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Aliases for ATP5O Gene

Aliases for ATP5O Gene

  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, O Subunit 2 3 5
  • Oligomycin Sensitivity Conferring Protein 2 3
  • ATPO 3 4
  • OSCP 3 4
  • Oligomycin Sensitivity Conferral Protein Oscp-Like Protein 3
  • Oligomycin Sensitivity Conferral Protein 4
  • ATP Synthase Subunit O, Mitochondrial 3
  • Human ATP Synthase OSCP Subunit 3
  • HMC08D05 3

External Ids for ATP5O Gene

Previous GeneCards Identifiers for ATP5O Gene

  • GC21M031853
  • GC21M034196
  • GC21M034197
  • GC21M034956
  • GC21M035275
  • GC21M020753

Summaries for ATP5O Gene

Entrez Gene Summary for ATP5O Gene

  • The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5O Gene

ATP5O (ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, O Subunit) is a Protein Coding gene. Diseases associated with ATP5O include Hashimoto Thyroiditis and Autoimmune Disease Of Endocrine System. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include transporter activity and drug binding. An important paralog of this gene is ENSG00000249209.

UniProtKB/Swiss-Prot for ATP5O Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Wiki entry for ATP5O Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5O Gene

Genomics for ATP5O Gene

Regulatory Elements for ATP5O Gene

Enhancers for ATP5O Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F033913 0.2 ENCODE 19.3 +0.6 599 3.0 ATF1 CREB3L1 ARID4B SIN3A ZNF48 ETS1 YY1 SLC30A9 ELK1 ZNF207 ATP5O RPS5P2 OLIG2 OLIG1 LINC00649 PIR61544
GH21F033894 0.5 Ensembl ENCODE 18.9 +21.1 21057 1.4 ATF1 PKNOX1 ZNF133 GLI4 ZNF48 RAD21 EGR1 ZNF366 SCRT2 ZNF143 ATP5O LINC01548 ENSG00000226433 C21orf140 LINC00649 GC21P033897 CRYZL1
GH21F033931 1 Ensembl ENCODE 16.3 -17.1 -17069 3.9 HDAC1 IRF2 ESRRA NFRKB ETV1 YY1 ZNF316 FOXK2 POLR2A PRDM10 LINC00649 ATP5O ENSG00000249209 LOC105372788
GH21F033935 1.5 FANTOM5 Ensembl ENCODE 15.8 -22.4 -22422 6.0 BCOR ZNF146 ZMYM3 MAX CEBPG ZBTB40 ZKSCAN1 ZNF316 ADNP CREM LINC00649 ATP5O SLC5A3 MRPS6 ENSG00000214955 GART SON ENSG00000249209 LOC105372788
GH21F033945 0.8 FANTOM5 ENCODE 15.7 -33.1 -33076 7.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 LINC00649 ATP5O BTF3P6 GART SON ENSG00000249209 LOC105372788
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ATP5O on UCSC Golden Path with GeneCards custom track

Promoters for ATP5O Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106597 480 2200 ATF1 CREB3L1 SIN3A ARID4B ZNF48 ETS1 YY1 SLC30A9 ELK1 ZNF207

Genomic Location for ATP5O Gene

Chromosome:
21
Start:
33,903,453 bp from pter
End:
33,915,980 bp from pter
Size:
12,528 bases
Orientation:
Minus strand

Genomic View for ATP5O Gene

Genes around ATP5O on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5O Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5O Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5O Gene

Proteins for ATP5O Gene

  • Protein details for ATP5O Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48047-ATPO_HUMAN
    Recommended name:
    ATP synthase subunit O, mitochondrial
    Protein Accession:
    P48047
    Secondary Accessions:
    • B2R4E2
    • Q5U042
    • Q6IBI2

    Protein attributes for ATP5O Gene

    Size:
    213 amino acids
    Molecular mass:
    23277 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5O Gene

Post-translational modifications for ATP5O Gene

  • Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3.
  • Ubiquitination at Lys 51, Lys 60, Lys 73, Lys 84, Lys 90, Lys 98, Lys 158, Lys 172, Lys 176, and Lys 199
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP5O Gene

No data available for DME Specific Peptides for ATP5O Gene

Domains & Families for ATP5O Gene

Suggested Antigen Peptide Sequences for ATP5O Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48047

UniProtKB/Swiss-Prot:

ATPO_HUMAN :
  • Belongs to the ATPase delta chain family.
Family:
  • Belongs to the ATPase delta chain family.
genes like me logo Genes that share domains with ATP5O: view

Function for ATP5O Gene

Molecular function for ATP5O Gene

GENATLAS Biochemistry:
ATP synthase 5O H+ transporting,inner mitochondrial membrane (F0 segment) subunit,oligomycin sensitivity conferring protein,yeast OSCP homolog,complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Ontology (GO) - Molecular Function for ATP5O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 7490082
GO:0005515 protein binding IPI 21516116
GO:0008144 drug binding IDA 15850986
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
genes like me logo Genes that share ontologies with ATP5O: view
genes like me logo Genes that share phenotypes with ATP5O: view

Animal Model Products

miRNA for ATP5O Gene

miRTarBase miRNAs that target ATP5O

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5O Gene

Localization for ATP5O Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5O Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5O Gene COMPARTMENTS Subcellular localization image for ATP5O gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for ATP5O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA,IDA 12110673
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex NAS 7490082
GO:0005886 plasma membrane IDA 17851741
genes like me logo Genes that share ontologies with ATP5O: view

Pathways & Interactions for ATP5O Gene

genes like me logo Genes that share pathways with ATP5O: view

Gene Ontology (GO) - Biological Process for ATP5O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IEA --
GO:0015992 proton transport NAS 17851741
genes like me logo Genes that share ontologies with ATP5O: view

No data available for SIGNOR curated interactions for ATP5O Gene

Drugs & Compounds for ATP5O Gene

(5) Drugs for ATP5O Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(5) Additional Compounds for ATP5O Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with ATP5O: view

Transcripts for ATP5O Gene

Unigene Clusters for ATP5O Gene

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5O Gene

No ASD Table

Relevant External Links for ATP5O Gene

GeneLoc Exon Structure for
ATP5O
ECgene alternative splicing isoforms for
ATP5O

Expression for ATP5O Gene

mRNA expression in normal human tissues for ATP5O Gene

mRNA differential expression in normal tissues according to GTEx for ATP5O Gene

This gene is overexpressed in Heart - Left Ventricle (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP5O Gene



Protein tissue co-expression partners for ATP5O Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP5O Gene:

ATP5O

SOURCE GeneReport for Unigene cluster for ATP5O Gene:

Hs.409140
genes like me logo Genes that share expression patterns with ATP5O: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP5O Gene

Orthologs for ATP5O Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP5O Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5O 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 88 (a)
ManyToMany
LOC100855541 34
  • 86.95 (n)
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 69 (a)
ManyToMany
-- 35
  • 69 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia ATP5O 34 35
  • 86.85 (n)
mouse
(Mus musculus)
Mammalia Atp5o 34 16 35
  • 79.81 (n)
rat
(Rattus norvegicus)
Mammalia Atp5o 34
  • 79.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ATP5O 34
  • 66.99 (n)
-- 35
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5o 34
  • 64.91 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23878 34
zebrafish
(Danio rerio)
Actinopterygii atp5o 34 35
  • 61.67 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9319 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003599 34
  • 54.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta Oscp 36 34 35
  • 53.03 (n)
worm
(Caenorhabditis elegans)
Secernentea atp-3 34 35
  • 47.62 (n)
F27C1.7 36
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL065C 34
  • 46.77 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP5 34 35 37
  • 45.96 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10384g 34
  • 45.52 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATP5 34
  • 45.33 (n)
rice
(Oryza sativa)
Liliopsida Os06g0646500 34
  • 45.62 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp5 34
  • 48.98 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01606 34
  • 44.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5137 35
  • 33 (a)
OneToMany
Species where no ortholog for ATP5O was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5O Gene

ENSEMBL:
Gene Tree for ATP5O (if available)
TreeFam:
Gene Tree for ATP5O (if available)

Paralogs for ATP5O Gene

Paralogs for ATP5O Gene

Pseudogenes.org Pseudogenes for ATP5O Gene

genes like me logo Genes that share paralogs with ATP5O: view

Variants for ATP5O Gene

Sequence variations from dbSNP and Humsavar for ATP5O Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs111271147 -- 33,905,362(+) CATTA(C/T)GCCCA intron-variant
rs111366437 -- 33,906,936(+) CAGAG(A/G)TGTGA intron-variant
rs111652244 -- 33,917,550(+) CCACT(C/G/T)GGAGG upstream-variant-2KB
rs111709685 -- 33,914,717(+) TCCCA(C/T)GAACC intron-variant
rs111799448 -- 33,903,666(+) AAATG(C/T)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5O Gene

Variant ID Type Subtype PubMed ID
nsv587399 CNV gain 21841781

Variation tolerance for ATP5O Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5O Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5O

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5O Gene

Disorders for ATP5O Gene

MalaCards: The human disease database

(2) MalaCards diseases for ATP5O Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hashimoto thyroiditis
  • autoimmune thyroiditis
autoimmune disease of endocrine system
- elite association - COSMIC cancer census association via MalaCards
Search ATP5O in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATP5O

Genetic Association Database (GAD)
ATP5O
Human Genome Epidemiology (HuGE) Navigator
ATP5O
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5O
genes like me logo Genes that share disorders with ATP5O: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP5O Gene

Publications for ATP5O Gene

  1. Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2. (PMID: 7490082) Chen H.M. … Antonarakis S.E. (Genomics 1995) 2 3 4 22 64
  2. Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins. (PMID: 19274082) RAPnn T. … Ling C. (PLoS ONE 2009) 3 22 46 64
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64

Products for ATP5O Gene

Sources for ATP5O Gene

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