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Aliases for ATP6V1G1 Gene

Aliases for ATP6V1G1 Gene

  • ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G1 2 3
  • ATP6G1 3 4 6
  • ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump), Member J 2 3
  • Vacuolar Proton Pump Subunit G 1 3 4
  • Vacuolar Proton Pump Subunit M16 3 4
  • V-ATPase 13 KDa Subunit 1 3 4
  • V-ATPase Subunit G 1 3 4
  • ATP6J 3 4
  • ATP6G 3 4
  • ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G Isoform 1 2
  • Vacuolar ATP Synthase Subunit M16 3
  • V-Type Proton ATPase Subunit G 1 3
  • Vacuolar H(+)-ATPase Subunit G 1 3
  • ATP6GL 3
  • Vma10 3

External Ids for ATP6V1G1 Gene

Previous HGNC Symbols for ATP6V1G1 Gene

  • ATP6J
  • ATP6G1

Previous GeneCards Identifiers for ATP6V1G1 Gene

  • GC09P108148
  • GC09P109082
  • GC09P110803
  • GC09P112726
  • GC09P114429
  • GC09P116389
  • GC09P117350
  • GC09P086955
  • GC09P117553

Summaries for ATP6V1G1 Gene

Entrez Gene Summary for ATP6V1G1 Gene

  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP6V1G1 Gene

ATP6V1G1 (ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include ATPase binding and hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. An important paralog of this gene is ATP6V1G3.

UniProtKB/Swiss-Prot for ATP6V1G1 Gene

  • Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Tocris Summary for ATP6V1G1 Gene

  • H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains. The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation. There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of sperm motility and maturation.

Gene Wiki entry for ATP6V1G1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V1G1 Gene

Genomics for ATP6V1G1 Gene

Regulatory Elements for ATP6V1G1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATP6V1G1 Gene

Start:
114,587,714 bp from pter
End:
114,598,872 bp from pter
Size:
11,159 bases
Orientation:
Plus strand

Genomic View for ATP6V1G1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP6V1G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP6V1G1 Gene

Proteins for ATP6V1G1 Gene

  • Protein details for ATP6V1G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75348-VATG1_HUMAN
    Recommended name:
    V-type proton ATPase subunit G 1
    Protein Accession:
    O75348
    Secondary Accessions:
    • Q6IB33

    Protein attributes for ATP6V1G1 Gene

    Size:
    118 amino acids
    Molecular mass:
    13758 Da
    Quaternary structure:
    • V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c, c and d)

neXtProt entry for ATP6V1G1 Gene

Proteomics data for ATP6V1G1 Gene at MOPED

Post-translational modifications for ATP6V1G1 Gene

  • Ubiquitination at Lys16
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP6V1G1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ATP6V1G1 Gene

Domains for ATP6V1G1 Gene

Gene Families for ATP6V1G1 Gene

HGNC:
  • VATP :ATPases / V-type
IUPHAR :

Protein Domains for ATP6V1G1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ATP6V1G1 Gene

Graphical View of Domain Structure for InterPro Entry

O75348

UniProtKB/Swiss-Prot:

VATG1_HUMAN :
  • O75348
Family:
  • Belongs to the V-ATPase G subunit family.
genes like me logo Genes that share domains with ATP6V1G1: view

Function for ATP6V1G1 Gene

Molecular function for ATP6V1G1 Gene

UniProtKB/Swiss-Prot Function: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Gene Ontology (GO) - Molecular Function for ATP6V1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism IEA --
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances --
GO:0016887 ATPase activity --
GO:0051117 ATPase binding IPI 17360703
genes like me logo Genes that share ontologies with ATP6V1G1: view

Phenotypes for ATP6V1G1 Gene

GenomeRNAi human phenotypes for ATP6V1G1:
genes like me logo Genes that share phenotypes with ATP6V1G1: view

Animal Model Products

CRISPR Products

miRNA for ATP6V1G1 Gene

miRTarBase miRNAs that target ATP6V1G1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP6V1G1 Gene

Localization for ATP6V1G1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP6V1G1 Gene COMPARTMENTS Subcellular localization image for ATP6V1G1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2
vacuole 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ATP6V1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS --
GO:0016471 vacuolar proton-transporting V-type ATPase complex IEA --
genes like me logo Genes that share ontologies with ATP6V1G1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ATP6V1G1 Gene

Pathways for ATP6V1G1 Gene

genes like me logo Genes that share pathways with ATP6V1G1: view

Gene Ontology (GO) - Biological Process for ATP6V1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0008152 metabolic process IEA --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0015992 proton transport --
genes like me logo Genes that share ontologies with ATP6V1G1: view

Compounds for ATP6V1G1 Gene

(3) Tocris Compounds for ATP6V1G1 Gene

Compound Action Cas Number
Bafilomycin A1 H+-ATPase (vacuolar) inhibitor [88899-55-2]
Concanamycin A H+-ATPase (vacuolar) inhibitor [80890-47-7]
Disulfiram Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities [97-77-8]

(4) HMDB Compounds for ATP6V1G1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with ATP6V1G1: view

Transcripts for ATP6V1G1 Gene

mRNA/cDNA for ATP6V1G1 Gene

(708) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP6V1G1 Gene

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP6V1G1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V1G1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: - - -

Relevant External Links for ATP6V1G1 Gene

GeneLoc Exon Structure for
ATP6V1G1
ECgene alternative splicing isoforms for
ATP6V1G1

Expression for ATP6V1G1 Gene

mRNA expression in normal human tissues for ATP6V1G1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP6V1G1 Gene

SOURCE GeneReport for Unigene cluster for ATP6V1G1 Gene Hs.388654

mRNA Expression by UniProt/SwissProt for ATP6V1G1 Gene

O75348-VATG1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with ATP6V1G1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ATP6V1G1 Gene

Orthologs for ATP6V1G1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP6V1G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP6V1G1 35
  • 99.72 (n)
  • 100 (a)
ATP6V1G1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP6V1G1 35
  • 91.24 (n)
  • 96.61 (a)
ATP6V1G1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
OneToMany
ATP6V1G1 35
  • 94.07 (n)
  • 97.78 (a)
mouse
(Mus musculus)
Mammalia Atp6v1g1 35
  • 91.53 (n)
  • 94.92 (a)
Atp6v1g1 16
Atp6v1g1 36
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ATP6V1G1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP6V1G1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp6v1g1 35
  • 91.24 (n)
  • 96.61 (a)
chicken
(Gallus gallus)
Aves ATP6V1G1 35
  • 80.79 (n)
  • 84.75 (a)
ATP6V1G1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP6V1G1 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia atp6v1g1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atp6v1g1 35
  • 72.6 (n)
  • 81.36 (a)
Str.62 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10199 35
zebrafish
(Danio rerio)
Actinopterygii atp6v1g1 35
  • 71.47 (n)
  • 77.12 (a)
atp6v1g1 36
  • 75 (a)
OneToOne
wufa12a02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004867 35
  • 57.89 (n)
  • 54.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vha13 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vha-10 35
  • 56.03 (n)
  • 51.72 (a)
vha-10 36
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA10 36
  • 36 (a)
OneToMany
Species with no ortholog for ATP6V1G1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP6V1G1 Gene

ENSEMBL:
Gene Tree for ATP6V1G1 (if available)
TreeFam:
Gene Tree for ATP6V1G1 (if available)

Paralogs for ATP6V1G1 Gene

Paralogs for ATP6V1G1 Gene

Selected SIMAP similar genes for ATP6V1G1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATP6V1G1: view

Variants for ATP6V1G1 Gene

Sequence variations from dbSNP and Humsavar for ATP6V1G1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs943843 -- 114,587,121(+) AAACT(A/G)TGAGC upstream-variant-2KB
rs1802167 -- 114,587,908(+) TGTCC(G/T)AGGCC reference, stop-gained
rs2274595 -- 114,592,663(+) GCACC(A/G)TTTGT intron-variant
rs3035395 -- 114,588,540(+) tgtgt(-/GT)tTCTG intron-variant
rs4585809 -- 114,585,809(+) ATGTC(C/T)TGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ATP6V1G1 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
dgv33e196 CNV Duplication 17116639
dgv948n27 CNV Gain 19166990
nsv831694 CNV Gain 17160897
nsv7433 OTHER Inversion 18451855

Relevant External Links for ATP6V1G1 Gene

HapMap Linkage Disequilibrium report
ATP6V1G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP6V1G1 Gene

Disorders for ATP6V1G1 Gene

Relevant External Links for ATP6V1G1

Genetic Association Database (GAD)
ATP6V1G1
genes like me logo Genes that share disorders with ATP6V1G1: view

No data available for UniProtKB/Swiss-Prot for ATP6V1G1 Gene

Publications for ATP6V1G1 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  2. Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis. (PMID: 12384298) Smith A.N. … Karet F.E. (Gene 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for ATP6V1G1 Gene

Sources for ATP6V1G1 Gene

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