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ATP6V0D2 Gene

protein-coding GIFtS: 53
GCID: GC08P086999

ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D2

(Previous names: ATPase, H+ transporting, lysosomal 38kD, V0 subunit d isoform...)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D2¹ ²		ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D Isoform 2¹
Vacuolar Proton Pump Subunit D 2² ³		ATP6D2²
V-ATPase Subunit D 2² ³		VMA6²
ATPase, H+ Transporting, Lysosomal 38kD, V0 Subunit D Isoform 2¹		V-Type Proton ATPase Subunit D 2²

External Ids:	HGNC: 18266¹	Entrez Gene: 245972²	Ensembl: ENSG00000147614⁷	UniProtKB: Q8N8Y2³

Export aliases for ATP6V0D2 gene to outside databases

Previous GC identifers: GC00U991214 GC08P086843 GC08P087067 GC08P087180 GC08P082320

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ATP6V0D2 Gene:

ATP6V0D2 (ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2) is a protein-coding gene. GO annotations related to this gene include hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP6V0D1.

UniProtKB/Swiss-Prot: VA0D2_HUMAN, Q8N8Y2

Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for

acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy

required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP

hydrolysis (By similarity)

summary for ATP6V0D2 Gene:

H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify

intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane

organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated

vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains.

The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation.

There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles

to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These

transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation

and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause

recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of

sperm motility and maturation.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000008.10 NC_018919.2 NT_008046.17

Regulatory elements:

Regulatory transcription factor binding sites in the ATP6V0D2 gene promoter:
Sox5 RP58 FOXD1 FOXD3 NF-E2 p45 C/EBPalpha SRY CP2 Sox9 NF-E2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATP6V0D2 promoter sequence

Search Chromatin IP Primers for ATP6V0D2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP6V0D2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band: 8q21.3 HGNC cytogenetic band: 8q21.3

ATP6V0D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP6V0D2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P086999: view genomic region (about GC identifiers)

Start:	86,999,552 bp from pter	End:	87,166,457 bp from pter
Size:	166,906 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: VA0D2_HUMAN, Q8N8Y2 (See protein sequence)

Recommended Name: V-type proton ATPase subunit d 2

Size: 350 amino acids; 40426 Da

Subunit: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H)

attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d)

Explore the universe of human proteins at neXtProt for ATP6V0D2: NX_Q8N8Y2

Explore proteomics data for ATP6V0D2 at MOPED

See ATP6V0D2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689778.1

ENSEMBL proteins:

ENSP00000429731 ENSP00000428382 ENSP00000285393

Reactome Protein details: Q8N8Y2

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	GeneTex Proteins for ATP6V0D2: ATP6V0D2 Protein (GTX111006-pro)
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	antibodies-online peptides for ATP6V0D2

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antibodies-online kits for ATP6V0D2 (10 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

VATP: ATPases / V-type

IUPHAR Guide to PHARMACOLOGY protein family classification: d2

V-type ATPase

2 InterPro protein domains:

IPR002843 ATPase_V0-cplx_csu/dsu

IPR016727 ATPase_V0-cplx_dsu

Graphical View of Domain Structure for InterPro Entry Q8N8Y2

ProtoNet protein and cluster: Q8N8Y2

1 Blocks protein domain: IPB002843 H+-transporting two-sector ATPase

UniProtKB/Swiss-Prot: VA0D2_HUMAN, Q8N8Y2

Similarity: Belongs to the V-ATPase V0D/AC39 subunit family

Find genes that share domains with ATP6V0D2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: VA0D2_HUMAN, Q8N8Y2

Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for

acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy

required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP

hydrolysis (By similarity)

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18752060
GO:0015078	hydrogen ion transmembrane transporter activity	IEA	--

Find genes that share ontologies with ATP6V0D2 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for ATP6V0D2:

Decreased viability with pacli

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Atp6v0d2):

cellular

hematopoietic system

immune system

skeleton

Find genes that share phenotypes with ATP6V0D2 About GenesLikeMe

Animal Models:
MGI mouse knock-out Atp6v0d2^tm1Ywc for ATP6V0D2

genOway: Develop your customized and physiologically relevant rodent model for ATP6V0D2

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
vacuole	5
endosome	4
cytosol	3
nucleus	2
mitochondrion	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005768	endosome	--	--
GO:0005769	early endosome	IEA	--
GO:0010008	endosome membrane	TAS	--
GO:0016020	membrane	IDA	18752060
GO:0016324	apical plasma membrane	IDA	15800125

Find genes that share ontologies with ATP6V0D2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for ATP6V0D2 About (see all 13)

See pathways by source

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SuperPath

Contained pathways About

Insulin receptor recycling

Insulin receptor recycling	0.74	Collecting duct acid secretion	0.66
Transferrin endocytosis and recycling	0.74	Vibrio cholerae infection	0.40
Iron uptake and transport	0.70	Epithelial cell signaling in Helicobacter pylori infection	0.32

Insulin receptor signalling cascade

Signaling by Insulin receptor

0.80

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Oxidative phosphorylation

0.64

Signaling by GPCR

Signal Transduction

0.58

Synaptic vesicle cycle

Synaptic vesicle cycle

0.50

Find genes that share SuperPaths with ATP6V0D2 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

3 Reactome Pathways for ATP6V0D2

	Insulin receptor recycling
	Phagosomal maturation (early endosomal stage)
	Transferrin endocytosis and recycling

Selected Kegg Pathways (Kegg details for ATP6V0D2) (see all 11):

	Oxidative phosphorylation
	Metabolic pathways
	Lysosome
	Phagosome
	Synaptic vesicle cycle

Pathway & Disease-focused RT² Profiler PCR Array including ATP6V0D2:

Mitochondrial Energy Metabolism in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for ATP6V0D2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ATP6V0D2 (ENSP00000285393⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 100)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATP5A1	ENSP00000282050⁴	STRING: ENSP00000282050
ATP5B	ENSP00000262030⁴	STRING: ENSP00000262030
ATP5C1	ENSP00000349142⁴	STRING: ENSP00000349142
ATP5D	ENSP00000215375⁴	STRING: ENSP00000215375
ATP5E	ENSP00000243997⁴	STRING: ENSP00000243997

About this table

Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006879	cellular iron ion homeostasis	TAS	--
GO:0008286	insulin receptor signaling pathway	TAS	--
GO:0015991	ATP hydrolysis coupled proton transport	IEA	--
GO:0033572	transferrin transport	TAS	--
GO:0051701	interaction with host	TAS	--

Find genes that share ontologies with ATP6V0D2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for ATP6V0D2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Bafilomycin A1	H+-ATPase (vacuolar) inhibitor	[88899-55-2]
Concanamycin A	H+-ATPase (vacuolar) inhibitor	[80890-47-7]
Disulfiram	Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities	[97-77-8]

4 HMDB Compounds for ATP6V0D2 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for ATP6V0D2 gene:

NM_152565.1

Unigene Cluster for ATP6V0D2:

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2

Hs.436360 [show with all ESTs]

Unigene Representative Sequence: BC065207

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000521564 ENST00000523635 ENST00000285393(uc003ydp.1)

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Additional mRNA sequence:

AK096027.1 AY079172.1 BC065207.1

2 DOTS entries:

DT.40128048 DT.99944955

Selected AceView cDNA sequences (see all 27):

AK096027 AY079172 BX282387 BI763514 BX093720 CB529551 NM_152565 BC065207

CD365338 BU195251 BX955380 BF820247 CA306616 AI733048 BG399722 BG433708

AI791537 AI948966 CD637882 AI344356 CD637885 AI763059 BI760294 AA887457

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATP6V0D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCTACCTGGA

About this image

ATP6V0D2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 2 entries
Human embryonic stem cells (family)

Ovary (Reproductive System)
Cumulus Cells Antral Follicle

Bone (Muscoskeletal System)
Zeugopod Periosteum

Kidney (Urinary System)

ATP6V0D2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ATP6V0D2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.436360

UniProtKB/Swiss-Prot: VA0D2_HUMAN, Q8N8Y2

Tissue specificity: Kidney, osteoclast and lung

Pathway & Disease-focused RT² Profiler PCR Array including ATP6V0D2:

Mitochondrial Energy Metabolism in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP6V0D2 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Atp6v0d2^{1 , 5}	ATPase, H+ transporting, lysosomal V0 subunit D2^{1, 5}	87.62(n)¹ 93.14(a)¹		4 (7.67 cM)⁵ 242341¹ NM_175406.3¹ NP_780615.2¹ 19876841⁵
chicken (Gallus gallus)	Aves	ATP6V0D2¹	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit more	71.77(n) 71.68(a)		420210 NM_001008455.1 NP_001008455.1
lizard (Anolis carolinensis)	Reptilia	ATP6V0D2⁶	ATPase, H+ transporting, lysosomal 38kDa, V0 subun...	72(a)	1 ↔ 1	4(22906921-22925500)
tropical clawed frog (Xenopus tropicalis)	Amphibia	atp6v0d2¹	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit more	69.53(n) 69.91(a)		394992 NM_204031.1 NP_989362.1
fruit fly (Drosophila melanogaster)	Insecta	VhaAC39-1⁶ VhaAC39-2⁶	Vacuolar H[+] ATPase subunit AC39-2	62(a) 41(a)	many ↔ many many ↔ many	X(3774777-3777000) 3R(18983739-18985038)
worm (Caenorhabditis elegans)	Secernentea	vha-16⁶	Protein VHA-16 (vha-16) mRNA, complete cds	61(a)	1 → many	I(5079910-5082279) WBGene00016258
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	VMA6⁶	Subunit d of the five-subunit V0 integral membrane...	43(a)	1 → many	XII(1026856-1027893) YLR447C
corn (Zea mays)	Liliopsida	Zm.5094²	Zea mays PCO113315 mRNA sequence	72.33(n)		AY104603.1

ENSEMBL Gene Tree for ATP6V0D2 (if available)
TreeFam Gene Tree for ATP6V0D2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for ATP6V0D2 gene

ATP6V0D1²

1 SIMAP similar gene for ATP6V0D2 using alignment to 3 protein entries: VA0D2_HUMAN (see all proteins):

ATP6V0D1

Find genes that share paralogs with ATP6V0D2 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73688589^1,2	C,F	--	87109285(+)	`TTAACG/CAAACA`	1	--	us2k¹		1		WA	2
rs149651813^1,2		--	87109352(+)	`TCCTGC/TCATGG`	1	--	us2k¹		0	--	--	--	--
rs76797371^1,2		--	87109510(+)	`AATTTA/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs181789924^1,2		--	87109621(+)	`TGACTG/TATTCA`	1	--	us2k¹		0	--	--	--	--
rs115318383^1,2	F	--	87109749(+)	`GAAAAG/TCTAGG`	1	--	us2k¹		1		WA	118
rs72686746^1,2		--	87109833(+)	`AGTTCA/GGAAAA`	1	--	us2k¹		0	--	--	--	--
rs143334695^1,2		--	87109899(+)	`ACAATA/GTATAT`	1	--	us2k¹		0	--	--	--	--
rs186863770^1,2		--	87110030(+)	`TTAAAC/TACTTA`	1	--	us2k¹		0	--	--	--	--
rs148342973^1,2		--	87110038(+)	`TTACTA/GTATTG`	1	--	us2k¹		0	--	--	--	--
rs141528385^1,2		--	87110086(+)	`GGCTGG/TTTCCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ATP6V0D2 (86999552 - 87166457 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for ATP6V0D2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2508953	CNV	Deletion	19546169
esv2585991	CNV	Deletion	19546169
esv2737262	CNV	Deletion	23290073
dgv7830n71	CNV	Gain	21882294
nsv891147	CNV	Gain	21882294
nsv428204	CNV	Gain	18775914

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ATP6V0D2 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with ATP6V0D2)

Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis. (PubMed id 12384298)^{1, 2, 3} Smith A.N.... Karet F.E. (Gene 2002)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PubMed id 22379998)¹ McCormack M....Cavalleri G.L. (Pharmacogenomics 2012)
Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (Mol. Syst. Biol. 2011)
Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)¹ Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
Adrm1 interacts with Atp6v0d2 and regulates osteoclast differentiation. (PubMed id 19818731)¹ Kim T....Choi Y. (Biochem. Biophys. Res. Commun. 2009)
The d subunit plays a central role in human vacuolar H(+)-ATPases. (PubMed id 18752060)¹ Smith A.N....Karet F.E. (J. Bioenerg. Biomembr. 2008)
Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation. (PubMed id 17662945)¹ Adachi K....Kinosita K. (Cell 2007)
Vacuolar H+-ATPase d2 subunit: molecular characterization, developmental regulation, and localization to specialized proton pumps in kidney and bone. (PubMed id 15800125)¹ Smith A.N....Karet F.E. (J. Am. Soc. Nephrol. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 245972	HGNC: 18266	AceView: ATP6V0D2	Ensembl:ENSG00000147614	euGenes: HUgn245972
ECgene: ATP6V0D2	Kegg: 245972	H-InvDB: ATP6V0D2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ATP6V0D2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ATP6V0D2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ATP6V0D2 gene:
Search GeneIP for patents involving ATP6V0D2

GeneCards and IP:
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Selected GeneTex proteins for ATP6V0D2: ATP6V0D2 Protein (GTX111006-pro)

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ATP6V0D2 Gene

ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D2

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ATP6V0D2 Gene

ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D2

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