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Aliases for ATP5O Gene

Aliases for ATP5O Gene

  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, O Subunit 2 3
  • Oligomycin Sensitivity Conferring Protein 2 3
  • Oligomycin Sensitivity Conferral Protein 3 4
  • OSCP 3 4
  • ATPO 3 4
  • ATP Synthase Subunit O, Mitochondrial 3
  • Human ATP Synthase OSCP Subunit 3

External Ids for ATP5O Gene

Summaries for ATP5O Gene

Entrez Gene Summary for ATP5O Gene

  • The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5O Gene

ATP5O (ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, O Subunit) is a Protein Coding gene. Diseases associated with ATP5O include autoimmune polyglandular syndrome type 2 and d-2-hydroxyglutaric aciduria. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include transporter activity and drug binding. An important paralog of this gene is ENSG00000249209.

UniProtKB/Swiss-Prot for ATP5O Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements

Gene Wiki entry for ATP5O Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5O Gene

Genomics for ATP5O Gene

Genomic Location for ATP5O Gene

Start:
33,903,453 bp from pter
End:
33,915,980 bp from pter
Size:
12,528 bases
Orientation:
Minus strand

Genomic View for ATP5O Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5O Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5O Gene

Regulatory Elements for ATP5O Gene

Proteins for ATP5O Gene

  • Protein details for ATP5O Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48047-ATPO_HUMAN
    Recommended name:
    ATP synthase subunit O, mitochondrial
    Protein Accession:
    P48047
    Secondary Accessions:
    • B2R4E2
    • Q5U042
    • Q6IBI2

    Protein attributes for ATP5O Gene

    Size:
    213 amino acids
    Molecular mass:
    23277 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5O Gene

Proteomics data for ATP5O Gene at MOPED

Post-translational modifications for ATP5O Gene

  • Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys51, Lys54, Lys60, Lys73, Lys84, Lys88, Lys90, Lys98, Lys158, Lys162, Lys172, Lys176, Lys192, and Lys199

Other Protein References for ATP5O Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5O Gene

Domains for ATP5O Gene

Gene Families for ATP5O Gene

HGNC:
  • FATP :Mitochondrial respiratory chain complex / Complex V
  • F1ATP :ATPases / F-type

Suggested Antigen Peptide Sequences for ATP5O Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48047

UniProtKB/Swiss-Prot:

ATPO_HUMAN
Family:
  • Belongs to the ATPase delta chain family.:
    • P48047
genes like me logo Genes that share domains with ATP5O: view

Function for ATP5O Gene

Molecular function for ATP5O Gene

GENATLAS Biochemistry: ATP synthase 5O H+ transporting,inner mitochondrial membrane (F0 segment) subunit,oligomycin sensitivity conferring protein,yeast OSCP homolog,complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements

Gene Ontology (GO) - Molecular Function for ATP5O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 7490082
GO:0005515 protein binding IPI 21516116
GO:0008144 drug binding IDA 15850986
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
genes like me logo Genes that share ontologies with ATP5O: view

Phenotypes for ATP5O Gene

GenomeRNAi human phenotypes for ATP5O:
genes like me logo Genes that share phenotypes with ATP5O: view

miRNA for ATP5O Gene

miRTarBase miRNAs that target ATP5O

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP5O Gene

Localization for ATP5O Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5O Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5O Gene COMPARTMENTS Subcellular localization image for ATP5O gene
Compartment Confidence
mitochondrion 5
plasma membrane 5
chloroplast 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP5O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 12110673
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex NAS 7490082
GO:0005886 plasma membrane IDA 17851741
genes like me logo Genes that share ontologies with ATP5O: view

Pathways for ATP5O Gene

genes like me logo Genes that share pathways with ATP5O: view

Gene Ontology (GO) - Biological Process for ATP5O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006754 ATP biosynthetic process NAS 17851741
GO:0015986 ATP synthesis coupled proton transport --
GO:0015992 proton transport NAS 17851741
GO:0022904 respiratory electron transport chain TAS --
genes like me logo Genes that share ontologies with ATP5O: view

Compounds for ATP5O Gene

(4) HMDB Compounds for ATP5O Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(6) Novoseek inferred chemical compound relationships for ATP5O Gene

Compound -log(P) Hits PubMed IDs
atpo 97.2 29
oligomycin 84.2 8
dccd 61.4 1
atp 54.6 13
magnesium 16.1 2
genes like me logo Genes that share compounds with ATP5O: view

Transcripts for ATP5O Gene

mRNA/cDNA for ATP5O Gene

Unigene Clusters for ATP5O Gene

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5O Gene

No ASD Table

Relevant External Links for ATP5O Gene

GeneLoc Exon Structure for
ATP5O
ECgene alternative splicing isoforms for
ATP5O

Expression for ATP5O Gene

mRNA expression in normal human tissues for ATP5O Gene

mRNA differential expression in normal tissues according to GTEx for ATP5O Gene

This gene is overexpressed in Heart - Left Ventricle (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5O Gene

SOURCE GeneReport for Unigene cluster for ATP5O Gene Hs.409140

genes like me logo Genes that share expressions with ATP5O: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATP5O Gene

Orthologs for ATP5O Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP5O Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5O 35
  • 99.37 (n)
  • 100 (a)
ATP5O 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5O 35
  • 86.85 (n)
  • 87.32 (a)
ATP5O 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 88 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
LOC100855541 35
  • 86.95 (n)
  • 88.21 (a)
mouse
(Mus musculus)
Mammalia Atp5o 35
  • 79.81 (n)
  • 82.16 (a)
Atp5o 16
Atp5o 36
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Atp5o 35
  • 79.03 (n)
  • 81.69 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 60 (a)
OneToMany
ATP5O 35
  • 66.99 (n)
  • 64.11 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.23878 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5o 35
  • 64.91 (n)
  • 62.2 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9319 35
zebrafish
(Danio rerio)
Actinopterygii atp5o 35
  • 61.67 (n)
  • 61.35 (a)
atp5o 36
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003599 35
  • 54.28 (n)
  • 49.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oscp 35
  • 53.03 (n)
  • 49.43 (a)
Oscp 36
  • 43 (a)
OneToMany
Oscp 37
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea atp-3 35
  • 47.62 (n)
  • 42.86 (a)
atp-3 36
  • 38 (a)
OneToMany
F27C1.7 37
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL065C 35
  • 46.77 (n)
  • 37.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP5 35
  • 45.96 (n)
  • 35.86 (a)
ATP5 36
  • 33 (a)
OneToMany
ATP5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10384g 35
  • 45.52 (n)
  • 36.55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATP5 35
  • 45.33 (n)
  • 35.5 (a)
rice
(Oryza sativa)
Liliopsida Os06g0646500 35
  • 45.62 (n)
  • 33.84 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01606 35
  • 44.78 (n)
  • 38.81 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp5 35
  • 48.98 (n)
  • 40.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5137 36
  • 33 (a)
OneToMany
Species with no ortholog for ATP5O:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5O Gene

ENSEMBL:
Gene Tree for ATP5O (if available)
TreeFam:
Gene Tree for ATP5O (if available)

Paralogs for ATP5O Gene

Paralogs for ATP5O Gene

Pseudogenes.org Pseudogenes for ATP5O Gene

genes like me logo Genes that share paralogs with ATP5O: view

Variants for ATP5O Gene

Sequence variations from dbSNP and Humsavar for ATP5O Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs4591 -- 33,909,089(-) ACCAA(A/C/G/T)CTGAT missense, synonymous-codon, reference
rs4842 - 33,909,117(-) AGCAA(A/G)AGAGA reference, missense
rs1892689 -- 33,913,703(+) ACTGG(A/G)AAGAA intron-variant
rs1892690 -- 33,913,997(+) CTGGT(A/C)TCAAA intron-variant
rs2032311 -- 33,917,413(+) ggtct(C/T)gaact upstream-variant-2KB

Relevant External Links for ATP5O Gene

HapMap Linkage Disequilibrium report
ATP5O

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATP5O Gene

Disorders for ATP5O Gene

(1) University of Copenhagen DISEASES for ATP5O Gene

(5) Novoseek inferred disease relationships for ATP5O Gene

Disease -log(P) Hits PubMed IDs
hashimotos thyroiditis 47 2
graves disease 36.1 2
autoimmunity 35 1
hypothyroidism 28.1 1
autoimmune diseases 24.5 1

Relevant External Links for ATP5O

Genetic Association Database (GAD)
ATP5O
Human Genome Epidemiology (HuGE) Navigator
ATP5O
genes like me logo Genes that share disorders with ATP5O: view

No data available for UniProtKB/Swiss-Prot for ATP5O Gene

Publications for ATP5O Gene

  1. Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2. (PMID: 7490082) Chen H.M. … Antonarakis S.E. (Genomics 1995) 2 3 4 23
  2. Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins. (PMID: 19274082) RAPnn T. … Ling C. (PLoS ONE 2009) 3 23 48
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ATP5O Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ATP5O
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5O
    • Block miRNA regulation of ATP5O using miScript Target Protectors

    Sources for ATP5O Gene

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