Aliases for ATP6AP1 Gene
External Ids for ATP6AP1 Gene
Previous HGNC Symbols for ATP6AP1 Gene
Previous GeneCards Identifiers for ATP6AP1 Gene
This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]
GeneCards Summary for ATP6AP1 Gene
ATP6AP1 (ATPase, H+ Transporting, Lysosomal Accessory Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include transporter activity and proton-transporting ATPase activity, rotational mechanism. An important paralog of this gene is ATP6AP1L.
UniProtKB/Swiss-Prot for ATP6AP1 Gene
Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.