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Aliases for ATP5L Gene

Aliases for ATP5L Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit G 2 3 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G 2 3
  • ATPase Subunit G 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit G 2
  • ATP Synthase, H+ Transporting, Mitochondrial F1F0, Subunit G 3
  • F1Fo-ATP Synthase Complex Fo Membrane Domain G Subunit 3
  • ATP Synthase Subunit G, Mitochondrial 3
  • ATP Synthase G Chain, Mitochondrial 3
  • F1F0-Type ATP Synthase Subunit G 3
  • ATP5JG 3

External Ids for ATP5L Gene

Previous GeneCards Identifiers for ATP5L Gene

  • GC11P120628
  • GC11P119784
  • GC11P118305
  • GC11P117809
  • GC11P117777
  • GC11P114206
  • GC11P118271

Summaries for ATP5L Gene

Entrez Gene Summary for ATP5L Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5L Gene

ATP5L (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit G) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and purine nucleotides de novo biosynthesis. GO annotations related to this gene include ATPase activity and hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5L2.

UniProtKB/Swiss-Prot for ATP5L Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Wiki entry for ATP5L Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5L Gene

Genomics for ATP5L Gene

Regulatory Elements for ATP5L Gene

Enhancers for ATP5L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G118433 1.9 VISTA Ensembl ENCODE dbSUPER 10.6 +36.9 36935 8.2 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 IFT46 THY1 CCDC84 LOC101929089 TMEM25 ATP5L ENSG00000254873 HINFP DSCAML1 ARCN1
GH11G118603 2 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +207.5 207474 9.9 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF207 IFT46 TREHP1 LOC105369519 TREH ENSG00000255176 ARCN1 TTC36 ENSG00000255384 KMT2A ENSG00000254873
GH11G118614 1.7 FANTOM5 ENCODE dbSUPER 9.4 +218.2 218216 9.2 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A ARID4B YBX1 DMAP1 ZBTB7B TREHP1 LOC105369519 TREH IFT46 RNU6-1157P ARCN1 RPL5P30 ENSG00000255384 KMT2A ATP5L
GH11G118442 1.3 Ensembl ENCODE dbSUPER 10.9 +42.1 42085 1.1 TBL1XR1 BACH1 BMI1 RELA ZFHX2 GATA3 ARID3A POLR2A EED ETV6 ATP5L ENSG00000254873 LOC101929089 TMEM25 TTC36 KMT2A GC11M118474
GH11G118601 0.9 ENCODE dbSUPER 9.3 +201.1 201063 1.1 HDAC1 FOXA2 NR2F2 ARID1B POLR2H IKZF1 HMBOX1 NBN MLLT1 IFT46 ENSG00000255176 TREH ARCN1 TTC36 ATP5L ENSG00000254873 PHLDB1 RNU6-1157P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP5L on UCSC Golden Path with GeneCards custom track

Promoters for ATP5L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045626 646 2001 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF207

Genomic Location for ATP5L Gene

Chromosome:
11
Start:
118,401,154 bp from pter
End:
118,431,496 bp from pter
Size:
30,343 bases
Orientation:
Plus strand

Genomic View for ATP5L Gene

Genes around ATP5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5L Gene

Proteins for ATP5L Gene

  • Protein details for ATP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75964-ATP5L_HUMAN
    Recommended name:
    ATP synthase subunit g, mitochondrial
    Protein Accession:
    O75964
    Secondary Accessions:
    • A8K0K3
    • Q96BV6
    • Q9UBZ7

    Protein attributes for ATP5L Gene

    Size:
    103 amino acids
    Molecular mass:
    11428 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5L Gene

Post-translational modifications for ATP5L Gene

  • Ubiquitination at posLast=2424 and Lys66
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP5L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5L Gene

Domains & Families for ATP5L Gene

Protein Domains for ATP5L Gene

Suggested Antigen Peptide Sequences for ATP5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75964

UniProtKB/Swiss-Prot:

ATP5L_HUMAN :
  • Belongs to the ATPase g subunit family.
Family:
  • Belongs to the ATPase g subunit family.
genes like me logo Genes that share domains with ATP5L: view

Function for ATP5L Gene

Molecular function for ATP5L Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Ontology (GO) - Molecular Function for ATP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
GO:0046933 contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA --
genes like me logo Genes that share ontologies with ATP5L: view
genes like me logo Genes that share phenotypes with ATP5L: view

Animal Models for ATP5L Gene

MGI Knock Outs for ATP5L:

Animal Model Products

CRISPR Products

miRNA for ATP5L Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5L Gene

Localization for ATP5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5L Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5L gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ATP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP5L: view

Pathways & Interactions for ATP5L Gene

genes like me logo Genes that share pathways with ATP5L: view

Gene Ontology (GO) - Biological Process for ATP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IEA,IBA --
GO:0015992 proton transport IEA --
genes like me logo Genes that share ontologies with ATP5L: view

No data available for SIGNOR curated interactions for ATP5L Gene

Drugs & Compounds for ATP5L Gene

No Compound Related Data Available

Transcripts for ATP5L Gene

Unigene Clusters for ATP5L Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3: - -
SP4:

Relevant External Links for ATP5L Gene

GeneLoc Exon Structure for
ATP5L
ECgene alternative splicing isoforms for
ATP5L

Expression for ATP5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP5L Gene

Protein differential expression in normal tissues from HIPED for ATP5L Gene

This gene is overexpressed in Nasal epithelium (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP5L Gene



Protein tissue co-expression partners for ATP5L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP5L Gene:

ATP5L

SOURCE GeneReport for Unigene cluster for ATP5L Gene:

Hs.486360

Evidence on tissue expression from TISSUES for ATP5L Gene

  • Nervous system(4.8)
  • Blood(4.5)
  • Kidney(4.5)
  • Liver(4.5)
  • Lung(4.5)
  • Heart(2.8)
  • Spleen(2.4)
  • Intestine(2.3)
  • Muscle(2.3)
  • Adrenal gland(2)
  • Lymph node(2)
  • Pancreas(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ATP5L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5L Gene

Orthologs for ATP5L Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5L 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia ATP5L 34
  • 92.56 (n)
-- 35
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ATP5L 34 35
  • 91.26 (n)
-- 35
  • 91 (a)
ManyToMany
-- 35
  • 91 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Atp5l 16 35 34
  • 87.7 (n)
Gm10221 35
  • 83 (a)
ManyToMany
Atp5l-ps1 35
  • 80 (a)
ManyToMany
Gm5426 35
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Atp5l 34
  • 86.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATP5L 34
  • 74.81 (n)
-- 35
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5l 34
  • 66.02 (n)
Str.2477 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23932 34
zebrafish
(Danio rerio)
Actinopterygii atp5l 34 35
  • 67.31 (n)
mgbb02g11 34
fruit fly
(Drosophila melanogaster)
Insecta l(2)06225 35 34
  • 57.39 (n)
ManyToMany
CG7211 35
  • 42 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009491 34
  • 51.2 (n)
Species where no ortholog for ATP5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5L Gene

ENSEMBL:
Gene Tree for ATP5L (if available)
TreeFam:
Gene Tree for ATP5L (if available)

Paralogs for ATP5L Gene

Paralogs for ATP5L Gene

(1) SIMAP similar genes for ATP5L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP5L: view

Variants for ATP5L Gene

Sequence variations from dbSNP and Humsavar for ATP5L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000696808 -- 118,401,075(+) CCACT(A/G)CACTT intron-variant, upstream-variant-2KB
rs1001185452 -- 118,408,510(+) TACTT(A/G)GTCAG intron-variant
rs1001672645 -- 118,408,192(+) AACTG(C/G)AACTT intron-variant
rs1003402595 -- 118,403,240(+) CCTGT(A/C)ATCTC intron-variant
rs1003455491 -- 118,402,890(+) GACGG(A/G)ATTTC intron-variant

Variation tolerance for ATP5L Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATP5L Gene

Disorders for ATP5L Gene

Relevant External Links for ATP5L

Genetic Association Database (GAD)
ATP5L
Human Genome Epidemiology (HuGE) Navigator
ATP5L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5L

No disorders were found for ATP5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5L Gene

Publications for ATP5L Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 46 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ATP5L Gene

Sources for ATP5L Gene

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