ATP6AP1L Gene
protein-coding GIFtS: 39
GCID: GC05P081612
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ATPase, H+ transporting, lysosomal accessory protein 1-like
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Aliases
for ATP6AP1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ATPase, H+ Transporting, Lysosomal Accessory Protein 1-Like1 2 | | Vacuolar Proton Pump Subunit S1-Like Protein2 3 | | V-Type Proton ATPase Subunit S1-Like Protein2 |
Export aliases for ATP6AP1L gene to outside databasesPrevious GC identifer: GC05P076809 |
Summaries
for ATP6AP1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ATP6AP1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATP6AP1L gene promoter:
Elk-1 AML1a SREBP-1c Olf-1 SREBP-1b MEF-2A SREBP-1a FOXJ2 (long isoform) aMEF-2 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATP6AP1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP6AP1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q14.2 Ensembl cytogenetic band: 5q14.2 HGNC cytogenetic band: 5q14.2ATP6AP1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P081612: view genomic region
(about GC identifiers)
Start:
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81,575,281 bp from pter |
End:
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81,682,796 bp from pter |
Size:
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107,516 bases |
Orientation:
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plus strand |
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Proteins
for ATP6AP1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VAS1L_HUMAN, Q52LC2 (See
protein sequence)Recommended Name: V-type proton ATPase subunit S1-like protein Size: 224 amino acids; 25310 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for ATP6AP1L: NX_Q52LC2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q52LC2
ATP6AP1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001017971.1
ENSEMBL proteins: ENSP00000369513 ENSP00000391381
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- | | GO:0033180 | proton-transporting V-type ATPase, V1 domain |
IEA | -- |
ATP6AP1L for ontologies About GeneDecksing
ATP6AP1L Antibody Products:
Assay Products for ATP6AP1L: |
Protein
Domains /
Families
for ATP6AP1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATP6AP1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q52LC2ProtoNet protein and cluster: Q52LC2 UniProtKB/Swiss-Prot: VAS1L_HUMAN, Q52LC2Similarity: Belongs to the vacuolar ATPase subunit S1 family |
Function
for ATP6AP1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6AP1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6AP1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ATP6AP1L (NM_001017971) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATP6AP1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP6AP1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP6AP1L |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism |
IEA | -- | | GO:0046961 | proton-transporting ATPase activity, rotational mechanism |
IEA | -- |
ATP6AP1L for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ATP6AP1L:
|
Pathways & Interactions
for ATP6AP1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP6AP1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/48 Interacting proteins for ATP6AP1L (ENSP000003695134) via UniProtKB, MINT, STRING, and/or I2D (see all 48)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015991 | ATP hydrolysis coupled proton transport |
IEA | -- |
ATP6AP1L for ontologies About GeneDecksing
|
Drugs & Compounds
for ATP6AP1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ATP6AP1L
Search CenterWatch for drugs/clinical trials and news about ATP6AP1L / VAS1L
|
Transcripts
for ATP6AP1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATP6AP1L gene: NM_001017971.1 Unigene Cluster for ATP6AP1L: ATPase, H+ transporting, lysosomal accessory protein 1-like Hs.729805 [show with all ESTs]Unigene Representative Sequence: AK0949735 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380167(uc003khv.3 uc003khw.3) ENST00000508366 ENST00000514672
ENST00000502523(uc010jat.1) ENST00000439350
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6AP1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6AP1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ATP6AP1L (NM_001017971) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATP6AP1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP6AP1L |
Additional cDNA sequence: AK022625.1 AK094973.1 BC093982.1 BC112191.1 BC132947.1 BC132949.1 XR_108587.2 XR_112744.2 XR_171513.1 9 DOTS entries: DT.75101745 DT.406926 DT.40191205 DT.120852244 DT.97788050 DT.95311916 DT.75109288 DT.75135124 DT.75122946 24/66 AceView cDNA sequences (see all 66): AA883786 BX115316 AI420460 CA840957 BQ788058 BQ631322 CA841215 BX104142 BM821122 AI263373 AA584127 CA432614 AI452811 AK022625 AU124970 CA748860 BF437675 AW086167 AI202269 AI690277 BU732280 AA626079 CD370831 AA701353
GeneLoc Exon Structure
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Expression
for ATP6AP1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATP6AP1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTACTCTG
About this image
See ATP6AP1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATP6AP1L
SOURCE GeneReport for Unigene cluster: Hs.729805
SABiosciences Custom PCR Arrays for ATP6AP1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP6AP1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ATP6AP1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP6AP1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP6AP1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP6AP1L |
Orthologs
for ATP6AP1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ATP6AP1L gene from 4/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Atp6ap1l5 |
ATPase, H+ transporting, lysosomal accessory protein more |
-- |
|
13 (46.45 cM) 90883460 |
chicken
(Gallus gallus) |
Aves |
ATP6AP1L6 |
Uncharacterized protein |
62(a) |
1 ↔ 1 |
Z(62004120-62019639) |
lizard
(Anolis carolinensis) |
Reptilia |
ATP6AP1L6 |
-- |
55(a) |
1 ↔ 1 |
2(18042925-18049382) |
zebrafish
(Danio rerio) |
Actinopterygii |
FP067440.16si:ch211-222g5.36 |
si:ch211-222g5.3 |
43(a)24(a) |
many → 1many → 1 |
11(43612220-43618494) 23(19847124-19872364) |
ENSEMBL Gene Tree for ATP6AP1L (if available)
TreeFam Gene Tree for ATP6AP1L (if available) |
Paralogs
for ATP6AP1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATP6AP1L gene
- ATP6AP12
3 SIMAP similar genes for ATP6AP1L using alignment to 1 protein entry: VAS1L_HUMAN:ATP6AP1 DKFZp434B0535 FLJ00383
ATP6AP1L for paralogs About GeneDecksing
|
Genomic Variants
for ATP6AP1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATP6AP1L (81575281 - 81682796 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATP6AP1L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP6AP1L |
|
Disorders
/ Diseases
for ATP6AP1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ATP6AP1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATP6AP1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with ATP6AP1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for ATP6AP1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ATP6AP1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATP6AP1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ATP6AP1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ATP6AP1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ATP6AP1L gene:
Search GeneIP for patents involving ATP6AP1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ATP6AP1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ATP6AP1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP6AP1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP6AP1L | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ATP6AP1L | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6AP1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP6AP1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATP6AP1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP6AP1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP6AP1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP6AP1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP6AP1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP6AP1L |
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 | | | ATP6AP1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP6AP1L |
|  |  |  | | | | Search ThermoFisher Antibodies for ATP6AP1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP6AP1L |
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