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Aliases for ATP5G3 Gene

Aliases for ATP5G3 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit C3 (Subunit 9) 2 3 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C3 (Subunit 9) 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit C3 (Subunit 9) 2 3
  • ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit C3 3 4
  • ATP Synthase Proteolipid P3 3 4
  • ATPase Subunit C 3 4
  • ATPase Protein 9 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C (Subunit 9) Isoform 3 2
  • ATP Synthase Lipid-Binding Protein, Mitochondrial 3
  • ATP Synthase, Mitochondrial, C Subunit-3 3
  • ATP Synthase Lipid-Binding Protein 4
  • ATP Synthase Subunit 9 3
  • P3 3

External Ids for ATP5G3 Gene

Previous GeneCards Identifiers for ATP5G3 Gene

  • GC02M174095
  • GC02M174704
  • GC02M176005
  • GC02M176245
  • GC02M175868
  • GC02M175750
  • GC02M176040
  • GC02M167922

Summaries for ATP5G3 Gene

Entrez Gene Summary for ATP5G3 Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified. [provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5G3 Gene

ATP5G3 (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit C3 (Subunit 9)) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include transporter activity and hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5G1.

UniProtKB/Swiss-Prot for ATP5G3 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Gene Wiki entry for ATP5G3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5G3 Gene

Genomics for ATP5G3 Gene

Regulatory Elements for ATP5G3 Gene

Enhancers for ATP5G3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATP5G3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ATP5G3 gene promoter:

Genomic Location for ATP5G3 Gene

Chromosome:
2
Start:
175,176,258 bp from pter
End:
175,184,607 bp from pter
Size:
8,350 bases
Orientation:
Minus strand

Genomic View for ATP5G3 Gene

Genes around ATP5G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5G3 Gene

Proteins for ATP5G3 Gene

  • Protein details for ATP5G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48201-AT5G3_HUMAN
    Recommended name:
    ATP synthase F(0) complex subunit C3, mitochondrial
    Protein Accession:
    P48201
    Secondary Accessions:
    • B2R4Z0
    • D3DPF0
    • Q4ZFX7

    Protein attributes for ATP5G3 Gene

    Size:
    142 amino acids
    Molecular mass:
    14693 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
    Miscellaneous:
    • There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

neXtProt entry for ATP5G3 Gene

Proteomics data for ATP5G3 Gene at MOPED

Post-translational modifications for ATP5G3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5G3 Gene

No data available for DME Specific Peptides for ATP5G3 Gene

Domains & Families for ATP5G3 Gene

Suggested Antigen Peptide Sequences for ATP5G3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48201

UniProtKB/Swiss-Prot:

AT5G3_HUMAN :
  • Belongs to the ATPase C chain family.
Family:
  • Belongs to the ATPase C chain family.
genes like me logo Genes that share domains with ATP5G3: view

Function for ATP5G3 Gene

Molecular function for ATP5G3 Gene

GENATLAS Biochemistry:
ATP synthase,H+ transporting,inner mitochondrial membrane (F0 segment),subunit C,isoform 3complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
genes like me logo Genes that share phenotypes with ATP5G3: view

Animal Model Products

miRNA for ATP5G3 Gene

miRTarBase miRNAs that target ATP5G3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5G3 Gene

Localization for ATP5G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5G3 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5G3 Gene COMPARTMENTS Subcellular localization image for ATP5G3 gene
Compartment Confidence
mitochondrion 5
vacuole 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ATP5G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain IEA --
genes like me logo Genes that share ontologies with ATP5G3: view

Pathways & Interactions for ATP5G3 Gene

genes like me logo Genes that share pathways with ATP5G3: view

Gene Ontology (GO) - Biological Process for ATP5G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007568 aging IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0045471 response to ethanol IEA --
genes like me logo Genes that share ontologies with ATP5G3: view

No data available for SIGNOR curated interactions for ATP5G3 Gene

Drugs & Compounds for ATP5G3 Gene

(1) Drugs for ATP5G3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for ATP5G3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ATP5G3: view

Transcripts for ATP5G3 Gene

Unigene Clusters for ATP5G3 Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5G3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - -
SP6: - - -

Relevant External Links for ATP5G3 Gene

GeneLoc Exon Structure for
ATP5G3
ECgene alternative splicing isoforms for
ATP5G3

Expression for ATP5G3 Gene

mRNA expression in normal human tissues for ATP5G3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP5G3 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.8).

Protein differential expression in normal tissues from HIPED for ATP5G3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP5G3 Gene



SOURCE GeneReport for Unigene cluster for ATP5G3 Gene Hs.429

genes like me logo Genes that share expression patterns with ATP5G3: view

Protein tissue co-expression partners for ATP5G3 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ATP5G3 Gene

Orthologs for ATP5G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP5G3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP5G3 35
  • 95.04 (n)
  • 95.04 (a)
ATP5G3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC478807 35
  • 97.64 (n)
  • 95.04 (a)
-- 36
  • 90 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atp5g3 35
  • 95.98 (n)
  • 95.74 (a)
Atp5g3 16
Atp5g3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATP5G3 35
  • 99.68 (n)
  • 100 (a)
ATP5G3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5g3 35
  • 94.8 (n)
  • 95.74 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5G3 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5G3 35
  • 83.92 (n)
  • 89.36 (a)
ATP5G3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5g3 35
  • 81.8 (n)
  • 86.52 (a)
Str.16904 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
atp5g3a 35
  • 71.94 (n)
  • 79.86 (a)
atp5g3a 36
  • 80 (a)
OneToMany
atp5g3b 36
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1746 36
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.3 36
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLI1 36
  • 62 (a)
OneToMany
OLI1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4895 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10146 36
  • 73 (a)
OneToMany
Species with no ortholog for ATP5G3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5G3 Gene

ENSEMBL:
Gene Tree for ATP5G3 (if available)
TreeFam:
Gene Tree for ATP5G3 (if available)

Paralogs for ATP5G3 Gene

Paralogs for ATP5G3 Gene

(3) SIMAP similar genes for ATP5G3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ATP5G3 Gene

genes like me logo Genes that share paralogs with ATP5G3: view

Variants for ATP5G3 Gene

Sequence variations from dbSNP and Humsavar for ATP5G3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_011922 -

Structural Variations from Database of Genomic Variants (DGV) for ATP5G3 Gene

Variant ID Type Subtype PubMed ID
nsv3044 CNV Loss 18451855

Variation tolerance for ATP5G3 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATP5G3 Gene

Disorders for ATP5G3 Gene

Relevant External Links for ATP5G3

Genetic Association Database (GAD)
ATP5G3
Human Genome Epidemiology (HuGE) Navigator
ATP5G3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5G3

No disorders were found for ATP5G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5G3 Gene

Publications for ATP5G3 Gene

  1. Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3). (PMID: 7698763) Yan W.L. … Gusella J.F. (Genomics 1994) 2 3 4 23 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  3. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for ATP5G3 Gene

Sources for ATP5G3 Gene

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