Aliases for ATP6V0A1 Gene
- ATPase, H+ Transporting, Lysosomal V0 Subunit A1 2 3
- ATP6N1A 3 4 6
- VPP1 3 4 6
- ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) Non-Catalytic Accessory Protein 1A (110/116kD) 2 3
- Clathrin-Coated Vesicle/Synaptic Vesicle Proton Pump 116 KDa Subunit 3 4
- Vacuolar Adenosine Triphosphatase Subunit Ac116 3 4
- Vacuolar Proton Pump Subunit 1 3 4
- ATP6N1 3 4
- ATPase, H+ Transporting, Lysosomal Non-Catalytic Accessory Protein 1 (110/116kD) 3
- H(+)-Transporting Two-Sector ATPase, 116 KDa Accessory Protein A1 3
- Vacuolar Proton Translocating ATPase 116 KDa Subunit A Isoform 1 4
- ATPase, H+ Transporting, Lysosomal V0 Subunit A Isoform 1 2
External Ids for ATP6V0A1 Gene
Previous Symbols for ATP6V0A1 Gene
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP6V0A1 Gene
ATP6V0A1 (ATPase, H+ Transporting, Lysosomal V0 Subunit A1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include ATPase binding and hydrogen ion transmembrane transporter activity. An important paralog of this gene is TCIRG1.
UniProtKB/Swiss-Prot for ATP6V0A1 Gene
Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. H+-ATPase is a multisubunit complex composed of two domains. The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation. There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex. These transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of sperm motility and maturation.