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Aliases for ATP5EP2 Gene

Aliases for ATP5EP2 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Epsilon Subunit Pseudogene 2 2 3

External Ids for ATP5EP2 Gene

Summaries for ATP5EP2 Gene

GeneCards Summary for ATP5EP2 Gene

ATP5EP2 (ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Epsilon Subunit Pseudogene 2) is a Pseudogene. Among its related pathways are purine nucleotide salvage and purine nucleotide salvage. GO annotations related to this gene include proton-transporting ATPase activity, rotational mechanism and proton-transporting ATP synthase activity, rotational mechanism. An important paralog of this gene is ATP5E.

UniProtKB/Swiss-Prot for ATP5EP2 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5EP2 Gene

Genomics for ATP5EP2 Gene

Genomic Location for ATP5EP2 Gene

Start:
27,945,206 bp from pter
End:
27,945,590 bp from pter
Size:
385 bases
Orientation:
Plus strand

Genomic View for ATP5EP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5EP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5EP2 Gene

Regulatory Elements for ATP5EP2 Gene

Transcription factor binding sites by QIAGEN in the ATP5EP2 gene promoter:

Proteins for ATP5EP2 Gene

  • Protein details for ATP5EP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTU8-AT5EL_HUMAN
    Recommended name:
    ATP synthase subunit epsilon-like protein, mitochondrial
    Protein Accession:
    Q5VTU8
    Secondary Accessions:

    Protein attributes for ATP5EP2 Gene

    Size:
    51 amino acids
    Molecular mass:
    5807 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L) (By similarity).

neXtProt entry for ATP5EP2 Gene

Proteomics data for ATP5EP2 Gene at MOPED

Post-translational modifications for ATP5EP2 Gene

No Post-translational modifications

Other Protein References for ATP5EP2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ATP5EP2 Gene

Domains for ATP5EP2 Gene

Protein Domains for ATP5EP2 Gene

UniProtKB/Swiss-Prot:

AT5EL_HUMAN
Family:
  • Belongs to the eukaryotic ATPase epsilon family.:
    • Q5VTU8
genes like me logo Genes that share domains with ATP5EP2: view

No data available for Gene Families for ATP5EP2 Gene

Function for ATP5EP2 Gene

Molecular function for ATP5EP2 Gene

UniProtKB/Swiss-Prot Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).

Gene Ontology (GO) - Molecular Function for ATP5EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016887 contributes_to ATPase activity IBA --
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism IEA --
GO:0046961 proton-transporting ATPase activity, rotational mechanism IEA --
genes like me logo Genes that share ontologies with ATP5EP2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATP5EP2 Gene

Localization for ATP5EP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5EP2 Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5EP2 Gene COMPARTMENTS Subcellular localization image for ATP5EP2 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ATP5EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) IEA --
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane IBA --
genes like me logo Genes that share ontologies with ATP5EP2: view

Pathways for ATP5EP2 Gene

genes like me logo Genes that share pathways with ATP5EP2: view

Pathways by source for ATP5EP2 Gene

Interacting Proteins for ATP5EP2 Gene

Gene Ontology (GO) - Biological Process for ATP5EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015986 ATP synthesis coupled proton transport IEA --
genes like me logo Genes that share ontologies with ATP5EP2: view

Compounds for ATP5EP2 Gene

(1) HMDB Compounds for ATP5EP2 Gene

Compound Synonyms Cas Number PubMed IDs
Clotrimazole
  • (Chlorotrityl)imidazole
23593-75-1
genes like me logo Genes that share compounds with ATP5EP2: view

Transcripts for ATP5EP2 Gene

mRNA/cDNA for ATP5EP2 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP5EP2 Gene

ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit pseudogene 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5EP2 Gene

No ASD Table

Relevant External Links for ATP5EP2 Gene

GeneLoc Exon Structure for
ATP5EP2
ECgene alternative splicing isoforms for
ATP5EP2

Expression for ATP5EP2 Gene

mRNA expression in normal human tissues for ATP5EP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATP5EP2 Gene

SOURCE GeneReport for Unigene cluster for ATP5EP2 Gene Hs.574118

genes like me logo Genes that share expressions with ATP5EP2: view

Orthologs for ATP5EP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATP5EP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5EP2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5E 37
  • 90 (a)
ManyToMany
ATP5E 37
  • 90 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Atp5e 37
  • 88 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii atp5e 37
  • 63 (a)
OneToMany
Species with no ortholog for ATP5EP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5EP2 Gene

ENSEMBL:
Gene Tree for ATP5EP2 (if available)
TreeFam:
Gene Tree for ATP5EP2 (if available)

Paralogs for ATP5EP2 Gene

Paralogs for ATP5EP2 Gene

Selected SIMAP similar genes for ATP5EP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATP5EP2: view

Variants for ATP5EP2 Gene

Sequence variations from dbSNP and Humsavar for ATP5EP2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1136579 -- 27,945,567(+) GGTTC(A/C)CTGTT nc-transcript-variant
rs2481956 -- 27,945,826(+) CACCT(A/T)AAACA downstream-variant-500B
rs2504220 -- 27,945,217(-) AAGAC(G/T)CTGGC nc-transcript-variant
rs2504221 -- 27,943,705(-) GACTA(C/T)AGGTG upstream-variant-2KB
rs2504222 -- 27,943,259(-) TGTTT(G/T)GTTTA upstream-variant-2KB

Relevant External Links for ATP5EP2 Gene

HapMap Linkage Disequilibrium report
ATP5EP2

No data available for Structural Variations from Database of Genomic Variants (DGV) for ATP5EP2 Gene

Disorders for ATP5EP2 Gene

No disorders were found for ATP5EP2 Gene.

No data available for UniProtKB/Swiss-Prot for ATP5EP2 Gene

Publications for ATP5EP2 Gene

  1. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. (PMID: 20833797) Zhao X. … Jensen O.N. (Mol. Cell Proteomics 2011) 3
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4

Products for ATP5EP2 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate ATP5EP2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5EP2
    • Block miRNA regulation of ATP5EP2 using miScript Target Protectors

    Sources for ATP5EP2 Gene

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