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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP5B Gene

protein-coding   GIFtS: 68
GCID: GC12M057031

ATP Synthase, H+ Transporting, Mitochondrial F1 Complex,...


(Previous symbol: ATPSB)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Beta
Polypeptide1 2
     ATP Synthase Subunit Beta, Mitochondrial2
ATPSB1 2 3 5     Mitochondrial ATP Synthase Beta Subunit2
ATPMB2 3     Mitochondrial ATP Synthetase, Beta Subunit2
EC 3.6.3.143 8     EC 3.6.38

External Ids:    HGNC: 8301   Entrez Gene: 5062   Ensembl: ENSG000001109557   OMIM: 1029105   UniProtKB: P065763   

Export aliases for ATP5B gene to outside databases

Previous GC identifers: GC12P057014 GC12M057256 GC12M056748 GC12M055318 GC12M054071


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATP5B Gene:
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis,
utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP
synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the
membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP
synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry
of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main
subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. (provided by RefSeq, Jul 2008)

GeneCards Summary for ATP5B Gene: 
ATP5B (ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide) is a protein-coding gene. Diseases associated with ATP5B include chondroblastoma, and endocarditis, and among its related super-pathways are Electron Transport Chain and adenosine ribonucleotides de novo biosynthesis. GO annotations related to this gene include transmembrane transporter activity and transporter activity.

UniProtKB/Swiss-Prot: ATPB_HUMAN, P06576
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
presence of a proton gradient across the membrane which is generated by electron transport complexes of the
respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous
catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a
peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary
mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core
in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of
ATP in three separate catalytic sites on the beta subunits

Gene Wiki entry for ATP5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP5B gene promoter:
         STAT1   STAT1beta   Lmo2   Meis-1b   Evi-1   STAT1alpha   Gfi-1   PPAR-gamma1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP5B promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12p13.3

ATP5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP5B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M057031:  view genomic region     (about GC identifiers)

Start:
57,031,959 bp from pter      End:
57,039,852 bp from pter
Size:
7,894 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATPB_HUMAN, P06576 (See protein sequence)
Recommended Name: ATP synthase subunit beta, mitochondrial precursor  
Size: 529 amino acids; 56560 Da
Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b
and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2,
MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68. Interacts with PPIF (By similarity)
Subcellular location: Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein
Secondary accessions: A8K4X0 Q14283

Explore the universe of human proteins at neXtProt for ATP5B: NX_P06576

Explore proteomics data for ATP5B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06576

  • 4/73 DME Specific Peptides for ATP5B (P06576) (see all 73)
     VPLKETI  EMIESGV  ELSEEDK  VGYQPTL 

    ATP5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATP5B Protein Expression
    REFSEQ proteins: NP_001677.2  
    ENSEMBL proteins: 
     ENSP00000262030   ENSP00000450297   ENSP00000450233   ENSP00000446677   ENSP00000446489  
     ENSP00000448428   ENSP00000447571  
    Reactome Protein details: P06576
    Human Recombinant Protein Products for ATP5B: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane ----
    GO:0005753mitochondrial proton-transporting ATP synthase complex IDA12110673
    GO:0005754mitochondrial proton-transporting ATP synthase, catalytic core NAS2870059
    GO:0005759mitochondrial matrix TAS--

    ATP5B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FATP: Mitochondrial respiratory chain complex / Complex V
    F1ATP: ATPases / F-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: &beta 
    F-type ATPase

    5/8 InterPro protein domains (see all 8):
     IPR000793 ATPase_F1/V1/A1-cplx_a/bsu_C
     IPR005722 ATPase_F1-cplx_bsu
     IPR004100 ATPase_a/bsu_N
     IPR027417 P-loop_NTPase
     IPR020003 ATPase_a/bsu_AS

    Graphical View of Domain Structure for InterPro Entry P06576

    ProtoNet protein and cluster: P06576

    1 Blocks protein domain: IPB000194 H+-transporting two-sector ATPase

    UniProtKB/Swiss-Prot: ATPB_HUMAN, P06576
    Similarity: Belongs to the ATPase alpha/beta chains family


    ATP5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATPB_HUMAN, P06576
    Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
    presence of a proton gradient across the membrane which is generated by electron transport complexes of the
    respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous
    catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a
    peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary
    mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core
    in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of
    ATP in three separate catalytic sites on the beta subunits
    Catalytic activity: ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out)

         Genatlas biochemistry entry for ATP5B:
    ATP synthase H+ transporting,mitochondrial matrix (F1 segment),catalytic,beta subunit,cardiac muscle,complex V of
    oxidative phosphorylation (OXPHOS)

         Enzyme Numbers (IUBMB): EC 3.6.3.141 2 EC 3.6.32

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005215transporter activity NAS2870059
    GO:0005515protein binding IPI10077593
    GO:0005524ATP binding IEA--
    GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances ----
         
    ATP5B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ATP5B:
     Upregulation of Wnt/beta-caten 

    Animal Models:
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ATP5B:
    hsa-miR-4261
    SwitchGear 3'UTR luciferase reporter plasmidATP5B 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ATP5B About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.61
    Electron Transport Chain0.75
    Oxidative phosphorylation0.51
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Huntington's disease0.47
    Oxidative phosphorylation0.64
    Alzheimer's disease0.46
    2adenosine ribonucleotides de novo biosynthesis
    adenosine ribonucleotides de novo biosynthesis0.49
    Formation of ATP by chemiosmotic coupling0.31
    superpathway of purine nucleotides de novo biosynthesis I0.49
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for ATP5B
        Electron Transport Chain
    Oxidative phosphorylation
    superpathway of purine nucleotides de novo biosynthesis I
    adenosine ribonucleotides de novo biosynthesis


    5/6        Reactome Pathways for ATP5B (see all 6)
        Formation of ATP by chemiosmotic coupling
    Metabolism
    Mitochondrial Protein Import
    Metabolism of proteins
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

    1 PharmGKB Pathway for ATP5B
        Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

    5         Kegg Pathways  (Kegg details for ATP5B):
        Oxidative phosphorylation
    Metabolic pathways
    Alzheimer's disease
    Parkinson's disease
    Huntington's disease


    ATP5B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/567 Interacting proteins for ATP5B (P065762, 3 ENSP000002620304) via UniProtKB, MINT, STRING, and/or I2D (see all 567)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IMP17510399
    GO:0006091generation of precursor metabolites and energy NAS2870059
    GO:0006200ATP catabolic process IDA12110673
    GO:0006629lipid metabolic process IEA--
    GO:0006754ATP biosynthetic process IMP17510399

    ATP5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATP5B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ATP5B (ATPB)

    4 HMDB Compounds for ATP5B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    5 DrugBank Compounds for ATP5B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-ACETYL-2-CARBOXYPIPERIDINE-- --target--10592235
    AUROVERTIN B-- --target--10592235
    N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE-- --target--10592235
    PICEATANNOL-- --target--10592235
    Quercetin-- 117-39-5target--10592235

    2 Novoseek inferred chemical compound relationships for ATP5B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerulein 75.5 2 14673794 (1), 14673795 (1)
    atp 60.5 14 14673794 (2), 1371933 (1), 1378836 (1), 17485861 (1) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about ATP5B / ATPB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ATP5B gene: 
    NM_001686.3  

    Unigene Cluster for ATP5B:

    ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
    Hs.406510  [show with all ESTs]
    Unigene Representative Sequence: BG177099
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262030(uc001slr.3) ENST00000548474 ENST00000552919 ENST00000551182
    ENST00000552104 ENST00000547808 ENST00000547250 ENST00000551020 ENST00000550162
    ENST00000552959 ENST00000551570 ENST00000553007 ENST00000548647
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK291085.1 BC016512.1 X05606.1 

    24/56 DOTS entries (see all 56):

    DT.91989369  DT.100699669  DT.100699655  DT.97816152  DT.95362451  DT.100846443  DT.100699671  DT.121163103 
    DT.95362408  DT.100699653  DT.100699673  DT.100799558  DT.100699682  DT.100699633  DT.100847401  DT.100645431 
    DT.100699680  DT.100699656  DT.100699676  DT.100852324  DT.121162995  DT.121163109  DT.91776463  DT.100759993 

    24/2203 AceView cDNA sequences (see all 2203):

    CR593868 BM792324 BX464060 CR611417 CR620227 CB112433 BQ223293 BM995682 
    CR615169 CD516399 BQ337804 BQ674006 BQ050935 BQ227770 CD678506 BQ068833 
    BQ421559 BU735948 BF982611 BU733187 CA389578 BQ316543 BQ944171 BM841798 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ATP5B (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^
    SP1:                                                  -                                                                                                         
    SP2:                          -     -     -           -                                                                                                         
    SP3:                                                                                      -     -     -     -                                                   
    SP4:                                            -     -     -     -     -                                                                                       
    SP5:                          -     -     -           -                                         -     -     -     -                                             

    ExUns: 12a · 12b · 12c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ATP5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP5B expression in normal human tissues (normalized intensities)      ATP5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCCAACA
    ATP5B Expression
    About this image


    ATP5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/midbrain   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Stem Bronchi
             lung ; pneumocytes   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See ATP5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP5B

    SOURCE GeneReport for Unigene cluster: Hs.406510
        SABiosciences Expression via Pathway-Focused PCR Array including ATP5B: 
              Mitochondrial Energy Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATP5B gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp5b1 , 5 ATP synthase, H+ transporting mitochondrial F1 complex, more1, 5 89.22(n)1
    96.22(a)1
      10 (76.39 cM)5
    119471  NM_016774.31  NP_058054.21 
     1280832735 
    chicken
    (Gallus gallus)
    Aves ATP5B1 ATP synthase, H+ transporting, mitochondrial F1 complex, more 77.97(n)
    92.42(a)
      426673  NM_001031391.1  NP_001026562.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATP5B6
    ATP synthase subunit beta
    90(a)
    1 ↔ 1
    2(92924737-92933786)
    African clawed frog
    (Xenopus laevis)
    Amphibia atp5b-prov2 ATP synthase, H+ transporting mitochondrial F1 complex, more 81.56(n)    BC046741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzehn05342 hmzehn0534 82.34(n)   337722  BI896684.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ATPsyn-&bgr;3
    ATPsyn-beta1
    hydrogen transport
    hydrogen-transporting two-sector
    more3
    ATP synthase-beta1
    90(a)
    (best of 2)3
    75.12(n)1
    89.81(a)1
      102D13
    438291  NM_166808.21  NP_726631.11 
    worm
    (Caenorhabditis elegans)
    Secernentea atp-21 Protein ATP-2 70.02(n)
    82.79(a)
      175716  NM_065710.4  NP_498111.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATP2(YJR121W)4
    ATP21
    Beta subunit of the F1 sector of mitochondrial F1F more4
    Atp2p1
    69.13(n)1
    79.7(a)1
      10(647607-649142)4
    8535851, 4  NP_012655.31  NP_012655.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G086701 F-type H+-transporting ATPase subunit beta 68.16(n)
    75.53(a)
      830768  NM_120953.3  NP_568203.2 
    rice
    (Oryza sativa)
    Liliopsida AK064953.12   -- 74.39(n)    AK064953.1 


    ENSEMBL Gene Tree for ATP5B (if available)
    TreeFam Gene Tree for ATP5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP5B gene

    ATP5B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ATP5B
    PGOHUM00000240812


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/109 SNPs in ATP5B are shown (see all 109)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1148258871,2
    C--57032217(+) ATGATA/GGGGGA 1 -- int10--------
    rs1114930121,2
    C,F--57032225(+) GGAGAG/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs3772947221,2
    C--57032246(+) GAAGCA/GGAGGG 1 -- int10--------
    rs1504244531,2
    --57032306(+) GTTAGA/GATGTG 1 -- int10--------
    rs1878252981,2
    --57032818(+) TTACAC/TATATT 1 -- int10--------
    rs1383457711,2
    --57032831(+) TTGACA/GGTTGT 1 -- int10--------
    rs1450152041,2
    C,F--57032900(+) AAAATC/ATGCTG 2 /Q /H mis12Minor allele frequency- A:0.00NA EU 5871
    rs1996877681,2
    --57032951(+) ATATGA/GCCTGT 2 G syn10--------
    rs2019183701,2
    --57032954(+) TGACCC/TGTGAA 2 T syn10--------
    rs2006108441,2
    --57032995(+) GAAACA/GCTGTA 2 R C mis10--------

    HapMap Linkage Disequilibrium report for ATP5B (57031959 - 57039852 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ATP5B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ATP5B
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 102910    OMIM disorders: --

    16 diseases for ATP5B:    About MalaCards
    chondroblastoma    endocarditis    acute pancreatitis    fanconi's anemia
    huntington's disease    anemia    pneumonia    parkinson's disease
    atherosclerosis    tuberculosis    endotheliitis    pancreatitis
    thyroiditis    alzheimer's disease    hepatitis    breast cancer


    ATP5B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ATP5B
    Human Genome Epidemiology (HuGE) Navigator: ATP5B (1 document)

    Export disorders for ATP5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP5B gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with ATP5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression. (PubMed id 2687158)1, 2, 3 Neckelmann N....Wallace D.C. (1989)
    2. Candidate genetic analysis of plasma high-density lip oprotein-cholesterol and severity of coronary atherosclerosis. (PubMed id 19878569)1, 4 Chen S.N....Marian A.J. (2009)
    3. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit. (PubMed id 2900241)1, 2 Ohta S.... Kagawa Y. (1988)
    6. Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations. (PubMed id 2896550)1, 2 Wallace D.C....Greenberg B.D. (1987)
    7. Human F1-ATPase: molecular cloning of cDNA for the beta subunit. (PubMed id 2870059)1, 2 Ohta S. and Kagawa Y. (1986)
    8. ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase beta-subunit. (PubMed id 7798271)1, 9 Villena J.A....Villarroya F. (1994)
    9. Inhibition of UBE2D3 expression attenuates radiosensit ivity of MCF-7 human breast cancer cells by increasing hTERT expression and acti vity. (PubMed id 23741361)1 Wang W....Zhou Y. (2013)
    10. Identification of ATP synthase as a lipid peroxide pro tein adduct in pancreatic islets from humans with and without type 2 diabetes me llitus. (PubMed id 23463654)1 MacDonald M.J....Ostenson C.G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 506 HGNC: 830 AceView: ATP5B Ensembl:ENSG00000110955 euGenes: HUgn506
    ECgene: ATP5B Kegg: 506 H-InvDB: ATP5B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATP5B gene:
    Search GeneIP for patents involving ATP5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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