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Aliases for ATP5B Gene

Aliases for ATP5B Gene

  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Beta Polypeptide 2 3 5
  • EC 3.6.3.14 4 63
  • ATPSB 3 4
  • ATPMB 3 4
  • Mitochondrial ATP Synthetase, Beta Subunit 3
  • Mitochondrial ATP Synthase Beta Subunit 3
  • Epididymis Secretory Protein Li 271 3
  • HEL-S-271 3
  • EC 3.6.3 63

External Ids for ATP5B Gene

Previous HGNC Symbols for ATP5B Gene

  • ATPSB

Previous GeneCards Identifiers for ATP5B Gene

  • GC12P057014
  • GC12M057256
  • GC12M056748
  • GC12M055318
  • GC12M057031
  • GC12M054071

Summaries for ATP5B Gene

Entrez Gene Summary for ATP5B Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5B Gene

ATP5B (ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Beta Polypeptide) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics. GO annotations related to this gene include transporter activity and transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5B Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene Wiki entry for ATP5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5B Gene

Genomics for ATP5B Gene

Regulatory Elements for ATP5B Gene

Enhancers for ATP5B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATP5B on UCSC Golden Path with GeneCards custom track

Promoters for ATP5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATP5B on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP5B Gene

Chromosome:
12
Start:
56,638,175 bp from pter
End:
56,646,068 bp from pter
Size:
7,894 bases
Orientation:
Minus strand

Genomic View for ATP5B Gene

Genes around ATP5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5B Gene

Proteins for ATP5B Gene

  • Protein details for ATP5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06576-ATPB_HUMAN
    Recommended name:
    ATP synthase subunit beta, mitochondrial
    Protein Accession:
    P06576
    Secondary Accessions:
    • A8K4X0
    • Q14283

    Protein attributes for ATP5B Gene

    Size:
    529 amino acids
    Molecular mass:
    56560 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68. Interacts with PPIF. Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficency (By similarity).

neXtProt entry for ATP5B Gene

Proteomics data for ATP5B Gene at MOPED

Post-translational modifications for ATP5B Gene

  • Ubiquitination at Lys 124, Lys 133, Lys 161, and Lys 201
  • Glycosylation at Ser 106
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP5B Gene

Domains & Families for ATP5B Gene

Suggested Antigen Peptide Sequences for ATP5B Gene

Graphical View of Domain Structure for InterPro Entry

P06576

UniProtKB/Swiss-Prot:

ATPB_HUMAN :
  • Belongs to the ATPase alpha/beta chains family.
Family:
  • Belongs to the ATPase alpha/beta chains family.
genes like me logo Genes that share domains with ATP5B: view

Function for ATP5B Gene

Molecular function for ATP5B Gene

GENATLAS Biochemistry:
ATP synthase H+ transporting,mitochondrial matrix (F1 segment),catalytic,beta subunit,cardiac muscle,complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Enzyme Numbers (IUBMB) for ATP5B Gene

Gene Ontology (GO) - Molecular Function for ATP5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10077593
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0042288 MHC class I protein binding IDA 17643490
genes like me logo Genes that share ontologies with ATP5B: view
genes like me logo Genes that share phenotypes with ATP5B: view

Animal Models for ATP5B Gene

MGI Knock Outs for ATP5B:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5B Gene

Localization for ATP5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5B Gene

Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5B Gene COMPARTMENTS Subcellular localization image for ATP5B gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 5
cytosol 2
chloroplast 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ATP5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA,IDA 2870059
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain IEA --
genes like me logo Genes that share ontologies with ATP5B: view

Pathways & Interactions for ATP5B Gene

genes like me logo Genes that share pathways with ATP5B: view

Gene Ontology (GO) - Biological Process for ATP5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IMP 17510399
GO:0006996 organelle organization TAS --
GO:0007005 mitochondrion organization TAS --
GO:0015986 ATP synthesis coupled proton transport IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ATP5B: view

No data available for SIGNOR curated interactions for ATP5B Gene

Drugs & Compounds for ATP5B Gene

(7) Drugs for ATP5B Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
1-ACETYL-2-CARBOXYPIPERIDINE Experimental Pharma Target 0
AUROVERTIN B Experimental Pharma Target 0
N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE Experimental Pharma Target 0
Piceatannol Experimental Pharma Target p56lck/Syk inhibitor, Inhibits TNF-induced NF-kappaB activation 0

(1) Additional Compounds for ATP5B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ATP5B: view

Transcripts for ATP5B Gene

Unigene Clusters for ATP5B Gene

ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^
SP1: -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - -
SP8:
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - - - - - - - - -

ExUns: 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ATP5B Gene

GeneLoc Exon Structure for
ATP5B
ECgene alternative splicing isoforms for
ATP5B

Expression for ATP5B Gene

mRNA expression in normal human tissues for ATP5B Gene

mRNA differential expression in normal tissues according to GTEx for ATP5B Gene

This gene is overexpressed in Heart - Left Ventricle (x6.0).

Protein differential expression in normal tissues from HIPED for ATP5B Gene

This gene is overexpressed in Heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5B Gene



SOURCE GeneReport for Unigene cluster for ATP5B Gene Hs.406510

genes like me logo Genes that share expression patterns with ATP5B: view

Protein tissue co-expression partners for ATP5B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATP5B Gene

Orthologs for ATP5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP5B 35
  • 92.68 (n)
  • 96.78 (a)
ATP5B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5B 35
  • 92.35 (n)
  • 96.39 (a)
-- 36
  • 74 (a)
OneToMany
ATP5B 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atp5b 35
  • 89.22 (n)
  • 96.22 (a)
Atp5b 16
Atp5b 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATP5B 35
  • 99.31 (n)
  • 99.24 (a)
ATP5B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5b 35
  • 89.1 (n)
  • 95.65 (a)
oppossum
(Monodelphis domestica)
Mammalia ATP5B 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5B 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5B 35
  • 78.03 (n)
  • 92.61 (a)
ATP5B 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5B 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5b 35
  • 78.93 (n)
  • 92.15 (a)
Str.20526 35
African clawed frog
(Xenopus laevis)
Amphibia atp5b-prov 35
zebrafish
(Danio rerio)
Actinopterygii atp5b 35
  • 78.79 (n)
  • 91.1 (a)
hmzehn0534 35
ATP5B 36
  • 83 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8681 35
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-bgr 37
  • 90 (a)
CG5389 37
  • 75 (a)
ATPsyn-beta 35
  • 74.67 (n)
  • 89.12 (a)
ATPsyn-beta 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012106 35
  • 70.05 (n)
  • 86.47 (a)
worm
(Caenorhabditis elegans)
Secernentea atp-2 35
  • 70.02 (n)
  • 82.79 (a)
atp-2 36
  • 78 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR169W 35
  • 68.4 (n)
  • 77.2 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10703g 35
  • 68.53 (n)
  • 77.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP2 35
  • 69.13 (n)
  • 79.7 (a)
ATP2 36
  • 74 (a)
OneToOne
ATP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G08670 35
  • 68.22 (n)
  • 75.53 (a)
soybean
(Glycine max)
eudicotyledons Gma.1312 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7062 35
barley
(Hordeum vulgare)
Liliopsida Hv.1223 35
rice
(Oryza sativa)
Liliopsida Os05g0553000 35
  • 69.2 (n)
  • 77.78 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5 35
corn
(Zea mays)
Liliopsida Zm.957 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4478 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05430 35
  • 68.79 (n)
  • 80.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp2 35
  • 70.18 (n)
  • 80.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4294 36
  • 74 (a)
OneToOne
Species with no ortholog for ATP5B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ATP5B Gene

ENSEMBL:
Gene Tree for ATP5B (if available)
TreeFam:
Gene Tree for ATP5B (if available)

Paralogs for ATP5B Gene

Pseudogenes.org Pseudogenes for ATP5B Gene

genes like me logo Genes that share paralogs with ATP5B: view

No data available for Paralogs for ATP5B Gene

Variants for ATP5B Gene

Sequence variations from dbSNP and Humsavar for ATP5B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1042001 - 56,642,804(-) TGAAT(C/G)AACCA reference, missense
VAR_074188 -
rs2272314 -- 56,642,916(+) CGACC(A/T)CAGAT intron-variant
rs34004174 -- 56,639,355(+) AATTT(-/G)GGACA intron-variant
rs34462028 -- 56,648,067(+) CCTGT(-/A)AATCC upstream-variant-2KB

Variation tolerance for ATP5B Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ATP5B Gene

Disorders for ATP5B Gene

Relevant External Links for ATP5B

Genetic Association Database (GAD)
ATP5B
Human Genome Epidemiology (HuGE) Navigator
ATP5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5B

No disorders were found for ATP5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5B Gene

Publications for ATP5B Gene

  1. The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression. (PMID: 2687158) Neckelmann N. … Wallace D.C. (Genomics 1989) 2 3 4 67
  2. ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase beta-subunit. (PMID: 7798271) Villena J.A. … Villarroya F. (J. Biol. Chem. 1994) 3 23
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  4. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for ATP5B Gene

Sources for ATP5B Gene

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