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Aliases for ATP5D Gene

Aliases for ATP5D Gene

  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Delta Subunit 2 3 5
  • F-ATPase Delta Subunit 4

External Ids for ATP5D Gene

Previous GeneCards Identifiers for ATP5D Gene

  • GC19P001299
  • GC19P001182
  • GC19P001192
  • GC19P001016

Summaries for ATP5D Gene

Entrez Gene Summary for ATP5D Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5D Gene

ATP5D (ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Delta Subunit) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics. GO annotations related to this gene include transporter activity and transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5D Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene Wiki entry for ATP5D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5D Gene

Genomics for ATP5D Gene

Regulatory Elements for ATP5D Gene

Enhancers for ATP5D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATP5D on UCSC Golden Path with GeneCards custom track

Promoters for ATP5D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATP5D on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP5D Gene

Chromosome:
19
Start:
1,241,746 bp from pter
End:
1,244,826 bp from pter
Size:
3,081 bases
Orientation:
Plus strand

Genomic View for ATP5D Gene

Genes around ATP5D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5D Gene

Proteins for ATP5D Gene

  • Protein details for ATP5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30049-ATPD_HUMAN
    Recommended name:
    ATP synthase subunit delta, mitochondrial
    Protein Accession:
    P30049
    Secondary Accessions:
    • D6W5Y3
    • Q6FG90

    Protein attributes for ATP5D Gene

    Size:
    168 amino acids
    Molecular mass:
    17490 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5D Gene

Proteomics data for ATP5D Gene at MOPED

Post-translational modifications for ATP5D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5D Gene

Antibody Products

  • Abcam antibodies for ATP5D
  • Santa Cruz Biotechnology (SCBT) Antibodies for ATP5D

No data available for DME Specific Peptides for ATP5D Gene

Domains & Families for ATP5D Gene

Suggested Antigen Peptide Sequences for ATP5D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30049

UniProtKB/Swiss-Prot:

ATPD_HUMAN :
  • Belongs to the ATPase epsilon chain family.
Family:
  • Belongs to the ATPase epsilon chain family.
genes like me logo Genes that share domains with ATP5D: view

Function for ATP5D Gene

Molecular function for ATP5D Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene Ontology (GO) - Molecular Function for ATP5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 1531933
genes like me logo Genes that share ontologies with ATP5D: view
genes like me logo Genes that share phenotypes with ATP5D: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ATP5D Gene

Localization for ATP5D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5D Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5D Gene COMPARTMENTS Subcellular localization image for ATP5D gene
Compartment Confidence
mitochondrion 5
cytoskeleton 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ATP5D Gene

Pathways & Interactions for ATP5D Gene

genes like me logo Genes that share pathways with ATP5D: view

Gene Ontology (GO) - Biological Process for ATP5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015986 ATP synthesis coupled proton transport IEA,IBA --
GO:0044281 small molecule metabolic process TAS --
GO:0046688 response to copper ion NAS 12539966
genes like me logo Genes that share ontologies with ATP5D: view

No data available for SIGNOR curated interactions for ATP5D Gene

Drugs & Compounds for ATP5D Gene

(7) Drugs for ATP5D Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desflurane Approved Pharma antagonist, Target, other/unknown 128
Enflurane Approved Pharma Target, other/unknown 2
Methoxyflurane Approved Pharma antagonist, Target, unknown 4
Sevoflurane Approved Pharma antagonist, Target, other/unknown 445
Isoflurane Approved Pharma Target, unknown 153

(4) Additional Compounds for ATP5D Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
trifluoroacetic acid
  • Acide trifluoroacetique
  • CF3COOH
  • Kyselina trifluoroctova
  • Perfluoroacetic acid
  • Trifluoracetic acid
76-05-1
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ATP5D: view

Transcripts for ATP5D Gene

Unigene Clusters for ATP5D Gene

ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5D Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for ATP5D Gene

GeneLoc Exon Structure for
ATP5D
ECgene alternative splicing isoforms for
ATP5D

Expression for ATP5D Gene

mRNA expression in normal human tissues for ATP5D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATP5D Gene

This gene is overexpressed in Heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5D Gene



SOURCE GeneReport for Unigene cluster for ATP5D Gene Hs.418668

genes like me logo Genes that share expression patterns with ATP5D: view

Protein tissue co-expression partners for ATP5D Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP5D Gene

Orthologs for ATP5D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP5D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP5D 35
  • 83.53 (n)
  • 91.07 (a)
ATP5D 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5D 35
  • 83.33 (n)
  • 89.29 (a)
ATP5D 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5d 35
  • 80.36 (n)
  • 86.31 (a)
Atp5d 16
Atp5d 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATP5D 35
  • 99.21 (n)
  • 100 (a)
ATP5D 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5d 35
  • 80.56 (n)
  • 86.9 (a)
oppossum
(Monodelphis domestica)
Mammalia ATP5D 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5D 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5D 35
  • 76.53 (n)
  • 74.4 (a)
ATP5D 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5D 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5d 35
  • 65.44 (n)
  • 74.26 (a)
Str.10780 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23716 35
zebrafish
(Danio rerio)
Actinopterygii atp5d 35
  • 70.96 (n)
  • 76.52 (a)
wufk58f09 35
atp5d 36
  • 71 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8822 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007841 35
  • 59.4 (n)
  • 51.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0230 35
  • 55.39 (n)
  • 50.74 (a)
l(1)G0230 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F58F12.1 35
  • 49.62 (n)
  • 50.38 (a)
F58F12.1 36
  • 47 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL008W 35
  • 52.42 (n)
  • 40.46 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F14773g 35
  • 45.48 (n)
  • 40.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP16 35
  • 43.17 (n)
  • 35.25 (a)
ATP16 36
  • 33 (a)
OneToOne
ATP16 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G47030 35
  • 45.45 (n)
  • 35.61 (a)
rice
(Oryza sativa)
Liliopsida Os07g0495200 35
  • 48.74 (n)
  • 37.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00385 35
  • 50.78 (n)
  • 32.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp16 35
  • 42.49 (n)
  • 35.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7960 36
  • 48 (a)
OneToOne
Species with no ortholog for ATP5D:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5D Gene

ENSEMBL:
Gene Tree for ATP5D (if available)
TreeFam:
Gene Tree for ATP5D (if available)

Paralogs for ATP5D Gene

No data available for Paralogs for ATP5D Gene

Variants for ATP5D Gene

Sequence variations from dbSNP and Humsavar for ATP5D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1051734 -- 1,244,776(+) CACCT(C/T)TGGAT utr-variant-3-prime
rs1051768 -- 1,244,726(+) CCCCT(C/T)TGCCC intron-variant, utr-variant-3-prime
rs1063633 -- 1,244,611(+) AAGCT(C/T)TGGGG intron-variant, utr-variant-3-prime
rs1063634 -- 1,244,685(+) CGCCT(C/T)TCAAG intron-variant, utr-variant-3-prime
rs1076230 -- 1,244,901(-) GGACA(C/T)GGAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ATP5D Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv1055e1 CNV Complex 17122850
dgv3575n71 CNV Loss 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3585n71 CNV Loss 21882294
dgv3586n71 CNV Loss 21882294
nsv470104 CNV Loss 18288195
dgv3587n71 CNV Loss 21882294
nsv910442 CNV Gain+Loss 21882294
dgv3588n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3590n71 CNV Loss 21882294
dgv3591n71 CNV Loss 21882294
dgv3592n71 CNV Loss 21882294
dgv3593n71 CNV Loss 21882294
nsv828368 CNV Gain 20364138
nsv910466 CNV Loss 21882294
dgv3594n71 CNV Loss 21882294
nsv910469 CNV Loss 21882294

Variation tolerance for ATP5D Gene

Gene Damage Index Score: 1.20; 24.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATP5D Gene

Disorders for ATP5D Gene

Relevant External Links for ATP5D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5D

No disorders were found for ATP5D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5D Gene

Publications for ATP5D Gene

  1. Molecular cloning of an import precursor of the delta-subunit of the human mitochondrial ATP synthase complex. (PMID: 1531933) Jordan E.M. … Breen G.A.M. (Biochim. Biophys. Acta 1992) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Inhibition of plasma membrane Ca(2+)-ATPase activity by volatile anesthetics. (PMID: 8214757) Kosk-Kosicka D. … Roszczynska G. (Anesthesiology 1993) 25 26
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for ATP5D Gene

Sources for ATP5D Gene

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