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Aliases for ATP5G1 Gene

Aliases for ATP5G1 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit C1 (Subunit 9) 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C1 (Subunit 9) 2 3
  • ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit C1 3 4
  • ATP Synthase Proteolipid P1 3 4
  • ATPase Subunit C 3 4
  • ATPase Protein 9 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C (Subunit 9), Isoform 1 2
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C (Subunit 9) 3
  • ATP Synthase F(0) Complex Subunit C1, Mitochondrial 3
  • ATP Synthase Lipid-Binding Protein, Mitochondrial 3
  • Mitochondrial ATP Synthase, Subunit 9 3
  • Mitochondrial ATP Synthase, Subunit C 3
  • ATP Synthase Lipid-Binding Protein 4
  • ATPase Subunit 9 3
  • ATP5A 3
  • ATP5G 3

External Ids for ATP5G1 Gene

Previous HGNC Symbols for ATP5G1 Gene

  • ATP5G

Previous GeneCards Identifiers for ATP5G1 Gene

  • GC17P046682
  • GC17P049450
  • GC17P047312
  • GC17P047444
  • GC17P044327
  • GC17P046970
  • GC17P042337

Summaries for ATP5G1 Gene

Entrez Gene Summary for ATP5G1 Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5G1 Gene

ATP5G1 (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit C1 (Subunit 9)) is a Protein Coding gene. Diseases associated with ATP5G1 include spindle cell hemangioma. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include transporter activity and hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5G3.

UniProtKB/Swiss-Prot for ATP5G1 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element

Gene Wiki entry for ATP5G1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5G1 Gene

Genomics for ATP5G1 Gene

Regulatory Elements for ATP5G1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATP5G1 Gene

Start:
48,892,765 bp from pter
End:
48,895,871 bp from pter
Size:
3,107 bases
Orientation:
Plus strand

Genomic View for ATP5G1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5G1 Gene

Proteins for ATP5G1 Gene

  • Protein details for ATP5G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05496-AT5G1_HUMAN
    Recommended name:
    ATP synthase F(0) complex subunit C1, mitochondrial
    Protein Accession:
    P05496
    Secondary Accessions:

    Protein attributes for ATP5G1 Gene

    Size:
    136 amino acids
    Molecular mass:
    14277 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).
    Miscellaneous:
    • There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease)

neXtProt entry for ATP5G1 Gene

Proteomics data for ATP5G1 Gene at MOPED

Post-translational modifications for ATP5G1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5G1 Gene

No data available for DME Specific Peptides for ATP5G1 Gene

Domains for ATP5G1 Gene

Gene Families for ATP5G1 Gene

HGNC:
  • F1ATP :ATPases / F-type
  • FATP :Mitochondrial respiratory chain complex / Complex V
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P05496

UniProtKB/Swiss-Prot:

AT5G1_HUMAN :
  • P05496
Family:
  • Belongs to the ATPase C chain family.
genes like me logo Genes that share domains with ATP5G1: view

Function for ATP5G1 Gene

Molecular function for ATP5G1 Gene

GENATLAS Biochemistry: ATP synthase H+ transporting,subunit C,inner mitochondrial membrane (F0 segment),subunit C,isoform 1,DCCD (dicyclohexylcarbodiimidine) reactive,complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element

Gene Ontology (GO) - Molecular Function for ATP5G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 8328972
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with ATP5G1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5G1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATP5G1 Gene

Localization for ATP5G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5G1 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5G1 Gene COMPARTMENTS Subcellular localization image for ATP5G1 gene
Compartment Confidence
mitochondrion 5
extracellular 2
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ATP5G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex ISS --
GO:0016021 integral component of membrane IEA --
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain --
genes like me logo Genes that share ontologies with ATP5G1: view

Pathways for ATP5G1 Gene

genes like me logo Genes that share pathways with ATP5G1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat

Gene Ontology (GO) - Biological Process for ATP5G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015986 ATP synthesis coupled proton transport --
GO:0015991 ATP hydrolysis coupled proton transport IEA --
GO:0022904 respiratory electron transport chain TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with ATP5G1: view

Compounds for ATP5G1 Gene

(4) HMDB Compounds for ATP5G1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with ATP5G1: view

Transcripts for ATP5G1 Gene

Unigene Clusters for ATP5G1 Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5G1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5G1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -

Relevant External Links for ATP5G1 Gene

GeneLoc Exon Structure for
ATP5G1
ECgene alternative splicing isoforms for
ATP5G1

Expression for ATP5G1 Gene

mRNA expression in normal human tissues for ATP5G1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP5G1 Gene

This gene is overexpressed in Heart - Left Ventricle (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATP5G1 Gene

SOURCE GeneReport for Unigene cluster for ATP5G1 Gene Hs.80986

genes like me logo Genes that share expressions with ATP5G1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ATP5G1 Gene

Orthologs for ATP5G1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP5G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5G1 35
  • 99.75 (n)
  • 100 (a)
ATP5G1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5G1 35
  • 91.42 (n)
  • 91.91 (a)
ATP5G1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5G1 35
  • 93.87 (n)
  • 91.18 (a)
ATP5G1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5g1 35
  • 89.46 (n)
  • 89.71 (a)
Atp5g1 16
Atp5g1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP5G1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5G1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5g1 35
  • 91.18 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 72 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
ATP5G1 35
  • 77.28 (n)
  • 80.74 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8970 35
zebrafish
(Danio rerio)
Actinopterygii atp5g1 36
  • 70 (a)
OneToOne
wufb01g06 35
fruit fly
(Drosophila melanogaster)
Insecta CG1746 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.3 36
  • 65 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLI1 36
  • 61 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10146 36
  • 73 (a)
OneToMany
Species with no ortholog for ATP5G1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATP5G1 Gene

ENSEMBL:
Gene Tree for ATP5G1 (if available)
TreeFam:
Gene Tree for ATP5G1 (if available)

Paralogs for ATP5G1 Gene

Paralogs for ATP5G1 Gene

Selected SIMAP similar genes for ATP5G1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ATP5G1: view

Variants for ATP5G1 Gene

Sequence variations from dbSNP and Humsavar for ATP5G1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13905 -- 48,895,709(+) GCCCT(A/C/G)TCTGA synonymous-codon, reference
rs519537 -- 48,893,778(-) GCAGC(C/T)TAGGC intron-variant
rs524808 -- 48,892,007(-) GCGTG(C/T)CTGTA upstream-variant-2KB
rs618000 -- 48,891,187(-) cctcc(C/G)gagta upstream-variant-2KB
rs684682 -- 48,893,474(-) AGCAC(C/T)GCGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5G1 Gene

Variant ID Type Subtype PubMed ID
nsv482969 CNV Loss 15286789
nsv833472 CNV Gain 17160897

Relevant External Links for ATP5G1 Gene

HapMap Linkage Disequilibrium report
ATP5G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5G1 Gene

Disorders for ATP5G1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ATP5G1 Gene including...

Search for ATP5G1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ATP5G1 Gene

Relevant External Links for ATP5G1

Genetic Association Database (GAD)
ATP5G1
Human Genome Epidemiology (HuGE) Navigator
ATP5G1
genes like me logo Genes that share disorders with ATP5G1: view

No data available for UniProtKB/Swiss-Prot for ATP5G1 Gene

Publications for ATP5G1 Gene

  1. Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase. (PMID: 8328972) Dyer M.R. … Walker J.E. (Biochem. J. 1993) 2 3 4
  2. Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria. (PMID: 8485160) Higuti T. … Tsujita H. (Biochim. Biophys. Acta 1993) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

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