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ATP6V1G2 Gene

protein-coding   GIFtS: 57
GCID: GC06M031512

ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G2

(Previous names: ATPase, H+ transporting, lysosomal (vacuolar proton pump),...)
(Previous symbols: ATP6G, ATP6G2)
  Search for ATP6V1G2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G21 2     VMA102
ATP6G1 2 3 5     H(+)-Transporting Two-Sector ATPase, Subunit G22
ATP6G21 2 3     V-Type Proton ATPase Subunit G 22
ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump)1 2     Vacuolar ATP Synthase Subunit G 22
NG382 3     Vacuolar Proton Pump G Subunit 22
V-ATPase 13 KDa Subunit 22 3     V-ATPase Subunit G 23
ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G Isoform 21     Vacuolar Proton Pump Subunit G 23

External Ids:    HGNC: 8621   Entrez Gene: 5342   Ensembl: ENSG000002137607   OMIM: 6068535   UniProtKB: O956703   

Export aliases for ATP6V1G2 gene to outside databases

Previous GC identifers: GC06M031567 GC06M031552 GC06M031282 GC06M031604 GC06M031616 GC06M031606 GC06M031621 GC06M031609 GC06M031624 GC06M031498 GC06M031299


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATP6V1G2 Gene:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of
intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such
intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic
vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain.
The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The
V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and
d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively
spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had
previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms
have been described. Read-through transcription also exists between this gene and the downstream DEAD
(Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for ATP6V1G2 Gene:
ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) is a protein-coding gene. GO annotations related to this gene include hydrogen-exporting ATPase activity, phosphorylative mechanism. An important paralog of this gene is ATP6V1G2-DDX39B.

UniProtKB/Swiss-Prot: VATG2_HUMAN, O95670
Function: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible
for acidifying a variety of intracellular compartments in eukaryotic cells

summary for ATP6V1G2 Gene:
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify
intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane
organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated
vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains.
The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation.
There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles
to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These
transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation
and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause
recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of
sperm motility and maturation.

Gene Wiki entry for ATP6V1G2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP6V1G2 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP6V1G2 promoter sequence
   Search Chromatin IP Primers for ATP6V1G2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP6V1G2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

ATP6V1G2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP6V1G2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031512:  view genomic region     (about GC identifiers)

Start:
31,512,228 bp from pter      End:
31,516,204 bp from pter
Size:
3,977 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167249 2,843,033-2,845,430      Chr6-,NT_167245 2,797,806-2,800,199      Chr6-,NT_167248 2,805,903-2,808,296     
Chr6-,NT_167247 2,891,975-2,894,368      Chr6-,NT_167246 2,855,124-2,857,517      Chr6-,NT_113891.2 3,021,887-3,024,280     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VATG2_HUMAN, O95670 (See protein sequence)
Recommended Name: V-type proton ATPase subunit G 2  
Size: 118 amino acids; 13604 Da
Subunit: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H)
attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d) (By similarity)
Secondary accessions: B5MEF0 Q2L6F8 Q5HYU8 Q5RJ63
Alternative splicing: 3 isoforms:  O95670-1   O95670-2   O95670-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP6V1G2: NX_O95670

Explore proteomics data for ATP6V1G2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys16
  • Modification sites at PhosphoSitePlus

  • See ATP6V1G2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001191007.1  NP_569730.1  NP_612139.1  

    ENSEMBL proteins: 
     ENSP00000365321   ENSP00000302194   ENSP00000419698   ENSP00000390148  
    Reactome Protein details: O95670

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VATP: ATPases / V-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: G2
    V-type ATPase

    1 InterPro protein domain:
     IPR005124 V-ATPase_G

    Graphical View of Domain Structure for InterPro Entry O95670

    ProtoNet protein and cluster: O95670

    1 Blocks protein domain: IPB005124 Vacuolar (H+)-ATPase G subunit

    UniProtKB/Swiss-Prot: VATG2_HUMAN, O95670
    Similarity: Belongs to the V-ATPase G subunit family


    Find genes that share domains with ATP6V1G2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VATG2_HUMAN, O95670
    Function: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible
    for acidifying a variety of intracellular compartments in eukaryotic cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008553hydrogen-exporting ATPase activity, phosphorylative mechanism IEA--
    GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances ----
    GO:0016887ATPase activity ----
         
    Find genes that share ontologies with ATP6V1G2           About GenesLikeMe


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidATP6V1G2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VATG2_HUMAN, O95670: Melanosome. Note=Highly enriched in late-stage melanosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    vacuole2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016471vacuolar proton-transporting V-type ATPase complex IEA--
    GO:0030285integral component of synaptic vesicle membrane IEA--
    GO:0042470melanosome IEA--

    Find genes that share ontologies with ATP6V1G2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATP6V1G2 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Insulin receptor recycling
    Insulin receptor recycling0.74
    Collecting duct acid secretion0.66
    Transferrin endocytosis and recycling0.74
    Vibrio cholerae infection0.40
    Iron uptake and transport0.70
    Epithelial cell signaling in Helicobacter pylori infection0.32
    2Insulin receptor signalling cascade
    Signaling by Insulin receptor0.80
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Oxidative phosphorylation0.64
    4Signaling by GPCR
    Signal Transduction0.58
    5Synaptic vesicle cycle
    Synaptic vesicle cycle0.50


    Find genes that share SuperPaths with ATP6V1G2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for ATP6V1G2
        Insulin receptor recycling
    Phagosomal maturation (early endosomal stage)
    Transferrin endocytosis and recycling


    Selected Kegg Pathways  (Kegg details for ATP6V1G2) (see all 8):
        Oxidative phosphorylation
    Metabolic pathways
    Phagosome
    Synaptic vesicle cycle
    Collecting duct acid secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATP6V1G2: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ATP6V1G2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for ATP6V1G2 (O956701, 2, 3 ENSP000003021944) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP6V1E1P365431, 2, 3, ENSP000002534134EBI-348290,EBI-348639 MINT-62638 MINT-62736 MINT-62812 I2D: score=7 STRING: ENSP00000253413
    ATP6V1B2P212813, ENSP000002763904I2D: score=1 STRING: ENSP00000276390
    ATP6V1FQ168643, ENSP000002492894I2D: score=1 STRING: ENSP00000249289
    ATG10Q9H0Y03I2D: score=1 
    ATG101Q9BSB43I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process ----
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0015992proton transport ----
    GO:0033572transferrin transport TAS--

    Find genes that share ontologies with ATP6V1G2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for ATP6V1G2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Bafilomycin A1H+-ATPase (vacuolar) inhibitor[88899-55-2]
    Concanamycin AH+-ATPase (vacuolar) inhibitor[80890-47-7]
    DisulfiramReversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities[97-77-8]

    4 HMDB Compounds for ATP6V1G2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATP6V1G2 gene (3 alternative transcripts): 
    NM_001204078.1  NM_130463.3  NM_138282.2  

    Unigene Cluster for ATP6V1G2:

    ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
    Hs.249227  [show with all ESTs]
    Unigene Representative Sequence: NM_130463
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376151 ENST00000303892(uc003ntz.3 uc003nua.3 uc021yur.1)
    ENST00000483251 ENST00000415099 ENST00000483170 ENST00000481998
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    Additional mRNA sequence: 

    BC047791.1 BC068023.1 BC119726.1 BC119727.1 

    9 DOTS entries:

    DT.100019994  DT.100019993  DT.100745549  DT.100707588  DT.432830  DT.100878266  DT.121310315  DT.86849562 
    DT.97777677 

    Selected AceView cDNA sequences (see all 157):

    CR620111 BC000361 AA230211 AJ243199 CR600093 CR618145 NM_130463 AA836543 
    BT009909 BC013006 CR601722 CR612476 CR623314 BC047791 NM_080598 CR590279 
    CR591582 F15252 CR608752 CR612427 BX445405 CR606599 NM_138282 BC004350 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATP6V1G2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTCCTTT
    ATP6V1G2 Expression
    About this image


    ATP6V1G2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Cerebral Cortex
             Globus Pallidus   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Spinal Cord (Nervous System)
    ATP6V1G2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATP6V1G2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249227

    UniProtKB/Swiss-Prot: VATG2_HUMAN, O95670
    Tissue specificity: Brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATP6V1G2: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ATP6V1G2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp6v1g21 , 5 ATPase, H+ transporting, lysosomal V1 subunit G21, 5 90.03(n)1
    95.73(a)1
      17 (18.60 cM)5
    662371  NM_023179.31  NP_075668.11 
     352336605 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    76(a)
    1 → many
    2(194088046-194091177)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atp6v1g21 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit more 66.1(n)
    66.95(a)
      780301  NM_001079372.1  NP_001072840.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vha131 Vacuolar H[+] ATPase G-subunit 58.19(n)
    49.12(a)
      42341  NM_058089.5  NP_477437.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vha-106
    Protein VHA-10 (vha-10) mRNA, complete cds
    44(a)
    1 → many
    I(5609310-5610270) WBGene00006919
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VMA106
    Subunit G of the eight-subunit V1 peripheral membr...
    31(a)
    1 → many
    VIII(187173-187679) YHR039C-A


    ENSEMBL Gene Tree for ATP6V1G2 (if available)
    TreeFam Gene Tree for ATP6V1G2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATP6V1G2 gene
    ATP6V1G2-DDX39B2  ATP6V1G32  ATP6V1G12  
    3 SIMAP similar genes for ATP6V1G2 using alignment to 3 protein entries:     VATG2_HUMAN (see all proteins):
    ATP6V1G2-DDX39B    ATP6V1G1    ATP6V1G3

    Find genes that share paralogs with ATP6V1G2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ATP6V1G2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    nsv470809CNV Loss18288195
    esv690CNV CNV17122850
    essv13266CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATP6V1G2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606853    OMIM disorders: --


    Find genes that share disorders with ATP6V1G2           About GenesLikeMe

    Genetic Association Database (GAD): ATP6V1G2
    Human Genome Epidemiology (HuGE) Navigator: ATP6V1G2 (8 documents)

    Export disorders for ATP6V1G2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ATP6V1G2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with ATP6V1G2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. (PubMed id 10202016)1, 2, 3 Neville M.J. and Campbell R.D. (J. Immunol. 1999)
    2. Characterization of tumor necrosis factor-I+ block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients. (PubMed id 20854863)1, 4 Tan J.H....Wallace H.J. (Hum. Immunol. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    6. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis. (PubMed id 12384298)1, 2 Smith A.N.... Karet F.E. (Gene 2002)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 534 HGNC: 862 AceView: BAT1andATP6V1G2 Ensembl:ENSG00000213760 euGenes: HUgn534
    ECgene: ATP6V1G2 Kegg: 534 H-InvDB: ATP6V1G2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATP6V1G2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ATP6V1G2 gene:
    Search GeneIP for patents involving ATP6V1G2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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