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Aliases for ATP5G3 Gene

Aliases for ATP5G3 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit C3 (Subunit 9) 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C3 (Subunit 9) 2 3
  • ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit C3 3 4
  • ATP Synthase Proteolipid P3 3 4
  • ATPase Subunit C 3 4
  • ATPase Protein 9 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C (Subunit 9) Isoform 3 2
  • ATP Synthase F(0) Complex Subunit C3, Mitochondrial 3
  • ATP Synthase Lipid-Binding Protein, Mitochondrial 3
  • ATP Synthase, Mitochondrial, C Subunit-3 3
  • ATP Synthase Lipid-Binding Protein 4
  • ATP Synthase Subunit 9 3
  • P3 3

External Ids for ATP5G3 Gene

Previous GeneCards Identifiers for ATP5G3 Gene

  • GC02M174095
  • GC02M174704
  • GC02M176005
  • GC02M176245
  • GC02M175868
  • GC02M175750
  • GC02M176040
  • GC02M167922

Summaries for ATP5G3 Gene

Entrez Gene Summary for ATP5G3 Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified. [provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5G3 Gene

ATP5G3 (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit C3 (Subunit 9)) is a Protein Coding gene. Diseases associated with ATP5G3 include spindle cell hemangioma. Among its related pathways are Metabolism and Alzheimers disease. GO annotations related to this gene include transporter activity and hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5G1.

UniProtKB/Swiss-Prot for ATP5G3 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element

Gene Wiki entry for ATP5G3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5G3 Gene

Genomics for ATP5G3 Gene

Regulatory Elements for ATP5G3 Gene

Transcription factor binding sites by QIAGEN in the ATP5G3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATP5G3 Gene

Start:
175,176,258 bp from pter
End:
175,184,607 bp from pter
Size:
8,350 bases
Orientation:
Minus strand

Genomic View for ATP5G3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5G3 Gene

Proteins for ATP5G3 Gene

  • Protein details for ATP5G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48201-AT5G3_HUMAN
    Recommended name:
    ATP synthase F(0) complex subunit C3, mitochondrial
    Protein Accession:
    P48201
    Secondary Accessions:
    • B2R4Z0
    • D3DPF0
    • Q4ZFX7

    Protein attributes for ATP5G3 Gene

    Size:
    142 amino acids
    Molecular mass:
    14693 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c
    Miscellaneous:
    • There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease)

neXtProt entry for ATP5G3 Gene

Proteomics data for ATP5G3 Gene at MOPED

Post-translational modifications for ATP5G3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5G3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5G3 Gene

Domains for ATP5G3 Gene

Gene Families for ATP5G3 Gene

HGNC:
  • F1ATP :ATPases / F-type
  • FATP :Mitochondrial respiratory chain complex / Complex V
IUPHAR :

Suggested Antigen Peptide Sequences for ATP5G3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48201

UniProtKB/Swiss-Prot:

AT5G3_HUMAN :
  • P48201
Family:
  • Belongs to the ATPase C chain family.
genes like me logo Genes that share domains with ATP5G3: view

Function for ATP5G3 Gene

Molecular function for ATP5G3 Gene

GENATLAS Biochemistry: ATP synthase,H+ transporting,inner mitochondrial membrane (F0 segment),subunit C,isoform 3complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element

Gene Ontology (GO) - Molecular Function for ATP5G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 7698763
GO:0008289 lipid binding IEA --
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with ATP5G3: view

Phenotypes for ATP5G3 Gene

GenomeRNAi human phenotypes for ATP5G3:
genes like me logo Genes that share phenotypes with ATP5G3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP5G3 Gene

Localization for ATP5G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5G3 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5G3 Gene COMPARTMENTS Subcellular localization image for ATP5G3 gene
Compartment Confidence
mitochondrion 5
extracellular 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ATP5G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex TAS 7698763
GO:0016021 integral component of membrane IEA --
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain --
genes like me logo Genes that share ontologies with ATP5G3: view

Pathways for ATP5G3 Gene

genes like me logo Genes that share pathways with ATP5G3: view

Pathways by source for ATP5G3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ATP5G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015986 ATP synthesis coupled proton transport --
GO:0015991 ATP hydrolysis coupled proton transport IEA --
GO:0022904 respiratory electron transport chain TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with ATP5G3: view

Compounds for ATP5G3 Gene

(4) HMDB Compounds for ATP5G3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with ATP5G3: view

Transcripts for ATP5G3 Gene

Unigene Clusters for ATP5G3 Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5G3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5G3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - -
SP6: - - -

Relevant External Links for ATP5G3 Gene

GeneLoc Exon Structure for
ATP5G3
ECgene alternative splicing isoforms for
ATP5G3

Expression for ATP5G3 Gene

mRNA expression in normal human tissues for ATP5G3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP5G3 Gene

This gene is overexpressed in Heart - Left Ventricle (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATP5G3 Gene

SOURCE GeneReport for Unigene cluster for ATP5G3 Gene Hs.429

genes like me logo Genes that share expressions with ATP5G3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ATP5G3 Gene

Orthologs for ATP5G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP5G3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5G3 35
  • 99.68 (n)
  • 100 (a)
ATP5G3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5G3 35
  • 95.04 (n)
  • 95.04 (a)
ATP5G3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
LOC478807 35
  • 97.64 (n)
  • 95.04 (a)
mouse
(Mus musculus)
Mammalia Atp5g3 35
  • 95.98 (n)
  • 95.74 (a)
Atp5g3 16
Atp5g3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5G3 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5g3 35
  • 94.8 (n)
  • 95.74 (a)
chicken
(Gallus gallus)
Aves ATP5G3 35
  • 83.92 (n)
  • 89.36 (a)
ATP5G3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5g3 35
  • 81.8 (n)
  • 86.52 (a)
Str.16904 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
atp5g3a 35
  • 71.94 (n)
  • 79.86 (a)
atp5g3a 36
  • 80 (a)
OneToMany
atp5g3b 36
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1746 36
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.3 36
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLI1 36
  • 62 (a)
OneToMany
OLI1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4895 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10146 36
  • 73 (a)
OneToMany
Species with no ortholog for ATP5G3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5G3 Gene

ENSEMBL:
Gene Tree for ATP5G3 (if available)
TreeFam:
Gene Tree for ATP5G3 (if available)

Paralogs for ATP5G3 Gene

Paralogs for ATP5G3 Gene

Selected SIMAP similar genes for ATP5G3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ATP5G3 Gene

genes like me logo Genes that share paralogs with ATP5G3: view

Variants for ATP5G3 Gene

Sequence variations from dbSNP and Humsavar for ATP5G3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8106 -- 175,178,369(-) TCATA(C/T)GCTAT synonymous-codon, reference, utr-variant-3-prime
rs185584 -- 175,176,702(+) tcacc(A/G)tggat utr-variant-3-prime
rs268219 -- 175,175,815(+) TAGTA(C/T)CTTTA downstream-variant-500B
rs268220 -- 175,175,867(+) TAGCA(C/T)TAATA downstream-variant-500B
rs268221 -- 175,175,923(+) TGGTG(C/T)ACAAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ATP5G3 Gene

Variant ID Type Subtype PubMed ID
nsv3044 CNV Loss 18451855

Relevant External Links for ATP5G3 Gene

HapMap Linkage Disequilibrium report
ATP5G3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5G3 Gene

Disorders for ATP5G3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ATP5G3 Gene including...

Search for ATP5G3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ATP5G3 Gene

Relevant External Links for ATP5G3

Genetic Association Database (GAD)
ATP5G3
Human Genome Epidemiology (HuGE) Navigator
ATP5G3
genes like me logo Genes that share disorders with ATP5G3: view

No data available for UniProtKB/Swiss-Prot for ATP5G3 Gene

Publications for ATP5G3 Gene

  1. Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3). (PMID: 7698763) Yan W.L. … Gusella J.F. (Genomics 1994) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3

Products for ATP5G3 Gene

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Sources for ATP5G3 Gene

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