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Aliases for ATP5G2 Gene

Aliases for ATP5G2 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit C2 (Subunit 9) 2 3 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C2 (Subunit 9) 2 3
  • ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit C2 3 4
  • ATP Synthase Proteolipid P2 3 4
  • ATPase Subunit C 3 4
  • ATPase Protein 9 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C (Subunit 9), Isoform 2 2
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit C2 (Subunit 9) 2
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C (Subunit 9) 3
  • ATP Synthase F(0) Complex Subunit C2, Mitochondrial 3
  • ATP Synthase Lipid-Binding Protein, Mitochondrial 3
  • Mitochondrial ATP Synthase, Subunit C (Subunit 9) 3
  • ATP Synthase Lipid-Binding Protein 4
  • ATP Synthase C Subunit 3
  • ATP5A 3

External Ids for ATP5G2 Gene

Previous GeneCards Identifiers for ATP5G2 Gene

  • GC12P054160
  • GC12M054171
  • GC12M053775
  • GC12M052345
  • GC12M054058
  • GC12M051097
  • GC12M054029
  • GC12M054030
  • GC12M053635
  • GC12M053638
  • GC12M053640
  • GC12M053642
  • GC12M053644

Summaries for ATP5G2 Gene

Entrez Gene Summary for ATP5G2 Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes. [provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5G2 Gene

ATP5G2 (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit C2 (Subunit 9)) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include transporter activity and hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5G3.

UniProtKB/Swiss-Prot for ATP5G2 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Gene Wiki entry for ATP5G2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5G2 Gene

Genomics for ATP5G2 Gene

Regulatory Elements for ATP5G2 Gene

Enhancers for ATP5G2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G053674 1.8 FANTOM5 ENCODE dbSUPER 41.5 -0.1 -77 5.4 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 ATP5G2 MAP3K12 SP1 ATF7 ZNF740 CBX5 AAAS CALCOCO1 CSAD GC12M053723
GH12G053595 1.5 Ensembl ENCODE dbSUPER 31.3 +80.4 80413 3.6 PKNOX1 FOXA2 FEZF1 ZNF2 GLIS2 ZNF766 GATA2 KLF7 ZNF263 REST ATP5G2 ATF7 NPFF MAP3K12 TARBP2 PRR13 LOC100419830 ENSG00000267281
GH12G053568 1.4 Ensembl ENCODE dbSUPER 30.5 +107.7 107745 2.4 PKNOX1 KLF17 FEZF1 ZBTB40 ZEB1 ZNF335 GLIS2 ZNF366 ZNF302 ZSCAN5C ATP5G2 ATF7 TARBP2 MAP3K12 PRR13 LOC100419830 LOC100652999
GH12G053617 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +58.8 58808 3.2 PKNOX1 FEZF1 ZNF2 ZNF121 KLF7 ZNF263 TSHZ1 REST SMARCA4 PBX2 ATP5G2 ENSG00000270175 PRR13 PFDN5 ENSG00000267281 LOC100419830
GH12G053657 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.3 +18.0 17953 3.6 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A DMAP1 FEZF1 ZNF2 YY1 ATP5G2 AAAS PRR13 GC12P053677 GC12P053639
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP5G2 on UCSC Golden Path with GeneCards custom track

Promoters for ATP5G2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052228 1008 2401 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610

Genomic Location for ATP5G2 Gene

Chromosome:
12
Start:
53,632,726 bp from pter
End:
53,677,408 bp from pter
Size:
44,683 bases
Orientation:
Minus strand

Genomic View for ATP5G2 Gene

Genes around ATP5G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5G2 Gene

Proteins for ATP5G2 Gene

  • Protein details for ATP5G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06055-AT5G2_HUMAN
    Recommended name:
    ATP synthase F(0) complex subunit C2, mitochondrial
    Protein Accession:
    Q06055
    Secondary Accessions:
    • B3KQQ6

    Protein attributes for ATP5G2 Gene

    Size:
    141 amino acids
    Molecular mass:
    14637 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
    Miscellaneous:
    • There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

    Alternative splice isoforms for ATP5G2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP5G2 Gene

Post-translational modifications for ATP5G2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATP5G2 Gene

Domains & Families for ATP5G2 Gene

Suggested Antigen Peptide Sequences for ATP5G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q06055

UniProtKB/Swiss-Prot:

AT5G2_HUMAN :
  • Belongs to the ATPase C chain family.
Family:
  • Belongs to the ATPase C chain family.
genes like me logo Genes that share domains with ATP5G2: view

Function for ATP5G2 Gene

Molecular function for ATP5G2 Gene

GENATLAS Biochemistry:
ATP synthase,H+ transporting,inner mitochondrial membrane (F0 segment),subunit 2,complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Gene Ontology (GO) - Molecular Function for ATP5G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 8328972
GO:0008289 lipid binding IEA --
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism IBA --
genes like me logo Genes that share ontologies with ATP5G2: view
genes like me logo Genes that share phenotypes with ATP5G2: view

Animal Models for ATP5G2 Gene

MGI Knock Outs for ATP5G2:

Animal Model Products

CRISPR Products

miRNA for ATP5G2 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5G2 Gene

Localization for ATP5G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5G2 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5G2 gene
Compartment Confidence
mitochondrion 5
extracellular 3
plasma membrane 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ATP5G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex TAS 8328972
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP5G2: view

Pathways & Interactions for ATP5G2 Gene

genes like me logo Genes that share pathways with ATP5G2: view

Gene Ontology (GO) - Biological Process for ATP5G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IBA --
GO:0015991 ATP hydrolysis coupled proton transport IEA --
genes like me logo Genes that share ontologies with ATP5G2: view

No data available for SIGNOR curated interactions for ATP5G2 Gene

Drugs & Compounds for ATP5G2 Gene

No Compound Related Data Available

Transcripts for ATP5G2 Gene

Unigene Clusters for ATP5G2 Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5G2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: -
SP6: -

Relevant External Links for ATP5G2 Gene

GeneLoc Exon Structure for
ATP5G2
ECgene alternative splicing isoforms for
ATP5G2

Expression for ATP5G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP5G2 Gene

Protein differential expression in normal tissues from HIPED for ATP5G2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP5G2 Gene



Protein tissue co-expression partners for ATP5G2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP5G2 Gene:

ATP5G2

SOURCE GeneReport for Unigene cluster for ATP5G2 Gene:

Hs.524464

Evidence on tissue expression from TISSUES for ATP5G2 Gene

  • Lung(4.5)
  • Liver(4.4)
  • Nervous system(4.1)
  • Muscle(2.7)
  • Skin(2.6)
  • Heart(2.5)
  • Eye(2.4)
  • Lymph node(2.3)
  • Stomach(2.3)
  • Adrenal gland(2.2)
  • Gall bladder(2.2)
  • Intestine(2.2)
  • Kidney(2.2)
  • Thyroid gland(2.2)
  • Bone marrow(2.1)
  • Pancreas(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with ATP5G2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5G2 Gene

Orthologs for ATP5G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP5G2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5G2 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
OneToMany
ATP5G2 34
  • 85.69 (n)
-- 35
  • 79 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ATP5G2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5g2 34 16 35
  • 89.13 (n)
Gm10175 35
  • 88 (a)
OneToMany
Gm17271 35
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Atp5g2 34
  • 87 (n)
cow
(Bos Taurus)
Mammalia ATP5G2 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 64 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 78 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii atp5g3b 34
  • 69.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1746 34 35
  • 64.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000523 34
  • 61.79 (n)
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.3 35
  • 65 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLI1 35
  • 62 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10146 35
  • 72 (a)
OneToMany
Species where no ortholog for ATP5G2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATP5G2 Gene

ENSEMBL:
Gene Tree for ATP5G2 (if available)
TreeFam:
Gene Tree for ATP5G2 (if available)

Paralogs for ATP5G2 Gene

Paralogs for ATP5G2 Gene

(3) SIMAP similar genes for ATP5G2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATP5G2: view

Variants for ATP5G2 Gene

Sequence variations from dbSNP and Humsavar for ATP5G2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000135264 -- 53,673,767(+) GGTGA(C/G)CCAAG intron-variant
rs1000402026 -- 53,673,608(+) CACGA(A/G)GTCAG intron-variant
rs1000514610 -- 53,668,670(+) AAATA(C/T)GGTTA intron-variant
rs1000818770 -- 53,666,136(+) AACCC(C/G)GTCTC intron-variant
rs1000912360 -- 53,666,360(+) ATCAC(A/G)AGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5G2 Gene

Variant ID Type Subtype PubMed ID
nsv526791 CNV gain 19592680

Variation tolerance for ATP5G2 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5G2 Gene

Disorders for ATP5G2 Gene

Relevant External Links for ATP5G2

Genetic Association Database (GAD)
ATP5G2
Human Genome Epidemiology (HuGE) Navigator
ATP5G2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5G2

No disorders were found for ATP5G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5G2 Gene

Publications for ATP5G2 Gene

  1. Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase. (PMID: 8328972) Dyer M.R. … Walker J.E. (Biochem. J. 1993) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y. … Kamatani N. (Hum. Mol. Genet. 2010) 3 46 64
  4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64

Products for ATP5G2 Gene

Sources for ATP5G2 Gene

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