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Aliases for ATP5J Gene

Aliases for ATP5J Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit F6 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit F6 2 3
  • Coupling Factor 6 2 3
  • ATPase Subunit F6 3 4
  • ATP5A 3 4
  • ATPM 3 4
  • ATP5 3 6
  • ATP Synthase-Coupling Factor 6, Mitochondrial 3
  • Mitochondrial ATP Synthase, Coupling Factor 6 3
  • Mitochondrial ATP Synthase, Subunit F6 3
  • Mitochondrial ATPase Coupling Factor 6 3
  • Proliferation-Inducing Protein 36 3
  • CF6 3
  • F6 3

External Ids for ATP5J Gene

Previous Symbols for ATP5J Gene

  • ATP5A
  • ATP5
  • ATPM

Summaries for ATP5J Gene

Entrez Gene Summary for ATP5J Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex, required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. A pseudogene exists on chromosome Yp11.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5J Gene

ATP5J (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit F6) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include transporter activity and transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5J Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes

Gene Wiki entry for ATP5J Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5J Gene

Genomics for ATP5J Gene

Genomic Location for ATP5J Gene

Start:
25,716,503 bp from pter
End:
25,735,673 bp from pter
Size:
19,171 bases
Orientation:
Minus strand

Genomic View for ATP5J Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5J Gene

Regulatory Elements for ATP5J Gene

Transcription factor binding sites by QIAGEN in the ATP5J gene promoter:

Proteins for ATP5J Gene

  • Protein details for ATP5J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18859-ATP5J_HUMAN
    Recommended name:
    ATP synthase-coupling factor 6, mitochondrial
    Protein Accession:
    P18859
    Secondary Accessions:
    • J3KQ83

    Protein attributes for ATP5J Gene

    Size:
    108 amino acids
    Molecular mass:
    12588 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

    Alternative splice isoforms for ATP5J Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP5J Gene

Proteomics data for ATP5J Gene at MOPED

Post-translational modifications for ATP5J Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys41, Lys46, Lys79, and Lys99

No data available for DME Specific Peptides for ATP5J Gene

Domains for ATP5J Gene

Gene Families for ATP5J Gene

HGNC:
  • FATP :Mitochondrial respiratory chain complex / Complex V
  • F1ATP :ATPases / F-type
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P18859

UniProtKB/Swiss-Prot:

ATP5J_HUMAN
Family:
  • Belongs to the eukaryotic ATPase subunit F6 family.:
    • P18859
genes like me logo Genes that share domains with ATP5J: view

Function for ATP5J Gene

Molecular function for ATP5J Gene

GENATLAS Biochemistry: ATP synthase H+ transporting,inner mitochondrial membrane,(F0 segment),subunit F6 (coupling factor),complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes

Gene Ontology (GO) - Molecular Function for ATP5J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 1830479
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
genes like me logo Genes that share ontologies with ATP5J: view
genes like me logo Genes that share phenotypes with ATP5J: view

miRNA for ATP5J Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP5J Gene

Localization for ATP5J Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5J Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5J Gene COMPARTMENTS Subcellular localization image for ATP5J gene
Compartment Confidence
mitochondrion 5
chloroplast 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ATP5J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
genes like me logo Genes that share ontologies with ATP5J: view

Pathways for ATP5J Gene

genes like me logo Genes that share pathways with ATP5J: view

Gene Ontology (GO) - Biological Process for ATP5J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0015986 ATP synthesis coupled proton transport --
GO:0021762 substantia nigra development IEP 22926577
GO:0022904 respiratory electron transport chain TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
genes like me logo Genes that share ontologies with ATP5J: view

Compounds for ATP5J Gene

(4) HMDB Compounds for ATP5J Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(6) Novoseek inferred chemical compound relationships for ATP5J Gene

Compound -log(P) Hits PubMed IDs
adma 69.9 6
prostacyclin 62.2 4
atp 52 12
arachidonic acid 33.4 2
nitric oxide 31.5 4
genes like me logo Genes that share compounds with ATP5J: view

Transcripts for ATP5J Gene

Unigene Clusters for ATP5J Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5J Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - -
SP9: -

Relevant External Links for ATP5J Gene

GeneLoc Exon Structure for
ATP5J
ECgene alternative splicing isoforms for
ATP5J

Expression for ATP5J Gene

mRNA expression in normal human tissues for ATP5J Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP5J Gene

This gene is overexpressed in Heart - Left Ventricle (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5J Gene

SOURCE GeneReport for Unigene cluster for ATP5J Gene Hs.246310

genes like me logo Genes that share expressions with ATP5J: view

No data available for mRNA Expression by UniProt/SwissProt for ATP5J Gene

Orthologs for ATP5J Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP5J Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5J 35
  • 98.56 (n)
  • 98.28 (a)
ATP5J 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5J 35
  • 85.19 (n)
  • 80.56 (a)
ATP5J 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5J 35
  • 89.37 (n)
  • 84.48 (a)
ATP5J 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5j 35
  • 88.27 (n)
  • 80.56 (a)
Atp5j 16
Atp5j 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP5J 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5j 35
  • 86.42 (n)
  • 76.85 (a)
chicken
(Gallus gallus)
Aves ATP5J 35
  • 66.34 (n)
  • 59.41 (a)
ATP5J 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5J 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68738 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5j 35
  • 72.94 (n)
  • 69.31 (a)
zebrafish
(Danio rerio)
Actinopterygii atp5j 35
  • 60.61 (n)
  • 57.95 (a)
atp5j 36
  • 48 (a)
OneToMany
ATP5J (2 of 4) 36
  • 9 (a)
OneToMany
ATP5J (3 of 4) 36
  • 9 (a)
OneToMany
ATP5J (4 of 4) 36
  • 9 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-Cf6 36
  • 42 (a)
OneToMany
CG12027 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5066 36
  • 35 (a)
OneToOne
Species with no ortholog for ATP5J:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5J Gene

ENSEMBL:
Gene Tree for ATP5J (if available)
TreeFam:
Gene Tree for ATP5J (if available)

Paralogs for ATP5J Gene

Pseudogenes.org Pseudogenes for ATP5J Gene

genes like me logo Genes that share paralogs with ATP5J: view

No data available for Paralogs for ATP5J Gene

Variants for ATP5J Gene

Sequence variations from dbSNP and Humsavar for ATP5J Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs1803181 -- 25,724,650(-) AAAAC(A/C)CCAGG missense, reference
rs1971497 -- 25,725,707(-) AATCC(A/G)AGCAC intron-variant
rs2829887 -- 25,731,303(+) TTTCT(C/T)AGATT intron-variant
rs3216073 -- 25,729,589(+) CATAC(-/T)TTGAA intron-variant
rs5843169 -- 25,729,003(+) TTGGG(-/C)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5J Gene

Variant ID Type Subtype PubMed ID
nsv913653 CNV Loss 21882294

Relevant External Links for ATP5J Gene

HapMap Linkage Disequilibrium report
ATP5J

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5J Gene

Disorders for ATP5J Gene

Relevant External Links for ATP5J

Genetic Association Database (GAD)
ATP5J
Human Genome Epidemiology (HuGE) Navigator
ATP5J
genes like me logo Genes that share disorders with ATP5J: view

No data available for UniProtKB/Swiss-Prot for ATP5J Gene

Publications for ATP5J Gene

  1. Human mitochondrial ATP synthase: cloning cDNA for the nuclear- encoded precursor of coupling factor 6. (PMID: 1825642) Javed A.A. … Sanadi D.R. (Gene 1991) 2 3 4
  2. Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria. (PMID: 1830479) Higuti T. … Ichihara A. (Biochem. Biophys. Res. Commun. 1991) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease. (PMID: 14633154) Osanai T. … Okumura K. (Kidney Int. 2003) 3 23

Products for ATP5J Gene

Sources for ATP5J Gene

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