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Aliases for ATP5D Gene

Aliases for ATP5D Gene

  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Delta Subunit 2 3
  • F-ATPase Delta Subunit 4

External Ids for ATP5D Gene

Summaries for ATP5D Gene

Entrez Gene Summary for ATP5D Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5D Gene

ATP5D (ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Delta Subunit) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include transporter activity and ADP binding.

UniProtKB/Swiss-Prot for ATP5D Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits

Gene Wiki entry for ATP5D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5D Gene

Genomics for ATP5D Gene

Genomic Location for ATP5D Gene

Start:
1,241,746 bp from pter
End:
1,244,826 bp from pter
Size:
3,081 bases
Orientation:
Plus strand

Genomic View for ATP5D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5D Gene

Regulatory Elements for ATP5D Gene

Proteins for ATP5D Gene

  • Protein details for ATP5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30049-ATPD_HUMAN
    Recommended name:
    ATP synthase subunit delta, mitochondrial
    Protein Accession:
    P30049
    Secondary Accessions:
    • D6W5Y3
    • Q6FG90

    Protein attributes for ATP5D Gene

    Size:
    168 amino acids
    Molecular mass:
    17490 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5D Gene

Proteomics data for ATP5D Gene at MOPED

Post-translational modifications for ATP5D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5D Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5D Gene

Domains for ATP5D Gene

Gene Families for ATP5D Gene

HGNC:
  • FATP :Mitochondrial respiratory chain complex / Complex V
  • F1ATP :ATPases / F-type
IUPHAR :

UniProtKB/Swiss-Prot:

ATPD_HUMAN
Family:
  • Belongs to the ATPase epsilon chain family.:
    • P30049
genes like me logo Genes that share domains with ATP5D: view

Function for ATP5D Gene

Molecular function for ATP5D Gene

UniProtKB/Swiss-Prot Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits

Gene Ontology (GO) - Molecular Function for ATP5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 1531933
GO:0005524 contributes_to ATP binding NAS 12539966
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
GO:0043531 contributes_to ADP binding NAS 12539966
genes like me logo Genes that share ontologies with ATP5D: view

Phenotypes for ATP5D Gene

GenomeRNAi human phenotypes for ATP5D:
genes like me logo Genes that share phenotypes with ATP5D: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATP5D Gene

Localization for ATP5D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5D Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5D Gene COMPARTMENTS Subcellular localization image for ATP5D gene
Compartment Confidence
mitochondrion 5
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) NAS 12539966
GO:0005739 mitochondrion NAS 12887009
GO:0005743 mitochondrial inner membrane ISS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex NAS 1531933
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ATP5D: view

Pathways for ATP5D Gene

genes like me logo Genes that share pathways with ATP5D: view

Gene Ontology (GO) - Biological Process for ATP5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006119 oxidative phosphorylation NAS 12539966
GO:0006200 obsolete ATP catabolic process --
GO:0006754 ATP biosynthetic process NAS 12539966
GO:0015986 ATP synthesis coupled proton transport IBA --
GO:0022904 respiratory electron transport chain TAS --
genes like me logo Genes that share ontologies with ATP5D: view

Compounds for ATP5D Gene

(4) HMDB Compounds for ATP5D Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(6) Drugbank Compounds for ATP5D Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Desflurane
  • Desflurano [INN-Spanish]
57041-67-5 target other/unknown
Enflurane
  • Anesthetic 347
13838-16-9 target other/unknown
Halothane
  • 2-Bromo-2-Chloro-1,1,1-Trifluoroethane
151-67-7 target other/unknown
Isoflurane
26675-46-7 target unknown
Methoxyflurane
  • Methoflurane
76-38-0 target unknown
genes like me logo Genes that share compounds with ATP5D: view

Transcripts for ATP5D Gene

Unigene Clusters for ATP5D Gene

ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5D Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for ATP5D Gene

GeneLoc Exon Structure for
ATP5D
ECgene alternative splicing isoforms for
ATP5D

Expression for ATP5D Gene

mRNA expression in normal human tissues for ATP5D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5D Gene

SOURCE GeneReport for Unigene cluster for ATP5D Gene Hs.418668

genes like me logo Genes that share expressions with ATP5D: view

Orthologs for ATP5D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP5D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5D 36
  • 99.21 (n)
  • 100 (a)
ATP5D 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5D 36
  • 83.53 (n)
  • 91.07 (a)
ATP5D 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5D 36
  • 83.33 (n)
  • 89.29 (a)
ATP5D 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5d 36
  • 80.36 (n)
  • 86.31 (a)
Atp5d 16
Atp5d 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP5D 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5D 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5d 36
  • 80.56 (n)
  • 86.9 (a)
chicken
(Gallus gallus)
Aves ATP5D 36
  • 76.53 (n)
  • 74.4 (a)
ATP5D 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5D 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23716 36
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5d 36
  • 65.44 (n)
  • 74.26 (a)
Str.10780 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8822 36
zebrafish
(Danio rerio)
Actinopterygii atp5d 36
  • 70.96 (n)
  • 76.52 (a)
atp5d 37
  • 71 (a)
OneToOne
wufk58f09 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007841 36
  • 59.4 (n)
  • 51.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0230 36
  • 55.39 (n)
  • 50.74 (a)
l(1)G0230 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F58F12.1 36
  • 49.62 (n)
  • 50.38 (a)
F58F12.1 37
  • 47 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL008W 36
  • 52.42 (n)
  • 40.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP16 36
  • 43.17 (n)
  • 35.25 (a)
ATP16 37
  • 33 (a)
OneToOne
ATP16 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F14773g 36
  • 45.48 (n)
  • 40.31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G47030 36
  • 45.45 (n)
  • 35.61 (a)
rice
(Oryza sativa)
Liliopsida Os07g0495200 36
  • 48.74 (n)
  • 37.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00385 36
  • 50.78 (n)
  • 32.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp16 36
  • 42.49 (n)
  • 35.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7960 37
  • 48 (a)
OneToOne
Species with no ortholog for ATP5D:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5D Gene

ENSEMBL:
Gene Tree for ATP5D (if available)
TreeFam:
Gene Tree for ATP5D (if available)

Paralogs for ATP5D Gene

No data available for Paralogs for ATP5D Gene

Variants for ATP5D Gene

Sequence variations from dbSNP and Humsavar for ATP5D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs735524 -- 1,244,519(+) GTCCC(C/G)GCCAC intron-variant, utr-variant-3-prime
rs1051734 -- 1,244,776(+) CACCT(C/T)TGGAT utr-variant-3-prime
rs1051768 -- 1,244,726(+) CCCCT(C/T)TGCCC intron-variant, utr-variant-3-prime
rs1063633 -- 1,244,611(+) AAGCT(C/T)TGGGG intron-variant, utr-variant-3-prime
rs1063634 -- 1,244,685(+) CGCCT(C/T)TCAAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATP5D Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv1055e1 CNV Complex 17122850
dgv3575n71 CNV Loss 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3585n71 CNV Loss 21882294
dgv3586n71 CNV Loss 21882294
nsv470104 CNV Loss 18288195
dgv3587n71 CNV Loss 21882294
nsv910442 CNV Gain+Loss 21882294
dgv3588n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3590n71 CNV Loss 21882294
dgv3591n71 CNV Loss 21882294
dgv3592n71 CNV Loss 21882294
dgv3593n71 CNV Loss 21882294
nsv828368 CNV Gain 20364138
nsv910466 CNV Loss 21882294
dgv3594n71 CNV Loss 21882294
nsv910469 CNV Loss 21882294

Relevant External Links for ATP5D Gene

HapMap Linkage Disequilibrium report
ATP5D

Disorders for ATP5D Gene

No disorders were found for ATP5D Gene.

No data available for UniProtKB/Swiss-Prot for ATP5D Gene

Publications for ATP5D Gene

  1. Molecular cloning of an import precursor of the delta-subunit of the human mitochondrial ATP synthase complex. (PMID: 1531933) Jordan E.M. … Breen G.A.M. (Biochim. Biophys. Acta 1992) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. Human liver protein map: a reference database established by microsequencing and gel comparison. (PMID: 1286669) Hochstrasser D.F. … Hughes G.J. (Electrophoresis 1992) 3 4
  5. A protein interaction framework for human mRNA degradation. (PMID: 15231747) Lehner B. … Sanderson C.M. (Genome Res. 2004) 3

Products for ATP5D Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ATP5D
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5D
    • Block miRNA regulation of ATP5D using miScript Target Protectors

    Sources for ATP5D Gene

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