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Aliases for ATP5I Gene

Aliases for ATP5I Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit E 2 3 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit E 2 3
  • ATPase Subunit E 3 4
  • ATP5K 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit E 2
  • ATP Synthase Subunit E, Mitochondrial 3
  • ATP Synthase E Chain, Mitochondrial 3
  • F1F0-ATP Synthase, Murine E Subunit 3

External Ids for ATP5I Gene

Previous GeneCards Identifiers for ATP5I Gene

  • GC04M000672
  • GC04M000656
  • GC04M000642

Summaries for ATP5I Gene

Entrez Gene Summary for ATP5I Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5I Gene

ATP5I (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit E) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and purine nucleotides de novo biosynthesis. GO annotations related to this gene include ATPase activity and hydrogen ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5I Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Wiki entry for ATP5I Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5I Gene

Genomics for ATP5I Gene

Regulatory Elements for ATP5I Gene

Enhancers for ATP5I Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G000617 0.6 ENCODE 10.9 +56.5 56512 0.1 TEAD4 SIN3A MNT DPF2 TBX21 CTBP1 TARDBP MLLT1 FOS FOSL2 ATP5I MYL5 GC04M000604 GC04P000592
GH04G000741 0.4 ENCODE 11.5 -66.8 -66770 0.2 MAFK PCGF3 MFSD7 MYL5 ATP5I GC04P000749 ENSG00000248416
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP5I on UCSC Golden Path with GeneCards custom track

Promoters for ATP5I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164687 -62 1601 HDGF HNRNPUL1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207

Genomic Location for ATP5I Gene

Chromosome:
4
Start:
672,436 bp from pter
End:
674,338 bp from pter
Size:
1,903 bases
Orientation:
Minus strand

Genomic View for ATP5I Gene

Genes around ATP5I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5I Gene

Proteins for ATP5I Gene

  • Protein details for ATP5I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56385-ATP5I_HUMAN
    Recommended name:
    ATP synthase subunit e, mitochondrial
    Protein Accession:
    P56385
    Secondary Accessions:
    • Q0D2L9

    Protein attributes for ATP5I Gene

    Size:
    69 amino acids
    Molecular mass:
    7933 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5I Gene

Post-translational modifications for ATP5I Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5I Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5I Gene

Domains & Families for ATP5I Gene

Protein Domains for ATP5I Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ATP5I Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56385

UniProtKB/Swiss-Prot:

ATP5I_HUMAN :
  • Belongs to the ATPase e subunit family.
Family:
  • Belongs to the ATPase e subunit family.
genes like me logo Genes that share domains with ATP5I: view

Function for ATP5I Gene

Molecular function for ATP5I Gene

GENATLAS Biochemistry:
ATP synthase H+ transporting,inner mitochondrial matrix (F0 segment),subunit e,complex V of oxidative phosphorylation (OXPHOS),mediating proton transport
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Ontology (GO) - Molecular Function for ATP5I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
genes like me logo Genes that share ontologies with ATP5I: view
genes like me logo Genes that share phenotypes with ATP5I: view

Animal Model Products

CRISPR Products

miRNA for ATP5I Gene

miRTarBase miRNAs that target ATP5I

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5I Gene

Localization for ATP5I Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5I Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5I gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ATP5I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP5I: view

Pathways & Interactions for ATP5I Gene

genes like me logo Genes that share pathways with ATP5I: view

Gene Ontology (GO) - Biological Process for ATP5I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IEA --
GO:0015992 proton transport IEA --
genes like me logo Genes that share ontologies with ATP5I: view

No data available for SIGNOR curated interactions for ATP5I Gene

Drugs & Compounds for ATP5I Gene

(2) Drugs for ATP5I Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for ATP5I Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with ATP5I: view

Transcripts for ATP5I Gene

Unigene Clusters for ATP5I Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5I Gene

No ASD Table

Relevant External Links for ATP5I Gene

GeneLoc Exon Structure for
ATP5I
ECgene alternative splicing isoforms for
ATP5I

Expression for ATP5I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP5I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATP5I Gene

This gene is overexpressed in Nasal epithelium (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP5I Gene



Protein tissue co-expression partners for ATP5I Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP5I Gene:

ATP5I

SOURCE GeneReport for Unigene cluster for ATP5I Gene:

Hs.85539

Evidence on tissue expression from TISSUES for ATP5I Gene

  • Liver(4.7)
  • Kidney(4.5)
  • Nervous system(4.4)
  • Heart(2.6)
  • Muscle(2.6)
  • Adrenal gland(2.3)
  • Stomach(2.2)
  • Bone marrow(2)
  • Intestine(2)
  • Lymph node(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ATP5I: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5I Gene

Orthologs for ATP5I Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATP5I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5I 34 35
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia ATP5I 35
  • 86 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5I 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5k 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ATP5I 35
  • 21 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBF 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5I 35
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii atp5ib 35
  • 65 (a)
OneToMany
atp5ia 35
  • 62 (a)
OneToMany
Species where no ortholog for ATP5I was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5I Gene

ENSEMBL:
Gene Tree for ATP5I (if available)
TreeFam:
Gene Tree for ATP5I (if available)

Paralogs for ATP5I Gene

No data available for Paralogs for ATP5I Gene

Variants for ATP5I Gene

Sequence variations from dbSNP and Humsavar for ATP5I Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1001512894 -- 673,541(+) AGTCA(A/G)CGCCT intron-variant, upstream-variant-2KB
rs1001610147 -- 672,978(+) CCAGA(C/G)CTCAG intron-variant, upstream-variant-2KB
rs1002173072 -- 673,763(+) TTCCA(A/C)TATCG intron-variant, upstream-variant-2KB
rs1002450535 -- 675,821(+) CTACT(G/T)TGAGC intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1003211430 -- 673,744(+) TGAGC(G/T)TTGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ATP5I Gene

Variant ID Type Subtype PubMed ID
esv2759217 CNV loss 17122850
nsv10413 CNV gain 18304495
nsv508986 CNV insertion 20534489
nsv593206 CNV loss 21841781
nsv593208 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv829834 CNV loss 17160897
nsv950325 CNV deletion 24416366

Variation tolerance for ATP5I Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5I Gene

Disorders for ATP5I Gene

Relevant External Links for ATP5I

Genetic Association Database (GAD)
ATP5I
Human Genome Epidemiology (HuGE) Navigator
ATP5I
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5I

No disorders were found for ATP5I Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5I Gene

Publications for ATP5I Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation. (PMID: 8702853) Swartz D.A. … Kaput J. (J. Biol. Chem. 1996) 2 3 64
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 64

Products for ATP5I Gene

Sources for ATP5I Gene

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