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Aliases for ATP5MD Gene

Aliases for ATP5MD Gene

  • ATP Synthase Membrane Subunit DAPIT 2 3
  • USMG5 3 4 5
  • Up-Regulated During Skeletal Muscle Growth 5 Homolog (Mouse) 2 5
  • Diabetes Associated Protein In Insulin-Sensitive Tissues 2 3
  • Diabetes-Associated Protein In Insulin-Sensitive Tissues 3 4
  • HCV F-Transactivated Protein 2 3 4
  • HCVFTP2 3 4
  • DAPIT 3 4
  • Upregulated During Skeletal Muscle Growth 5 Homolog (Mouse) 2
  • Up-Regulated During Skeletal Muscle Growth 5 Homolog 3
  • Up-Regulated During Skeletal Muscle Growth Protein 5 3
  • Upregulated During Skeletal Muscle Growth 5 Homolog 3
  • Upregulated During Skeletal Muscle Growth 5 2
  • BA792D24.4 3

External Ids for ATP5MD Gene

Previous HGNC Symbols for ATP5MD Gene

  • USMG5

Summaries for ATP5MD Gene

GeneCards Summary for ATP5MD Gene

ATP5MD (ATP Synthase Membrane Subunit DAPIT) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

UniProtKB/Swiss-Prot for ATP5MD Gene

  • Plays a critical role in maintaining the ATP synthase population in mitochondria.

Additional gene information for ATP5MD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5MD Gene

Genomics for ATP5MD Gene

GeneHancer (GH) Regulatory Elements for ATP5MD Gene

Promoters and enhancers for ATP5MD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I103394 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 0.0 -3 3.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 PDCD11 ATP5MD TAF5 PCGF6 CALHM2 AS3MT
GH10I103395 Promoter 1 EPDnew 550.8 +2.2 2195 0.1 HDAC1 MEIS2 PKNOX1 TAF9B ZKSCAN1 TCF12 NCOR1 CBFA2T2 ZSCAN29 NFE2 ATP5MD MIR1307 CALHM2 GC10P103388
GH10I103398 Promoter 0.5 EPDnew 550.8 -1.9 -1884 0.1 ATP5MD PDCD11 GC10M103406
GH10I103349 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.5 +45.6 45614 1.9 HDGF ZNF133 SIN3A DMAP1 GLI4 ZNF2 ZNF48 ETS1 GLIS2 ZNF213 PCGF6 PDCD11 ENSG00000260461 SLK MIR1307 ATP5MD RNU11-3P NEURL1-AS1 CALHM2 GC10M103313
GH10I103244 Enhancer 1 Ensembl ENCODE 9.9 +151.7 151746 0.3 CTCF ARID4B MAX CEBPG ZNF2 IRF4 RAD21 RFX5 TEAD3 CC2D1A RPEL1 INA RNU11-3P CNNM2 CYP17A1 MIR1307 ATP5MD PDCD11 AS3MT PFN1P11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATP5MD on UCSC Golden Path with GeneCards custom track

Genomic Locations for ATP5MD Gene

Genomic Locations for ATP5MD Gene
chr10:103,389,041-103,396,513
(GRCh38/hg38)
Size:
7,473 bases
Orientation:
Minus strand
chr10:105,148,798-105,156,270
(GRCh37/hg19)

Genomic View for ATP5MD Gene

Genes around ATP5MD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5MD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5MD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5MD Gene

Proteins for ATP5MD Gene

  • Protein details for ATP5MD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IX5-USMG5_HUMAN
    Recommended name:
    Up-regulated during skeletal muscle growth protein 5
    Protein Accession:
    Q96IX5
    Secondary Accessions:
    • B2R4N2
    • D3DR92

    Protein attributes for ATP5MD Gene

    Size:
    58 amino acids
    Molecular mass:
    6458 Da
    Quaternary structure:
    • Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.

neXtProt entry for ATP5MD Gene

Post-translational modifications for ATP5MD Gene

No Post-translational modifications

Other Protein References for ATP5MD Gene

No data available for DME Specific Peptides for ATP5MD Gene

Domains & Families for ATP5MD Gene

Gene Families for ATP5MD Gene

Protein Domains for ATP5MD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATP5MD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ATP5MD: view

No data available for UniProtKB/Swiss-Prot for ATP5MD Gene

Function for ATP5MD Gene

Molecular function for ATP5MD Gene

UniProtKB/Swiss-Prot Function:
Plays a critical role in maintaining the ATP synthase population in mitochondria.
UniProtKB/Swiss-Prot Induction:
Transactivated by SBP1.

Phenotypes From GWAS Catalog for ATP5MD Gene

genes like me logo Genes that share phenotypes with ATP5MD: view

Animal Models for ATP5MD Gene

MGI Knock Outs for ATP5MD:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5MD Gene

Localization for ATP5MD Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5MD Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5MD gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATP5MD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IBA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP5MD: view

Pathways & Interactions for ATP5MD Gene

genes like me logo Genes that share pathways with ATP5MD: view

Pathways by source for ATP5MD Gene

1 BioSystems pathway for ATP5MD Gene

Gene Ontology (GO) - Biological Process for ATP5MD Gene

None

No data available for SIGNOR curated interactions for ATP5MD Gene

Drugs & Compounds for ATP5MD Gene

No Compound Related Data Available

Transcripts for ATP5MD Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5MD Gene

No ASD Table

Relevant External Links for ATP5MD Gene

GeneLoc Exon Structure for
ATP5MD
ECgene alternative splicing isoforms for
ATP5MD

Expression for ATP5MD Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP5MD Gene:

ATP5MD

Evidence on tissue expression from TISSUES for ATP5MD Gene

  • Muscle(4.5)
  • Blood(4.4)
  • Lung(4.3)
  • Heart(2.7)
  • Kidney(2.1)
  • Adrenal gland(2)
  • Nervous system(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5MD Gene

Orthologs for ATP5MD Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATP5MD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USMG5 34 33
  • 100 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Usmg5 34 16 33
  • 90.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia USMG5 34 34 33
  • 90.23 (n)
OneToMany
dog
(Canis familiaris)
Mammalia USMG5 34 33
  • 89.66 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usmg5 33
  • 89.66 (n)
oppossum
(Monodelphis domestica)
Mammalia USMG5 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USMG5 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves USMG5 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii USMG5 34
  • 64 (a)
OneToOne
Species where no ortholog for ATP5MD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5MD Gene

ENSEMBL:
Gene Tree for ATP5MD (if available)
TreeFam:
Gene Tree for ATP5MD (if available)

Paralogs for ATP5MD Gene

Pseudogenes.org Pseudogenes for ATP5MD Gene

genes like me logo Genes that share paralogs with ATP5MD: view

No data available for Paralogs for ATP5MD Gene

Variants for ATP5MD Gene

Sequence variations from dbSNP and Humsavar for ATP5MD Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000296052 -- 103,395,727(-) T/C intron_variant
rs1001056807 -- 103,396,992(-) A/G upstream_transcript_variant
rs1001124857 -- 103,390,492(-) A/G intron_variant
rs1001297268 -- 103,396,721(-) C/T upstream_transcript_variant
rs1001468382 -- 103,398,212(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5MD Gene

Variant ID Type Subtype PubMed ID
dgv280e212 CNV gain 25503493
dgv965n100 CNV gain 25217958
dgv966n100 CNV gain 25217958
esv3577694 CNV gain 25503493
esv3624413 CNV gain 21293372
nsv7529 CNV insertion 18451855

Variation tolerance for ATP5MD Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP5MD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5MD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5MD Gene

Disorders for ATP5MD Gene

Additional Disease Information for ATP5MD

No disorders were found for ATP5MD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5MD Gene

Publications for ATP5MD Gene

  1. Organization of Subunits in the Membrane Domain of the Bovine F-ATPase Revealed by Covalent Cross-linking. (PMID: 25851905) Lee J … Walker JE (The Journal of biological chemistry 2015) 2 3 58
  2. Cellular and tissue expression of DAPIT, a phylogenetically conserved peptide. (PMID: 22688299) Kontro H … Kainulainen H (European journal of histochemistry : EJH 2012) 2 3 58
  3. Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondria. (PMID: 21345788) Ohsakaya S … Yoshida M (The Journal of biological chemistry 2011) 3 4 58
  4. Association of two proteolipids of unknown function with ATP synthase from bovine heart mitochondria. (PMID: 17570365) Chen R … Walker JE (FEBS letters 2007) 2 3 58
  5. Identification of two proteins associated with mammalian ATP synthase. (PMID: 17575325) Meyer B … Schägger H (Molecular & cellular proteomics : MCP 2007) 2 3 58

Products for ATP5MD Gene

Sources for ATP5MD Gene

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