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Aliases for ATP5B Gene

Aliases for ATP5B Gene

  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Beta Polypeptide 2 3
  • ATPSB 3 4 6
  • EC 3.6.3.14 4 63
  • ATPMB 3 4
  • Mitochondrial ATP Synthetase, Beta Subunit 3
  • ATP Synthase Subunit Beta, Mitochondrial 3
  • Mitochondrial ATP Synthase Beta Subunit 3
  • Epididymis Secretory Protein Li 271 3
  • HEL-S-271 3
  • EC 3.6.3 63

External Ids for ATP5B Gene

Previous HGNC Symbols for ATP5B Gene

  • ATPSB

Previous GeneCards Identifiers for ATP5B Gene

  • GC12P057014
  • GC12M057256
  • GC12M056748
  • GC12M055318
  • GC12M057031
  • GC12M054071

Summaries for ATP5B Gene

Entrez Gene Summary for ATP5B Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5B Gene

ATP5B (ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Beta Polypeptide) is a Protein Coding gene. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include transporter activity and transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5B Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits

Gene Wiki entry for ATP5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5B Gene

Genomics for ATP5B Gene

Regulatory Elements for ATP5B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATP5B Gene

Start:
56,638,175 bp from pter
End:
56,646,068 bp from pter
Size:
7,894 bases
Orientation:
Minus strand

Genomic View for ATP5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5B Gene

Proteins for ATP5B Gene

  • Protein details for ATP5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06576-ATPB_HUMAN
    Recommended name:
    ATP synthase subunit beta, mitochondrial
    Protein Accession:
    P06576
    Secondary Accessions:
    • A8K4X0
    • Q14283

    Protein attributes for ATP5B Gene

    Size:
    529 amino acids
    Molecular mass:
    56560 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68. Interacts with PPIF. Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficency (By similarity).

neXtProt entry for ATP5B Gene

Proteomics data for ATP5B Gene at MOPED

Post-translational modifications for ATP5B Gene

  • Ubiquitination at Lys124, Lys133, Lys161, Lys201, and Lys426
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP5B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for ATP5B Gene

Gene Families for ATP5B Gene

HGNC:
  • F1ATP :ATPases / F-type
  • FATP :Mitochondrial respiratory chain complex / Complex V
IUPHAR :

Suggested Antigen Peptide Sequences for ATP5B Gene

Graphical View of Domain Structure for InterPro Entry

P06576

UniProtKB/Swiss-Prot:

ATPB_HUMAN :
  • P06576
Family:
  • Belongs to the ATPase alpha/beta chains family.
genes like me logo Genes that share domains with ATP5B: view

Function for ATP5B Gene

Molecular function for ATP5B Gene

GENATLAS Biochemistry:
ATP synthase H+ transporting,mitochondrial matrix (F1 segment),catalytic,beta subunit,cardiac muscle,complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out)
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits

Enzyme Numbers (IUBMB) for ATP5B Gene

Gene Ontology (GO) - Molecular Function for ATP5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 2870059
GO:0005515 protein binding IPI 10077593
GO:0005524 ATP binding IEA --
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances --
GO:0016887 contributes_to ATPase activity IDA 12110673
genes like me logo Genes that share ontologies with ATP5B: view

Phenotypes for ATP5B Gene

genes like me logo Genes that share phenotypes with ATP5B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5B

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP5B Gene

Localization for ATP5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5B Gene

Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5B Gene COMPARTMENTS Subcellular localization image for ATP5B gene
Compartment Confidence
mitochondrion 5
plasma membrane 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ATP5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
GO:0005754 mitochondrial proton-transporting ATP synthase, catalytic core NAS 2870059
genes like me logo Genes that share ontologies with ATP5B: view

Pathways for ATP5B Gene

genes like me logo Genes that share pathways with ATP5B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ATP5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IMP 17510399
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006091 generation of precursor metabolites and energy NAS 2870059
GO:0006200 obsolete ATP catabolic process --
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with ATP5B: view

Compounds for ATP5B Gene

(4) HMDB Compounds for ATP5B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(5) Drugbank Compounds for ATP5B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-ACETYL-2-CARBOXYPIPERIDINE
target
AUROVERTIN B
target
N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
target
PICEATANNOL
target
Quercetin
117-39-5 target

(2) Novoseek inferred chemical compound relationships for ATP5B Gene

Compound -log(P) Hits PubMed IDs
cerulein 75.5 2
atp 60.5 12
genes like me logo Genes that share compounds with ATP5B: view

Transcripts for ATP5B Gene

mRNA/cDNA for ATP5B Gene

Unigene Clusters for ATP5B Gene

ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^
SP1: -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - -
SP8:
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - - - - - - - - -

ExUns: 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ATP5B Gene

GeneLoc Exon Structure for
ATP5B
ECgene alternative splicing isoforms for
ATP5B

Expression for ATP5B Gene

mRNA expression in normal human tissues for ATP5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP5B Gene

This gene is overexpressed in Heart - Left Ventricle (6.0).

Protein differential expression in normal tissues for ATP5B Gene

This gene is overexpressed in Heart (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5B Gene

SOURCE GeneReport for Unigene cluster for ATP5B Gene Hs.406510

genes like me logo Genes that share expressions with ATP5B: view

Expression partners for ATP5B Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ATP5B Gene

Orthologs for ATP5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP5B 35
  • 92.68 (n)
  • 96.78 (a)
ATP5B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5B 35
  • 92.35 (n)
  • 96.39 (a)
-- 36
  • 74 (a)
OneToMany
ATP5B 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atp5b 35
  • 89.22 (n)
  • 96.22 (a)
Atp5b 16
Atp5b 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATP5B 35
  • 99.31 (n)
  • 99.24 (a)
ATP5B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5b 35
  • 89.1 (n)
  • 95.65 (a)
oppossum
(Monodelphis domestica)
Mammalia ATP5B 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5B 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5B 35
  • 78.03 (n)
  • 92.61 (a)
ATP5B 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5B 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5b 35
  • 78.93 (n)
  • 92.15 (a)
Str.20526 35
African clawed frog
(Xenopus laevis)
Amphibia atp5b-prov 35
zebrafish
(Danio rerio)
Actinopterygii atp5b 35
  • 78.79 (n)
  • 91.1 (a)
hmzehn0534 35
ATP5B 36
  • 83 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8681 35
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-bgr 37
  • 90 (a)
CG5389 37
  • 75 (a)
ATPsyn-beta 35
  • 74.67 (n)
  • 89.12 (a)
ATPsyn-beta 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012106 35
  • 70.05 (n)
  • 86.47 (a)
worm
(Caenorhabditis elegans)
Secernentea atp-2 35
  • 70.02 (n)
  • 82.79 (a)
atp-2 36
  • 78 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR169W 35
  • 68.4 (n)
  • 77.2 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10703g 35
  • 68.53 (n)
  • 77.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP2 35
  • 69.13 (n)
  • 79.7 (a)
ATP2 36
  • 74 (a)
OneToOne
ATP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G08670 35
  • 68.22 (n)
  • 75.53 (a)
soybean
(Glycine max)
eudicotyledons Gma.1312 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7062 35
barley
(Hordeum vulgare)
Liliopsida Hv.1223 35
rice
(Oryza sativa)
Liliopsida Os05g0553000 35
  • 69.2 (n)
  • 77.78 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5 35
corn
(Zea mays)
Liliopsida Zm.957 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4478 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05430 35
  • 68.79 (n)
  • 80.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp2 35
  • 70.18 (n)
  • 80.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4294 36
  • 74 (a)
OneToOne
Species with no ortholog for ATP5B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ATP5B Gene

ENSEMBL:
Gene Tree for ATP5B (if available)
TreeFam:
Gene Tree for ATP5B (if available)

Paralogs for ATP5B Gene

Pseudogenes.org Pseudogenes for ATP5B Gene

genes like me logo Genes that share paralogs with ATP5B: view

No data available for Paralogs for ATP5B Gene

Variants for ATP5B Gene

Sequence variations from dbSNP and Humsavar for ATP5B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1042001 - 56,642,804(-) TGAAT(C/G)AACCA missense, reference
rs1042002 -- 56,642,512(-) ATGGG(C/T)ACTAT synonymous-codon, reference
rs1800638 -- 56,639,542(-) CCCAC(C/T)GTGGC intron-variant
rs1800641 -- 56,643,070(-) TTTTG(G/T)ACTTT intron-variant
rs2272314 -- 56,642,916(+) CGACC(A/T)CAGAT intron-variant

Relevant External Links for ATP5B Gene

HapMap Linkage Disequilibrium report
ATP5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATP5B Gene

Disorders for ATP5B Gene

Relevant External Links for ATP5B

Genetic Association Database (GAD)
ATP5B
Human Genome Epidemiology (HuGE) Navigator
ATP5B

No disorders were found for ATP5B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ATP5B Gene

Publications for ATP5B Gene

  1. The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression. (PMID: 2687158) Neckelmann N. … Wallace D.C. (Genomics 1989) 2 3 4
  2. Human F1-ATPase: molecular cloning of cDNA for the beta subunit. (PMID: 2870059) Ohta S. … Kagawa Y. (J. Biochem. 1986) 3 4
  3. Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations. (PMID: 2896550) Wallace D.C. … Greenberg B.D. (Curr. Genet. 1987) 3 4
  4. Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit. (PMID: 2900241) Ohta S. … Kagawa Y. (J. Biol. Chem. 1988) 3 4
  5. ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase beta-subunit. (PMID: 7798271) Villena J.A. … Villarroya F. (J. Biol. Chem. 1994) 3 23

Products for ATP5B Gene

Sources for ATP5B Gene

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