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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ATP6V0C Gene

protein-coding GIFtS: 63
GCID: GC16P002563

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

(Previous names: ATPase, H+ transporting, lysosomal (vacuolar proton pump)...)
(Previous symbols: ATPL, ATP6C, ATP6L)

Explore 13 diseases affiliated with
ATP6V0C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ATPase, H+ Transporting, Lysosomal 16kDa, V0 Subunit C¹ ²		V-ATPase 16 KDa Proteolipid Subunit² ³
ATP6C¹ ² ³ ⁵		ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 16kD¹
ATP6L¹ ² ³ ⁵		VPPC²
ATPL¹ ² ³		H(+)-Transporting Two-Sector ATPase, 16 KDa Subunit²
VATL¹ ²		V-Type Proton ATPase 16 KDa Proteolipid Subunit²
Vma3¹ ²		Vacuolar ATP Synthase 16 KDa Proteolipid Subunit²
Vacuolar Proton Pump 16 KDa Proteolipid Subunit² ³		Vacuolar H+ ATPase Proton Channel Subunit²

External Ids:	HGNC: 855¹	Entrez Gene: 527²	Ensembl: ENSG00000185883⁷	OMIM: 108745⁵	UniProtKB: P27449³

Export aliases for ATP6V0C gene to outside databases

Previous GC identifers: GC16P002565 GC16P002503

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATP6V0C:

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of

eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular

processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient

generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of

three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP

catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. This gene encodes the V0

subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and

17. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: VATL_HUMAN, P27449

Function: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is

responsible for acidifying a variety of intracellular compartments in eukaryotic cells

summary for ATP6V0C:

H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify

intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane

organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated

vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains.

The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation.

There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles

to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These

transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation

and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause

recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of

sperm motility and maturation.

Gene Wiki entry for ATP6V0C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ATP6V0C gene promoter:
p53 SREBP-1c CUTL1 SREBP-1b CREB POU2F1 SREBP-1a POU2F1a ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATP6V0C promoter sequence

Search SABiosciences Chromatin IP Primers for ATP6V0C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP6V0C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

ATP6V0C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP6V0C gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P002563: view genomic region (about GC identifiers)

Start:	2,563,727 bp from pter	End:	2,570,219 bp from pter
Size:	6,493 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VATL_HUMAN, P27449 (See protein sequence)

Recommended Name: V-type proton ATPase 16 kDa proteolipid subunit

Size: 155 amino acids; 15736 Da

Subunit: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits

A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid

protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with LASS2. Interacts with

HTLV-1 accessory protein p12I. Interacts with RNF182; this interaction leads to ubiquitination and degradation via the

proteasome pathway

Subcellular location: Vacuole membrane; Multi-pass membrane protein

Secondary accessions: Q6FH26

Explore the universe of human proteins at neXtProt for ATP6V0C: NX_P27449

Post-translational modifications:

Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P27449

ATP6V0C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001185498.1 NP_001685.1

ENSEMBL proteins:

ENSP00000454796 ENSP00000329757 ENSP00000454597 ENSP00000456077 ENSP00000457782

ENSP00000454868

Reactome Protein details: P27449
Human Recombinant Protein Products:

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	Novus Biologicals ATP6V0C Protein Novus Biologicals ATP6V0C Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ATP6V0C

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005774	vacuolar membrane	IEA	--
GO:0010008	endosome membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0030670	phagocytic vesicle membrane	TAS	--
GO:0033179	proton-transporting V-type ATPase, V0 domain	IEA	--

ATP6V0C for ontologies About GeneDecksing

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	Search for Antibodies for ATP6V0C at Abcam
	Uscn Antibodies for ATP6V0C
	ThermoFisher Antibodies for ATP6V0C

Assay Products for ATP6V0C:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	Uscn ELISAs and CLIAs for ATP6V0C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATP6V0C for domains About GeneDecksing

3 InterPro domains/families:

IPR002379 ATPase_F0/V0-cplx_csu

IPR011555 ATPase_V0-cplx_csu_euk

IPR000245 ATPase_V0-cplx_csu

Graphical View of Domain Structure for InterPro Entry P27449

ProtoNet protein and cluster: P27449

2 Blocks protein families:

IPB000245 Vacuolar ATP synthase 16kD subunit signature

IPB011555 ATPase

UniProtKB/Swiss-Prot: VATL_HUMAN, P27449

Similarity: Belongs to the V-ATPase proteolipid subunit family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: VATL_HUMAN, P27449

Function: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is

responsible for acidifying a variety of intracellular compartments in eukaryotic cells

miRNA Products:		OriGene 3'-UTR Clone: ATP6V0C Browse MicroRNA Expression Plasmids
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		hsa-miR-1197 hsa-miR-340
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ATP6V0C
		Search LifeMap BioReagents cell lines for ATP6V0C

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ATP6V0C

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0015078	hydrogen ion transmembrane transporter activity	--	--
GO:0031625	ubiquitin protein ligase binding	IPI	18298843
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	TAS	1709739
GO:0046961	proton-transporting ATPase activity, rotational mechanism	TAS	1709739

ATP6V0C for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for ATP6V0C:

Decreased Hepatitis C virus re	Decreased influenza A H1N1 (A/	Decreased influenza A H1N1 (A/	Decreased influenza A/WSN/33 r
Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-out Atp6v0c^tm1Hka for ATP6V0C
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Atp6v0c):

embryogenesis

mortality/aging

ATP6V0C for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Insulin receptor recycling

Insulin receptor recycling	1.00	Latent infection of Homo sapiens with Mycobacterium tuberculosis	0.64
Transferrin endocytosis and recycling	0.79	Iron uptake and transport	0.56
Collecting duct acid secretion	0.68	Vibrio cholerae infection	0.41
Phagosomal maturation (early endosomal stage)	0.64	Epithelial cell signaling in Helicobacter pylori infection	0.33

Disease

Disease

1.00

Rheumatoid arthritis

Rheumatoid arthritis

1.00

Tuberculosis

Tuberculosis

1.00

Lysosome

Lysosome

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 Reactome Pathways for ATP6V0C (see all 9)

	Insulin receptor recycling
	Phagosomal maturation (early endosomal stage)
	Latent infection of Homo sapiens with Mycobacterium tuberculosis
	Iron uptake and transport
	Disease

5/9 Kegg Pathways (Kegg details for ATP6V0C) (see all 9):

	Oxidative phosphorylation
	Metabolic pathways
	Lysosome
	Phagosome
	Collecting duct acid secretion

ATP6V0C for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ATP6V0C

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/121 Interacting proteins for ATP6V0C (P27449^{1, 2, 3} ENSP00000329757⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 121)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MARK3	P27448²^,³, ENSP00000411397⁴	MINT-63621 I2D: score=5 STRING: ENSP00000411397
CERS2	Q96G23¹^,³, ENSP00000271688⁴	EBI-721179,EBI-1057080 I2D: score=3 STRING: ENSP00000271688
PDGFRB	P09619²^,³, ENSP00000261799⁴	MINT-6628528 I2D: score=1 STRING: ENSP00000261799
RPL9	P32969³, ENSP00000346022⁴	I2D: score=5 STRING: ENSP00000346022
RPL9P7	P32969³	I2D: score=5

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006879	cellular iron ion homeostasis	TAS	--
GO:0008286	insulin receptor signaling pathway	TAS	--
GO:0015991	ATP hydrolysis coupled proton transport	IEA	--
GO:0015992	proton transport	TAS	1709739
GO:0019048	virus-host interaction	IEA	--

ATP6V0C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for ATP6V0C:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for ATP6V0C available from Tocris Bioscience About this table

Compound	Action	CAS #
Bafilomycin A1	H+-ATPase (vacuolar) inhibitor	[88899-55-2]
Concanamycin A	H+-ATPase (vacuolar) inhibitor	[80890-47-7]

4 HMDB Compounds for ATP6V0C About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

Search CenterWatch for drugs/clinical trials and news about ATP6V0C / VATL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATP6V0C gene (2 alternative transcripts):

NM_001198569.1 NM_001694.3

Unigene Cluster for ATP6V0C:

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

Hs.389107 [show with all ESTs]

Unigene Representative Sequence: BM467334

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000568694 ENST00000330398(uc021tav.1 uc002cqn.3) ENST00000568562

ENST00000562353 ENST00000565223 ENST00000564973

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		2 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP6V0C:
		hsa-miR-1197 hsa-miR-340
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Additional cDNA sequence:

BC004537.2 BC007389.2 BC007759.2 BC009290.2 BT007155.1 CR541930.1 CR541951.1 M62762.1

20 DOTS entries:

DT.102837014 DT.91766846 DT.85104710 DT.101973294 DT.100830702 DT.100787573 DT.100787561 DT.120680301

DT.91766853 DT.95273032 DT.97855864 DT.100787577 DT.100829797 DT.100833867 DT.120680098 DT.120680247

DT.85104709 DT.91766851 DT.95273024 DT.95273001

24/585 AceView cDNA sequences (see all 585):

BU838206 BU617833 CF127865 BU620642 AI962597 AI114460 CR541951 CK430754

F30715 CR616464 BG697408 BM820227 BF475400 BX111121 BQ719173 AI262866

BU166538 BQ232887 AI140316 CA425429 CA426172 BC007759 CR541930 BQ224964

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V0C About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d
SP1:							-		-
SP2:					-		-		-
SP3:									-
SP4:

ECgene alternative splicing isoforms for ATP6V0C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATP6V0C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCAGTGTCC

About this image

ATP6V0C expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ATP6V0C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATP6V0C

SOURCE GeneReport for Unigene cluster: Hs.389107

SABiosciences Expression via Pathway-Focused PCR Array including ATP6V0C:

Drug Transporters in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP6V0C Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ATP6V0C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP6V0C gene from 10/40 species (see all 40) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Atp6v0c^{1 , 5}	ATPase, H+ transporting, lysosomal V0 subunit C^{1, 5}	86.88(n)¹ 90.97(a)¹		17 (12.29 cM)⁵ 11984¹ NM_009729.3¹ NP_033859.1¹ 24163866⁵
chicken (Gallus gallus)	Aves	ATP6V0C¹	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit more	78.27(n) 93.75(a)		416753 XM_003642168.1 XP_003642216.1
lizard (Anolis carolinensis)	Reptilia	ATP6V0C⁶	--	82(a)	1 ↔ 1	GL343621.1(323132-339202)
African clawed frog (Xenopus laevis)	Amphibia	MGC64475²	hypothetical protein MGC64475	78.43(n)		BC043805.1
zebrafish (Danio rerio)	Actinopterygii	atp6v0c²	ATPase, H+ transporting, lysosomal, V0 subunit c	82.72(n)		192336 AY099523.1
fruit fly (Drosophila melanogaster)	Insecta	Vha16³ Vha16-1¹	proton transport hydrogen-transporting two-sector more³ Vacuolar H[+] ATPase subunit 16-1¹	81(a) (best of 2)³ 74.78(n)¹ 82.24(a)¹		42C1³ 44307¹ NM_057453.4¹ NP_476801.1¹
worm (Caenorhabditis elegans)	Secernentea	vha-2³ vha-1¹	Vacuolar ATP synthase subunit³ Protein VHA-1¹	67(a)³ 62.7(n)¹ 64.34(a)¹		III(9853715-9854585)³ 176383¹ NM_066764.4¹ NP_499165.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	VMA11(YPL234C)⁴ VMA3¹	Vacuolar ATPase V0 domain subunit c', involved in proton more⁴ Vma3p¹	59.23(n)¹ 71.62(a)¹		16(105440-104946)⁴ 856686¹ NP_010887.3¹ 855842⁴ NP_015090.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	ATVHA-C1⁶ AT2G16510⁶ (see all 5)	V-type proton ATPase proteolipid subunit c1/c3/c5 (see all 5)	59(a) 59(a) (see all 5)	many → 1 many → 1 (see all 5)	4(16567824-16569295) 2(7159629-7160892)
rice (Oryza sativa)	Liliopsida	Os.5911²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.69(n)		AK099459.1

ENSEMBL Gene Tree for ATP6V0C (if available)
TreeFam Gene Tree for ATP6V0C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ATP6V0C gene

2 SIMAP similar genes for ATP6V0C using alignment to 4 protein entries: VATL_HUMAN (see all proteins):

ATP6C ATP6V0B

ATP6V0C for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for ATP6V0C
PGOHUM00000236907 PGOHUM00000243988 PGOHUM00000238132 PGOHUM00000243624

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112731299^1,2	C,	--	2496652(+)	`GGTGCC/AGGGTG`	1	--	int¹		1		WA	2
rs75544552^1,2	C	--	2562044(+)	`GCCACC/TGTGCC`	2	--	us2k¹		0	--	--	--	--
rs11861952^1,2	C,F,H,	--	2562127(+)	`AATTCG/AGCCCC`	2	--	us2k¹		11		NS EA NA WA	1370
rs78327465^1,2	F,	--	2562390(+)	`GAGGGC/TGTCTG`	2	--	us2k¹		1		NA	120
rs77818036^1,2	F,	--	2562411(+)	`AGTCCG/CCAGGA`	2	--	us2k¹		1		NA	120
rs74003017^1,2	C,	--	2562540(+)	`AGGAGC/GTGGAG`	2	--	us2k¹		2		WA	120
rs182703498^1,2		--	2562587(+)	`GATTCA/GTCTTC`	2	--	us2k¹		0	--	--	--	--
rs78246764^1,2	C,F,	--	2562625(+)	`GGGAGG/AAGCAG`	2	--	us2k¹		1		WA	118
rs12102805^1,2	C,H	--	2562630(+)	`GAGCAG/AAAAGG`	2	--	us2k¹		6		NS EA NA	420
rs148228067^1,2		--	2562660(+)	`GCCTCC/TTCTCC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ATP6V0C (2563727 - 2570219 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ATP6V0C
3 CNVs: 4918 3988 5329

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ATP6V0C for disorders           About GeneDecksing

OMIM gene information: 108745    OMIM disorders: --

13 diseases for ATP6V0C:    About MalaCards

osteopetrosis autism spectrum disorder polycystic kidney disease kidney disease

rheumatoid arthritis cholera twinning neurodegeneration

arthritis breast cancer pneumonia tuberculosis

malaria

Human Genome Epidemiology (HuGE) Navigator: ATP6V0C (1 document)

Export disorders for ATP6V0C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ATP6V0C gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with ATP6V0C)

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CpG island in the region of an autosomal dominant polycystic kidney disease locus defines the 5' end of a gene encoding a putative proton channel. (PubMed id 1709739)^{1, 2, 3} Gillespie G.A.J....Reeders S.T. (1991)
A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degr adation. (PubMed id 18298843)^{1, 2} Liu Q.Y....Liu R. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)^{1, 2} Pan H....Gu J.-R. (2001)
Mapping of the intermolecular association of human T cell leukaemia/lymphotropic virus type I p12I and the vacuolar H+-ATPase 16 kDa subunit protein. (PubMed id 7636472)^{1, 2} Koralnik I.J.... Franchini G. (1995)
Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase. (PubMed id 8250920)^{1, 3} van Hille B.... Bilbe G. (1993)
Vacuolar type H(+)-ATPase genes: presence of four genes including pseudogenes for the 16-kDa proteolipid subunit in the human genome. (PubMed id 1532310)^{1, 2} Hasebe M.... Futai M. (1992)
Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells. (PubMed id 19299075)^{1, 9} You H....Qin W. (2009)
Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome. (PubMed id 12438748)^{1, 9} Simckes A.M....White R.A. (2002)
A cytotoxic type III secretion effector of Vibrio para haemolyticus targets vacuolar H+-ATPase subunit c and ruptures host cell lysosom es. (PubMed id 22829766)¹ Matsuda S....Iida T. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 527	HGNC: 855	AceView: ATP6V0CandCGI-14andKIAA1171	Ensembl:ENSG00000185883	euGenes: HUgn527
ECgene: ATP6V0C	Kegg: 527	H-InvDB: ATP6V0C

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ATP6V0C	Pharmacogenomics, SNPs, Pathways

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ATP6V0C Gene

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

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ATP6V0C Gene

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

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