G2 Gene

  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for ATP6V1G2 Gene

ATP6V1G2 (ATPase H+ Transporting V1 Subunit G2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include ATPase activity and hydrogen-exporting ATPase activity, phosphorylative mechanism. An important paralog of this gene is ATP6V1G3.

UniProtKB/Swiss-Prot for ATP6V1G2 Gene

  • Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Tocris Summary for ATP6V1G2 Gene

  • H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.

Gene Wiki entry for ATP6V1G2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V1G2 Gene

Genomics for ATP6V1G2 Gene

Regulatory Elements for ATP6V1G2 Gene

Promoters for ATP6V1G2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATP6V1G2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ATP6V1G2 gene promoter:

Genomic Location for ATP6V1G2 Gene

31,544,451 bp from pter
31,548,427 bp from pter
3,977 bases
Minus strand

Genomic View for ATP6V1G2 Gene

Genes around ATP6V1G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP6V1G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP6V1G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ATP6V1G2 Gene

  • Protein details for ATP6V1G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-type proton ATPase subunit G 2
    Protein Accession:
    Secondary Accessions:
    • B5MEF0
    • Q2L6F8
    • Q5HYU8
    • Q5RJ63

    Protein attributes for ATP6V1G2 Gene

    118 amino acids
    Molecular mass:
    13604 Da
    Quaternary structure:
    • V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c, c and d).

    Alternative splice isoforms for ATP6V1G2 Gene


neXtProt entry for ATP6V1G2 Gene

Proteomics data for ATP6V1G2 Gene at MOPED

Post-translational modifications for ATP6V1G2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP6V1G2 Gene

No data available for DME Specific Peptides for ATP6V1G2 Gene

Domains & Families for ATP6V1G2 Gene

Gene Families for ATP6V1G2 Gene


Protein Domains for ATP6V1G2 Gene


Suggested Antigen Peptide Sequences for ATP6V1G2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the V-ATPase G subunit family.
  • Belongs to the V-ATPase G subunit family.
genes like me logo Genes that share domains with ATP6V1G2: view

Function for ATP6V1G2 Gene

Molecular function for ATP6V1G2 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
genes like me logo Genes that share phenotypes with ATP6V1G2: view

Animal Models for ATP6V1G2 Gene

MGI Knock Outs for ATP6V1G2:

Animal Model Products

miRNA for ATP6V1G2 Gene

miRTarBase miRNAs that target ATP6V1G2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP6V1G2 Gene

Localization for ATP6V1G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP6V1G2 Gene

Melanosome. Note=Highly enriched in late-stage melanosomes.

Subcellular locations from

Jensen Localization Image for ATP6V1G2 Gene COMPARTMENTS Subcellular localization image for ATP6V1G2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ATP6V1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with ATP6V1G2: view

Pathways & Interactions for ATP6V1G2 Gene

genes like me logo Genes that share pathways with ATP6V1G2: view

Gene Ontology (GO) - Biological Process for ATP6V1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008286 insulin receptor signaling pathway TAS --
GO:0016241 regulation of macroautophagy NAS 22982048
GO:0033572 transferrin transport TAS --
GO:0055085 transmembrane transport IEA --
GO:0090383 phagosome acidification TAS --
genes like me logo Genes that share ontologies with ATP6V1G2: view

No data available for SIGNOR curated interactions for ATP6V1G2 Gene

Drugs & Compounds for ATP6V1G2 Gene

(3) Drugs for ATP6V1G2 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Disulfiram Approved Pharma Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities 34
Bafilomycin A1 Experimental Pharma H+-ATPase (vacuolar) inhibitor 0

(5) Additional Compounds for ATP6V1G2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • Dihydrogen oxide
  • Steam
Concanamycin A
genes like me logo Genes that share compounds with ATP6V1G2: view

Transcripts for ATP6V1G2 Gene

Unigene Clusters for ATP6V1G2 Gene

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V1G2 Gene

No ASD Table

Relevant External Links for ATP6V1G2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP6V1G2 Gene

mRNA expression in normal human tissues for ATP6V1G2 Gene

Protein differential expression in normal tissues from HIPED for ATP6V1G2 Gene

This gene is overexpressed in Frontal cortex (50.9) and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP6V1G2 Gene

SOURCE GeneReport for Unigene cluster for ATP6V1G2 Gene Hs.249227

mRNA Expression by UniProt/SwissProt for ATP6V1G2 Gene

Tissue specificity: Brain.
genes like me logo Genes that share expression patterns with ATP6V1G2: view

Protein tissue co-expression partners for ATP6V1G2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ATP6V1G2 Gene

Orthologs for ATP6V1G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP6V1G2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP6V1G2 35
  • 99.15 (n)
  • 100 (a)
ATP6V1G2 36
  • 100 (a)
(Bos Taurus)
Mammalia ATP6V1G2 36
  • 97 (a)
ATP6V1G2 35
  • 93.5 (n)
  • 97.46 (a)
(Canis familiaris)
Mammalia ATP6V1G2 35
  • 94.02 (n)
  • 97.44 (a)
ATP6V1G1 36
  • 97 (a)
(Mus musculus)
Mammalia Atp6v1g2 16
Atp6v1g2 36
  • 95 (a)
Atp6v1g2 35
  • 90.03 (n)
  • 95.73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Atp6v1g2 35
  • 92.02 (n)
  • 97.44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp6v1g2 35
  • 66.1 (n)
  • 66.95 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001823 35
  • 55.65 (n)
  • 46.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vha13 36
  • 46 (a)
Vha13 35
  • 58.19 (n)
  • 49.12 (a)
(Caenorhabditis elegans)
Secernentea vha-10 36
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA10 36
  • 31 (a)
Species with no ortholog for ATP6V1G2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ATP6V1G2 Gene

Gene Tree for ATP6V1G2 (if available)
Gene Tree for ATP6V1G2 (if available)

Paralogs for ATP6V1G2 Gene

Paralogs for ATP6V1G2 Gene

(3) SIMAP similar genes for ATP6V1G2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATP6V1G2: view

Variants for ATP6V1G2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ATP6V1G2 Gene

Variant ID Type Subtype PubMed ID
esv690 CNV CNV 17122850
essv13266 CNV CNV 17122850
nsv830627 CNV Loss 17160897
nsv470809 CNV Loss 18288195

Variation tolerance for ATP6V1G2 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP6V1G2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ATP6V1G2 Gene

Disorders for ATP6V1G2 Gene

Relevant External Links for ATP6V1G2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ATP6V1G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP6V1G2 Gene

Publications for ATP6V1G2 Gene

  1. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. (PMID: 10202016) Neville M.J. … Campbell R.D. (J. Immunol. 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L. … Jackson P.K. (Cell 2011) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3

Products for ATP6V1G2 Gene

Sources for ATP6V1G2 Gene

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