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Aliases for ATP6V1C1 Gene

Aliases for ATP6V1C1 Gene

  • ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 2 3
  • ATP6C 3 4 6
  • ATP6D 3 4 6
  • Vacuolar Proton Pump Subunit C 1 3 4
  • V-ATPase Subunit C 1 3 4
  • VATC 3 4
  • ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C, Isoform 1 2
  • ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 42kD 2
  • H(+)-Transporting Two-Sector ATPase, Subunit C 3
  • Subunit C Of Vacuolar Proton-ATPase V1 Domain 3
  • Vacuolar Proton-ATPase, Subunit C, VI Domain 3
  • H+-Transporting ATPase Chain C, Vacuolar 3
  • Vacuolar Proton Pump, 42-KD Subunit 3
  • V-Type Proton ATPase Subunit C 1 3
  • Vacuolar ATP Synthase Subunit C 3
  • Vacuolar Proton Pump C Subunit 3
  • H+ -ATPase C Subunit 3
  • V-ATPase C Subunit 3
  • VMA5 3

External Ids for ATP6V1C1 Gene

Previous Symbols for ATP6V1C1 Gene

  • ATP6D
  • ATP6C

Summaries for ATP6V1C1 Gene

Entrez Gene Summary for ATP6V1C1 Gene

  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP6V1C1 Gene

ATP6V1C1 (ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include transporter activity and hydrogen-exporting ATPase activity, phosphorylative mechanism. An important paralog of this gene is ATP6V1C2.

UniProtKB/Swiss-Prot for ATP6V1C1 Gene

  • Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Tocris Summary for ATP6V1C1 Gene

  • H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains. The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation. There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of sperm motility and maturation.

Gene Wiki entry for ATP6V1C1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V1C1 Gene

Genomics for ATP6V1C1 Gene

Genomic Location for ATP6V1C1 Gene

103,021,020 bp from pter
103,073,057 bp from pter
52,038 bases
Plus strand

Genomic View for ATP6V1C1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP6V1C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP6V1C1 Gene

Regulatory Elements for ATP6V1C1 Gene

Proteins for ATP6V1C1 Gene

  • Protein details for ATP6V1C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-type proton ATPase subunit C 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ATP6V1C1 Gene

    382 amino acids
    Molecular mass:
    43942 Da
    Quaternary structure:
    • V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c, c and d)

neXtProt entry for ATP6V1C1 Gene

Proteomics data for ATP6V1C1 Gene at MOPED

Post-translational modifications for ATP6V1C1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys147

Other Protein References for ATP6V1C1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP6V1C1 Gene

Domains for ATP6V1C1 Gene

Gene Families for ATP6V1C1 Gene

  • VATP :ATPases / V-type

Protein Domains for ATP6V1C1 Gene



  • Belongs to the V-ATPase C subunit family.:
    • P21283
genes like me logo Genes that share domains with ATP6V1C1: view

Function for ATP6V1C1 Gene

Molecular function for ATP6V1C1 Gene

UniProtKB/Swiss-Prot Function: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Gene Ontology (GO) - Molecular Function for ATP6V1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 8250920
GO:0005515 protein binding IPI 16415858
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism IEA --
GO:0015078 hydrogen ion transmembrane transporter activity --
GO:0046961 proton-transporting ATPase activity, rotational mechanism TAS 8250920
genes like me logo Genes that share ontologies with ATP6V1C1: view

Phenotypes for ATP6V1C1 Gene

GenomeRNAi human phenotypes for ATP6V1C1:
genes like me logo Genes that share phenotypes with ATP6V1C1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP6V1C1 Gene

Localization for ATP6V1C1 Gene

Subcellular locations from

Jensen Localization Image for ATP6V1C1 Gene COMPARTMENTS Subcellular localization image for ATP6V1C1 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ATP6V1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS --
GO:0016469 proton-transporting two-sector ATPase complex TAS 8250920
genes like me logo Genes that share ontologies with ATP6V1C1: view

Pathways for ATP6V1C1 Gene

genes like me logo Genes that share pathways with ATP6V1C1: view

Gene Ontology (GO) - Biological Process for ATP6V1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006879 cellular iron ion homeostasis TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0015991 ATP hydrolysis coupled proton transport IEA --
GO:0015992 proton transport TAS 8250920
GO:0033572 transferrin transport TAS --
genes like me logo Genes that share ontologies with ATP6V1C1: view

Compounds for ATP6V1C1 Gene

(3) Tocris Compounds for ATP6V1C1 Gene

Compound Action Cas Number
Bafilomycin A1 H+-ATPase (vacuolar) inhibitor [88899-55-2]
Concanamycin A H+-ATPase (vacuolar) inhibitor [80890-47-7]
Disulfiram Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities [97-77-8]

(4) HMDB Compounds for ATP6V1C1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • NFB Orthophosphate
  • Dihydrogen oxide

(1) Drugbank Compounds for ATP6V1C1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
D-tartaric acid
  • (-)-Tartaric acid
147-71-7 target
genes like me logo Genes that share compounds with ATP6V1C1: view

Transcripts for ATP6V1C1 Gene

Unigene Clusters for ATP6V1C1 Gene

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V1C1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: -

Relevant External Links for ATP6V1C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP6V1C1 Gene

mRNA expression in normal human tissues for ATP6V1C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP6V1C1 Gene

SOURCE GeneReport for Unigene cluster for ATP6V1C1 Gene Hs.86905

mRNA Expression by UniProt/SwissProt for ATP6V1C1 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with ATP6V1C1: view

Orthologs for ATP6V1C1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP6V1C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP6V1C1 36
  • 99.91 (n)
  • 100 (a)
ATP6V1C1 37
  • 100 (a)
(Bos Taurus)
Mammalia ATP6V1C1 36
  • 93.89 (n)
  • 98.95 (a)
ATP6V1C1 37
  • 99 (a)
(Canis familiaris)
Mammalia ATP6V1C1 36
  • 94.42 (n)
  • 99.21 (a)
ATP6V1C1 37
  • 94 (a)
(Mus musculus)
Mammalia Atp6v1c1 36
  • 89.44 (n)
  • 98.17 (a)
Atp6v1c1 16
Atp6v1c1 37
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 78 (a)
-- 37
  • 60 (a)
-- 37
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia ATP6V1C1 37
  • 90 (a)
(Rattus norvegicus)
Mammalia Atp6v1c1 36
  • 89.97 (n)
  • 97.91 (a)
(Gallus gallus)
Aves ATP6V1C1 36
  • 83.6 (n)
  • 94.5 (a)
ATP6V1C1 37
  • 95 (a)
(Anolis carolinensis)
Reptilia ATP6V1C1 37
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp6v1c1 36
  • 81.5 (n)
  • 95.03 (a)
MGC75601 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2415 36
(Danio rerio)
Actinopterygii atp6v1c1 36
atp6v1c1a 36
  • 76.44 (n)
  • 88.48 (a)
atp6v1c1a 37
  • 88 (a)
atp6v1c1b 37
  • 82 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005845 36
  • 61.17 (n)
  • 66.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vha44 36
  • 60.79 (n)
  • 65 (a)
Vha44 37
  • 29 (a)
Vha44 38
  • 63 (a)
(Caenorhabditis elegans)
Secernentea vha-11 37
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA5 36
  • 48.35 (n)
  • 39.34 (a)
VMA5 37
  • 35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F26114g 36
  • 47.16 (n)
  • 39.41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DET3 36
  • 49.24 (n)
  • 40.16 (a)
(Oryza sativa)
Liliopsida Os05g0593100 36
  • 49.37 (n)
  • 42.16 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09897 36
  • 48.27 (n)
  • 38.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes vma5 36
  • 46.29 (n)
  • 31.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3174 37
  • 57 (a)
Species with no ortholog for ATP6V1C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP6V1C1 Gene

Gene Tree for ATP6V1C1 (if available)
Gene Tree for ATP6V1C1 (if available)

Paralogs for ATP6V1C1 Gene

Paralogs for ATP6V1C1 Gene

Selected SIMAP similar genes for ATP6V1C1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP6V1C1: view

Variants for ATP6V1C1 Gene

Sequence variations from dbSNP and Humsavar for ATP6V1C1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs8079 -- 103,068,998(+) AAACA(A/G)AATAG utr-variant-3-prime
rs9992 -- 103,068,857(+) CTTAC(C/G)CCCTT utr-variant-3-prime
rs15202 -- 103,069,076(+) GTGCA(C/T)AAAAG utr-variant-3-prime
rs868936 -- 103,034,506(+) ACATA(C/T)TCATC intron-variant
rs924211 -- 103,025,927(-) TGCTG(A/G)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP6V1C1 Gene

Variant ID Type Subtype PubMed ID
esv33118 CNV Loss 17666407
nsv831413 CNV Gain 17160897

Relevant External Links for ATP6V1C1 Gene

HapMap Linkage Disequilibrium report

Disorders for ATP6V1C1 Gene

Relevant External Links for ATP6V1C1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ATP6V1C1: view

No data available for UniProtKB/Swiss-Prot for ATP6V1C1 Gene

Publications for ATP6V1C1 Gene

  1. Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase. (PMID: 8250920) van Hille B. … Bilbe G. (Biochem. Biophys. Res. Commun. 1993) 2 3 4
  2. Molecular cloning of cDNA encoding the C subunit of H(+)-ATPase from bovine chromaffin granules. (PMID: 2147024) Nelson H. … Nelson N. (J. Biol. Chem. 1990) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 49

Products for ATP6V1C1 Gene

Sources for ATP6V1C1 Gene

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