Aliases for ATP6V1C1 Gene
- ATPase H+ Transporting V1 Subunit C1 2 3
- ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 2 3 5
- Vacuolar Proton Pump Subunit C 1 3 4
- V-ATPase Subunit C 1 3 4
- ATP6C 3 4
- ATP6D 3 4
- VATC 3 4
- ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C, Isoform 1 2
- ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 42kD 2
- H(+)-Transporting Two-Sector ATPase, Subunit C 3
- Subunit C Of Vacuolar Proton-ATPase V1 Domain 3
External Ids for ATP6V1C1 Gene
Previous HGNC Symbols for ATP6V1C1 Gene
Previous GeneCards Identifiers for ATP6V1C1 Gene
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP6V1C1 Gene
ATP6V1C1 (ATPase H+ Transporting V1 Subunit C1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include transporter activity and proton-transporting ATPase activity, rotational mechanism. An important paralog of this gene is ATP6V1C2.
UniProtKB/Swiss-Prot for ATP6V1C1 Gene
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.