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ATP5J Gene

protein-coding   GIFtS: 63
GCID: GC21M027088

ATP Synthase, H+ Transporting, Mitochondrial Fo Complex,...

(Previous names: ATP synthase, H+ transporting, mitochondrial F0 complex,...)
(Previous symbols: ATP5A, ATP5, ATPM)
  Search for ATP5J
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit F61 2     CF62
ATP5A1 2 3     F62
ATPM1 2 3     ATP Synthase-Coupling Factor 6, Mitochondrial2
ATP51 2 5     Mitochondrial ATP Synthase, Coupling Factor 62
ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit F61 2     Mitochondrial ATP Synthase, Subunit F62
Coupling Factor 61 2     Mitochondrial ATPase Coupling Factor 62
ATPase Subunit F62 3     Proliferation-Inducing Protein 362

External Ids:    HGNC: 8471   Entrez Gene: 5222   Ensembl: ENSG000001547237   OMIM: 6031525   UniProtKB: P188593   

Export aliases for ATP5J gene to outside databases

Previous GC identifers: GC21M023675 GC21M026018 GC21M012499


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATP5J Gene:
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the
inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the
soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1
complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3
alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f,
g, F6 and 8). This gene encodes the F6 subunit of the Fo complex, required for F1 and Fo interactions.
Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. A
pseudogene exists on chromosome Yp11.(provided by RefSeq, Jun 2010)

GeneCards Summary for ATP5J Gene:
ATP5J (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6) is a protein-coding gene. GO annotations related to this gene include transmembrane transporter activity and transporter activity.

UniProtKB/Swiss-Prot: ATP5J_HUMAN, P18859
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
presence of a proton gradient across the membrane which is generated by electron transport complexes of the
respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous
catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a
peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary
mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the
peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6
static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity
to depleted F1-F0 complexes

Gene Wiki entry for ATP5J Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP5J gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ATP5J promoter sequence
   Search Chromatin IP Primers for ATP5J

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP5J


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.1

ATP5J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP5J gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M027088:  view genomic region     (about GC identifiers)

Start:
27,088,815 bp from pter      End:
27,107,984 bp from pter
Size:
19,170 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATP5J_HUMAN, P18859 (See protein sequence)
Recommended Name: ATP synthase-coupling factor 6, mitochondrial precursor  
Size: 108 amino acids; 12588 Da
Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex
composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1,
ATP5O, ATP5L, USMG5 and MP68 (By similarity)
Secondary accessions: J3KQ83
Alternative splicing: 2 isoforms:  P18859-1   P18859-2   

Explore the universe of human proteins at neXtProt for ATP5J: NX_P18859

Explore proteomics data for ATP5J at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys41, Lys46, Lys79, Lys99
  • Modification sites at PhosphoSitePlus

  • See ATP5J Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001003696.1  NP_001003697.1  NP_001003701.1  NP_001003703.1  NP_001676.2  

    ENSEMBL proteins: 
     ENSP00000382971   ENSP00000382966   ENSP00000284971   ENSP00000389649   ENSP00000382962  
     ENSP00000382959   ENSP00000382965  
    Reactome Protein details: P18859

    ATP5J Human Recombinant Protein Products:

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    Novus Biologicals ATP5J Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ATP5J 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FATP: Mitochondrial respiratory chain complex / Complex V
    F1ATP: ATPases / F-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: F6
    F-type ATPase

    2 InterPro protein domains:
     IPR008387 ATPase_F0-cplx_f6su_mt
     IPR016349 ATPase_F0-cplx_f6su_mt_subgr

    Graphical View of Domain Structure for InterPro Entry P18859

    ProtoNet protein and cluster: P18859

    1 Blocks protein domain: IPB008387 Mitochondrial ATP synthase coupling factor 6

    UniProtKB/Swiss-Prot: ATP5J_HUMAN, P18859
    Similarity: Belongs to the eukaryotic ATPase subunit F6 family


    Find genes that share domains with ATP5J           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATP5J_HUMAN, P18859
    Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
    presence of a proton gradient across the membrane which is generated by electron transport complexes of the
    respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous
    catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a
    peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary
    mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the
    peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6
    static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity
    to depleted F1-F0 complexes

         Genatlas biochemistry entry for ATP5J:
    ATP synthase H+ transporting,inner mitochondrial membrane,(F0 segment),subunit F6 (coupling factor),complex V of
    oxidative phosphorylation (OXPHOS)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity NAS1830479
    GO:0015078hydrogen ion transmembrane transporter activity IEA--
    GO:0016887contributes to ATPase activity IDA12110673
    GO:0022857transmembrane transporter activity IC12110673
         
    Find genes that share ontologies with ATP5J           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ATP5J:
     Decreased homologous recombina  Decreased viability of wild-ty 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target ATP5J:
    hsa-mir-1301-3p (MIRT036000), hsa-mir-331-3p (MIRT043352), hsa-mir-92a-3p (MIRT049819), hsa-mir-484 (MIRT041867)

    Block miRNA regulation of human, mouse, rat ATP5J using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ATP5J:
    hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidATP5J 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP5J


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATP5J_HUMAN, P18859: Mitochondrion. Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000276mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005753mitochondrial proton-transporting ATP synthase complex IDA12110673

    Find genes that share ontologies with ATP5J           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATP5J About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Oxidative phosphorylation0.51
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Huntington's disease0.45
    Oxidative phosphorylation0.64
    Formation of ATP by chemiosmotic coupling0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4FOXA1 transcription factor network
    FOXA1 transcription factor network


    Find genes that share SuperPaths with ATP5J           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ATP5J
        Oxidative phosphorylation
    Electron Transport Chain
    FOXA1 transcription factor network


    1 Reactome Pathway for ATP5J
        Formation of ATP by chemiosmotic coupling


    5 Kegg Pathways  (Kegg details for ATP5J):
        Oxidative phosphorylation
    Metabolic pathways
    Alzheimer's disease
    Parkinson's disease
    Huntington's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATP5J: 
              Mitochondrial Energy Metabolism in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ATP5J

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATP5J (P188592, 3 ENSP000003896494) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8260746 I2D: score=2 
    RPS6KA3P518122, 3, ENSP000003688844MINT-8269505 I2D: score=2 STRING: ENSP00000368884
    ATP5F1P245393, ENSP000003587374I2D: score=1 STRING: ENSP00000358737
    BANF1O755313, ENSP000003102754I2D: score=1 STRING: ENSP00000310275
    NFKB1P198383I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA12110673
    GO:0015986ATP synthesis coupled proton transport ----
    GO:0021762substantia nigra development IEP--
    GO:0022904respiratory electron transport chain TAS--
    GO:0042776mitochondrial ATP synthesis coupled proton transport TAS--

    Find genes that share ontologies with ATP5J           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATP5J

    4 HMDB Compounds for ATP5J    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    6 Novoseek inferred chemical compound relationships for ATP5J gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adma 69.9 6 14633154 (4), 16467652 (2)
    prostacyclin 62.2 4 19488738 (1), 15785006 (1), 18243211 (1), 14633154 (1)
    atp 52 14 16230521 (4), 19488738 (2), 11167019 (2), 1824914 (1) (see all 7)
    arachidonic acid 33.4 2 16230521 (1), 16467652 (1)
    nitric oxide 31.5 6 18243211 (3), 19488738 (1)
    creatinine 16.3 2 15785006 (1), 14633154 (1)



    Find genes that share compounds with ATP5J           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATP5J gene (5 alternative transcripts): 
    NM_001003696.1  NM_001003697.1  NM_001003701.1  NM_001003703.1  NM_001685.4  

    Unigene Cluster for ATP5J:

    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
    Hs.246310  [show with all ESTs]
    Unigene Representative Sequence: CF993935
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400099 ENST00000400094 ENST00000284971 ENST00000457143 ENST00000400090
    ENST00000400087 ENST00000400093(uc002ylw.3 uc002yls.3 uc002ylt.3 uc002ylv.3 uc002ylu.3)
    ENST00000486002
    miRNA
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    hsa-miR-3133
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): ATP5J (NM_001003701)
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      QuantiFast Probe-based Assays in human, mouse, rat ATP5J

    Additional mRNA sequence: 

    AK311899.1 AL110183.1 AY544129.1 BC001178.1 BC066310.1 BT007244.1 CR456950.1 M37104.1 
    M73031.1 

    Selected DOTS entries (see all 25):

    DT.101986034  DT.95070836  DT.121138086  DT.121138049  DT.70104921  DT.100044393  DT.449898  DT.121138153 
    DT.95361146  DT.99933995  DT.121138070  DT.95361145  DT.100729667  DT.121138003  DT.121138033  DT.92444638 
    DT.99992826  DT.87079507  DT.95207113  DT.97785152  DT.120677168  DT.92444640  DT.121138084  DT.75178331 

    Selected AceView cDNA sequences (see all 428):

    BU174560 AV682292 BF149305 BM662012 BG030146 N90674 W72873 M37104 
    CD370588 W63711 AI344694 AV711606 BP871259 CD106181 W70137 H99605 
    BX093308 NM_001003696 AI336031 BM695427 H92619 BM737859 AI337577 BQ877333 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATP5J (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d
    SP1:        -     -     -     -     -     -     -     -           -                       -                           
    SP2:                          -     -     -     -     -           -                       -                           
    SP3:                                -     -     -     -           -                       -                           
    SP4:                                                  -           -                       -                           
    SP5:                                                  -           -                 -     -                           


    ECgene alternative splicing isoforms for ATP5J

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATP5J expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTCATAA
    ATP5J Expression
    About this image


    ATP5J expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Kidney (Urinary System)
             Metanephros
     
     Thymus (Hematopoietic System)
             Thymus
    ATP5J Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATP5J Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.246310
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATP5J: 
              Mitochondrial Energy Metabolism in human mouse rat
              Cardiotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ATP5J gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp5j1 , 5 ATP synthase, H+ transporting, mitochondrial F0 complex, more1, 5 88.27(n)1
    80.56(a)1
      16 (46.92 cM)5
    119571  NM_016755.21  NP_058035.11 
     848278665 
    chicken
    (Gallus gallus)
    Aves ATP5J1 ATP synthase, H+ transporting, mitochondrial Fo complex, more 66.34(n)
    59.41(a)
      418477  XM_001231638.2  XP_001231639.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATP5J6
    ATP synthase, H+ transporting, mitochondrial Fo co...
    57(a)
    1 ↔ 1
    3(148278752-148282133)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687382 hypothetical protein MGC68738 77.04(n)    BC057213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atp5j1 ATP synthase, H+ transporting, mitochondrial F0 complex, more 60.61(n)
    57.95(a)
      406599  NM_213307.1  NP_998472.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ATPsyn-Cf66
    CG120276
    --
    42(a)
    22(a)
    many → 1
    many → 1
    3R(19180942-19181786)
    3L(5011444-5012133)


    ENSEMBL Gene Tree for ATP5J (if available)
    TreeFam Gene Tree for ATP5J (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATP5J gene

    Find genes that share paralogs with ATP5J           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for ATP5J
    PGOHUM00000246521 PGOHUM00000235275 PGOHUM00000249755 PGOHUM00000233903


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATP5J (see all 192)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756080931,2
    C,F--27096497(+) CTCTGT/CGATCT 5 -- ds50013Minor allele frequency- C:0.03WA NA EA 358
    rs1434310001,2
    C--27096601(+) AAAAAA/CTTACA 5 -- ds50010--------
    rs2007008111,2
    C--27096915(+) TAATCC/TGTGAC 5 -- ut311Minor allele frequency- T:0.00EU 1187
    rs115398671,2
    C--27096960(-) AAACCC/TCAGGC 10 P syn1 ese30--------
    rs2013921591,2
    C--27097000(+) AGAGGA/GGGAAA 5 -- int10--------
    rs733359931,2
    C,F--27097011(+) AAAGGG/ATCAAG 5 -- int14Minor allele frequency- A:0.11WA EA 242
    rs731617641,2
    C--27097053(+) AGAATG/TCTCAA 5 -- int15Minor allele frequency- T:0.23CSA WA NA EA 361
    rs768860631,2
    C--27097139(+) TTTATA/GCAACA 5 -- int10--------
    rs119101221,2
    C,H--27097351(+) tatgtT/CatGTG 5 -- int14Minor allele frequency- C:0.00NS EA 418
    rs1917861931,2
    --27097416(+) GCACAC/GGTCAT 5 -- int10--------

    HapMap Linkage Disequilibrium report for ATP5J (27088815 - 27107984 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ATP5J:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv913653CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATP5J
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP5J

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603152    OMIM disorders: --


    Find genes that share disorders with ATP5J           About GenesLikeMe

    Genetic Association Database (GAD): ATP5J
    Human Genome Epidemiology (HuGE) Navigator: ATP5J (2 documents)

    Export disorders for ATP5J gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATP5J gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with ATP5J)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria. (PubMed id 1830479)1, 2, 3 Higuti T.... Ichihara A. (Biochem. Biophys. Res. Commun. 1991)
    2. Human mitochondrial ATP synthase: cloning cDNA for the nuclear- encoded precursor of coupling factor 6. (PubMed id 1825642)1, 2, 3 Javed A.A.... Sanadi D.R. (Gene 1991)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    8. Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)1, 2 Hochstrasser D.F.... Hughes G.J. (Electrophoresis 1992)
    9. Plasma mitochondrial coupling factor 6 in patients with acute myocardial infarction. (PubMed id 15785006)1, 9 Ding W.H....Qi Y.F. (Hypertens. Res. 2004)
    10. Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor. (PubMed id 16230521)1, 9 Osanai T....Okumura K. (Hypertension 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 522 HGNC: 847 AceView: ATP5J Ensembl:ENSG00000154723 euGenes: HUgn522
    ECgene: ATP5J Kegg: 522 H-InvDB: ATP5J

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATP5J Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATP5J gene:
    Search GeneIP for patents involving ATP5J

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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