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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP5F1 Gene

protein-coding   GIFtS: 57
GCID: GC01P111991

ATP synthase, H+ transporting, mitochondrial Fo complex,...

(Previous names: ATP synthase, H+ transporting, mitochondrial F0 complex,...)
 Explore 10 diseases affiliated with
ATP5F1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATP5F1    

Aliases
for ATP5F1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit B11 2     ATP Synthase B Chain, Mitochondrial2
ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B11 2     ATP Synthase Subunit B, Mitochondrial2
ATPase Subunit B2 3     ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B2
ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B, Isoform 11     Cell Proliferation-Inducing Protein 472
PIG472     H+-ATP Synthase Subunit B2

External Ids:    HGNC: 8401   Entrez Gene: 5152   Ensembl: ENSG000001164597   OMIM: 6032705   UniProtKB: P245393   

Export aliases for ATP5F1 gene to outside databases

Previous GC identifers: GC01P112408 GC01P110863 GC01P111093 GC01P111290 GC01P111703 GC01P111793 GC01P109863


Summaries
for ATP5F1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ATP5F1:
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis,
utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP
synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning
component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5
different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a
single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8).
This gene encodes the b subunit of the proton channel. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AT5F1_HUMAN, P24539
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
presence of a proton gradient across the membrane which is generated by electron transport complexes of the
respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic
core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.
During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk
subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to
hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements

Gene Wiki entry for ATP5F1


Genomic Views
for ATP5F1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP5F1 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pbx1a   Nkx2-5   Nkx3-1 v1   Evi-1   Nkx3-1 v2   Ik-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATP5F1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP5F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP5F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

ATP5F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP5F1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P111991:  view genomic region     (about GC identifiers)

Start:
 111,991,486 bp from pter      End:
 112,005,395 bp from pter
Size:
 13,910 bases      Orientation:
 plus strand

Proteins
for ATP5F1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AT5F1_HUMAN, P24539 (See protein sequence)
Recommended Name: ATP synthase subunit b, mitochondrial precursor  
Size: 256 amino acids; 28909 Da
Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1)
has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8,
ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity)
Subcellular location: Mitochondrion. Mitochondrion inner membrane
Secondary accessions: Q9BQ68 Q9BRU8

Explore the universe of human proteins at neXtProt for ATP5F1: NX_P24539

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P24539

    • ATP5F1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001679.2  
    ENSEMBL proteins: 
     ENSP00000358737   ENSP00000420366  
    Reactome Protein details: P24539
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    Uscn Proteins for ATP5F1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000276mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA--
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005753mitochondrial proton-transporting ATP synthase complex IDA12110673
    GO:0005759mitochondrial matrix NAS1831354


    ATP5F1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ATP5F1

    Protein Domains /
    Families
    for ATP5F1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATP5F1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR008688 ATPase_B_chain/sub_B/MI25
     IPR013837 ATPase_F0_sub_B/B_chain

    Graphical View of Domain Structure for InterPro Entry P24539

    ProtoNet protein and cluster: P24539

    1 Blocks protein family: IPB008688 Mitochondrial ATP synthase B chain

    UniProtKB/Swiss-Prot: AT5F1_HUMAN, P24539
    Similarity: Belongs to the eukaryotic ATPase B chain family


    Function
    for ATP5F1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AT5F1_HUMAN, P24539
    Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
    presence of a proton gradient across the membrane which is generated by electron transport complexes of the
    respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic
    core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.
    During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk
    subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to
    hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements

         Genatlas biochemistry entry for ATP5F1:
    ATP synthase H+ transporting,inner mitochondrial membrane (F0 segment),subunit b,isoform 1,complex V of oxidative
    phosphorylation (OXPHOS)

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    hsa-miR-579 hsa-miR-193a-3p hsa-miR-539 hsa-miR-489 hsa-miR-1255a hsa-miR-205* hsa-miR-651 hsa-miR-626
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19016746
    GO:0015078hydrogen ion transmembrane transporter activity ----
    GO:0016887contributes to ATPase activity IDA12110673
    GO:0022857transmembrane transporter activity IC12110673
    GO:0046933proton-transporting ATP synthase activity, rotational mechanism IBA--


    ATP5F1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ATP5F1:
     Decreased influenza A virus in  Increased number of cells in m  Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for ATP5F1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.1.00
    		Parkinson's disease0.61
    		Electron Transport Chain0.76
    		Oxidative phosphorylation0.52
    		The citric acid (TCA) cycle and respiratory electron transport0.72
    		Alzheimer's disease0.43
    		Oxidative phosphorylation0.63
    		Huntington's disease0.40
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
    		Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics1.00
    4Formation of ATP by chemiosmotic coupling
    		Formation of ATP by chemiosmotic coupling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for ATP5F1 
        Oxidative phosphorylation
    Electron Transport Chain

    4        Reactome Pathways for ATP5F1
        Formation of ATP by chemiosmotic coupling
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport

    1 PharmGKB Pathway for ATP5F1
        Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

    5         Kegg Pathways  (Kegg details for ATP5F1):
        Oxidative phosphorylation
    Metabolic pathways
    Alzheimer's disease
    Parkinson's disease
    Huntington's disease


    ATP5F1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP5F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/297 Interacting proteins for ATP5F1 (P245392, 3 ENSP000003587374) via UniProtKB, MINT, STRING, and/or I2D (see all 297)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5BP065762, 3, ENSP000002620304MINT-8079030 I2D: score=1 STRING: ENSP00000262030
    ATP5C1P365422, 3, ENSP000003491424MINT-8079030 I2D: score=1 STRING: ENSP00000349142
    ATP5A1P257052, 3, ENSP000002820504MINT-8079030 I2D: score=1 STRING: ENSP00000282050
    ATP5HO759472, 3, ENSP000003015874MINT-8079030 I2D: score=1 STRING: ENSP00000301587
    ATP5LO759642, 3, ENSP000003006884MINT-8079030 I2D: score=1 STRING: ENSP00000300688
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA12110673
    GO:0015986ATP synthesis coupled proton transport IBA--
    GO:0022904respiratory electron transport chain TAS--
    GO:0042776mitochondrial ATP synthesis coupled proton transport TAS--
    GO:0044281small molecule metabolic process TAS--


    ATP5F1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATP5F1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ATP5F1

    5 HMDB Compounds for ATP5F1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Clotrimazole(Chlorotrityl)imidazole (see all 72)23593-75-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about ATP5F1 / AT5F1 

    Transcripts
    for ATP5F1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATP5F1 gene: 
    NM_001688.4  

    Unigene Cluster for ATP5F1:

    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
    Hs.514870  [show with all ESTs]
    Unigene Representative Sequence: NM_001688
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493119 ENST00000369722(uc009wgf.1 uc001ebc.3) ENST00000369721
    ENST00000483994 ENST00000468818 ENST00000464154

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    hsa-miR-579 hsa-miR-193a-3p hsa-miR-539 hsa-miR-489 hsa-miR-1255a hsa-miR-205* hsa-miR-651 hsa-miR-626
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK223018.1 AK291077.1 AK308266.1 AK311287.1 AK313541.1 AY871272.1 BC005366.1 BC005960.1 
    BC016350.1 X60221.1 

    24/40 DOTS entries (see all 40):

    DT.95320239  DT.91775154  DT.453418  DT.95320121  DT.100860312  DT.100861085  DT.100687198  DT.91876202 
    DT.95320135  DT.100039585  DT.95320112  DT.121362520  DT.121362544  DT.95312610  DT.99932255  DT.92045462 
    DT.95320114  DT.100860313  DT.121362464  DT.121362484  DT.100640295  DT.100799327  DT.102839017  DT.120666461 

    24/1094 AceView cDNA sequences (see all 1094):

    AA356416 CR597718 NM_001002014 CA437199 BM755903 CA443246 BV178779 AW068897 
    CB242631 CD678604 CA941068 CR624650 F07452 BU521346 BM979693 BM999420 
    CR606746 AW768494 BU557338 BQ439928 BM423426 BM971449 AA115691 AA234352 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ATP5F1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d
    SP1:                                                                    -                           
    SP2:                                                                                                
    SP3:              -     -     -                                         -                           
    SP4:                    -     -                                         -                           
    SP5:                    -                                                                           


    ECgene alternative splicing isoforms for ATP5F1

    Expression
    for ATP5F1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP5F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATAAATTGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ATP5F1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP5F1

    SOURCE GeneReport for Unigene cluster: Hs.514870
        SABiosciences Expression via Pathway-Focused PCR Array including ATP5F1: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
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    Orthologs
    for ATP5F1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ATP5F1 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Atp5f11 , 5 ATP synthase, H+ transporting, mitochondrial F0 complex, more1, 5 84.77(n)1
    82.81(a)1    		   3 (46.46 cM)5
    119501  NM_009725.31  NP_033855.21 
     1059426985 
    chicken
    (Gallus gallus)    		 Aves ATP5F11 ATP synthase, H+ transporting, mitochondrial Fo complex, more 65.21(n)
    60.16(a)    		   419866  XM_417993.3  XP_417993.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ATP5F16
    		 --
    		 60(a)
    		 1 ↔ 1
    		 4(126353624-126365885)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.92242 Xenopus laevis transcribed sequence with weak similarity more 71.5(n)    CD329541.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii atp5f11 ATP synthase, H+ transporting, mitochondrial F0 complex, more 60.24(n)
    58.23(a)    		   449787  NM_001005960.1  NP_001005960.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ATPsyn-b1 , 3 hydrogen transport hydrogen-transporting
    two-sector more3
    ATP synthase, subunit b1    		 46(a)3
    52.78(n)1
    47.06(a)1    		   3 67C53
    391431  NM_079287.11  NP_524011.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea asb-26
    asb-16
    		 ATP Synthase B homolog family member (asb-1)
    		 18(a)
    15(a)
    		 many → 1
    many → 1
    		 X(4469718-4471455)
    III(4594509-4595912)


    ENSEMBL Gene Tree for ATP5F1 (if available)
    TreeFam Gene Tree for ATP5F1 (if available) 

    Paralogs
    for ATP5F1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP5F1 gene

    ATP5F1 for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for ATP5F1 (see all 9)
    PGOHUM00000242912 PGOHUM00000248596 PGOHUM00000248937 PGOHUM00000234957 PGOHUM00000240988


    Genomic Variants
    for ATP5F1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/274 NCBI SNPs in ATP5F1 are shown (see all 274)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1468474051,2
    		--111989823(+) AAAAAC/TGTGTT 2 -- us2k1 int10--------
    rs1393287361,2
    		--111989884(+) CTGCTA/GCTATG 2 -- us2k1 int10--------
    rs1878620001,2
    		--111989937(+) AGACAA/TGCTAA 2 -- us2k1 int10--------
    rs1931676211,2
    		--111989966(+) TAGAAC/TAAGCC 2 -- us2k1 int10--------
    rs1432900681,2
    		--111990260(+) ACTTCC/TAGGAT 2 -- us2k1 int10--------
    rs22981851,2
    		C,F,O,A,H,--111990265(+) TAGGAT/CTCAAA 2 -- us2k1 int137Minor allele frequency- C:0.13EA NS NA WA 4926
    rs111022761,2
    		--111990335(+) ATCATC/TGGAGA 2 -- int1 us2k10--------
    rs799307231,2
    		F,--111990377(+) TCTGCG/TTTACT 2 -- us2k1 int11Minor allele frequency- T:0.06WA 118
    rs1153002021,2
    		F,--111990456(+) CTGTAA/CAATTC 2 -- us2k1 int11Minor allele frequency- C:0.02WA 118
    rs1844469711,2
    		--111990572(+) CCCCAA/GTATTT 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for ATP5F1 (111991486 - 112005395 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ATP5F1: --

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    Disorders / Diseases
    for ATP5F1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATP5F1 for disorders           About GeneDecksing

    OMIM gene information: 603270    OMIM disorders: --

    10 diseases for ATP5F1:    About MalaCards
    complex v    chronic myeloid leukemia    myeloid leukemia    huntington's disease
    parkinson's disease    hermaphroditism    colon cancer    leukemia
    prostatitis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: ATP5F1 (3 documents)

    Export disorders for ATP5F1 gene to outside databases

    Publications
    for ATP5F1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP5F1 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with ATP5F1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria. (PubMed id 1831354)1, 2, 3 Higuti T.... Ichirara A. (1991)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (2012)
    6. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    7. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for ATP5F1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing ATP5F1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 515 HGNC: 840 AceView: ATP5F1 Ensembl:ENSG00000116459 euGenes: HUgn515
    ECgene: ATP5F1 Kegg: 515 H-InvDB: ATP5F1

    Other Databases showing ATP5F1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATP5F1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP5F1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATP5F1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATP5F1 gene:
    Search GeneIP for patents involving ATP5F1

    GeneCards and IP:
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