Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATP5L2 Gene

Aliases for ATP5L2 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit G2 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G2 Pseudogene 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial F1F0, Subunit G 2 3
  • ATPase Subunit G 2 3 4
  • ATP5K2 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G, Isoform 2 2
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G2 2
  • ATP Synthase Subunit G 2, Mitochondrial 3

External Ids for ATP5L2 Gene

Previous HGNC Symbols for ATP5L2 Gene

  • ATP5K2

Previous GeneCards Identifiers for ATP5L2 Gene

  • GC22U900021
  • GC22M041266
  • GC22M041360
  • GC22M043036
  • GC22M025996

Summaries for ATP5L2 Gene

GeneCards Summary for ATP5L2 Gene

ATP5L2 (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit G2) is a Protein Coding gene. Among its related pathways are purine nucleotide salvage and purine nucleotide salvage. GO annotations related to this gene include hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5L.

UniProtKB/Swiss-Prot for ATP5L2 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5L2 Gene

Genomics for ATP5L2 Gene

Genomic Location for ATP5L2 Gene

Start:
42,639,803 bp from pter
End:
42,640,601 bp from pter
Size:
799 bases
Orientation:
Minus strand

Genomic View for ATP5L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5L2 Gene

No data available for Regulatory Elements for ATP5L2 Gene

Proteins for ATP5L2 Gene

  • Protein details for ATP5L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4Y8-AT5L2_HUMAN
    Recommended name:
    ATP synthase subunit g 2, mitochondrial
    Protein Accession:
    Q7Z4Y8
    Secondary Accessions:

    Protein attributes for ATP5L2 Gene

    Size:
    100 amino acids
    Molecular mass:
    11037 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L)

neXtProt entry for ATP5L2 Gene

Proteomics data for ATP5L2 Gene at MOPED

Post-translational modifications for ATP5L2 Gene

No Post-translational modifications

Other Protein References for ATP5L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ATP5L2 Gene

Domains for ATP5L2 Gene

Gene Families for ATP5L2 Gene

HGNC:
  • F1ATP :ATPases / F-type
  • FATP :Mitochondrial respiratory chain complex / Complex V
IUPHAR :

Protein Domains for ATP5L2 Gene

Suggested Antigen Peptide Sequences for ATP5L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z4Y8

UniProtKB/Swiss-Prot:

AT5L2_HUMAN :
  • Q7Z4Y8
Family:
  • Belongs to the ATPase g subunit family.
genes like me logo Genes that share domains with ATP5L2: view

Function for ATP5L2 Gene

Molecular function for ATP5L2 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).

Gene Ontology (GO) - Molecular Function for ATP5L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with ATP5L2: view

Phenotypes for ATP5L2 Gene

GenomeRNAi human phenotypes for ATP5L2:
genes like me logo Genes that share phenotypes with ATP5L2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATP5L2 Gene

Localization for ATP5L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5L2 Gene

Mitochondrion membrane.

Gene Ontology (GO) - Cellular Components for ATP5L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
genes like me logo Genes that share ontologies with ATP5L2: view

No data available for Subcellular locations from COMPARTMENTS for ATP5L2 Gene

Pathways for ATP5L2 Gene

genes like me logo Genes that share pathways with ATP5L2: view

Pathways by source for ATP5L2 Gene

Interacting Proteins for ATP5L2 Gene

Gene Ontology (GO) - Biological Process for ATP5L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015986 ATP synthesis coupled proton transport IEA --
genes like me logo Genes that share ontologies with ATP5L2: view

Transcripts for ATP5L2 Gene

mRNA/cDNA for ATP5L2 Gene

(6) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP5L2 Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5L2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5L2 Gene

No ASD Table

Relevant External Links for ATP5L2 Gene

GeneLoc Exon Structure for
ATP5L2
ECgene alternative splicing isoforms for
ATP5L2

Expression for ATP5L2 Gene

mRNA expression in normal human tissues for ATP5L2 Gene

SOURCE GeneReport for Unigene cluster for ATP5L2 Gene Hs.664737

genes like me logo Genes that share expressions with ATP5L2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ATP5L2 Gene

Orthologs for ATP5L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP5L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5L2 35
  • 98 (n)
  • 97 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 81 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
ATP5L 36
  • 83 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atp5l 36
  • 72 (a)
ManyToMany
Atp5l-ps1 36
  • 73 (a)
ManyToMany
Gm10221 36
  • 72 (a)
ManyToMany
Gm5426 36
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii atp5l 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7211 36
  • 36 (a)
ManyToMany
l(2)06225 36
  • 49 (a)
ManyToMany
Species with no ortholog for ATP5L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5L2 Gene

ENSEMBL:
Gene Tree for ATP5L2 (if available)
TreeFam:
Gene Tree for ATP5L2 (if available)

Paralogs for ATP5L2 Gene

Paralogs for ATP5L2 Gene

Selected SIMAP similar genes for ATP5L2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ATP5L2 Gene

genes like me logo Genes that share paralogs with ATP5L2: view

Variants for ATP5L2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ATP5L2 Gene

Variant ID Type Subtype PubMed ID
dgv1407e1 CNV Complex 17122850
nsv428391 CNV Gain 18775914
essv4940 CNV CNV 17122850
essv20414 CNV CNV 17122850
nsv915180 CNV Loss 21882294
dgv4983n71 CNV Loss 21882294
nsv915185 CNV Gain 21882294

Relevant External Links for ATP5L2 Gene

HapMap Linkage Disequilibrium report
ATP5L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ATP5L2 Gene

Disorders for ATP5L2 Gene

No disorders were found for ATP5L2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ATP5L2 Gene

Publications for ATP5L2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Sequence of a cDNA encoding mouse F1F0-ATP synthase g subunit. (PMID: 10361692) Jeon D. … Baik M. (Biosci. Biotechnol. Biochem. 1999) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ATP5L2 Gene

Sources for ATP5L2 Gene

Back to Top

Content