Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP6V0D2 Gene

protein-coding   GIFtS: 52
GCID: GC08P086999

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2

(Previous names: ATPase, H+ transporting, lysosomal 38kD, V0 subunit d isoform...)
 Explore 8 diseases affiliated with
ATP6V0D2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATP6V0D2    

Aliases
for ATP6V0D2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D21 2     FLJ387081
ATP6D21 2     ATPase, H+ Transporting, Lysosomal 38kD, V0 Subunit D Isoform 21
VMA61 2     ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D Isoform 21
Vacuolar Proton Pump Subunit D 22 3     V-Type Proton ATPase Subunit D 22
V-ATPase Subunit D 22 3     

External Ids:    HGNC: 182661   Entrez Gene: 2459722   Ensembl: ENSG000001476147   UniProtKB: Q8N8Y23   

Export aliases for ATP6V0D2 gene to outside databases

Previous GC identifers: GC00U991214 GC08P086843 GC08P087067 GC08P087180 GC08P082320


Summaries
for ATP6V0D2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: VA0D2_HUMAN, Q8N8Y2
Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying
a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport
processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity)

summary for ATP6V0D2:
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify
intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane
organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated
vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains.
The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation.
There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles
to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These
transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation
and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause
recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of
sperm motility and maturation.




Genomic Views
for ATP6V0D2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP6V0D2 gene promoter:
         Sox5   RP58   FOXD1   FOXD3   NF-E2 p45   C/EBPalpha   SRY   CP2   Sox9   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATP6V0D2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP6V0D2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP6V0D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q21.3

ATP6V0D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP6V0D2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P086999:  view genomic region     (about GC identifiers)

Start:
 86,999,552 bp from pter      End:
 87,166,457 bp from pter
Size:
 166,906 bases      Orientation:
 plus strand

Proteins
for ATP6V0D2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VA0D2_HUMAN, Q8N8Y2 (See protein sequence)
Recommended Name: V-type proton ATPase subunit d 2  
Size: 350 amino acids; 40426 Da
Subunit: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H)
attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d)

Explore the universe of human proteins at neXtProt for ATP6V0D2: NX_Q8N8Y2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N8Y2

    • ATP6V0D2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689778.1  
    ENSEMBL proteins: 
     ENSP00000429731   ENSP00000428382   ENSP00000285393  
    Reactome Protein details: Q8N8Y2
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ATP6V0D2
    OriGene Custom Protein Services for ATP6V0D2 
    GenScript Custom Purified and Recombinant Proteins Services for ATP6V0D2
    Novus Biologicals ATP6V0D2 Protein
    Novus Biologicals ATP6V0D2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ATP6V0D2

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome ----
    GO:0005769early endosome IEA--
    GO:0010008endosome membrane TAS--
    GO:0016020membrane IDA18752060
    GO:0016324apical plasma membrane IDA15800125


    ATP6V0D2 for ontologies           About GeneDecksing



    ATP6V0D2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ATP6V0D2 
    GenScript Custom Superior Antibodies Services for ATP6V0D2
    Novus Biologicals ATP6V0D2 Antibodies
    Search for Antibodies for ATP6V0D2 at Abcam  
    Uscn Antibodies for ATP6V0D2
    Search ThermoFisher Antibodies for ATP6V0D2

    Assay Products for ATP6V0D2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATP6V0D2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ATP6V0D2

    Protein Domains /
    Families
    for ATP6V0D2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATP6V0D2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002843 ATPase_V0-cplx_csu/dsu
     IPR016727 ATPase_V0-cplx_dsu

    Graphical View of Domain Structure for InterPro Entry Q8N8Y2

    ProtoNet protein and cluster: Q8N8Y2

    1 Blocks protein family: IPB002843 H+-transporting two-sector ATPase

    UniProtKB/Swiss-Prot: VA0D2_HUMAN, Q8N8Y2
    Similarity: Belongs to the V-ATPase V0D/AC39 subunit family


    Function
    for ATP6V0D2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VA0D2_HUMAN, Q8N8Y2
    Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying
    a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport
    processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity)

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATP6V0D2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP6V0D2 (see all 9):
    hsa-miR-577 hsa-miR-3688-3p hsa-miR-7-2* hsa-miR-513c hsa-miR-3190 hsa-miR-4261 hsa-miR-7-1* hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ATP6V0D2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP6V0D2 (see all 7)
    OriGene shRNA RFP: ATP6V0D2
    OriGene siRNA: ATP6V0D2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP6V0D2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ATP6V0D2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6V0D2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6V0D2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ATP6V0D2 (NM_152565)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP6V0D2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP6V0D2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ATP6V0D2
    Search LifeMap BioReagents cell lines for ATP6V0D2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP6V0D2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18752060
    GO:0015078hydrogen ion transmembrane transporter activity IEA--


    ATP6V0D2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ATP6V0D2:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Atp6v0d2tm1Ywc for ATP6V0D2
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Atp6v0d2):
     cellular  hematopoietic system  immune system  skeleton 

    ATP6V0D2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ATP6V0D2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Insulin receptor recycling
    		Insulin receptor recycling1.00
    		Latent infection of Homo sapiens with Mycobacterium tuberculosis0.64
    		Transferrin endocytosis and recycling0.79
    		Iron uptake and transport0.56
    		Collecting duct acid secretion0.68
    		Vibrio cholerae infection0.41
    		Phagosomal maturation (early endosomal stage)0.64
    		Epithelial cell signaling in Helicobacter pylori infection0.33
    2Disease
    		Disease1.00
    3Rheumatoid arthritis
    		Rheumatoid arthritis1.00
    4Tuberculosis
    		Tuberculosis1.00
    5Lysosome
    		Lysosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/9        Reactome Pathways for ATP6V0D2 (see all 9)
        Insulin receptor recycling
    Phagosomal maturation (early endosomal stage)
    Latent infection of Homo sapiens with Mycobacterium tuberculosis
    Iron uptake and transport
    Disease


    5/9         Kegg Pathways  (Kegg details for ATP6V0D2) (see all 9):
        Oxidative phosphorylation
    Metabolic pathways
    Lysosome
    Phagosome
    Collecting duct acid secretion


    ATP6V0D2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP6V0D2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for ATP6V0D2 (ENSP000002853934) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5A1ENSP000002820504STRING: ENSP00000282050
    ATP5C1ENSP000003491424STRING: ENSP00000349142
    ATP5DENSP000002153754STRING: ENSP00000215375
    ATP5HENSP000003015874STRING: ENSP00000301587
    ATP5IENSP000003060034STRING: ENSP00000306003
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0015991ATP hydrolysis coupled proton transport IEA--
    GO:0033572transferrin transport TAS--
    GO:0051701interaction with host TAS--


    ATP6V0D2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATP6V0D2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for ATP6V0D2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ATP6V0D2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Bafilomycin A1H+-ATPase (vacuolar) inhibitor[88899-55-2]
    Concanamycin AH+-ATPase (vacuolar) inhibitor[80890-47-7]

    4 HMDB Compounds for ATP6V0D2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about ATP6V0D2 / VA0D2 

    Transcripts
    for ATP6V0D2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATP6V0D2 gene: 
    NM_152565.1  

    Unigene Cluster for ATP6V0D2:

    ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
    Hs.436360  [show with all ESTs]
    Unigene Representative Sequence: BC065207
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521564 ENST00000523635 ENST00000285393(uc003ydp.1)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATP6V0D2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP6V0D2 (see all 9):
    hsa-miR-577 hsa-miR-3688-3p hsa-miR-7-2* hsa-miR-513c hsa-miR-3190 hsa-miR-4261 hsa-miR-7-1* hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ATP6V0D2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP6V0D2 (see all 7)
    OriGene shRNA RFP: ATP6V0D2
    OriGene siRNA: ATP6V0D2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP6V0D2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6V0D2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6V0D2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ATP6V0D2 (NM_152565)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP6V0D2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP6V0D2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP6V0D2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATP6V0D2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP6V0D2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP6V0D2

    Additional cDNA sequence: 

    AK096027.1 AY079172.1 BC065207.1 

    2 DOTS entries:

    DT.40128048  DT.99944955 

    24/27 AceView cDNA sequences (see all 27):

    BX093720 AY079172 AK096027 BI763514 BC065207 CB529551 NM_152565 BX282387 
    BG399722 CA306616 AI733048 BF820247 BU195251 BX955380 BG433708 AI791537 
    CD365338 CD637882 AI344356 AI948966 CD637885 AI763059 AA887457 BI760294 

    GeneLoc Exon Structure


    Expression
    for ATP6V0D2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP6V0D2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTACCTGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ATP6V0D2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    BoneZeugopod PeriosteumBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ATP6V0D2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP6V0D2

    SOURCE GeneReport for Unigene cluster: Hs.436360

    UniProtKB/Swiss-Prot: VA0D2_HUMAN, Q8N8Y2
    Tissue specificity: Kidney, osteoclast and lung

        SABiosciences Expression via Pathway-Focused PCR Array including ATP6V0D2: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP6V0D2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATP6V0D2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP6V0D2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP6V0D2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP6V0D2

    Orthologs
    for ATP6V0D2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATP6V0D2 gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Atp6v0d21 , 5 ATPase, H+ transporting, lysosomal V0 subunit D21, 5 87.62(n)1
    93.14(a)1    		   4 (7.67 cM)5
    2423411  NM_175406.31  NP_780615.21 
     198768415 
    chicken
    (Gallus gallus)    		 Aves ATP6V0D21 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit more 71.79(n)
    71.88(a)    		   420210  NM_001008455.1  NP_001008455.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ATP6V0D26
    		 --
    		 72(a)
    		 1 ↔ 1
    		 4(22908340-22925339)
    fruit fly
    (Drosophila melanogaster)    		 Insecta VhaAC39-16
    VhaAC39-26
    		 Vacuolar H[+] ATPase subunit AC39-2
    		 62(a)
    41(a)
    		 many → 1
    possible ortholog
    		 X(3774777-3777000)
    3R(18983739-18985038)
    worm
    (Caenorhabditis elegans)    		 Secernentea vha-166
    		 Vacuolar H ATPase family member (vha-16)
    		 61(a)
    		 1 → many
    		 I(5079913-5082284)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G287106
    AT3G287156
    		 V-type proton ATPase subunit d2
    		 46(a)
    46(a)
    		 many ↔ many
    many ↔ many
    		 3(10772903-10775727)
    3(10777837-10780633)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 vacuolar ATP synthase subunit d, putative, express...
    		 46(a)
    		 1 → many
    		 1(22854414-22858709)


    ENSEMBL Gene Tree for ATP6V0D2 (if available)
    TreeFam Gene Tree for ATP6V0D2 (if available) 

    Paralogs
    for ATP6V0D2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP6V0D2 gene
    ATP6V0D12  
    1 SIMAP similar gene for ATP6V0D2 using alignment to 3 protein entries:     VA0D2_HUMAN (see all proteins):
    ATP6V0D1

    ATP6V0D2 for paralogs           About GeneDecksing



    Genomic Variants
    for ATP6V0D2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1143 NCBI SNPs in ATP6V0D2 are shown (see all 1143)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs736885891,2
    		C,--87109285(+) TTAACG/CAAACA 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1496518131,2
    		--87109352(+) TCCTGC/TCATGG 1 -- us2k10--------
    rs767973711,2
    		--87109510(+) AATTTA/TAAAAA 1 -- us2k10--------
    rs1817899241,2
    		--87109621(+) TGACTG/TATTCA 1 -- us2k10--------
    rs1153183831,2
    		F,--87109749(+) GAAAAG/TCTAGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs726867461,2
    		--87109833(+) AGTTCA/GGAAAA 1 -- us2k10--------
    rs1433346951,2
    		--87109899(+) ACAATA/GTATAT 1 -- us2k10--------
    rs1868637701,2
    		--87110030(+) TTAAAC/TACTTA 1 -- us2k10--------
    rs1483429731,2
    		--87110038(+) TTACTA/GTATTG 1 -- us2k10--------
    rs1415283851,2
    		--87110086(+) GGCTGG/TTTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATP6V0D2 (86999552 - 87166457 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ATP6V0D2
         2 CNVs: 100414 100415

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP6V0D2
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP6V0D2

    Disorders / Diseases
    for ATP6V0D2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATP6V0D2 for disorders           About GeneDecksing

    8 diseases for ATP6V0D2:    About MalaCards
    osteopetrosis    renal tubular acidosis    rheumatoid arthritis    cholera
    arthritis    tuberculosis    malaria    neuronitis


    Export disorders for ATP6V0D2 gene to outside databases

    Publications
    for ATP6V0D2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP6V0D2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ATP6V0D2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis. (PubMed id 12384298)1, 2, 3 Smith A.N.... Karet F.E. (2002)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PubMed id 22379998)1 McCormack M....Cavalleri G.L. (2012)
    4. Adrm1 interacts with Atp6v0d2 and regulates osteoclas t differentiation. (PubMed id 19818731)1 Kim T....Choi Y. (2009)
    5. The d subunit plays a central role in human vacuolar H(+)-ATPases. (PubMed id 18752060)1 Smith A.N....Karet F.E. (2008)
    6. Coupling of rotation and catalysis in F(1)-ATPase rev ealed by single-molecule imaging and manipulation. (PubMed id 17662945)1 Adachi K....Kinosita K. (2007)
    7. Vacuolar H+-ATPase d2 subunit: molecular characteriza tion, developmental regulation, and localization to specialized proton pumps in kidney and bone. (PubMed id 15800125)1 Smith A.N....Karet F.E. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Neurotransmitter release: the dark side of the vacuolar-H+ATPase. (PubMed id 14597263)1 Morel N. (2003)
    10. Proton translocation driven by ATP hydrolysis in V-ATPases. (PubMed id 12788495)1 Kawasaki-Nishi S....Forgac M. (2003)

    External Searches for ATP6V0D2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ATP6V0D2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 245972 HGNC: 18266 AceView: ATP6V0D2 Ensembl:ENSG00000147614 euGenes: HUgn245972
    ECgene: ATP6V0D2 Kegg: 245972 H-InvDB: ATP6V0D2

    Other Databases showing ATP6V0D2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATP6V0D2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP6V0D2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATP6V0D2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATP6V0D2 gene:
    Search GeneIP for patents involving ATP6V0D2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ATP6V0D2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore small molecules (inhibitor) for ATP6V0D2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ATP6V0D2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP6V0D2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP6V0D2  
     OriGene Protein Over-expression Lysate for ATP6V0D2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ATP6V0D2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6V0D2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6V0D2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ATP6V0D2   OriGene Custom Protein Services for ATP6V0D2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATP6V0D2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP6V0D2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP6V0D2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP6V0D2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP6V0D2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP6V0D2
     GenScript Custom Purified and Recombinant Proteins Services for ATP6V0D2 GenScript cDNA clones with any tag delivered in your preferred vector for ATP6V0D2
     GenScript Custom Assay Services for ATP6V0D2 GenScript Custom Superior Antibodies Services for ATP6V0D2
     GenScript Custom overexpressing Cell Line Services for ATP6V0D2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ATP6V0D2 promoter
     Search Chromatin IP Primers for ATP6V0D2
     RT2 qPCR Primer Assay in human, mouse, rat ATP6V0D2
     Search GNC Networks for ATP6V0D2
     SABiosciences PCR Arrays including human, mouse, rat ATP6V0D2
     Tocris compounds for ATP6V0D2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ATP6V0D2 antibodies
     ATP6V0D2 proteins
     ATP6V0D2 lysates
     Search for Antibodies for ATP6V0D2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ATP6V0D2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ATP6V0D2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ATP6V0D2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP6V0D2
     SwitchGear 3'UTR luciferase reporter plasmids for ATP6V0D2
     SwitchGear Promoter luciferase reporter plasmids for ATP6V0D2
     Search ThermoFisher Antibodies for ATP6V0D2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP6V0D2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ATP6V0D2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4