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ATP5F1 Gene

protein-coding   GIFtS: 66
GCID: GC01P111991

ATP Synthase, H+ Transporting, Mitochondrial Fo Complex,...

(Previous names: ATP synthase, H+ transporting, mitochondrial F0 complex,...)
  Search for ATP5F1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit B11 2     ATP Synthase F(0) Complex Subunit B1, Mitochondrial2
ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B11 2     ATP Synthase Subunit B, Mitochondrial2
ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit B12 3     ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B2
ATPase Subunit B2 3     Cell Proliferation-Inducing Protein 472
ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B,
Isoform 11
     H+-ATP Synthase Subunit B2
PIG472     ATP Synthase Subunit B3
ATP Synthase B Chain, Mitochondrial2     

External Ids:    HGNC: 8401   Entrez Gene: 5152   Ensembl: ENSG000001164597   OMIM: 6032705   UniProtKB: P245393   
ORGUL members:         

Export aliases for ATP5F1 gene to outside databases

Previous GC identifers: GC01P112408 GC01P110863 GC01P111093 GC01P111290 GC01P111703 GC01P111793 GC01P109863


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATP5F1 Gene:
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis,
utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP
synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the
membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP
synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry
of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits
(a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. (provided by RefSeq, Jul
2008)

GeneCards Summary for ATP5F1 Gene:
ATP5F1 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1) is a protein-coding gene. GO annotations related to this gene include proton-transporting ATP synthase activity, rotational mechanism and ATPase activity.

UniProtKB/Swiss-Prot: AT5F1_HUMAN, P24539
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
presence of a proton gradient across the membrane which is generated by electron transport complexes of the
respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous
catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a
peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary
mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the
peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6
static relative to the rotary elements

Gene Wiki entry for ATP5F1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP5F1 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pbx1a   Nkx2-5   Nkx3-1 v1   Evi-1   Nkx3-1 v2   Ik-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP5F1 promoter sequence
   Search Chromatin IP Primers for ATP5F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP5F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

ATP5F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP5F1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P111991:  view genomic region     (about GC identifiers)

Start:
111,991,486 bp from pter      End:
112,005,395 bp from pter
Size:
13,910 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AT5F1_HUMAN, P24539 (See protein sequence)
Recommended Name: ATP synthase F(0) complex subunit B1, mitochondrial precursor  
Size: 256 amino acids; 28909 Da
Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b
and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2,
MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity)
Secondary accessions: Q9BQ68 Q9BRU8

Explore the universe of human proteins at neXtProt for ATP5F1: NX_P24539

Explore proteomics data for ATP5F1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ATP5F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001679.2  
    ENSEMBL proteins: 
     ENSP00000358737   ENSP00000420366  
    Reactome Protein details: P24539

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FATP: Mitochondrial respiratory chain complex / Complex V
    F1ATP: ATPases / F-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: B
    F-type ATPase

    2 InterPro protein domains:
     IPR008688 ATPase_B_chain/sub_B/MI25
     IPR013837 ATPase_F0_sub_B/B_chain

    Graphical View of Domain Structure for InterPro Entry P24539

    ProtoNet protein and cluster: P24539

    1 Blocks protein domain: IPB008688 Mitochondrial ATP synthase B chain

    UniProtKB/Swiss-Prot: AT5F1_HUMAN, P24539
    Similarity: Belongs to the eukaryotic ATPase B chain family


    Find genes that share domains with ATP5F1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AT5F1_HUMAN, P24539
    Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
    presence of a proton gradient across the membrane which is generated by electron transport complexes of the
    respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous
    catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a
    peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary
    mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the
    peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6
    static relative to the rotary elements

         Genatlas biochemistry entry for ATP5F1:
    ATP synthase H+ transporting,inner mitochondrial membrane (F0 segment),subunit b,isoform 1,complex V of oxidative
    phosphorylation (OXPHOS)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19016746
    GO:0015078hydrogen ion transmembrane transporter activity ----
    GO:0016887contributes to ATPase activity IDA12110673
    GO:0022857transmembrane transporter activity IC12110673
    GO:0046933proton-transporting ATP synthase activity, rotational mechanism IBA--
         
    Find genes that share ontologies with ATP5F1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ATP5F1:
     Decreased influenza A virus in  Increased number of cells in m  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATP5F1
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    miRNA
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    miRTarBase miRNAs that target ATP5F1:
    hsa-mir-10a-5p (MIRT047665)

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    Selected qRT-PCR Assays for microRNAs that regulate ATP5F1 (see all 16):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-539 hsa-miR-489 hsa-miR-1255a hsa-miR-205* hsa-miR-651 hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidATP5F1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AT5F1_HUMAN, P24539: Mitochondrion. Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000276mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005753mitochondrial proton-transporting ATP synthase complex IDA12110673
    GO:0005759mitochondrial matrix NAS1831354

    Find genes that share ontologies with ATP5F1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATP5F1 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Oxidative phosphorylation0.51
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Huntington's disease0.45
    Oxidative phosphorylation0.64
    Formation of ATP by chemiosmotic coupling0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
    Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics


    Find genes that share SuperPaths with ATP5F1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ATP5F1
        Oxidative phosphorylation
    Electron Transport Chain


    1 Reactome Pathway for ATP5F1
        Formation of ATP by chemiosmotic coupling

    1 PharmGKB Pathway for ATP5F1
        Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

    5 Kegg Pathways  (Kegg details for ATP5F1):
        Oxidative phosphorylation
    Metabolic pathways
    Alzheimer's disease
    Parkinson's disease
    Huntington's disease

        Pathway & Disease-focused RT2 Profiler PCR Array including ATP5F1: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ATP5F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATP5F1 (P245392, 3 ENSP000003587374) via UniProtKB, MINT, STRING, and/or I2D (see all 333)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5BP065762, 3, ENSP000002620304MINT-8079030 I2D: score=1 STRING: ENSP00000262030
    ATP5C1P365422, 3, ENSP000003491424MINT-8079030 I2D: score=1 STRING: ENSP00000349142
    ATP5A1P257052, 3, ENSP000002820504MINT-8079030 I2D: score=1 STRING: ENSP00000282050
    ATP5HO759472, 3, ENSP000003015874MINT-8079030 I2D: score=1 STRING: ENSP00000301587
    ATP5LO759642, 3, ENSP000003006884MINT-8079030 I2D: score=1 STRING: ENSP00000300688
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA12110673
    GO:0015986ATP synthesis coupled proton transport IBA--
    GO:0021762substantia nigra development IEP--
    GO:0022904respiratory electron transport chain TAS--
    GO:0042776mitochondrial ATP synthesis coupled proton transport TAS--

    Find genes that share ontologies with ATP5F1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATP5F1 (AT5F1)

    5 HMDB Compounds for ATP5F1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Clotrimazole(Chlorotrityl)imidazole (see all 72)23593-75-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATP5F1 gene: 
    NM_001688.4  

    Unigene Cluster for ATP5F1:

    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
    Hs.514870  [show with all ESTs]
    Unigene Representative Sequence: NM_001688
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493119 ENST00000369722(uc009wgf.1 uc001ebc.3) ENST00000369721
    ENST00000483994 ENST00000468818 ENST00000464154
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    hsa-miR-579 hsa-miR-193a-3p hsa-miR-539 hsa-miR-489 hsa-miR-1255a hsa-miR-205* hsa-miR-651 hsa-miR-626
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      QuantiFast Probe-based Assays in human, mouse, rat ATP5F1

    Additional mRNA sequence: 

    AK223018.1 AK291077.1 AK308266.1 AK311287.1 AK313541.1 AY871272.1 BC005366.1 BC005960.1 
    BC016350.1 X60221.1 

    Selected DOTS entries (see all 41):

    DT.95320239  DT.91775154  DT.453418  DT.95320121  DT.100860312  DT.100861085  DT.100687198  DT.91876202 
    DT.95320135  DT.100039585  DT.95320112  DT.121362520  DT.121362544  DT.95312610  DT.95320114  DT.99932255 
    DT.92045462  DT.100860313  DT.121362464  DT.121362484  DT.100640295  DT.100799327  DT.102839017  DT.120666461 

    Selected AceView cDNA sequences (see all 1094):

    F09195 BU682313 CA422636 CB119020 H65094 CA307302 CR598017 CR612409 
    AA584236 BM761289 CD723907 BF196857 AJ705420 BM921590 CR626581 BE889087 
    AI076341 AI499868 BM825724 BQ026534 CB123884 CR600353 N53507 AW327870 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATP5F1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d
    SP1:                                                                    -                           
    SP2:                                                                                                
    SP3:              -     -     -                                         -                           
    SP4:                    -     -                                         -                           
    SP5:                    -                                                                           


    ECgene alternative splicing isoforms for ATP5F1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ATP5F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAATTGGG
    ATP5F1 Expression
    About this image


    ATP5F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    ATP5F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATP5F1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514870
        Pathway & Disease-focused RT2 Profiler PCR Array including ATP5F1: 
              Mitochondrial Energy Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ATP5F1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp5f11 , 5 ATP synthase, H+ transporting, mitochondrial F0 complex, more1, 5 84.77(n)1
    82.81(a)1
      3 (46.46 cM)5
    119501  NM_009725.31  NP_033855.21 
     1059426985 
    chicken
    (Gallus gallus)
    Aves ATP5F11 ATP synthase, H+ transporting, mitochondrial Fo complex, more 66.4(n)
    62.1(a)
      419866  XM_417993.4  XP_417993.3 
    lizard
    (Anolis carolinensis)
    Reptilia ATP5F16
    ATP synthase, H+ transporting, mitochondrial Fo co...
    59(a)
    1 ↔ 1
    4(126353202-126370305)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.92242 Xenopus laevis transcribed sequence with weak similarity more 71.5(n)    CD329541.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atp5f11 ATP synthase, H+ transporting, mitochondrial F0 complex, more 60.24(n)
    58.23(a)
      449787  NM_001005960.1  NP_001005960.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ATPsyn-b1 , 3 hydrogen transport
    hydrogen-transporting two-sector
    more3
    ATP synthase, subunit b1
    46(a)3
    53.37(n)1
    47.98(a)1
      3 67C53
    391431  NM_079287.21  NP_524011.11 
    worm
    (Caenorhabditis elegans)
    Secernentea asb-26
    asb-16
    Protein ASB-1 (asb-1) mRNA, complete cds
    18(a)
    18(a)
    many → 1
    many → 1
    X(4469743-4471480) WBGene00000207
    III(4594541-4595944) WBGene00000206


    ENSEMBL Gene Tree for ATP5F1 (if available)
    TreeFam Gene Tree for ATP5F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATP5F1 gene

    Find genes that share paralogs with ATP5F1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for ATP5F1 (see all 9)
    PGOHUM00000242912 PGOHUM00000248596 PGOHUM00000248937 PGOHUM00000234957 PGOHUM00000240988


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATP5F1 (see all 252)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862890161,2
    --111993845(+) TTGACA/CCCATC 1 -- int10--------
    rs785676051,2
    F--111993883(+) TCCAAC/TCTTGG 1 -- int11Minor allele frequency- T:0.06WA 118
    rs13433481,2
    C,F,A,H--111993963(-) CCAATC/GATCTG 1 -- int114Minor allele frequency- G:0.42NS EA NA WA CSA 762
    rs13433471,2
    C,F,A--111994028(-) GTAAGC/GGGATA 1 -- int115Minor allele frequency- G:0.44NA EA MN WA CSA 785
    rs1911096721,2
    --111994054(+) TCCATA/GGCACT 1 -- int10--------
    rs1443537161,2
    C--111994106(+) TTCCC-/ATACCC 1 -- int10--------
    rs1824146591,2
    --111994275(+) GGTAGG/TCATTG 1 -- int10--------
    rs1877955541,2
    --111994386(+) GTTTGG/TTTTTG 1 -- int10--------
    rs1392124711,2
    --111994471(+) CAGTGA/GTGGTT 1 -- int10--------
    rs1912845011,2
    --111994566(+) AAACAA/GCAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ATP5F1 (111991486 - 112005395 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ATP5F1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268646CNV Insertion20981092
    nsv463250CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATP5F1
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP5F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603270    OMIM disorders: --


    Find genes that share disorders with ATP5F1           About GenesLikeMe

    Genetic Association Database (GAD): ATP5F1
    Human Genome Epidemiology (HuGE) Navigator: ATP5F1 (3 documents)

    Export disorders for ATP5F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATP5F1 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with ATP5F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria. (PubMed id 1831354)1, 2, 3 Higuti T.... Ichirara A. (Biochem. Biophys. Res. Commun. 1991)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    10. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 515 HGNC: 840 AceView: ATP5F1 Ensembl:ENSG00000116459 euGenes: HUgn515
    ECgene: ATP5F1 Kegg: 515 H-InvDB: ATP5F1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATP5F1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATP5F1 gene:
    Search GeneIP for patents involving ATP5F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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