Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATP5F1 Gene

Aliases for ATP5F1 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit B1 2 3 5
  • ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit B1 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B1 2 3
  • ATPase Subunit B 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B, Isoform 1 2
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit B1 2
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B 3
  • ATP Synthase F(0) Complex Subunit B1, Mitochondrial 3
  • Cell Proliferation-Inducing Protein 47 3
  • ATP Synthase Subunit B, Mitochondrial 3
  • ATP Synthase B Chain, Mitochondrial 3
  • H+-ATP Synthase Subunit B 3
  • ATP Synthase Subunit B 4
  • PIG47 3

External Ids for ATP5F1 Gene

Previous GeneCards Identifiers for ATP5F1 Gene

  • GC01P112408
  • GC01P110863
  • GC01P111093
  • GC01P111290
  • GC01P111703
  • GC01P111793
  • GC01P111991
  • GC01P109863

Summaries for ATP5F1 Gene

Entrez Gene Summary for ATP5F1 Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5F1 Gene

ATP5F1 (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit B1) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ATPase activity and hydrogen ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5F1 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Wiki entry for ATP5F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5F1 Gene

Genomics for ATP5F1 Gene

Regulatory Elements for ATP5F1 Gene

Enhancers for ATP5F1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F111211 1.8 FANTOM5 Ensembl ENCODE 10.5 -226.5 -226463 21.2 MLX CREB3L1 YBX1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 CHI3L2 DENND2D ENSG00000232240 LOC105378903 PIFO WDR77 ATP5F1 OVGP1 CEPT1 CD53
GH01F111618 1.4 FANTOM5 ENCODE 10.5 +171.7 171748 4.6 HDGF CREB3L1 WRNIP1 SIN3A ARID4B SLC30A9 GLIS2 ELK1 KDM4B ZNF263 RAP1A RNU6-151P KRT18P57 ATP5F1 WDR77 FAM212B UBE2FP3 LINC01160 PIFO C1orf162
GH01F111469 1.1 FANTOM5 ENCODE 11.4 +22.5 22545 3.0 HDGF PKNOX1 MTA2 HCFC1 SP1 NFYB IKZF1 HMBOX1 ZNF207 RCOR1 ENSG00000260948 RAP1A ATP5F1 WDR77 OVGP1 FAM212B C1orf162 GC01M111493 RNU6-792P
GH01F111406 0.9 Ensembl ENCODE 10.8 -42.3 -42326 0.7 HDGF PKNOX1 KLF17 KLF4 ZIC2 TBX21 RELA SP1 SMARCA4 ZNF341 ENSG00000260948 WDR77 ATP5F1 DENND2D PGCP1 OVGP1
GH01F111689 0.9 Ensembl ENCODE 10.4 +241.3 241338 0.8 HDGF ZNF202 REST OSR2 IKZF1 ZNF26 NBN ZBTB33 ENSG00000243960 DDX20 CEPT1 RNU6-151P KRT18P57 FAM212B ATP5F1 WDR77 C1orf162 UBE2FP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP5F1 on UCSC Golden Path with GeneCards custom track

Promoters for ATP5F1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000542653 336 2401 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for ATP5F1 Gene

Chromosome:
1
Start:
111,448,864 bp from pter
End:
111,462,773 bp from pter
Size:
13,910 bases
Orientation:
Plus strand

Genomic View for ATP5F1 Gene

Genes around ATP5F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5F1 Gene

Proteins for ATP5F1 Gene

  • Protein details for ATP5F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24539-AT5F1_HUMAN
    Recommended name:
    ATP synthase F(0) complex subunit B1, mitochondrial
    Protein Accession:
    P24539
    Secondary Accessions:
    • Q9BQ68
    • Q9BRU8

    Protein attributes for ATP5F1 Gene

    Size:
    256 amino acids
    Molecular mass:
    28909 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5F1 Gene

Post-translational modifications for ATP5F1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5F1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5F1 Gene

Domains & Families for ATP5F1 Gene

Protein Domains for ATP5F1 Gene

Suggested Antigen Peptide Sequences for ATP5F1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24539

UniProtKB/Swiss-Prot:

AT5F1_HUMAN :
  • Belongs to the eukaryotic ATPase B chain family.
Family:
  • Belongs to the eukaryotic ATPase B chain family.
genes like me logo Genes that share domains with ATP5F1: view

Function for ATP5F1 Gene

Molecular function for ATP5F1 Gene

GENATLAS Biochemistry:
ATP synthase H+ transporting,inner mitochondrial membrane (F0 segment),subunit b,isoform 1,complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Ontology (GO) - Molecular Function for ATP5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19016746
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
GO:0046933 contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA --
genes like me logo Genes that share ontologies with ATP5F1: view
genes like me logo Genes that share phenotypes with ATP5F1: view

Animal Models for ATP5F1 Gene

MGI Knock Outs for ATP5F1:

Animal Model Products

miRNA for ATP5F1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5F1 Gene

Localization for ATP5F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5F1 Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5F1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ATP5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane IEA,TAS --
genes like me logo Genes that share ontologies with ATP5F1: view

Pathways & Interactions for ATP5F1 Gene

genes like me logo Genes that share pathways with ATP5F1: view

Gene Ontology (GO) - Biological Process for ATP5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IEA,IBA --
GO:0015992 proton transport IEA --
genes like me logo Genes that share ontologies with ATP5F1: view

No data available for SIGNOR curated interactions for ATP5F1 Gene

Drugs & Compounds for ATP5F1 Gene

(3) Drugs for ATP5F1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clotrimazole Approved, Vet_approved Pharma Inhibition, Pore Blocker Cytochrome P450 inhibitor; antifungal 35
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for ATP5F1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with ATP5F1: view

Transcripts for ATP5F1 Gene

Unigene Clusters for ATP5F1 Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5F1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d
SP1: -
SP2:
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ATP5F1 Gene

GeneLoc Exon Structure for
ATP5F1
ECgene alternative splicing isoforms for
ATP5F1

Expression for ATP5F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATP5F1 Gene

mRNA differential expression in normal tissues according to GTEx for ATP5F1 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for ATP5F1 Gene

This gene is overexpressed in Nasal epithelium (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP5F1 Gene



Protein tissue co-expression partners for ATP5F1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP5F1 Gene:

ATP5F1

SOURCE GeneReport for Unigene cluster for ATP5F1 Gene:

Hs.514870
genes like me logo Genes that share expression patterns with ATP5F1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATP5F1 Gene

Orthologs for ATP5F1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP5F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5F1 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia ATP5F1 34 35
  • 88.15 (n)
dog
(Canis familiaris)
Mammalia LOC479901 34
  • 85.94 (n)
ATP5F1 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5f1 34 16 35
  • 84.77 (n)
rat
(Rattus norvegicus)
Mammalia Atp5f1 34
  • 84.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5F1 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP5F1 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5F1 34 35
  • 66.4 (n)
lizard
(Anolis carolinensis)
Reptilia ATP5F1 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5f1 34
  • 63.71 (n)
MGC75766 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9224 34
zebrafish
(Danio rerio)
Actinopterygii atp5f1 34 35
  • 60.24 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9026 34
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-b 36 34 35
  • 53.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001138 34
  • 49.72 (n)
worm
(Caenorhabditis elegans)
Secernentea asb-1 35
  • 18 (a)
OneToMany
asb-2 35
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP4 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7988 35
  • 27 (a)
OneToOne
Species where no ortholog for ATP5F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5F1 Gene

ENSEMBL:
Gene Tree for ATP5F1 (if available)
TreeFam:
Gene Tree for ATP5F1 (if available)

Paralogs for ATP5F1 Gene

No data available for Paralogs for ATP5F1 Gene

Variants for ATP5F1 Gene

Sequence variations from dbSNP and Humsavar for ATP5F1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10489793 -- 111,461,500(+) AATAA(C/G)TAAAT upstream-variant-2KB, utr-variant-3-prime
rs11102276 -- 111,447,713(+) ATCAT(C/T)GGAGA intron-variant, upstream-variant-2KB
rs11102277 -- 111,452,334(+) aggcc(A/G)agacg intron-variant
rs11102278 -- 111,453,936(+) CTAAT(A/G)ATAGA intron-variant
rs111290112 -- 111,455,607(+) ATTCA(A/T)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5F1 Gene

Variant ID Type Subtype PubMed ID
nsv946140 CNV duplication 23825009
nsv547535 CNV loss 21841781
nsv463250 CNV loss 19166990
esv3451263 CNV insertion 20981092

Variation tolerance for ATP5F1 Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5F1 Gene

Disorders for ATP5F1 Gene

Relevant External Links for ATP5F1

Genetic Association Database (GAD)
ATP5F1
Human Genome Epidemiology (HuGE) Navigator
ATP5F1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5F1

No disorders were found for ATP5F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5F1 Gene

Publications for ATP5F1 Gene

  1. Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria. (PMID: 1831354) Higuti T. … Ichirara A. (Biochem. Biophys. Res. Commun. 1991) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 46 64
  4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for ATP5F1 Gene

Sources for ATP5F1 Gene

Content
Loading form....