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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP6V0E1 Gene

protein-coding   GIFtS: 55
GCID: GC05P172410

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1

(Previous names: ATPase, H+ transporting, lysosomal (vacuolar proton pump)...)
(Previous symbols: ATP6H, ATP6V0E)
 Explore 6 diseases affiliated with
ATP6V0E1 via our new
 Human Malady Compendium 
Biological research products
for ATP6V0E1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ATPase, H+ Transporting, Lysosomal 9kDa, V0 Subunit E11 2     ATPase, H+ Transporting, Lysosomal 9kDa, V0 Subunit E1
ATP6H1 2 3 5     Vma212
ATP6V0E1 2 3 5     Vma21p2
M9.21 2     H(+)-Transporting Two-Sector ATPase, Subunit H2
Vacuolar Proton Pump Subunit E 12 3     V-ATPase H Subunit2
V-ATPase 9.2 KDa Membrane Accessory Protein2 3     V-Type Proton ATPase Subunit E 12
V-ATPase M9.2 Subunit2 3     Vacuolar ATP Synthase Subunit H2
V-ATPase Subunit E 12 3     Vacuolar Proton Pump H Subunit2
ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 9kD1     Vacuolar Proton-ATPase Subunit M9.22

External Ids:    HGNC: 8631   Entrez Gene: 89922   Ensembl: ENSG000001137327   OMIM: 6039315   UniProtKB: O153423   

Export aliases for ATP6V0E1 gene to outside databases

Previous GC identifers: GC05P172344 GC05P167505


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATP6V0E1:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of
eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular
processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient
generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of
three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP
catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of
the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This
encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is
possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene.
Genomic mapping puts the chromosomal location on 5q35.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VA0E1_HUMAN, O15342
Function: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

summary for ATP6V0E1:
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify
intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane
organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated
vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains.
The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation.
There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles
to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These
transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation
and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause
recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of
sperm motility and maturation.

Gene Wiki entry for ATP6V0E1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP6V0E1 gene promoter:
         C/EBPbeta   AML1a   Pax-2   Pax-2a   IRF-1   c-Ets-1   HNF-1A   FAC1   Pax-2b   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP6V0E1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP6V0E1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP6V0E1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.2

ATP6V0E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP6V0E1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P172410:  view genomic region     (about GC identifiers)

Start:
172,410,760 bp from pter      End:
172,462,448 bp from pter
Size:
51,689 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VA0E1_HUMAN, O15342 (See protein sequence)
Recommended Name: V-type proton ATPase subunit e 1  
Size: 81 amino acids; 9374 Da
Subunit: Composed of at least 10 subunits
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=CAA75571.1; Type=Erroneous initiation;
Secondary accessions: B2R557 D3DQM1 Q6IBE8

Explore the universe of human proteins at neXtProt for ATP6V0E1: NX_O15342

ATP6V0E1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_003936.1  
ENSEMBL proteins: 
 ENSP00000429690   ENSP00000430896   ENSP00000265093   ENSP00000427941  
Reactome Protein details: O15342
Human Recombinant Protein Products: 
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Uscn Proteins for ATP6V0E1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005624membrane fraction ----
GO:0005773vacuole ----
GO:0010008endosome membrane TAS--
GO:0016020membrane TAS9556572
GO:0016021integral to membrane IEA--


ATP6V0E1 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATP6V0E1 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR008389 ATPase_V0-cplx_e1/e2_su
 IPR017385 ATPase_V0-cplx_e1/e2_su_met

Graphical View of Domain Structure for InterPro Entry O15342

ProtoNet protein and cluster: O15342

1 Blocks protein family: IPB008389 ATP synthase subunit H

UniProtKB/Swiss-Prot: VA0E1_HUMAN, O15342
Similarity: Belongs to the V-ATPase e1/e2 subunit family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: VA0E1_HUMAN, O15342
Function: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

miRNA
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miRTarBase miRNAs that target ATP6V0E1:
hsa-mir-124 (MIRT003839)

OriGene 3'-UTR Clone: ATP6V0E1
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hsa-miR-146a* hsa-miR-587 hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-431 hsa-miR-3714
SwitchGear 3'UTR luciferase reporter plasmidATP6V0E1 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP6V0E1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005215transporter activity NAS9556572
GO:0015078hydrogen ion transmembrane transporter activity ----
GO:0042625ATPase activity, coupled to transmembrane movement of ions ISS--
GO:0046961proton-transporting ATPase activity, rotational mechanism TAS9556572


ATP6V0E1 for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for ATP6V0E1:
 Synthetic lethal with imatinib 


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Insulin receptor recycling
Insulin receptor recycling1.00
Latent infection of Homo sapiens with Mycobacterium tuberculosis0.64
Transferrin endocytosis and recycling0.79
Iron uptake and transport0.56
Collecting duct acid secretion0.68
Vibrio cholerae infection0.41
Phagosomal maturation (early endosomal stage)0.64
Epithelial cell signaling in Helicobacter pylori infection0.33
2Disease
Disease1.00
3Rheumatoid arthritis
Rheumatoid arthritis1.00
4Phagosome
Phagosome1.00
5IRS-related events
Signaling by Insulin receptor0.74

Pathway sources
See GeneCards unified pathways
Show all pathways


5/9        Reactome Pathways for ATP6V0E1 (see all 9)
    Insulin receptor recycling
Phagosomal maturation (early endosomal stage)
Latent infection of Homo sapiens with Mycobacterium tuberculosis
Iron uptake and transport
Disease


5/7         Kegg Pathways  (Kegg details for ATP6V0E1) (see all 7):
    Oxidative phosphorylation
Metabolic pathways
Phagosome
Collecting duct acid secretion
Vibrio cholerae infection


ATP6V0E1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP6V0E1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/55 Interacting proteins for ATP6V0E1 (O153423 ENSP000002650934) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
InteractantInteraction Details
GeneCardExternal ID(s)
ATP6V1E1P365433, ENSP000002534134I2D: score=1 STRING: ENSP00000253413
ATP6V0A1ENSP000002646494STRING: ENSP00000264649
ATP6V0BENSP000002360674STRING: ENSP00000236067
ATP6V0CENSP000003297574STRING: ENSP00000329757
ATP6V0E2ENSP000004116724STRING: ENSP00000411672
About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport ----
GO:0006879cellular iron ion homeostasis TAS--
GO:0007035vacuolar acidification ISS--
GO:0008286insulin receptor signaling pathway TAS--
GO:0015991ATP hydrolysis coupled proton transport IEA--


ATP6V0E1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ATP6V0E1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for ATP6V0E1 available from Tocris Bioscience    About this table
CompoundAction CAS #
Bafilomycin A1H+-ATPase (vacuolar) inhibitor[88899-55-2]
Concanamycin AH+-ATPase (vacuolar) inhibitor[80890-47-7]

4 HMDB Compounds for ATP6V0E1    About this table
CompoundSynonyms CAS #PubMed Ids
ADPadenosindiphosphorsaeure (see all 8)58-64-0--
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
PhosphateNFB Orthophosphate (see all 13)14265-44-2--
WaterDihydrogen oxide (see all 2)7732-18-5--
1 Novoseek chemical compound relationship for ATP6V0E1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hydrogen 23.7 3 19379689 (1), 19379691 (1)

Search CenterWatch for drugs/clinical trials and news about ATP6V0E1 / VA0E1 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATP6V0E1 gene: 
NM_003945.3  

Unigene Cluster for ATP6V0E1:

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
Hs.484188  [show with all ESTs]
Unigene Representative Sequence: AV763803
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000519374(uc003mcd.1) ENST00000519911 ENST00000265093 ENST00000517669


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hsa-miR-146a* hsa-miR-587 hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-431 hsa-miR-3714
SwitchGear 3'UTR luciferase reporter plasmidATP6V0E1 3' UTR sequence
Inhib. RNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP6V0E1

Additional cDNA sequence: 

AK312068.1 BC119714.1 BC119715.1 CR456856.1 CR542131.1 Y15286.1 

14 DOTS entries:

DT.92021411  DT.92024475  DT.91771067  DT.75183228  DT.100753138  DT.406514  DT.91771066  DT.120850937 
DT.95170928  DT.100058001  DT.120850948  DT.120850949  DT.97862313  DT.120850930 

24/620 AceView cDNA sequences (see all 620):

BP366360 AA505533 AA515215 CB995436 AI523440 BM809437 AA041536 BM674721 
AI479180 CA775616 CR599928 AA877076 CR613914 AI288779 BI857480 BQ286134 
BU151547 BU951872 CA427875 BU784781 BM508157 AL545302 BM510808 AA282532 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V0E1    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:                                                
SP2:                          -                     
SP3:                    -                           


ECgene alternative splicing isoforms for ATP6V0E1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATP6V0E1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTACAGTG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See ATP6V0E1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATP6V0E1

SOURCE GeneReport for Unigene cluster: Hs.484188

UniProtKB/Swiss-Prot: VA0E1_HUMAN, O15342
Tissue specificity: Ubiquitous

    SABiosciences Custom PCR Arrays for ATP6V0E1
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP6V0E1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ATP6V0E1 gene from 7/19 species (see all 19)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Atp6v0e1 , 5 ATPase, H+ transporting, lysosomal V0 subunit E1, 5 90.53(n)1
98.77(a)1
  17 (13.46 cM)5
119741  NM_025272.21  NP_079548.11 
 266763965 
chicken
(Gallus gallus)
Aves ATP6V0E11 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit more 76.54(n)
83.95(a)
  768854  NM_001097532.2  NP_001091001.1 
lizard
(Anolis carolinensis)
Reptilia ATP6V0E16
--
80(a)
1 ↔ 1
2(124489105-124510291)
African clawed frog
(Xenopus laevis)
Amphibia Xl.41662 Xenopus laevis transcribed sequence with moderate similarity more 77.14(n)    48046320 
zebrafish
(Danio rerio)
Actinopterygii Dr.110592 Transcribed sequence with weak similarity to protein more 72.46(n)    BI428494.1 
fruit fly
(Drosophila melanogaster)
Insecta VhaM9.7-b6
VhaM9.7-a6
(see all 4)
Vacuolar H[+] ATPase subunit M9.7-a
(see all 4)
34(a)
33(a)
(see all 4)
many ↔ many
many ↔ many
(see all 4)
3L(21532962-21534315)
3L(4262705-4263464)
worm
(Caenorhabditis elegans)
Secernentea vha-176
V-type proton ATPase subunit e
41(a)
1 → many
IV(9321782-9322511)


ENSEMBL Gene Tree for ATP6V0E1 (if available)
TreeFam Gene Tree for ATP6V0E1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ATP6V0E1 gene
ATP6V0E22  
1 SIMAP similar gene for ATP6V0E1 using alignment to 3 protein entries:     VA0E1_HUMAN (see all proteins):
ATP6V0E2

ATP6V0E1 for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for ATP6V0E1
PGOHUM00000244706 PGOHUM00000240617 PGOHUM00000237598 PGOHUM00000235760


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/934 NCBI SNPs in ATP6V0E1 are shown (see all 934    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1891354551,2
--172409050(+) TTGGCA/GCATAC 1 -- us2k10--------
rs738036871,2
C,--172409088(+) GCAAGC/TGTTCT 1 -- us2k12Minor allele frequency- T:0.11WA 120
rs1453119571,2
--172409196(+) CCCACC/TGGGGC 1 -- us2k10--------
rs1818990361,2
--172409293(+) CTGAGC/GCAGAA 1 -- us2k10--------
rs1859103011,2
--172409295(+) GAGGCA/CGAAGG 1 -- us2k10--------
rs1912215061,2
--172409313(+) GAGCCC/TGGGAG 1 -- us2k10--------
rs1476463821,2
--172409316(+) CCCGGA/GAGTTC 1 -- us2k10--------
rs571822481,2
C,F,--172409347(+) AGCACC/GACTGC 1 -- us2k13Minor allele frequency- G:0.10WA 122
rs1829059721,2
--172409374(+) CAGAGA/CAAGGC 1 -- us2k10--------
rs2006715991,2
--172409441(+) TCTTT-/CTTTTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ATP6V0E1 (172410760 - 172462448 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ATP6V0E1
     2 CNVs: 51621 6467

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ATP6V0E1 for disorders           About GeneDecksing

OMIM gene information: 603931    OMIM disorders: --

6 diseases for ATP6V0E1:    About MalaCards
osteopetrosis    renal tubular acidosis    rheumatoid arthritis    myopathy
cholera    arthritis

1 Novoseek disease relationship for ATP6V0E1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
myopathy 53.9 1 19379691 (1)


Export disorders for ATP6V0E1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ATP6V0E1 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with ATP6V0E1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules. (PubMed id 9556572)1, 2, 3 Ludwig J....Schaegger H. (1998)
  2. Molecular cloning and characterization of a novel form of the human vacuolar H+-ATPase e-subunit: an essential proton pump component. (PubMed id 17350184)1, 2 Blake-Palmer K.G.... Karet F.E. (2007)
  3. The yeast vacuolar proton-translocating ATPase contains a subunit homologous to the Manduca sexta and bovine e subunits that is essential for function. (PubMed id 14970230)1, 3 Sambade M. and Kane P.M. (2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Coupling of rotation and catalysis in F(1)-ATPase rev ealed by single-molecule imaging and manipulation. (PubMed id 17662945)1 Adachi K....Kinosita K. (2007)
  6. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. (PubMed id 17576770)1 Lu M....Gluck S.L. (2007)
  7. Full-length coding sequences and mapping of porcine ATP6VOE and ATP5G1 genes. (PubMed id 15906478)1 Wang H.L....Li K. (2005)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  9. Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes. (PubMed id 14580332)1 Smith A.N....Karet F.E. (2003)
  10. Neurotransmitter release: the dark side of the vacuolar-H+ATPase. (PubMed id 14597263)1 Morel N. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8992 HGNC: 863 AceView: ATP6V0E Ensembl:ENSG00000113732 euGenes: HUgn8992
ECgene: ATP6V0E1 Kegg: 8992 H-InvDB: ATP6V0E1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ATP6V0E1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ATP6V0E1 gene:
Search GeneIP for patents involving ATP6V0E1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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