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Aliases for ATP6V0B Gene

Aliases for ATP6V0B Gene

  • ATPase, H+ Transporting, Lysosomal 21kDa, V0 Subunit B 2 3
  • ATP6F 3 4 6
  • Vacuolar Proton Pump 21 KDa Proteolipid Subunit 3 4
  • V-ATPase 21 KDa Proteolipid Subunit 3 4
  • HATPL 3 4
  • ATPase, H+ Transporting, Lysosomal, 21-KD, V0 Subunit C-Prime, Prime 3
  • ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 21kD 2
  • ATPase, H+ Transporting, Lysosomal 21kDa, V0 Subunit C 2
  • Vacuolar ATP Synthase 21 KDa Proteolipid Subunit 3
  • V-Type Proton ATPase 21 KDa Proteolipid Subunit 3
  • H(+)-Transporting Two-Sector ATPase, Subunit F 3
  • ATPase, H+ Transporting, Lysosomal, Subunit F 3
  • V-ATPase Subunit C 3
  • VMA16 3

External Ids for ATP6V0B Gene

Previous Symbols for ATP6V0B Gene

  • ATP6F

Summaries for ATP6V0B Gene

Entrez Gene Summary for ATP6V0B Gene

  • This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for ATP6V0B Gene

ATP6V0B (ATPase, H+ Transporting, Lysosomal 21kDa, V0 Subunit B) is a Protein Coding gene. Diseases associated with ATP6V0B include cannabis abuse. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include transporter activity and hydrogen ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP6V0B Gene

  • Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Tocris Summary for ATP6V0B Gene

  • H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains. The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation. There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of sperm motility and maturation.

Gene Wiki entry for ATP6V0B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V0B Gene

Genomics for ATP6V0B Gene

Genomic Location for ATP6V0B Gene

43,974,446 bp from pter
43,978,300 bp from pter
3,855 bases
Plus strand

Genomic View for ATP6V0B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP6V0B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP6V0B Gene

Regulatory Elements for ATP6V0B Gene

Proteins for ATP6V0B Gene

  • Protein details for ATP6V0B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-type proton ATPase 21 kDa proteolipid subunit
    Protein Accession:
    Secondary Accessions:
    • D3DPY5
    • Q6IB32

    Protein attributes for ATP6V0B Gene

    205 amino acids
    Molecular mass:
    21406 Da
    Quaternary structure:
    • Interacts with IFITM3.

    Alternative splice isoforms for ATP6V0B Gene


neXtProt entry for ATP6V0B Gene

Proteomics data for ATP6V0B Gene at MOPED

Post-translational modifications for ATP6V0B Gene

No Post-translational modifications

Other Protein References for ATP6V0B Gene

No data available for DME Specific Peptides for ATP6V0B Gene

Domains for ATP6V0B Gene

Gene Families for ATP6V0B Gene

  • VATP :ATPases / V-type


  • Belongs to the V-ATPase proteolipid subunit family.:
    • Q99437
genes like me logo Genes that share domains with ATP6V0B: view

Function for ATP6V0B Gene

Molecular function for ATP6V0B Gene

UniProtKB/Swiss-Prot Function: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Gene Ontology (GO) - Molecular Function for ATP6V0B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9653649
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with ATP6V0B: view

Phenotypes for ATP6V0B Gene

GenomeRNAi human phenotypes for ATP6V0B:
genes like me logo Genes that share phenotypes with ATP6V0B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATP6V0B Gene

Localization for ATP6V0B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP6V0B Gene

Vacuole membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ATP6V0B Gene COMPARTMENTS Subcellular localization image for ATP6V0B gene
Compartment Confidence
vacuole 5
endosome 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ATP6V0B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005773 vacuole --
GO:0005774 vacuolar membrane IEA --
GO:0010008 endosome membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP6V0B: view

Pathways for ATP6V0B Gene

genes like me logo Genes that share pathways with ATP6V0B: view

Interacting Proteins for ATP6V0B Gene

Gene Ontology (GO) - Biological Process for ATP6V0B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006879 cellular iron ion homeostasis TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0015991 ATP hydrolysis coupled proton transport IEA --
GO:0015992 proton transport TAS 9653649
GO:0033572 transferrin transport TAS --
genes like me logo Genes that share ontologies with ATP6V0B: view

Compounds for ATP6V0B Gene

(3) Tocris Compounds for ATP6V0B Gene

Compound Action Cas Number
Bafilomycin A1 H+-ATPase (vacuolar) inhibitor [88899-55-2]
Concanamycin A H+-ATPase (vacuolar) inhibitor [80890-47-7]
Disulfiram Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities [97-77-8]
genes like me logo Genes that share compounds with ATP6V0B: view

Transcripts for ATP6V0B Gene

Unigene Clusters for ATP6V0B Gene

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V0B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - -
SP10: -

Relevant External Links for ATP6V0B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP6V0B Gene

mRNA expression in normal human tissues for ATP6V0B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP6V0B Gene

This gene is overexpressed in Whole Blood (7.5).

SOURCE GeneReport for Unigene cluster for ATP6V0B Gene Hs.596514

mRNA Expression by UniProt/SwissProt for ATP6V0B Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ATP6V0B: view

Orthologs for ATP6V0B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP6V0B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP6V0B 36
  • 94.44 (n)
  • 93.63 (a)
ATP6V0B 37
  • 92 (a)
(Bos Taurus)
Mammalia ATP6V0B 36
  • 93.01 (n)
  • 98.05 (a)
ATP6V0B 37
  • 98 (a)
(Canis familiaris)
Mammalia ATP6V0B 36
  • 92.36 (n)
  • 97.56 (a)
ATP6V0B 37
  • 98 (a)
(Mus musculus)
Mammalia Atp6v0b 36
  • 89.59 (n)
  • 96.1 (a)
Atp6v0b 16
Atp6v0b 37
  • 96 (a)
(Monodelphis domestica)
Mammalia ATP6V0B 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia ATP6V0B 37
  • 95 (a)
(Rattus norvegicus)
Mammalia Atp6v0b 36
  • 92.67 (n)
  • 97.8 (a)
(Gallus gallus)
Aves ATP6V0B 36
  • 80.98 (n)
  • 89.76 (a)
ATP6V0B 37
  • 85 (a)
(Anolis carolinensis)
Reptilia ATP6V0B 37
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp6v0b 36
  • 73.33 (n)
  • 87.32 (a)
Str.10702 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3902 36
(Danio rerio)
Actinopterygii atp6v0b 36
  • 75.61 (n)
  • 85.85 (a)
atp6v0b 37
  • 83 (a)
wufb33a01 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009334 36
  • 66.28 (n)
  • 71.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta VhaPPA1-1 36
  • 62.3 (n)
  • 64.92 (a)
VhaPPA1-1 37
  • 58 (a)
VhaPPA1-2 37
  • 50 (a)
VhaPPA1-1 38
  • 63 (a)
CG7026 38
  • 56 (a)
(Caenorhabditis elegans)
Secernentea vha-4 36
  • 60.57 (n)
  • 65.59 (a)
vha-4 37
  • 57 (a)
T01H3.1 38
  • 63 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR071W 36
  • 57.59 (n)
  • 59.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA16 36
  • 55.12 (n)
  • 56.98 (a)
VMA16 37
  • 47 (a)
VMA16 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11529g 36
  • 56.69 (n)
  • 59.89 (a)
(Glycine max)
eudicotyledons Gma.17713 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G25610 36
  • 59.28 (n)
  • 56.96 (a)
(Zea mays)
Liliopsida Zm.3672 36
(Oryza sativa)
Liliopsida Os.20543 36
Os01g0610100 36
  • 63.68 (n)
  • 60.9 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09747 36
  • 61.11 (n)
  • 61.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes vma16 36
  • 56.63 (n)
  • 55.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4230 37
  • 56 (a)
Species with no ortholog for ATP6V0B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP6V0B Gene

Gene Tree for ATP6V0B (if available)
Gene Tree for ATP6V0B (if available)

Paralogs for ATP6V0B Gene

Selected SIMAP similar genes for ATP6V0B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ATP6V0B: view

No data available for Paralogs for ATP6V0B Gene

Variants for ATP6V0B Gene

Sequence variations from dbSNP and Humsavar for ATP6V0B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2286241 -- 43,975,097(+) TGCGC(C/G)CTGGC utr-variant-5-prime, synonymous-codon, reference
rs2286242 -- 43,975,683(+) TGGGG(A/G)CAGCC intron-variant
rs2286243 -- 43,975,861(+) AGGGC(A/G)GGGGG intron-variant
rs2486008 -- 43,974,113(+) TTAAG(C/T)GGGGT upstream-variant-2KB
rs4660761 -- 43,974,474(+) ATCGC(A/G)GGAGC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ATP6V0B Gene

Variant ID Type Subtype PubMed ID
nsv870606 CNV Loss 21882294
dgv217n71 CNV Loss 21882294
nsv732 CNV Insertion 18451855
nsv822498 CNV Gain 20364138

Relevant External Links for ATP6V0B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ATP6V0B Gene

(1) MalaCards Diseases for ATP6V0B Gene

Search for ATP6V0B Gene in MalaCards »

(1) University of Copenhagen DISEASES for ATP6V0B Gene

genes like me logo Genes that share disorders with ATP6V0B: view

No data available for UniProtKB/Swiss-Prot for ATP6V0B Gene

Publications for ATP6V0B Gene

  1. Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F). (PMID: 9653649) Nishigori H. … Takeda J. (Genomics 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. (PMID: 17576770) Lu M. … Gluck S.L. (J. Biol. Chem. 2007) 3
  4. Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation. (PMID: 17662945) Adachi K. … Kinosita K. (Cell 2007) 3
  5. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3

Products for ATP6V0B Gene

  • antibodies-online peptides for ATP6V0B
  • antibodies-online antibodies for ATP6V0B
  • antibodies-online kits for ATP6V0B

Sources for ATP6V0B Gene

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