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Aliases for ATP6V1F Gene

Aliases for ATP6V1F Gene

  • ATPase, H+ Transporting, Lysosomal 14kDa, V1 Subunit F 2 3
  • Vacuolar Proton Pump Subunit F 3 4
  • V-ATPase 14 KDa Subunit 3 4
  • V-ATPase Subunit F 3 4
  • ATP6S14 3 4
  • VATF 3 4
  • H(+)-Transporting Two-Sector ATPase, 14kD Subunit 3
  • Adenosinetriphosphatase 14k Chain 3
  • Vacuolar ATP Synthase Subunit F 3
  • V-Type Proton ATPase Subunit F 3
  • Vacuolar Proton Pump F Subunit 3
  • ATPase, Vacuolar, 14 KD 3
  • V-ATPase F Subunit 3
  • Vma7 3

External Ids for ATP6V1F Gene

Summaries for ATP6V1F Gene

Entrez Gene Summary for ATP6V1F Gene

  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP6V1F Gene

ATP6V1F (ATPase, H+ Transporting, Lysosomal 14kDa, V1 Subunit F) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include hydrogen ion transmembrane transporter activity and ATPase activity, uncoupled.

UniProtKB/Swiss-Prot for ATP6V1F Gene

  • Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Tocris Summary for ATP6V1F Gene

  • H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains. The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation. There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of sperm motility and maturation.

Gene Wiki entry for ATP6V1F Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V1F Gene

Genomics for ATP6V1F Gene

Genomic Location for ATP6V1F Gene

Start:
128,862,803 bp from pter
End:
128,865,849 bp from pter
Size:
3,047 bases
Orientation:
Plus strand

Genomic View for ATP6V1F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP6V1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP6V1F Gene

Regulatory Elements for ATP6V1F Gene

Proteins for ATP6V1F Gene

  • Protein details for ATP6V1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16864-VATF_HUMAN
    Recommended name:
    V-type proton ATPase subunit F
    Protein Accession:
    Q16864
    Secondary Accessions:
    • C9J2K4
    • Q6IBA8

    Protein attributes for ATP6V1F Gene

    Size:
    119 amino acids
    Molecular mass:
    13370 Da
    Quaternary structure:
    • V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c, c and d)

    Alternative splice isoforms for ATP6V1F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP6V1F Gene

Proteomics data for ATP6V1F Gene at MOPED

Post-translational modifications for ATP6V1F Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys94 and Lys102

Other Protein References for ATP6V1F Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP6V1F Gene

Domains for ATP6V1F Gene

Gene Families for ATP6V1F Gene

HGNC:
  • VATP :ATPases / V-type
IUPHAR :

Suggested Antigen Peptide Sequences for ATP6V1F Gene

Graphical View of Domain Structure for InterPro Entry

Q16864

UniProtKB/Swiss-Prot:

VATF_HUMAN
Family:
  • Belongs to the V-ATPase F subunit family.:
    • Q16864
genes like me logo Genes that share domains with ATP6V1F: view

Function for ATP6V1F Gene

Molecular function for ATP6V1F Gene

UniProtKB/Swiss-Prot Function: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Gene Ontology (GO) - Molecular Function for ATP6V1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18752060
GO:0015078 hydrogen ion transmembrane transporter activity NAS 8581736
GO:0042624 ATPase activity, uncoupled NAS 8581736
GO:0042625 ATPase activity, coupled to transmembrane movement of ions IBA --
GO:0046961 proton-transporting ATPase activity, rotational mechanism IEA --
genes like me logo Genes that share ontologies with ATP6V1F: view

miRNA for ATP6V1F Gene

miRTarBase miRNAs that target ATP6V1F

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP6V1F Gene

Localization for ATP6V1F Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP6V1F Gene COMPARTMENTS Subcellular localization image for ATP6V1F gene
Compartment Confidence
vacuole 5
cytosol 4
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ATP6V1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 18752060
GO:0016469 proton-transporting two-sector ATPase complex NAS 8581736
GO:0016471 vacuolar proton-transporting V-type ATPase complex IDA 18752060
GO:0033180 proton-transporting V-type ATPase, V1 domain IEA --
genes like me logo Genes that share ontologies with ATP6V1F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ATP6V1F Gene

Pathways for ATP6V1F Gene

genes like me logo Genes that share pathways with ATP6V1F: view

Gene Ontology (GO) - Biological Process for ATP6V1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0008152 metabolic process NAS 8581736
GO:0008286 insulin receptor signaling pathway TAS --
GO:0015991 ATP hydrolysis coupled proton transport IEA --
genes like me logo Genes that share ontologies with ATP6V1F: view

Compounds for ATP6V1F Gene

(3) Tocris Compounds for ATP6V1F Gene

Compound Action Cas Number
Bafilomycin A1 H+-ATPase (vacuolar) inhibitor [88899-55-2]
Concanamycin A H+-ATPase (vacuolar) inhibitor [80890-47-7]
Disulfiram Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities [97-77-8]

(4) HMDB Compounds for ATP6V1F Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with ATP6V1F: view

Transcripts for ATP6V1F Gene

mRNA/cDNA for ATP6V1F Gene

Unigene Clusters for ATP6V1F Gene

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V1F Gene

No ASD Table

Relevant External Links for ATP6V1F Gene

GeneLoc Exon Structure for
ATP6V1F
ECgene alternative splicing isoforms for
ATP6V1F

Expression for ATP6V1F Gene

mRNA expression in normal human tissues for ATP6V1F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP6V1F Gene

SOURCE GeneReport for Unigene cluster for ATP6V1F Gene Hs.78089

genes like me logo Genes that share expressions with ATP6V1F: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP6V1F Gene

Orthologs for ATP6V1F Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP6V1F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
ATP6V1F 35
  • 99.72 (n)
  • 100 (a)
ATP6V1F 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 98 (a)
OneToMany
ATP6V1F 35
  • 92.44 (n)
  • 99.16 (a)
ATP6V1F 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ATP6V1F 35
  • 91.6 (n)
  • 98.32 (a)
ATP6V1F 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp6v1f 35
  • 91.04 (n)
  • 98.32 (a)
Atp6v1f 16
Atp6v1f 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ATP6V1F 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp6v1f 35
  • 90.76 (n)
  • 98.32 (a)
African clawed frog
(Xenopus laevis)
Amphibia atp6v1f-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atp6v1f 35
  • 74.79 (n)
  • 88.24 (a)
Str.8618 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4942 35
zebrafish
(Danio rerio)
Actinopterygii atp6v1f 35
  • 75.91 (n)
  • 84.03 (a)
atp6v1f 36
  • 83 (a)
OneToOne
Dr.13658 35
African malaria mosquito
(Anopheles gambiae)
Insecta VATF_ANOGA 35
  • 67.24 (n)
  • 69.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vha14-1 35
  • 70.37 (n)
  • 71.79 (a)
Vha14-2 36
  • 36 (a)
OneToOne
Vha14 37
  • 72 (a)
CG1076 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea vha-9 35
  • 66.95 (n)
  • 70.34 (a)
vha-9 36
  • 69 (a)
OneToOne
ZK970.4 37
  • 70 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL052W 35
  • 58.48 (n)
  • 47.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA7 35
  • 55.56 (n)
  • 53.51 (a)
VMA7 36
  • 52 (a)
OneToOne
VMA7 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04400g 35
  • 52.92 (n)
  • 52.63 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G02620 35
  • 60.73 (n)
  • 53.39 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6353 35
rice
(Oryza sativa)
Liliopsida Os02g0824700 35
  • 61.58 (n)
  • 52.54 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04387 35
  • 57.8 (n)
  • 55.05 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes vma7 35
  • 54.21 (n)
  • 51.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for ATP6V1F:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP6V1F Gene

ENSEMBL:
Gene Tree for ATP6V1F (if available)
TreeFam:
Gene Tree for ATP6V1F (if available)

Paralogs for ATP6V1F Gene

Pseudogenes.org Pseudogenes for ATP6V1F Gene

genes like me logo Genes that share paralogs with ATP6V1F: view

No data available for Paralogs for ATP6V1F Gene

Variants for ATP6V1F Gene

Sequence variations from dbSNP and Humsavar for ATP6V1F Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs10958 - 128,862,975(+) GGGCG(G/T)CATAG reference, missense
rs1472146 -- 128,863,888(-) AGAGA(A/T)TGGCA intron-variant
rs1472147 -- 128,863,489(-) GGTTG(A/G)GATTG intron-variant
rs1804887 -- 128,862,927(+) GCTCA(C/T)CGCAG missense, reference
rs2951199 -- 128,861,860(-) agact(C/T)tgtct upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ATP6V1F Gene

Variant ID Type Subtype PubMed ID
esv2735137 CNV Deletion 23290073
esv2670312 CNV Deletion 23128226
nsv831125 CNV Loss 17160897
esv22837 CNV Gain 19812545
nsv889192 CNV Loss 21882294
nsv517923 CNV Gain 19592680
nsv464713 CNV Loss 19166990
nsv818553 CNV Gain 17921354
dgv7490n71 CNV Loss 21882294
nsv464715 CNV Loss 19166990
nsv464717 CNV Loss 19166990
nsv470392 CNV Gain 18288195
nsv517371 CNV Gain+Loss 19592680

Relevant External Links for ATP6V1F Gene

HapMap Linkage Disequilibrium report
ATP6V1F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP6V1F Gene

Disorders for ATP6V1F Gene

No disorders were found for ATP6V1F Gene.

No data available for UniProtKB/Swiss-Prot for ATP6V1F Gene

Publications for ATP6V1F Gene

  1. Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit). (PMID: 8581736) Fujiwara T. … Shin S. (DNA Res. 1995) 2 3 4
  2. Identification of a 14-kDa subunit associated with the catalytic sector of clathrin-coated vesicle H+-ATPase. (PMID: 8621738) Peng S.B. … Stone D.K. (J. Biol. Chem. 1996) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation. (PMID: 17662945) Adachi K. … Kinosita K. (Cell 2007) 3

Products for ATP6V1F Gene

Sources for ATP6V1F Gene

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