Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATP5G1 Gene

Aliases for ATP5G1 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit C1 (Subunit 9) 2 3 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C1 (Subunit 9) 2 3
  • ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit C1 3 4
  • ATP Synthase Proteolipid P1 3 4
  • ATPase Subunit C 3 4
  • ATPase Protein 9 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C (Subunit 9), Isoform 1 2
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit C1 (Subunit 9) 2
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C (Subunit 9) 3
  • ATP Synthase F(0) Complex Subunit C1, Mitochondrial 3
  • ATP Synthase Lipid-Binding Protein, Mitochondrial 3
  • Mitochondrial ATP Synthase, Subunit 9 3
  • Mitochondrial ATP Synthase, Subunit C 3
  • ATP Synthase Lipid-Binding Protein 4
  • ATPase Subunit 9 3
  • ATP5A 3
  • ATP5G 3

External Ids for ATP5G1 Gene

Previous HGNC Symbols for ATP5G1 Gene

  • ATP5G

Previous GeneCards Identifiers for ATP5G1 Gene

  • GC17P046682
  • GC17P049450
  • GC17P047312
  • GC17P047444
  • GC17P044327
  • GC17P046970
  • GC17P042337

Summaries for ATP5G1 Gene

Entrez Gene Summary for ATP5G1 Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5G1 Gene

ATP5G1 (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit C1 (Subunit 9)) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include transporter activity and hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5G3.

UniProtKB/Swiss-Prot for ATP5G1 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Gene Wiki entry for ATP5G1 Gene

Additional gene information for ATP5G1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5G1 Gene

Genomics for ATP5G1 Gene

Regulatory Elements for ATP5G1 Gene

Enhancers for ATP5G1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H048869 1.3 Ensembl ENCODE 30.6 -21.1 -21060 5 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 SP5 MXD4 ATP5G1 TTLL6 CALCOCO2 UBE2Z ENSG00000230532 HOXB13 PRAC1 PRAC2 SUMO2P17 LOC105371811
GH17H048906 1.4 ENCODE dbSUPER 17.6 +16.0 16046 4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B UBE2Z ENSG00000262837 ENSG00000266601 ATP5G1 CALCOCO2 GIP ENSG00000250838 ENSG00000251461 RN7SL125P LINC02075
GH17H048799 0.9 ENCODE 27.2 -91.9 -91854 3 ELF3 ARID4B THRB RAD21 RARA YY1 ZNF366 MIXL1 SP5 MXD4 ATP5G1 TTLL6 PRAC1 PRAC2 LOC105371811 HOXB13 ENSG00000238804 ENSG00000230532 RNU1-42P SNF8
GH17H048891 1.2 ENCODE 20.3 +0.7 661 4 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 ZNF610 UBE2Z ENSG00000266601 ENSG00000262837 SP2 ENSG00000264701 ATP5G1 CDK5RAP3 ENSG00000263412 ENSG00000230532 CALCOCO2
GH17H048840 0.8 ENCODE 29.4 -50.8 -50826 3 HDGF BMI1 BATF RAD21 ZNF766 ATF7 ETV6 RUNX3 IKZF2 CREM ATP5G1 TTLL6 PRAC1 PRAC2 HOXB13 LOC105371811 CALCOCO2 UBE2Z FAM117A GC17P048882
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP5G1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP5G1 Gene

Chromosome:
17
Start:
48,892,765 bp from pter
End:
48,895,871 bp from pter
Size:
3,107 bases
Orientation:
Plus strand

Genomic View for ATP5G1 Gene

Genes around ATP5G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5G1 Gene

Proteins for ATP5G1 Gene

  • Protein details for ATP5G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05496-AT5G1_HUMAN
    Recommended name:
    ATP synthase F(0) complex subunit C1, mitochondrial
    Protein Accession:
    P05496

    Protein attributes for ATP5G1 Gene

    Size:
    136 amino acids
    Molecular mass:
    14277 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).
    Miscellaneous:
    • There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

neXtProt entry for ATP5G1 Gene

Post-translational modifications for ATP5G1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5G1 Gene

No data available for DME Specific Peptides for ATP5G1 Gene

Domains & Families for ATP5G1 Gene

Gene Families for ATP5G1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P05496

UniProtKB/Swiss-Prot:

AT5G1_HUMAN :
  • Belongs to the ATPase C chain family.
Family:
  • Belongs to the ATPase C chain family.
genes like me logo Genes that share domains with ATP5G1: view

Function for ATP5G1 Gene

Molecular function for ATP5G1 Gene

GENATLAS Biochemistry:
ATP synthase H+ transporting,subunit C,inner mitochondrial membrane (F0 segment),subunit C,isoform 1,DCCD (dicyclohexylcarbodiimidine) reactive,complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Phenotypes From GWAS Catalog for ATP5G1 Gene

Gene Ontology (GO) - Molecular Function for ATP5G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 8328972
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism IBA --
genes like me logo Genes that share ontologies with ATP5G1: view
genes like me logo Genes that share phenotypes with ATP5G1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ATP5G1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5G1 Gene

Localization for ATP5G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5G1 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5G1 gene
Compartment Confidence
mitochondrion 5
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ATP5G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex TAS,ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP5G1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATP5G1 Gene

Pathways & Interactions for ATP5G1 Gene

genes like me logo Genes that share pathways with ATP5G1: view

Gene Ontology (GO) - Biological Process for ATP5G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IBA,IEA --
GO:0015991 ATP hydrolysis coupled proton transport IEA --
genes like me logo Genes that share ontologies with ATP5G1: view

No data available for SIGNOR curated interactions for ATP5G1 Gene

Drugs & Compounds for ATP5G1 Gene

(2) Drugs for ATP5G1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
ATP Nutra Agonist 0

(2) Additional Compounds for ATP5G1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with ATP5G1: view

Transcripts for ATP5G1 Gene

Unigene Clusters for ATP5G1 Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ATP5G1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5G1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -

Relevant External Links for ATP5G1 Gene

GeneLoc Exon Structure for
ATP5G1
ECgene alternative splicing isoforms for
ATP5G1

Expression for ATP5G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP5G1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP5G1 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.0).

Protein differential expression in normal tissues from HIPED for ATP5G1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP5G1 Gene



Protein tissue co-expression partners for ATP5G1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP5G1 Gene:

ATP5G1

SOURCE GeneReport for Unigene cluster for ATP5G1 Gene:

Hs.80986

Evidence on tissue expression from TISSUES for ATP5G1 Gene

  • Nervous system(4.7)
  • Lung(4.5)
  • Liver(4.4)
  • Muscle(2.6)
  • Heart(2.5)
  • Kidney(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ATP5G1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5G1 Gene

Orthologs for ATP5G1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP5G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5G1 33 34
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia ATP5G1 34 33
  • 93.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5G1 33 34
  • 91.42 (n)
rat
(Rattus norvegicus)
Mammalia Atp5g1 33
  • 91.18 (n)
mouse
(Mus musculus)
Mammalia Atp5g1 33 16 34
  • 89.46 (n)
oppossum
(Monodelphis domestica)
Mammalia ATP5G1 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5G1 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5G1 33
  • 77.28 (n)
-- 34
  • 72 (a)
OneToMany
-- 34
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 79 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii atp5g1 34
  • 70 (a)
OneToOne
wufb01g06 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8970 33
fruit fly
(Drosophila melanogaster)
Insecta CG1746 34
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.3 34
  • 65 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLI1 34
  • 61 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10146 34
  • 73 (a)
OneToMany
Species where no ortholog for ATP5G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATP5G1 Gene

ENSEMBL:
Gene Tree for ATP5G1 (if available)
TreeFam:
Gene Tree for ATP5G1 (if available)

Paralogs for ATP5G1 Gene

Paralogs for ATP5G1 Gene

(3) SIMAP similar genes for ATP5G1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ATP5G1: view

Variants for ATP5G1 Gene

Sequence variations from dbSNP and Humsavar for ATP5G1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000949019 -- 48,894,256(+) TGACC(C/T)TGAAA intron-variant
rs1001406504 -- 48,890,836(+) CATGG(C/T)GGTGC intron-variant, upstream-variant-2KB
rs1002339370 -- 48,894,102(+) TTCTT(C/G/T)TTCCA intron-variant
rs1002865420 -- 48,893,790(+) CCTTA(G/T)ACCAT intron-variant
rs1003163232 -- 48,891,602(+) CTGCT(G/T)TCAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ATP5G1 Gene

Variant ID Type Subtype PubMed ID
nsv482969 CNV loss 15286789
nsv833472 CNV gain 17160897

Variation tolerance for ATP5G1 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5G1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5G1 Gene

Disorders for ATP5G1 Gene

Relevant External Links for ATP5G1

Genetic Association Database (GAD)
ATP5G1
Human Genome Epidemiology (HuGE) Navigator
ATP5G1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5G1

No disorders were found for ATP5G1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5G1 Gene

Publications for ATP5G1 Gene

  1. Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase. (PMID: 8328972) Dyer MR … Walker JE (The Biochemical journal 1993) 2 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60
  5. Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria. (PMID: 8485160) Higuti T … Tsujita H (Biochimica et biophysica acta 1993) 3 4 60

Products for ATP5G1 Gene

Sources for ATP5G1 Gene

Content
Loading form....