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Aliases for ATP5L Gene

Aliases for ATP5L Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit G 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G 2 3
  • ATPase Subunit G 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F1F0, Subunit G 3
  • F1Fo-ATP Synthase Complex Fo Membrane Domain G Subunit 3
  • ATP Synthase Subunit G, Mitochondrial 3
  • ATP Synthase G Chain, Mitochondrial 3
  • F1F0-Type ATP Synthase Subunit G 3
  • ATP5JG 3

External Ids for ATP5L Gene

Previous GeneCards Identifiers for ATP5L Gene

  • GC11P120628
  • GC11P119784
  • GC11P118305
  • GC11P117809
  • GC11P117777
  • GC11P114206
  • GC11P118271

Summaries for ATP5L Gene

Entrez Gene Summary for ATP5L Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5L Gene

ATP5L (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit G) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ATPase activity and hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5L2.

UniProtKB/Swiss-Prot for ATP5L Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane

Gene Wiki entry for ATP5L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5L Gene

Genomics for ATP5L Gene

Regulatory Elements for ATP5L Gene

Genomic Location for ATP5L Gene

Start:
118,401,154 bp from pter
End:
118,431,496 bp from pter
Size:
30,343 bases
Orientation:
Plus strand

Genomic View for ATP5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5L Gene

Proteins for ATP5L Gene

  • Protein details for ATP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75964-ATP5L_HUMAN
    Recommended name:
    ATP synthase subunit g, mitochondrial
    Protein Accession:
    O75964
    Secondary Accessions:
    • A8K0K3
    • Q96BV6
    • Q9UBZ7

    Protein attributes for ATP5L Gene

    Size:
    103 amino acids
    Molecular mass:
    11428 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5L Gene

Proteomics data for ATP5L Gene at MOPED

Post-translational modifications for ATP5L Gene

  • Ubiquitination at Lys24 and Lys66
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP5L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5L Gene

Domains for ATP5L Gene

Gene Families for ATP5L Gene

HGNC:
  • F1ATP :ATPases / F-type
  • FATP :Mitochondrial respiratory chain complex / Complex V

Protein Domains for ATP5L Gene

Suggested Antigen Peptide Sequences for ATP5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75964

UniProtKB/Swiss-Prot:

ATP5L_HUMAN :
  • O75964
Family:
  • Belongs to the ATPase g subunit family.
genes like me logo Genes that share domains with ATP5L: view

Function for ATP5L Gene

Molecular function for ATP5L Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane

Gene Ontology (GO) - Molecular Function for ATP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
genes like me logo Genes that share ontologies with ATP5L: view

Animal Model Products

miRNA for ATP5L Gene

miRTarBase miRNAs that target ATP5L

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP5L Gene

Localization for ATP5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5L Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5L Gene COMPARTMENTS Subcellular localization image for ATP5L gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ATP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ATP5L: view

Pathways for ATP5L Gene

genes like me logo Genes that share pathways with ATP5L: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat

Gene Ontology (GO) - Biological Process for ATP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0015986 ATP synthesis coupled proton transport --
GO:0022904 respiratory electron transport chain TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with ATP5L: view

Transcripts for ATP5L Gene

Unigene Clusters for ATP5L Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3: - -
SP4:

Relevant External Links for ATP5L Gene

GeneLoc Exon Structure for
ATP5L
ECgene alternative splicing isoforms for
ATP5L

Expression for ATP5L Gene

mRNA expression in normal human tissues for ATP5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ATP5L Gene

This gene is overexpressed in Nasal epithelium (22.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5L Gene

SOURCE GeneReport for Unigene cluster for ATP5L Gene Hs.486360

genes like me logo Genes that share expressions with ATP5L: view

Expression partners for ATP5L Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP5L Gene

Orthologs for ATP5L Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP5L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP5L 35
  • 91.26 (n)
  • 93.2 (a)
-- 36
  • 91 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
ATP5L 36
  • 93 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ATP5L 35
  • 92.56 (n)
  • 90.29 (a)
-- 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atp5l 35
  • 87.7 (n)
  • 82.52 (a)
Atp5l 16
Atp5l 36
  • 83 (a)
ManyToMany
Atp5l-ps1 36
  • 80 (a)
ManyToMany
Gm10221 36
  • 83 (a)
ManyToMany
Gm5426 36
  • 76 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ATP5L 35
  • 100 (n)
  • 100 (a)
ATP5L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5l 35
  • 86.41 (n)
  • 78.64 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATP5L 35
  • 74.81 (n)
  • 76.74 (a)
-- 36
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5l 35
  • 66.02 (n)
  • 66.02 (a)
Str.2477 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23932 35
zebrafish
(Danio rerio)
Actinopterygii atp5l 35
  • 67.31 (n)
  • 70.87 (a)
mgbb02g11 35
atp5l 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009491 35
  • 51.2 (n)
  • 45.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)06225 35
  • 57.39 (n)
  • 54.64 (a)
CG7211 36
  • 42 (a)
ManyToMany
l(2)06225 36
  • 56 (a)
ManyToMany
Species with no ortholog for ATP5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5L Gene

ENSEMBL:
Gene Tree for ATP5L (if available)
TreeFam:
Gene Tree for ATP5L (if available)

Paralogs for ATP5L Gene

Paralogs for ATP5L Gene

Selected SIMAP similar genes for ATP5L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP5L: view

Variants for ATP5L Gene

Relevant External Links for ATP5L Gene

HapMap Linkage Disequilibrium report
ATP5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for ATP5L Gene

Disorders for ATP5L Gene

Relevant External Links for ATP5L

Genetic Association Database (GAD)
ATP5L
Human Genome Epidemiology (HuGE) Navigator
ATP5L

No disorders were found for ATP5L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ATP5L Gene

Publications for ATP5L Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 48
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ATP5L Gene

Sources for ATP5L Gene

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