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Aliases for ATP5J2 Gene

Aliases for ATP5J2 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit F2 2 3 5
  • F1Fo-ATP Synthase Complex Fo Membrane Domain F Subunit 2 3
  • ATP Synthase F Chain, Mitochondrial 2 3
  • F1Fo-ATPase Synthase F Subunit 2 3
  • ATP5JL 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit F, Isoform 2 2
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit F2 2
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit F2 2
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit F 3
  • ATP Synthase Subunit F, Mitochondrial 3
  • F1F0-Type ATPase Subunit F 3

External Ids for ATP5J2 Gene

Previous GeneCards Identifiers for ATP5J2 Gene

  • GC07M097590
  • GC07M098653
  • GC07M098667
  • GC07M098700
  • GC07M098893
  • GC07M099046
  • GC07M093692

Summaries for ATP5J2 Gene

Entrez Gene Summary for ATP5J2 Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for ATP5J2 Gene

ATP5J2 (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit F2) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ATPase activity and transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5J2 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Wiki entry for ATP5J2 Gene

Additional gene information for ATP5J2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5J2 Gene

Genomics for ATP5J2 Gene

Regulatory Elements for ATP5J2 Gene

Enhancers for ATP5J2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H099557 1.7 Ensembl ENCODE dbSUPER 18.6 -94.7 -94656 7 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZSCAN25 PTCD1 ZNF655 TRIM4 ZNF394 LOC101927550 ZNF3 LOC100419643 PPP1R35 TRRAP
GH07H099373 1.8 FANTOM5 ENCODE dbSUPER 7 +88.0 88023 8 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 ZNF207 ZSCAN25 TRRAP LOC101927550 ZNF655 ZNF394 TRIM4 ENSG00000242798 AP4M1 PTCD1 ZNF3
GH07H099371 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.6 +93.6 93581 1 ATF1 MLX ZFP64 ARID4B DMAP1 ATF7 SP5 MXD4 NFYC MIER2 ARPC1B ATP5J2 PILRB CPSF4 PTCD1 PIR48819
GH07H099392 1.4 FANTOM5 ENCODE dbSUPER 7.3 +73.2 73193 1 HDAC1 MXI1 KLF1 ATF1 BACH1 SIN3A MAX CCNT2 CTBP1 POLR2A ARPC1B ATP5J2 GC07P099389 BUD31
GH07H099471 1.1 ENCODE 9 -6.3 -6273 2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZSCAN25 PTCD1 PPP1R35 TRRAP TRIM4 MEPCE STAG3L5P LOC100419643 AP4M1 LOC101927550
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP5J2 on UCSC Golden Path with GeneCards custom track

Promoters for ATP5J2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215668 331 1201 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for ATP5J2 Gene

Chromosome:
7
Start:
99,448,475 bp from pter
End:
99,466,331 bp from pter
Size:
17,857 bases
Orientation:
Minus strand

Genomic View for ATP5J2 Gene

Genes around ATP5J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5J2 Gene

Proteins for ATP5J2 Gene

  • Protein details for ATP5J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56134-ATPK_HUMAN
    Recommended name:
    ATP synthase subunit f, mitochondrial
    Protein Accession:
    P56134
    Secondary Accessions:
    • C9J8H9
    • F8W7V3
    • O76079
    • Q6IBB3
    • Q96L83
    • Q9BTI8

    Protein attributes for ATP5J2 Gene

    Size:
    94 amino acids
    Molecular mass:
    10918 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

    Alternative splice isoforms for ATP5J2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP5J2 Gene

Post-translational modifications for ATP5J2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATP5J2 Gene

Domains & Families for ATP5J2 Gene

Gene Families for ATP5J2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ATP5J2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATP5J2 Gene

Graphical View of Domain Structure for InterPro Entry

P56134

UniProtKB/Swiss-Prot:

ATPK_HUMAN :
  • Belongs to the ATPase F chain family.
Family:
  • Belongs to the ATPase F chain family.
genes like me logo Genes that share domains with ATP5J2: view

Function for ATP5J2 Gene

Molecular function for ATP5J2 Gene

GENATLAS Biochemistry:
ATP synthase H+ transporting,inner mitochondrial membrane (F0 segment),subunit F6,isoform 2,complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Phenotypes From GWAS Catalog for ATP5J2 Gene

Gene Ontology (GO) - Molecular Function for ATP5J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
genes like me logo Genes that share ontologies with ATP5J2: view
genes like me logo Genes that share phenotypes with ATP5J2: view

Animal Model Products

CRISPR Products

miRNA for ATP5J2 Gene

miRTarBase miRNAs that target ATP5J2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ATP5J2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5J2 Gene

Localization for ATP5J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5J2 Gene

Mitochondrion. Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5J2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
peroxisome 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATP5J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with ATP5J2: view

Pathways & Interactions for ATP5J2 Gene

genes like me logo Genes that share pathways with ATP5J2: view

Gene Ontology (GO) - Biological Process for ATP5J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015992 proton transport NAS 11959398
GO:0042407 cristae formation TAS --
genes like me logo Genes that share ontologies with ATP5J2: view

No data available for SIGNOR curated interactions for ATP5J2 Gene

Drugs & Compounds for ATP5J2 Gene

(2) Drugs for ATP5J2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
ATP Nutra Agonist 0

(2) Additional Compounds for ATP5J2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with ATP5J2: view

Transcripts for ATP5J2 Gene

Unigene Clusters for ATP5J2 Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ATP5J2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5J2 Gene

No ASD Table

Relevant External Links for ATP5J2 Gene

GeneLoc Exon Structure for
ATP5J2
ECgene alternative splicing isoforms for
ATP5J2

Expression for ATP5J2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP5J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATP5J2 Gene

This gene is overexpressed in Heart (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP5J2 Gene



Protein tissue co-expression partners for ATP5J2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP5J2 Gene:

ATP5J2

SOURCE GeneReport for Unigene cluster for ATP5J2 Gene:

Hs.521056

Evidence on tissue expression from TISSUES for ATP5J2 Gene

  • Kidney(4.6)
  • Blood(4.2)
  • Heart(3.2)
  • Lung(2.9)
  • Nervous system(2.8)
  • Intestine(2.6)
  • Muscle(2.6)
  • Adrenal gland(2.3)
  • Bone marrow(2.2)
  • Liver(2.2)
  • Lymph node(2.2)
  • Stomach(2.2)
  • Gall bladder(2.1)
  • Thyroid gland(2.1)
  • Skin(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ATP5J2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5J2 Gene

Orthologs for ATP5J2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATP5J2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP5J2 33 34
  • 80.68 (n)
mouse
(Mus musculus)
Mammalia Atp5j2 33 16 34
  • 80.56 (n)
rat
(Rattus norvegicus)
Mammalia Atp5j2 33
  • 80.56 (n)
dog
(Canis familiaris)
Mammalia LOC102151856 33
  • 80.23 (n)
-- 34
  • 80 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
-- 34
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5J2 34
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP5J2 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5J2 33 34
  • 70.2 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5j2 33
  • 61.18 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC402883 33
  • 64.02 (n)
ATP5J2 34
  • 8 (a)
OneToOne
Species where no ortholog for ATP5J2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5J2 Gene

ENSEMBL:
Gene Tree for ATP5J2 (if available)
TreeFam:
Gene Tree for ATP5J2 (if available)

Paralogs for ATP5J2 Gene

No data available for Paralogs for ATP5J2 Gene

Variants for ATP5J2 Gene

Sequence variations from dbSNP and Humsavar for ATP5J2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000093689 -- 99,467,355(+) GGCCT(C/T)CGATT upstream-variant-2KB
rs1000230096 -- 99,461,027(+) TTCCA(A/G)TGGGA intron-variant
rs1000312676 -- 99,466,647(+) CTCCC(A/G)GAGTC upstream-variant-2KB
rs1000325486 -- 99,461,377(+) GCTAA(C/T)GATAA intron-variant
rs1000363478 -- 99,466,911(+) GAAGG(C/T)GTCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ATP5J2 Gene

Variant ID Type Subtype PubMed ID
nsv831069 CNV loss 17160897

Variation tolerance for ATP5J2 Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5J2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5J2 Gene

Disorders for ATP5J2 Gene

Relevant External Links for ATP5J2

Genetic Association Database (GAD)
ATP5J2
Human Genome Epidemiology (HuGE) Navigator
ATP5J2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5J2

No disorders were found for ATP5J2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5J2 Gene

Publications for ATP5J2 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60

Products for ATP5J2 Gene

Sources for ATP5J2 Gene

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