ATP5L2 Gene
protein-coding GIFtS: 35
GCID: GC22M043036
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|
ATP synthase, H+ transporting, mitochondrial Fo complex,...(Previous names: ATP synthase, H+ transporting, mitochondrial F1F0, subunit...)
(Previous symbol: ATP5K2)
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Aliases
for ATP5L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit G21 2 | | ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G, Isoform 21 | | ATP5K21 2 3 | | ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G21 | | ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G2 Pseudogene1 2 | | DJ222E13.51 | | ATP Synthase, H+ Transporting, Mitochondrial F1F0, Subunit G1 2 | | ATP Synthase Subunit G 2, Mitochondrial2 | | ATPase Subunit G 22 3 | | |
| External Ids: | HGNC: 132131 | Entrez Gene: 2670202 | Ensembl: ENSG000002492227 | UniProtKB: Q7Z4Y83 | | ORGUL members: | |
|---|
| NONCODE:n384181 | |
Export aliases for ATP5L2 gene to outside databasesPrevious GC identifers: GC22U900021 GC22M041266 GC22M041360 GC22M025996
|---|
Summaries
for ATP5L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AT5L2_HUMAN, Q7Z4Y8Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in thepresence of a proton gradient across the membrane which is generated by electron transport complexes of therespiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalyticcore, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalksubunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in themembrane (By similarity)
|
Genomic Views
for ATP5L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ATP5L2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATP5L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP5L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2ATP5L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M043036: view genomic region
(about GC identifiers)
Start:
|
43,035,809 bp from pter |
End:
|
43,036,607 bp from pter |
Size:
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799 bases |
Orientation:
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minus strand |
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Proteins
for ATP5L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AT5L2_HUMAN, Q7Z4Y8 (See
protein sequence)Recommended Name: ATP synthase subunit g 2, mitochondrial Size: 100 amino acids; 11037 Da
Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0)seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L)
Subcellular location: Mitochondrion membrane (By similarity)
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for ATP5L2: NX_Q7Z4Y8
ATP5L2 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001159349.1
ENSEMBL proteins: ENSP00000421076
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) |
IEA | -- |
ATP5L2 for ontologies About GeneDecksing
ATP5L2 Antibody Products:
Assay Products for ATP5L2: |
Protein
Domains /
Families
for ATP5L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATP5L2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z4Y8ProtoNet protein and cluster: Q7Z4Y8 1 Blocks protein family: IPB006808 Mitochondrial ATP synthase g subunit
UniProtKB/Swiss-Prot: AT5L2_HUMAN, Q7Z4Y8Similarity: Belongs to the ATPase g subunit family |
Function
for ATP5L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AT5L2_HUMAN, Q7Z4Y8Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in thepresence of a proton gradient across the membrane which is generated by electron transport complexes of therespiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalyticcore, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalksubunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in themembrane (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP5L2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP5L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015078 | hydrogen ion transmembrane transporter activity |
IEA | -- |
ATP5L2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ATP5L2:
|
Pathways & Interactions
for ATP5L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP5L2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015986 | ATP synthesis coupled proton transport |
IEA | -- |
ATP5L2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ATP5L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ATP5L2
Search CenterWatch for drugs/clinical trials and news about ATP5L2 / AT5L2
|
Transcripts
for ATP5L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATP5L2 gene: NM_001165877.1 Unigene Cluster for ATP5L2: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2 Hs.664737 [show with all ESTs]Unigene Representative Sequence: BG1139281 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000505920(uc003bda.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP5L2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP5L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ATP5L2 (NM_001165877) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATP5L2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP5L2 |
Additional cDNA sequence: AF092923.1 BC093719.1 BC093721.1 3 DOTS entries: DT.101986295 DT.40122977 DT.95374133 6 AceView cDNA sequences: NM_198822 AF092923 AI242903 AI249062 AA699849 BU584668
GeneLoc Exon Structure
|
Expression
for ATP5L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATP5L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTCCATTTG
About this image
SOURCE GeneReport for Unigene cluster: Hs.664737
SABiosciences Custom PCR Arrays for ATP5L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP5L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ATP5L2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP5L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP5L2 |
Orthologs
for ATP5L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ATP5L2 gene from 5/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
Uncharacterized protein |
55(a) |
1 → many |
24(4426650-4429477) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
62(a) |
1 → many |
GL343767.1(76879-78696) |
zebrafish
(Danio rerio) |
Actinopterygii |
atp5l6 |
ATP synthase, H+ transporting, mitochondrial F0 co... |
59(a) |
1 → many |
5(32338277-32340908) |
fruit fly
(Drosophila melanogaster) |
Insecta |
l(2)062256CG72116 |
-- |
46(a)35(a) |
many ↔ manymany ↔ many |
2L(10975552-10976422) 2L(7747343-7747874) |
worm
(Caenorhabditis elegans) |
Secernentea |
asg-26asg-16 |
Probable ATP synthase subunit g 1, mitochondrial |
24(a)24(a) |
many ↔ manymany ↔ many |
X(6841216-6842164) I(8692938-8693463) |
Species with no ortholog for ATP5L2
ENSEMBL Gene Tree for ATP5L2 (if available)
TreeFam Gene Tree for ATP5L2 (if available) |
Paralogs
for ATP5L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATP5L2 gene
- ATP5L2
1 SIMAP similar gene for ATP5L2 using alignment to 1 protein entry: AT5L2_HUMAN:ATP5L
ATP5L2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ATP5L2
PGOHUM00000250702
|
Genomic Variants
for ATP5L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ATP5L2
2 CNVs: 3242 4129 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ATP5L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATP5L2 for disorders About GeneDecksing
3  diseases for ATP5L2: About MalaCardscomplex v hermaphroditism neuronitis
Export disorders for ATP5L2 gene to outside databases
|
Publications
for ATP5L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATP5L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ATP5L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Sequence of a cDNA encoding mouse F1F0-ATP synthase g subunit. (PubMed id 10361692)1 Jeon D....Baik M. (1999)
|
External Searches for ATP5L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ATP5L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATP5L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ATP5L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ATP5L2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ATP5L2 gene:
Search GeneIP for patents involving ATP5L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ATP5L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | Search Tocris compounds for ATP5L2 |
| |  |  |  |  | | | | |
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 |
 | | | ATP5L2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ATP5L2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP5L2 |
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