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Aliases for ATP6V1F Gene

Aliases for ATP6V1F Gene

  • ATPase H+ Transporting V1 Subunit F 2 3
  • ATPase, H+ Transporting, Lysosomal 14kDa, V1 Subunit F 2 3 5
  • Vacuolar Proton Pump Subunit F 3 4
  • V-ATPase 14 KDa Subunit 3 4
  • V-ATPase Subunit F 3 4
  • ATP6S14 3 4
  • VATF 3 4
  • H(+)-Transporting Two-Sector ATPase, 14kD Subunit 3
  • Adenosinetriphosphatase 14k Chain 3
  • Vacuolar ATP Synthase Subunit F 3
  • Vacuolar Proton Pump F Subunit 3
  • ATPase, Vacuolar, 14 KD 3
  • V-ATPase F Subunit 3
  • Vma7 3

External Ids for ATP6V1F Gene

Previous GeneCards Identifiers for ATP6V1F Gene

  • GC07P126980
  • GC07P128043
  • GC07P128056
  • GC07P128096
  • GC07P128290
  • GC07P128502
  • GC07P122864

Summaries for ATP6V1F Gene

Entrez Gene Summary for ATP6V1F Gene

  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP6V1F Gene

ATP6V1F (ATPase H+ Transporting V1 Subunit F) is a Protein Coding gene. Among its related pathways are Synaptic vesicle cycle and Immune System. GO annotations related to this gene include hydrogen ion transmembrane transporter activity and ATPase coupled ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP6V1F Gene

  • Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Tocris Summary for ATP6V1F Gene

  • H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.

Gene Wiki entry for ATP6V1F Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V1F Gene

Genomics for ATP6V1F Gene

Regulatory Elements for ATP6V1F Gene

Enhancers for ATP6V1F Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATP6V1F on UCSC Golden Path with GeneCards custom track

Promoters for ATP6V1F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATP6V1F on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP6V1F Gene

128,862,803 bp from pter
128,865,849 bp from pter
3,047 bases
Plus strand

Genomic View for ATP6V1F Gene

Genes around ATP6V1F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP6V1F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP6V1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP6V1F Gene

Proteins for ATP6V1F Gene

  • Protein details for ATP6V1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-type proton ATPase subunit F
    Protein Accession:
    Secondary Accessions:
    • C9J2K4
    • Q6IBA8

    Protein attributes for ATP6V1F Gene

    119 amino acids
    Molecular mass:
    13370 Da
    Quaternary structure:
    • V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c, c and d).

    Alternative splice isoforms for ATP6V1F Gene


neXtProt entry for ATP6V1F Gene

Proteomics data for ATP6V1F Gene at MOPED

Post-translational modifications for ATP6V1F Gene

  • Ubiquitination at Lys 94 and Lys 102
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP6V1F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP6V1F Gene

Domains & Families for ATP6V1F Gene

Gene Families for ATP6V1F Gene


Suggested Antigen Peptide Sequences for ATP6V1F Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the V-ATPase F subunit family.
  • Belongs to the V-ATPase F subunit family.
genes like me logo Genes that share domains with ATP6V1F: view

Function for ATP6V1F Gene

Molecular function for ATP6V1F Gene

UniProtKB/Swiss-Prot Function:
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Phenotypes for ATP6V1F Gene

genes like me logo Genes that share phenotypes with ATP6V1F: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP6V1F

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP6V1F Gene

Localization for ATP6V1F Gene

Subcellular locations from

Jensen Localization Image for ATP6V1F Gene COMPARTMENTS Subcellular localization image for ATP6V1F gene
Compartment Confidence
cytosol 5
extracellular 5
vacuole 5
nucleus 3
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ATP6V1F Gene

Pathways & Interactions for ATP6V1F Gene

genes like me logo Genes that share pathways with ATP6V1F: view

Gene Ontology (GO) - Biological Process for ATP6V1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015991 ATP hydrolysis coupled proton transport IEA --
GO:0090383 phagosome acidification TAS --
genes like me logo Genes that share ontologies with ATP6V1F: view

No data available for SIGNOR curated interactions for ATP6V1F Gene

Drugs & Compounds for ATP6V1F Gene

(3) Drugs for ATP6V1F Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Disulfiram Approved Pharma Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities 34
Bafilomycin A1 Experimental Pharma H+-ATPase (vacuolar) inhibitor 0

(5) Additional Compounds for ATP6V1F Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • Dihydrogen oxide
  • Steam
Concanamycin A

(4) Tocris Compounds for ATP6V1F Gene

Compound Action Cas Number
Bafilomycin A1 H+-ATPase (vacuolar) inhibitor 88899-55-2
Concanamycin A H+-ATPase (vacuolar) inhibitor 80890-47-7
Disulfiram Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities 97-77-8
Enterostatin Binds to beta-subunit of F1-ATPase; anorexigenic peptide 117830-79-2
genes like me logo Genes that share compounds with ATP6V1F: view

Transcripts for ATP6V1F Gene

mRNA/cDNA for ATP6V1F Gene

Unigene Clusters for ATP6V1F Gene

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V1F Gene

No ASD Table

Relevant External Links for ATP6V1F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP6V1F Gene

mRNA expression in normal human tissues for ATP6V1F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATP6V1F Gene

This gene is overexpressed in Brain (16.5) and Frontal cortex (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP6V1F Gene

SOURCE GeneReport for Unigene cluster for ATP6V1F Gene Hs.78089

genes like me logo Genes that share expression patterns with ATP6V1F: view

Protein tissue co-expression partners for ATP6V1F Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP6V1F Gene

Orthologs for ATP6V1F Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP6V1F Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATP6V1F 35
  • 92.44 (n)
  • 99.16 (a)
-- 36
  • 98 (a)
ATP6V1F 36
  • 99 (a)
(Canis familiaris)
Mammalia ATP6V1F 35
  • 91.6 (n)
  • 98.32 (a)
ATP6V1F 36
  • 98 (a)
(Mus musculus)
Mammalia Atp6v1f 35
  • 91.04 (n)
  • 98.32 (a)
Atp6v1f 16
Atp6v1f 36
  • 98 (a)
(Pan troglodytes)
Mammalia ATP6V1F 35
  • 99.72 (n)
  • 100 (a)
-- 36
  • 99 (a)
ATP6V1F 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Atp6v1f 35
  • 90.76 (n)
  • 98.32 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
-- 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia ATP6V1F 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp6v1f 35
  • 74.79 (n)
  • 88.24 (a)
Str.8618 35
African clawed frog
(Xenopus laevis)
Amphibia atp6v1f-A 35
(Danio rerio)
Actinopterygii atp6v1f 35
  • 75.91 (n)
  • 84.03 (a)
Dr.13658 35
atp6v1f 36
  • 83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4942 35
fruit fly
(Drosophila melanogaster)
Insecta CG1076 37
  • 60 (a)
Vha14 37
  • 72 (a)
Vha14-1 35
  • 70.37 (n)
  • 71.79 (a)
Vha14-2 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta VATF_ANOGA 35
  • 67.24 (n)
  • 69.23 (a)
(Caenorhabditis elegans)
Secernentea ZK970.4 37
  • 70 (a)
vha-9 35
  • 66.95 (n)
  • 70.34 (a)
vha-9 36
  • 69 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL052W 35
  • 58.48 (n)
  • 47.37 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04400g 35
  • 52.92 (n)
  • 52.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA7 35
  • 55.56 (n)
  • 53.51 (a)
VMA7 36
  • 52 (a)
VMA7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G02620 35
  • 60.73 (n)
  • 53.39 (a)
(Hordeum vulgare)
Liliopsida Hv.6353 35
(Oryza sativa)
Liliopsida Os02g0824700 35
  • 61.58 (n)
  • 52.54 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04387 35
  • 57.8 (n)
  • 55.05 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes vma7 35
  • 54.21 (n)
  • 51.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
Species with no ortholog for ATP6V1F:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP6V1F Gene

Gene Tree for ATP6V1F (if available)
Gene Tree for ATP6V1F (if available)

Paralogs for ATP6V1F Gene Pseudogenes for ATP6V1F Gene

genes like me logo Genes that share paralogs with ATP6V1F: view

No data available for Paralogs for ATP6V1F Gene

Variants for ATP6V1F Gene

Sequence variations from dbSNP and Humsavar for ATP6V1F Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10958 - 128,862,975(+) GGGCG(G/T)CATAG reference, missense
rs1472146 -- 128,863,888(-) AGAGA(A/T)TGGCA intron-variant
rs1472147 -- 128,863,489(-) GGTTG(A/G)GATTG intron-variant
rs1804887 -- 128,862,927(+) GCTCA(C/T)CGCAG reference, missense
rs7784172 -- 128,861,999(+) cccgg(C/G)taatt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ATP6V1F Gene

Variant ID Type Subtype PubMed ID
esv2735137 CNV Deletion 23290073
esv2670312 CNV Deletion 23128226
nsv831125 CNV Loss 17160897
esv22837 CNV Gain 19812545
nsv889192 CNV Loss 21882294
nsv517923 CNV Gain 19592680
nsv464713 CNV Loss 19166990
nsv818553 CNV Gain 17921354
dgv7490n71 CNV Loss 21882294
nsv464715 CNV Loss 19166990
nsv464717 CNV Loss 19166990
nsv470392 CNV Gain 18288195
nsv517371 CNV Gain+Loss 19592680

Variation tolerance for ATP6V1F Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATP6V1F Gene

Disorders for ATP6V1F Gene

Relevant External Links for ATP6V1F

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ATP6V1F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP6V1F Gene

Publications for ATP6V1F Gene

  1. Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit). (PMID: 8581736) Fujiwara T. … Shin S. (DNA Res. 1995) 2 3 4 67
  2. Identification of a 14-kDa subunit associated with the catalytic sector of clathrin-coated vesicle H+-ATPase. (PMID: 8621738) Peng S.B. … Stone D.K. (J. Biol. Chem. 1996) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ATP6V1F Gene

Sources for ATP6V1F Gene