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Aliases for ATP5G3 Gene

Aliases for ATP5G3 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit C3 (Subunit 9) 2 3 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C3 (Subunit 9) 2 3
  • ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit C3 3 4
  • ATP Synthase Proteolipid P3 3 4
  • ATPase Subunit C 3 4
  • ATPase Protein 9 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C (Subunit 9) Isoform 3 2
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit C3 (Subunit 9) 2
  • ATP Synthase F(0) Complex Subunit C3, Mitochondrial 3
  • ATP Synthase Lipid-Binding Protein, Mitochondrial 3
  • ATP Synthase, Mitochondrial, C Subunit-3 3
  • ATP Synthase Lipid-Binding Protein 4
  • ATP Synthase Subunit 9 3
  • P3 3

External Ids for ATP5G3 Gene

Previous GeneCards Identifiers for ATP5G3 Gene

  • GC02M174095
  • GC02M174704
  • GC02M176005
  • GC02M176245
  • GC02M175868
  • GC02M175750
  • GC02M176040
  • GC02M167922

Summaries for ATP5G3 Gene

Entrez Gene Summary for ATP5G3 Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified. [provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5G3 Gene

ATP5G3 (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit C3 (Subunit 9)) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include transporter activity and hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5G2.

UniProtKB/Swiss-Prot for ATP5G3 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Gene Wiki entry for ATP5G3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5G3 Gene

Genomics for ATP5G3 Gene

Regulatory Elements for ATP5G3 Gene

Enhancers for ATP5G3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G175180 1.2 ENCODE 28.8 +3.4 3361 2.2 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ATP5G3 GC02P175182 GC02M175180
GH02G175165 1.2 ENCODE 28 +17.3 17277 4.2 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ATP5G3 MIR933 GC02P175143
GH02G175061 1 ENCODE 25.2 +121.7 121666 2.1 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 TCF12 SLC30A9 CBX5 ATP5G3 CHRNA1 CHN1 MIR933 ENSG00000229750 ATF2 GC02M175073 RPL21P31
GH02G175154 1.1 Ensembl ENCODE 15.4 +29.9 29878 0.9 HDAC1 FOSL1 ZNF766 ARID3A GATA2 ZNF239 FOS NFE2 TRIM24 MAFK ATP5G3 GC02P175143 MIR933
GH02G175096 0.5 ENCODE 16.1 +87.1 87086 1.3 RFX1 FOS NFE2L2 ATP5G3 ATF2 MIR933 ENSG00000229750 ENSG00000277948 GC02P175143
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP5G3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ATP5G3 gene promoter:

Genomic Location for ATP5G3 Gene

Chromosome:
2
Start:
175,176,258 bp from pter
End:
175,184,607 bp from pter
Size:
8,350 bases
Orientation:
Minus strand

Genomic View for ATP5G3 Gene

Genes around ATP5G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5G3 Gene

Proteins for ATP5G3 Gene

  • Protein details for ATP5G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48201-AT5G3_HUMAN
    Recommended name:
    ATP synthase F(0) complex subunit C3, mitochondrial
    Protein Accession:
    P48201
    Secondary Accessions:
    • B2R4Z0
    • D3DPF0
    • Q4ZFX7

    Protein attributes for ATP5G3 Gene

    Size:
    142 amino acids
    Molecular mass:
    14693 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
    Miscellaneous:
    • There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

neXtProt entry for ATP5G3 Gene

Post-translational modifications for ATP5G3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5G3 Gene

No data available for DME Specific Peptides for ATP5G3 Gene

Domains & Families for ATP5G3 Gene

Suggested Antigen Peptide Sequences for ATP5G3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48201

UniProtKB/Swiss-Prot:

AT5G3_HUMAN :
  • Belongs to the ATPase C chain family.
Family:
  • Belongs to the ATPase C chain family.
genes like me logo Genes that share domains with ATP5G3: view

Function for ATP5G3 Gene

Molecular function for ATP5G3 Gene

GENATLAS Biochemistry:
ATP synthase,H+ transporting,inner mitochondrial membrane (F0 segment),subunit C,isoform 3complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Gene Ontology (GO) - Molecular Function for ATP5G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 7698763
GO:0008289 lipid binding IEA --
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism IBA --
genes like me logo Genes that share ontologies with ATP5G3: view
genes like me logo Genes that share phenotypes with ATP5G3: view

Animal Model Products

CRISPR Products

miRNA for ATP5G3 Gene

miRTarBase miRNAs that target ATP5G3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5G3 Gene

Localization for ATP5G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5G3 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5G3 gene
Compartment Confidence
mitochondrion 5
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ATP5G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex TAS 7698763
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP5G3: view

Pathways & Interactions for ATP5G3 Gene

genes like me logo Genes that share pathways with ATP5G3: view

Gene Ontology (GO) - Biological Process for ATP5G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IBA --
GO:0015991 ATP hydrolysis coupled proton transport IEA --
genes like me logo Genes that share ontologies with ATP5G3: view

No data available for SIGNOR curated interactions for ATP5G3 Gene

Drugs & Compounds for ATP5G3 Gene

(2) Drugs for ATP5G3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for ATP5G3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with ATP5G3: view

Transcripts for ATP5G3 Gene

Unigene Clusters for ATP5G3 Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5G3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - -
SP6: - - -

Relevant External Links for ATP5G3 Gene

GeneLoc Exon Structure for
ATP5G3
ECgene alternative splicing isoforms for
ATP5G3

Expression for ATP5G3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP5G3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP5G3 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.8).

Protein differential expression in normal tissues from HIPED for ATP5G3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP5G3 Gene



Protein tissue co-expression partners for ATP5G3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP5G3 Gene:

ATP5G3

SOURCE GeneReport for Unigene cluster for ATP5G3 Gene:

Hs.429

Evidence on tissue expression from TISSUES for ATP5G3 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Pancreas(3.3)
  • Skin(3.2)
  • Lung(2.7)
  • Muscle(2.7)
  • Heart(2.6)
  • Kidney(2.3)
  • Intestine(2.2)
  • Stomach(2.2)
  • Adrenal gland(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ATP5G3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5G3 Gene

Orthologs for ATP5G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP5G3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5G3 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia LOC478807 34
  • 97.64 (n)
-- 35
  • 95 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atp5g3 34 16 35
  • 95.98 (n)
cow
(Bos Taurus)
Mammalia ATP5G3 34 35
  • 95.04 (n)
rat
(Rattus norvegicus)
Mammalia Atp5g3 34
  • 94.8 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5G3 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5G3 34 35
  • 83.92 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 80 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5g3 34
  • 81.8 (n)
Str.16904 34
zebrafish
(Danio rerio)
Actinopterygii atp5g3b 35
  • 79 (a)
OneToMany
atp5g3a 34 35
  • 71.94 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG1746 35
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.3 35
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLI1 35 37
  • 62 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10146 35
  • 73 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4895 34
Species where no ortholog for ATP5G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5G3 Gene

ENSEMBL:
Gene Tree for ATP5G3 (if available)
TreeFam:
Gene Tree for ATP5G3 (if available)

Paralogs for ATP5G3 Gene

Paralogs for ATP5G3 Gene

(3) SIMAP similar genes for ATP5G3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ATP5G3 Gene

genes like me logo Genes that share paralogs with ATP5G3: view

Variants for ATP5G3 Gene

Sequence variations from dbSNP and Humsavar for ATP5G3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000006288 -- 175,178,582(+) AAAGG(C/T)AGGGA intron-variant, utr-variant-3-prime
rs1000313646 -- 175,177,883(+) CTTGA(A/G)TATTA utr-variant-3-prime
rs1000569638 -- 175,183,463(+) GTCTT(C/T)TTACT upstream-variant-2KB
rs1000635497 -- 175,177,365(+) AACTT(C/G)GATGA utr-variant-3-prime
rs1000857866 -- 175,176,676(+) TTCCT(A/G/T)ATAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATP5G3 Gene

Variant ID Type Subtype PubMed ID
nsv1012709 CNV gain 25217958
nsv3044 CNV deletion 18451855

Variation tolerance for ATP5G3 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5G3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5G3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5G3 Gene

Disorders for ATP5G3 Gene

Relevant External Links for ATP5G3

Genetic Association Database (GAD)
ATP5G3
Human Genome Epidemiology (HuGE) Navigator
ATP5G3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5G3

No disorders were found for ATP5G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5G3 Gene

Publications for ATP5G3 Gene

  1. Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3). (PMID: 7698763) Yan W.L. … Gusella J.F. (Genomics 1994) 2 3 4 22 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64

Products for ATP5G3 Gene

Sources for ATP5G3 Gene

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