Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP5J Gene

protein-coding   GIFtS: 56
GCID: GC21M027088

ATP synthase, H+ transporting, mitochondrial Fo complex,...

(Previous names: ATP synthase, H+ transporting, mitochondrial F0 complex,...)
(Previous symbols: ATP5A, ATP5, ATPM)
 Explore 7 diseases affiliated with
ATP5J via our new
 Human Malady Compendium 
Biological research products
for ATP5J
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit F61 2     F62
ATP5A1 2 3     ATP Synthase-Coupling Factor 6, Mitochondrial2
ATPM1 2 3     Coupling Factor 62
ATP51 2 5     Mitochondrial ATP Synthase, Coupling Factor 62
CF61 2     Mitochondrial ATP Synthase, Subunit F62
ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit F61 2     Mitochondrial ATPase Coupling Factor 62
ATPase Subunit F62 3     Proliferation-Inducing Protein 362

External Ids:    HGNC: 8471   Entrez Gene: 5222   Ensembl: ENSG000001547237   OMIM: 6031525   UniProtKB: P188593   

Export aliases for ATP5J gene to outside databases

Previous GC identifers: GC21M023675 GC21M026018 GC21M012499


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATP5J:
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner
membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic
core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5
different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single
representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes
the F6 subunit of the Fo complex, required for F1 and Fo interactions. Alternatively spliced transcript variants
encoding different isoforms have been identified for this gene. A pseudogene exists on chromosome Yp11.(provided by
RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: ATP5J_HUMAN, P18859
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
presence of a proton gradient across the membrane which is generated by electron transport complexes of the
respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic
core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.
During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk
subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to
hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved
in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes

Gene Wiki entry for ATP5J


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP5J gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ATP5J promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP5J

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP5J


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.1

ATP5J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP5J gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M027088:  view genomic region     (about GC identifiers)

Start:
27,088,815 bp from pter      End:
27,107,984 bp from pter
Size:
19,170 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATP5J_HUMAN, P18859 (See protein sequence)
Recommended Name: ATP synthase-coupling factor 6, mitochondrial precursor  
Size: 108 amino acids; 12588 Da
Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0)
seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of
ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L,
USMG5 and MP68 (By similarity)
Subcellular location: Mitochondrion. Mitochondrion inner membrane
Secondary accessions: J3KQ83
Alternative splicing: 2 isoforms:  P18859-1   P18859-2   

Explore the universe of human proteins at neXtProt for ATP5J: NX_P18859

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P18859

  • ATP5J Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001003696.1  NP_001003697.1  NP_001003701.1  NP_001003703.1  NP_001676.2  

    ENSEMBL proteins: 
     ENSP00000382971   ENSP00000382966   ENSP00000284971   ENSP00000389649   ENSP00000382962  
     ENSP00000382959   ENSP00000382965  
    Reactome Protein details: P18859
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): ATP5J
    OriGene Protein Over-expression Lysate (see all 7): ATP5J
    OriGene Custom Protein Services for ATP5J 
    GenScript Custom Purified and Recombinant Proteins Services for ATP5J
    Novus Biologicals ATP5J Proteins
    Novus Biologicals ATP5J Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ATP5J

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000276mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005753mitochondrial proton-transporting ATP synthase complex IDA12110673


    ATP5J for ontologies           About GeneDecksing



    ATP5J Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ATP5J 
    GenScript Custom Superior Antibodies Services for ATP5J
    Novus Biologicals ATP5J Antibodies
    Search for Antibodies for ATP5J at Abcam  
    Uscn Antibodies for ATP5J
    Search ThermoFisher Antibodies for ATP5J

    Assay Products for ATP5J: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATP5J
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ATP5J


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ATP5J for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR008387 ATPase_F0-cplx_f6su_mt
     IPR016349 ATPase_F0-cplx_f6su_mt_subgr

    Graphical View of Domain Structure for InterPro Entry P18859

    ProtoNet protein and cluster: P18859

    1 Blocks protein family: IPB008387 Mitochondrial ATP synthase coupling factor 6

    UniProtKB/Swiss-Prot: ATP5J_HUMAN, P18859
    Similarity: Belongs to the eukaryotic ATPase subunit F6 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ATP5J_HUMAN, P18859
    Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
    presence of a proton gradient across the membrane which is generated by electron transport complexes of the
    respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic
    core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.
    During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk
    subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to
    hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved
    in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes

         Genatlas biochemistry entry for ATP5J:
    ATP synthase H+ transporting,inner mitochondrial membrane,(F0 segment),subunit F6 (coupling factor),complex V of
    oxidative phosphorylation (OXPHOS)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 5): ATP5J
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATP5J
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ATP5J:
    hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidATP5J 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP5J (see all 7)
    OriGene shRNA RFP: ATP5J
    OriGene siRNA: ATP5J
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP5J

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATP5J

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP5J (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP5J (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): ATP5J (NM_001003701)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP5J
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP5J 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATP5J
    Search LifeMap BioReagents cell lines for ATP5J

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP5J

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity NAS1830479
    GO:0015078hydrogen ion transmembrane transporter activity IEA--
    GO:0016887contributes to ATPase activity IDA12110673
    GO:0022857transmembrane transporter activity IC12110673


    ATP5J for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ATP5J:
     Decreased homologous recombina  Decreased viability of wild-ty 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.1.00
    Parkinson's disease0.61
    Electron Transport Chain0.76
    Oxidative phosphorylation0.52
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Alzheimer's disease0.43
    Oxidative phosphorylation0.63
    Huntington's disease0.40
    2Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    3FOXA1 transcription factor network
    FOXA1 transcription factor network1.00
    4Formation of ATP by chemiosmotic coupling
    Formation of ATP by chemiosmotic coupling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for ATP5J 
        Electron Transport Chain
    Oxidative phosphorylation
    FOXA1 transcription factor network

    4        Reactome Pathways for ATP5J
        Formation of ATP by chemiosmotic coupling
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5         Kegg Pathways  (Kegg details for ATP5J):
        Oxidative phosphorylation
    Metabolic pathways
    Alzheimer's disease
    Parkinson's disease
    Huntington's disease


    ATP5J for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP5J

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for ATP5J (P188592, 3 ENSP000003896494) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8260746 I2D: score=2 
    RPS6KA3P518122, 3, ENSP000003688844MINT-8269505 I2D: score=2 STRING: ENSP00000368884
    ATP5F1P245393, ENSP000003587374I2D: score=1 STRING: ENSP00000358737
    BANF1O755313, ENSP000003102754I2D: score=1 STRING: ENSP00000310275
    NFKB1P198383I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA12110673
    GO:0006810transport ----
    GO:0015986ATP synthesis coupled proton transport ----
    GO:0022904respiratory electron transport chain TAS--
    GO:0042776mitochondrial ATP synthesis coupled proton transport TAS--


    ATP5J for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATP5J for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATP5J

    4 HMDB Compounds for ATP5J    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    6 Novoseek chemical compound relationships for ATP5J gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adma 69.9 6 14633154 (4), 16467652 (2)
    prostacyclin 62.2 4 19488738 (1), 15785006 (1), 18243211 (1), 14633154 (1)
    atp 52 14 16230521 (4), 19488738 (2), 11167019 (2), 1824914 (1) (see all 7)
    arachidonic acid 33.4 2 16230521 (1), 16467652 (1)
    nitric oxide 31.5 6 18243211 (3), 19488738 (1)
    creatinine 16.3 2 15785006 (1), 14633154 (1)

    Search CenterWatch for drugs/clinical trials and news about ATP5J 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATP5J gene (5 alternative transcripts): 
    NM_001003696.1  NM_001003697.1  NM_001003701.1  NM_001003703.1  NM_001685.4  

    Unigene Cluster for ATP5J:

    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
    Hs.246310  [show with all ESTs]
    Unigene Representative Sequence: CF993935
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400099 ENST00000400094 ENST00000284971 ENST00000457143 ENST00000400090
    ENST00000400087 ENST00000400093(uc002ylw.3 uc002yls.3 uc002ylt.3 uc002ylv.3 uc002ylu.3)
    ENST00000486002

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 5): ATP5J
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATP5J
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ATP5J:
    hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidATP5J 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP5J (see all 7)
    OriGene shRNA RFP: ATP5J
    OriGene siRNA: ATP5J
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP5J
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP5J (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP5J (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): ATP5J (NM_001003701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP5J
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP5J 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP5J
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATP5J
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP5J
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP5J

    Additional cDNA sequence: 

    AK311899.1 AL110183.1 AY544129.1 BC001178.1 BC066310.1 BT007244.1 CR456950.1 M37104.1 
    M73031.1 

    24/26 DOTS entries (see all 26):

    DT.101986034  DT.95070836  DT.121138086  DT.121138049  DT.70104921  DT.100044393  DT.449898  DT.121138153 
    DT.95361146  DT.99933995  DT.121138070  DT.95361145  DT.100729667  DT.121138003  DT.121138033  DT.92444638 
    DT.99992826  DT.87079507  DT.95207113  DT.97785152  DT.120677168  DT.92444640  DT.121138084  DT.75178331 

    24/428 AceView cDNA sequences (see all 428):

    NM_001003701 AA995287 CB158599 BG112318 BM839808 F36601 AI215663 H99605 
    BX093308 N90674 CD370588 AJ710402 AA128762 NM_001685 AI336031 AL701877 
    AI721038 F26353 CD678939 H91579 W84339 F35377 BG286962 D11876 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ATP5J (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d
    SP1:        -     -     -     -     -     -     -     -           -                       -                           
    SP2:                          -     -     -     -     -           -                       -                           
    SP3:                                -     -     -     -           -                       -                           
    SP4:                                                  -           -                       -                           
    SP5:                                                  -           -                 -     -                           


    ECgene alternative splicing isoforms for ATP5J

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP5J expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTTCATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ATP5J Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP5J

    SOURCE GeneReport for Unigene cluster: Hs.246310
        SABiosciences Expression via Pathway-Focused PCR Arrays including ATP5J: 
              Mitochondrial Energy Metabolism in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP5J
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATP5J
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP5J
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP5J
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP5J

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ATP5J gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp5j1 , 5 ATP synthase, H+ transporting, mitochondrial F0 complex, more1, 5 88.27(n)1
    80.56(a)1
      16 (46.92 cM)5
    119571  NM_016755.21  NP_058035.11 
     848278665 
    chicken
    (Gallus gallus)
    Aves ATP5J1 ATP synthase, H+ transporting, mitochondrial Fo complex, more 65.4(n)
    58.1(a)
      418477  XM_001231638.1  XP_001231639.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATP5J6
    --
    57(a)
    1 ↔ 1
    3(148279811-148281320)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687382 hypothetical protein MGC68738 77.04(n)    BC057213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atp5j1 ATP synthase, H+ transporting, mitochondrial F0 complex, more 60.61(n)
    57.95(a)
      406599  NM_213307.1  NP_998472.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ATPsyn-Cf66
    CG120276
    --
    40(a)
    22(a)
    many → 1
    many → 1
    3R(19180942-19181786)
    3L(5011444-5012133)


    ENSEMBL Gene Tree for ATP5J (if available)
    TreeFam Gene Tree for ATP5J (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP5J gene

    ATP5J for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ATP5J
    PGOHUM00000246521 PGOHUM00000235275 PGOHUM00000249755 PGOHUM00000233903


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/238 NCBI SNPs in ATP5J are shown (see all 238    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs747714541,2
    F--12508835(+) AGGCAA/TGATGG 2 -- us2k11Minor allele frequency- T:0.33NA 6
    rs748974001,2
    C--12508863(-) CCCGAG/ATAGCT 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs716496331,2
    C,F,--12509018(+) TAACAC/TATATA 2 -- us2k16Minor allele frequency- T:0.02NS WA 172
    rs716496351,2
    C,--12509458(+) TAAGTC/TCTACG 2 -- us2k15Minor allele frequency- T:0.01NS 186
    rs716496361,2
    C,--12509544(+) CACTGA/TTTAGT 2 -- us2k15Minor allele frequency- T:0.01NS 186
    rs37613271,2
    C,F,H,--12509565(+) TGTCCA/TCTAAA 2 -- us2k123Minor allele frequency- T:0.05EA NA MN NS WA CSA 3176
    rs170013331,2
    C,F,--12509648(+) GGGTGC/TCACGA 2 -- us2k111Minor allele frequency- T:0.03MN EA NS NA WA 784
    rs680108111,2
    C,F,--12509685(+) CAGAAA/GGACTG 2 -- us2k17Minor allele frequency- G:0.03NS WA 306
    rs170013351,2
    C,F,H,--12509891(+) TTCAAT/GATTAT 2 -- us2k116Minor allele frequency- G:0.11NS NA WA CSA 1348
    rs170013401,2
    C,F,--12510159(+) CCCCGG/CGCCAG 2 -- us2k17Minor allele frequency- C:0.10NS NA WA 306

    HapMap Linkage Disequilibrium report for ATP5J (27088815 - 27107984 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ATP5J: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP5J
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP5J

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ATP5J for disorders           About GeneDecksing

    OMIM gene information: 603152    OMIM disorders: --

    7 diseases for ATP5J:    About MalaCards
    complex v    myocardial infarction    acute myocardial infarction    coronary heart disease
    huntington's disease    parkinson's disease    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: ATP5J (2 documents)

    Export disorders for ATP5J gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP5J gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with ATP5J)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria. (PubMed id 1830479)1, 2, 3 Higuti T.... Ichihara A. (1991)
    2. Human mitochondrial ATP synthase: cloning cDNA for the nuclear-encoded precursor of coupling factor 6. (PubMed id 1825642)1, 2, 3 Javed A.A....Sanadi D.R. (1991)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    6. Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)1, 2 Hochstrasser D.F.... Hughes G.J. (1992)
    7. Plasma mitochondrial coupling factor 6 in patients with acute myocardial infarction. (PubMed id 15785006)1, 9 Ding W.H....Qi Y.F. (2004)
    8. Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor. (PubMed id 16230521)1, 9 Osanai T....Okumura K. (2005)
    9. Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule. (PubMed id 18243211)1, 9 Kumagai A....Okumura K. (2008)
    10. Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease. (PubMed id 14633154)1, 9 Osanai T....Okumura K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 522 HGNC: 847 AceView: ATP5J Ensembl:ENSG00000154723 euGenes: HUgn522
    ECgene: ATP5J Kegg: 522 H-InvDB: ATP5J

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP5J Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATP5J gene:
    Search GeneIP for patents involving ATP5J

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ATP5J  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP5J   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP5J  
     OriGene Protein Over-expression Lysate for ATP5J   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ATP5J   OriGene 3'-UTR Clone for ATP5J  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP5J   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP5J  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ATP5J   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ATP5J   OriGene Custom Protein Services for ATP5J  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATP5J
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP5J
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP5J
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP5J
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP5J
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP5J
     GenScript Custom Purified and Recombinant Proteins Services for ATP5J GenScript cDNA clones with any tag delivered in your preferred vector for ATP5J
     GenScript Custom Assay Services for ATP5J GenScript Custom Superior Antibodies Services for ATP5J
     GenScript Custom overexpressing Cell Line Services for ATP5J CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ATP5J promoter
     Search Chromatin IP Primers for ATP5J
     RT2 qPCR Primer Assay in human, mouse, rat ATP5J
     Search GNC Networks for ATP5J
     SABiosciences PCR Arrays including human, mouse, rat ATP5J
     Search Tocris compounds for ATP5J
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ATP5J antibodies
     ATP5J proteins
     ATP5J lysates
     Search for Antibodies for ATP5J at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ATP5J
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ATP5J Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ATP5J
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP5J
     SwitchGear 3'UTR luciferase reporter plasmids for ATP5J
     SwitchGear Promoter luciferase reporter plasmids for ATP5J
     Search ThermoFisher Antibodies for ATP5J
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP5J
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ATP5J gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4