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Aliases for ATP5EP2 Gene

Aliases for ATP5EP2 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Epsilon Subunit Pseudogene 2 2 3 5

External Ids for ATP5EP2 Gene

Previous GeneCards Identifiers for ATP5EP2 Gene

  • GC13P027420
  • GC13P028519
  • GC13P009339

Summaries for ATP5EP2 Gene

GeneCards Summary for ATP5EP2 Gene

ATP5EP2 (ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Epsilon Subunit Pseudogene 2) is a Pseudogene. Among its related pathways are purine nucleotides de novo biosynthesis. GO annotations related to this gene include ATPase activity and proton-transporting ATP synthase activity, rotational mechanism. An important paralog of this gene is ATP5E.

UniProtKB/Swiss-Prot for ATP5EP2 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5EP2 Gene

Genomics for ATP5EP2 Gene

Regulatory Elements for ATP5EP2 Gene

Transcription factor binding sites by QIAGEN in the ATP5EP2 gene promoter:

Genomic Location for ATP5EP2 Gene

Chromosome:
13
Start:
27,945,206 bp from pter
End:
27,945,590 bp from pter
Size:
385 bases
Orientation:
Plus strand

Genomic View for ATP5EP2 Gene

Genes around ATP5EP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5EP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5EP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5EP2 Gene

Proteins for ATP5EP2 Gene

  • Protein details for ATP5EP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTU8-AT5EL_HUMAN
    Recommended name:
    ATP synthase subunit epsilon-like protein, mitochondrial
    Protein Accession:
    Q5VTU8

    Protein attributes for ATP5EP2 Gene

    Size:
    51 amino acids
    Molecular mass:
    5807 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L) (By similarity).

neXtProt entry for ATP5EP2 Gene

Proteomics data for ATP5EP2 Gene at MOPED

Post-translational modifications for ATP5EP2 Gene

No Post-translational modifications

Other Protein References for ATP5EP2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ATP5EP2 Gene

Domains & Families for ATP5EP2 Gene

Protein Domains for ATP5EP2 Gene

Suggested Antigen Peptide Sequences for ATP5EP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VTU8

UniProtKB/Swiss-Prot:

AT5EL_HUMAN :
  • Belongs to the eukaryotic ATPase epsilon family.
Family:
  • Belongs to the eukaryotic ATPase epsilon family.
genes like me logo Genes that share domains with ATP5EP2: view

No data available for Gene Families for ATP5EP2 Gene

Function for ATP5EP2 Gene

Molecular function for ATP5EP2 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).

Gene Ontology (GO) - Molecular Function for ATP5EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism IEA --
genes like me logo Genes that share ontologies with ATP5EP2: view
genes like me logo Genes that share phenotypes with ATP5EP2: view

miRNA for ATP5EP2 Gene

miRTarBase miRNAs that target ATP5EP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5EP2 Gene

Localization for ATP5EP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5EP2 Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5EP2 Gene COMPARTMENTS Subcellular localization image for ATP5EP2 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ATP5EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA,IBA --
genes like me logo Genes that share ontologies with ATP5EP2: view

Pathways & Interactions for ATP5EP2 Gene

genes like me logo Genes that share pathways with ATP5EP2: view

Interacting Proteins for ATP5EP2 Gene

Gene Ontology (GO) - Biological Process for ATP5EP2 Gene

None

No data available for SIGNOR curated interactions for ATP5EP2 Gene

Drugs & Compounds for ATP5EP2 Gene

(1) Drugs for ATP5EP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clotrimazole Approved Pharma Inhibition, Pore Blocker Cytochrome P450 inhibitor; antifungal 26
genes like me logo Genes that share compounds with ATP5EP2: view

Transcripts for ATP5EP2 Gene

mRNA/cDNA for ATP5EP2 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP5EP2 Gene

ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit pseudogene 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5EP2 Gene

No ASD Table

Relevant External Links for ATP5EP2 Gene

GeneLoc Exon Structure for
ATP5EP2
ECgene alternative splicing isoforms for
ATP5EP2

Expression for ATP5EP2 Gene

mRNA expression in normal human tissues for ATP5EP2 Gene

Protein differential expression in normal tissues from HIPED for ATP5EP2 Gene

This gene is overexpressed in Heart (36.4) and Peripheral blood mononuclear cells (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP5EP2 Gene



SOURCE GeneReport for Unigene cluster for ATP5EP2 Gene Hs.574118

genes like me logo Genes that share expression patterns with ATP5EP2: view

Protein tissue co-expression partners for ATP5EP2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP5EP2 Gene

Orthologs for ATP5EP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATP5EP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP5E 36
  • 90 (a)
ManyToMany
ATP5E 36
  • 90 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atp5e 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ATP5EP2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii atp5e 36
  • 63 (a)
OneToMany
Species with no ortholog for ATP5EP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5EP2 Gene

ENSEMBL:
Gene Tree for ATP5EP2 (if available)
TreeFam:
Gene Tree for ATP5EP2 (if available)

Paralogs for ATP5EP2 Gene

Paralogs for ATP5EP2 Gene

(1) SIMAP similar genes for ATP5EP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATP5EP2: view

Variants for ATP5EP2 Gene

Sequence variations from dbSNP and Humsavar for ATP5EP2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1136579 -- 27,945,567(+) GGTTC(A/C)CTGTT nc-transcript-variant
rs2504220 -- 27,945,217(-) AAGAC(A/G/T)CTGGC nc-transcript-variant
rs2504221 -- 27,943,705(-) GACTA(C/T)AGGTG upstream-variant-2KB
rs2504222 -- 27,943,259(-) TGTTT(G/T)GTTTA upstream-variant-2KB
rs2481956 -- 27,945,826(+) CACCT(A/T)AAACA downstream-variant-500B

Variation tolerance for ATP5EP2 Gene

Gene Damage Index Score: 1.20; 24.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5EP2 Gene

HapMap Linkage Disequilibrium report
ATP5EP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATP5EP2 Gene

Disorders for ATP5EP2 Gene

Relevant External Links for ATP5EP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5EP2

No disorders were found for ATP5EP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5EP2 Gene

Publications for ATP5EP2 Gene

  1. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3 67
  2. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3
  3. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. (PMID: 20833797) Zhao X. … Jensen O.N. (Mol. Cell Proteomics 2011) 3

Products for ATP5EP2 Gene

Sources for ATP5EP2 Gene

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