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ATP5L2 Gene

protein-coding   GIFtS: 37
GCID: GC22M043036

ATP Synthase, H+ Transporting, Mitochondrial Fo Complex,...

(Previous names: ATP synthase, H+ transporting, mitochondrial F1F0, subunit...)
(Previous symbol: ATP5K2)
  Search for ATP5L2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit G21 2     ATPase Subunit G 22 3
ATP5K21 2 3     ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G,
Isoform 21
ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G2
Pseudogene1 2
     ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G21
ATP Synthase, H+ Transporting, Mitochondrial F1F0, Subunit G1 2     ATP Synthase Subunit G 2, Mitochondrial2

External Ids:    HGNC: 132131   Entrez Gene: 2670202   Ensembl: ENSG000002492227   UniProtKB: Q7Z4Y83   

Export aliases for ATP5L2 gene to outside databases

Previous GC identifers: GC22U900021 GC22M041266 GC22M041360 GC22M025996


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATP5L2 Gene:
ATP5L2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2) is a protein-coding gene. GO annotations related to this gene include hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5L.

UniProtKB/Swiss-Prot: AT5L2_HUMAN, Q7Z4Y8
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
presence of a proton gradient across the membrane which is generated by electron transport complexes of the
respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous
catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a
peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary
mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit
located with subunit a in the membrane (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ATP5L2
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP5L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

ATP5L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP5L2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M043036:  view genomic region     (about GC identifiers)

Start:
43,035,809 bp from pter      End:
43,036,607 bp from pter
Size:
799 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB/Swiss-Prot: AT5L2_HUMAN, Q7Z4Y8 (See protein sequence)
Recommended Name: ATP synthase subunit g 2, mitochondrial  
Size: 100 amino acids; 11037 Da
Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L)
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for ATP5L2: NX_Q7Z4Y8

REFSEQ proteins: NP_001159349.1  
ENSEMBL proteins: 
 ENSP00000421076  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FATP: Mitochondrial respiratory chain complex / Complex V
F1ATP: ATPases / F-type

IUPHAR Guide to PHARMACOLOGY protein family classification: G2
F-type ATPase

2 InterPro protein domains:
 IPR016702 ATP-Synthase_su_G_mt_met
 IPR006808 ATPase_F0-cplx_gsu_mt

Graphical View of Domain Structure for InterPro Entry Q7Z4Y8

ProtoNet protein and cluster: Q7Z4Y8

1 Blocks protein domain: IPB006808 Mitochondrial ATP synthase g subunit

UniProtKB/Swiss-Prot: AT5L2_HUMAN, Q7Z4Y8
Similarity: Belongs to the ATPase g subunit family


Find genes that share domains with ATP5L2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AT5L2_HUMAN, Q7Z4Y8
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
presence of a proton gradient across the membrane which is generated by electron transport complexes of the
respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous
catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a
peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary
mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit
located with subunit a in the membrane (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0015078hydrogen ion transmembrane transporter activity IEA--
     
Find genes that share ontologies with ATP5L2           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for ATP5L2:
 Elongated cells  Increased gamma-H2AX phosphory 

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
AT5L2_HUMAN, Q7Z4Y8: Mitochondrion membrane (By similarity)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000276mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA--

Find genes that share ontologies with ATP5L2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ATP5L2 About    
See pathways by source

SuperPathContained pathways About
1purine nucleotide salvage
purine nucleotide salvage0.78
adenosine ribonucleotides de novo biosynthesis0.51
purine nucleotides de novo biosynthesis0.78


3 BioSystems Pathways for ATP5L2
    purine nucleotides de novo biosynthesis
purine nucleotide salvage
adenosine ribonucleotides de novo biosynthesis


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Interactions:

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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0015986ATP synthesis coupled proton transport IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ATP5L2 (AT5L2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ATP5L2 gene: 
NM_001165877.1  

Unigene Cluster for ATP5L2:

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
Hs.664737  [show with all ESTs]
Unigene Representative Sequence: BG113928
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000505920(uc003bda.1)
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Additional mRNA sequence: 

AF092923.1 BC093719.1 BC093721.1 

3 DOTS entries:

DT.101986295  DT.40122977  DT.95374133 

6 AceView cDNA sequences:

NM_198822 AF092923 AI249062 AI242903 AA699849 BU584668 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ATP5L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTCCATTTG
ATP5L2 Expression
About this image

ATP5L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.664737
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ATP5L2 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
58(a)
1 → many
24(4389355-4392182)
zebrafish
(Danio rerio)
Actinopterygii atp5l6
ATP synthase, H+ transporting, mitochondrial F0 co...
59(a)
1 → many
5(32338277-32340908) ENSDARG00000011841
fruit fly
(Drosophila melanogaster)
Insecta l(2)062256
CG72116
--
49(a)
36(a)
many ↔ many
many ↔ many
2L(10975552-10976422)
2L(7747343-7747874)
        Species with no ortholog for ATP5L2

ENSEMBL Gene Tree for ATP5L2 (if available)
TreeFam Gene Tree for ATP5L2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ATP5L2 gene
ATP5L2  
1 SIMAP similar gene for ATP5L2 using alignment to 1 protein entry:     AT5L2_HUMAN:
ATP5L

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1 Pseudogenes.org Pseudogene for ATP5L2
PGOHUM00000250702


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 7 variations for ATP5L2:    About this table    
Variant IDTypeSubtypePubMed ID
dgv4983n71CNV Loss21882294
nsv915180CNV Loss21882294
nsv915185CNV Gain21882294
nsv428391CNV Gain18775914
essv4940CNV CNV17122850
essv20414CNV CNV17122850
dgv1407e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ATP5L2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ATP5L2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Sequence of a cDNA encoding mouse F1F0-ATP synthase g subunit. (PubMed id 10361692)1 Jeon D....Baik M. (Biosci. Biotechnol. Biochem. 1999)
  4. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 267020 HGNC: 13213 AceView: ATP5L2 Ensembl:ENSG00000249222 euGenes: HUgn267020
ECgene: ATP5L2 H-InvDB: ATP5L2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ATP5L2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ATP5L2 gene:
Search GeneIP for patents involving ATP5L2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Proteins for ATP5L2
 Antibodies for ATP5L2
 ELISAs for ATP5L2
 CLIAs for ATP5L2



 Browse ESI BIO Cell Lines and PureStem Progenitors for ATP5L2
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP5L2
 Browse SwitchGear 3'UTR luciferase reporter plasmids for ATP5L2
 Browse SwitchGear Promoter luciferase reporter plasmids for ATP5L2
 Search ThermoFisher Antibodies for ATP5L2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP5L2
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATP5L2
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATP5L2
 LSBio Antibodies in human, mouse, rat for ATP5L2
Customized transgenic rodents for:
 Humanization
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 Tissue-specific gene expresssion
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 Browse compounds at ApexBio
 Search Addgene for plasmids for ATP5L2
  Search eBioscience for proteins for ATP5L2
  Search eBioscience for elisas for ATP5L2
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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