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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ATP5B Gene

protein-coding GIFtS: 64
GCID: GC12M057031

ATP synthase, H+ transporting, mitochondrial F1 complex,...

(Previous symbol: ATPSB)

Explore 22 diseases affiliated with
ATP5B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Beta Polypeptide¹ ²		ATP Synthase Subunit Beta, Mitochondrial²
ATPSB¹ ² ³ ⁵		Mitochondrial ATP Synthase Beta Subunit²
ATPMB² ³		Mitochondrial ATP Synthetase, Beta Subunit²
EC 3.6.3.14³ ⁸		EC 3.6.3⁸

External Ids:	HGNC: 830¹	Entrez Gene: 506²	Ensembl: ENSG00000110955⁷	OMIM: 102910⁵	UniProtKB: P06576³

Export aliases for ATP5B gene to outside databases

Previous GC identifers: GC12P057014 GC12M057256 GC12M056748 GC12M055318 GC12M054071

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATP5B:

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis,

utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP

synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning

component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5

different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a

single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes

the beta subunit of the catalytic core. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATPB_HUMAN, P06576

Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the

presence of a proton gradient across the membrane which is generated by electron transport complexes of the

respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic

core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.

During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk

subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central

stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on

the beta subunits

Gene Wiki entry for ATP5B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ATP5B gene promoter:
STAT1 STAT1beta Lmo2 Meis-1b Evi-1 STAT1alpha Gfi-1 PPAR-gamma1 Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATP5B promoter sequence

Search SABiosciences Chromatin IP Primers for ATP5B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP5B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12p13.3

ATP5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP5B gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M057031: view genomic region (about GC identifiers)

Start:	57,031,959 bp from pter	End:	57,039,852 bp from pter
Size:	7,894 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATPB_HUMAN, P06576 (See protein sequence)

Recommended Name: ATP synthase subunit beta, mitochondrial precursor

Size: 529 amino acids; 56560 Da

Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1)

has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8,

ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68. Interacts with PPIF (By similarity)

Subcellular location: Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein

Secondary accessions: A8K4X0 Q14283

Explore the universe of human proteins at neXtProt for ATP5B: NX_P06576

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P06576

4/73 DME Specific Peptides for ATP5B (P06576) (see all 73)

VPLKETI

EMIESGV

ELSEEDK

VGYQPTL

ATP5B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001677.2

ENSEMBL proteins:

ENSP00000262030 ENSP00000450297 ENSP00000450233 ENSP00000446677 ENSP00000446489

ENSP00000448428 ENSP00000447571

Reactome Protein details: P06576
Human Recombinant Protein Products for ATP5B:

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	Browse Proteins at Uscn

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	--	--
GO:0005739	mitochondrion	IDA	--
GO:0005743	mitochondrial inner membrane	--	--
GO:0005753	mitochondrial proton-transporting ATP synthase complex	IDA	12110673
GO:0005754	mitochondrial proton-transporting ATP synthase, catalytic core	NAS	2870059

ATP5B for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATP5B for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000793 ATPase_F1/V1/A1-cplx_a/bsu_C

IPR005722 ATPase_F1-cplx_bsu

IPR004100 ATPase_a/bsu_N

IPR020003 ATPase_a/bsu_AS

IPR003593 AAA+_ATPase

Graphical View of Domain Structure for InterPro Entry P06576

ProtoNet protein and cluster: P06576

1 Blocks protein family: IPB000194 H+-transporting two-sector ATPase

UniProtKB/Swiss-Prot: ATPB_HUMAN, P06576

Similarity: Belongs to the ATPase alpha/beta chains family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ATPB_HUMAN, P06576

Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the

presence of a proton gradient across the membrane which is generated by electron transport complexes of the

respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic

core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.

During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk

subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central

stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on

the beta subunits

Catalytic activity: ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out)

Genatlas biochemistry entry for ATP5B:

ATP synthase H+ transporting,mitochondrial matrix (F1 segment),catalytic,beta subunit,cardiac muscle,complex V of

oxidative phosphorylation (OXPHOS)

Enzyme Numbers (IUBMB): EC 3.6.3.14¹ ² EC 3.6.3²

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	NAS	2870059
GO:0005509	calcium ion binding	--	--
GO:0005515	protein binding	IPI	10077593
GO:0005524	ATP binding	IEA	--
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	IEA	--

ATP5B for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ATP5B:

Upregulation of Wnt/beta-caten

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ATP5B

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP5B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	1.00	Parkinson's disease	0.61
Electron Transport Chain	0.76	Oxidative phosphorylation	0.52
The citric acid (TCA) cycle and respiratory electron transport	0.72	Alzheimer's disease	0.43
Oxidative phosphorylation	0.63	Huntington's disease	0.40

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Mitochondrial Protein Import

Mitochondrial Protein Import

1.00

Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

1.00

Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for ATP5B

	Electron Transport Chain
	Oxidative phosphorylation

5/6 Reactome Pathways for ATP5B (see all 6)

	Formation of ATP by chemiosmotic coupling
	Metabolism
	Mitochondrial Protein Import
	Metabolism of proteins
	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

1 PharmGKB Pathway for ATP5B

Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

5 Kegg Pathways (Kegg details for ATP5B):

	Oxidative phosphorylation
	Metabolic pathways
	Alzheimer's disease
	Parkinson's disease
	Huntington's disease

ATP5B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ATP5B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/546 Interacting proteins for ATP5B (P06576^{2, 3} ENSP00000262030⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 546)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3A	P68431³	I2D: score=1
HIST1H3B	P68431³	I2D: score=1
HIST1H3C	P68431³	I2D: score=1
HIST1H3D	P68431³	I2D: score=1
HIST1H3E	P68431³	I2D: score=1

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IMP	17510399
GO:0006091	generation of precursor metabolites and energy	NAS	2870059
GO:0006172	ADP biosynthetic process	--	--
GO:0006200	ATP catabolic process	IDA	12110673
GO:0006629	lipid metabolic process	IEA	--

ATP5B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ATP5B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ATP5B

4 HMDB Compounds for ATP5B About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

5 DrugBank Compounds for ATP5B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1-ACETYL-2-CARBOXYPIPERIDINE	--	--	target	--	10592235
AUROVERTIN B	--	--	target	--	10592235
N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE	--	--	target	--	10592235
PICEATANNOL	--	--	target	--	10592235
Quercetin	--	117-39-5	target	--	10592235

2 Novoseek chemical compound relationships for ATP5B gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cerulein	75.5	2	14673794 (1), 14673795 (1)
atp	60.5	14	14673794 (2), 1371933 (1), 1378836 (1), 17485861 (1) (see all 11)

Search CenterWatch for drugs/clinical trials and news about ATP5B / ATPB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATP5B gene:

NM_001686.3

Unigene Cluster for ATP5B:

ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

Hs.406510 [show with all ESTs]

Unigene Representative Sequence: BG177099

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262030(uc001slr.3) ENST00000548474 ENST00000552919 ENST00000551182

ENST00000552104 ENST00000547808 ENST00000547250 ENST00000551020 ENST00000550162

ENST00000552959 ENST00000551570 ENST00000553007 ENST00000548647

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Additional cDNA sequence:

AK291085.1 BC016512.1 X05606.1

24/56 DOTS entries (see all 56):

DT.91989369 DT.100699669 DT.100699655 DT.97816152 DT.95362451 DT.100846443 DT.100699671 DT.121163103

DT.95362408 DT.100699653 DT.100699673 DT.100799558 DT.100699682 DT.100699633 DT.100847401 DT.100645431

DT.100699680 DT.100699656 DT.100699676 DT.100852324 DT.121162995 DT.121163109 DT.91776463 DT.100759993

24/2203 AceView cDNA sequences (see all 2203):

BQ058006 BF725304 BM474265 BU849714 CR625161 CD107581 CR625698 CB146836

CR594490 CR608193 BQ216381 CA310300 BQ654238 BE795310 BQ944144 BX397540

AL538834 CK822407 BQ674006 CB142475 BQ929589 CB118328 BU676789 BG319537

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ATP5B (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	^
SP1:																	-
SP2:									-		-		-				-
SP3:																													-		-		-		-
SP4:															-		-		-		-		-
SP5:									-		-		-				-														-		-		-		-

ExUns:	12a	·	12b	·	12c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ATP5B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATP5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCCCAACA

About this image

ATP5B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ATP5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATP5B

SOURCE GeneReport for Unigene cluster: Hs.406510

SABiosciences Expression via Pathway-Focused PCR Array including ATP5B:

Mitochondrial Energy Metabolism in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP5B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ATP5B gene from 10/44 species (see all 44) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ATP5B¹	ATP synthase, H+ transporting, mitochondrial F1 complex, more	77.97(n) 92.42(a)		426673 NM_001031391.1 NP_001026562.1
lizard (Anolis carolinensis)	Reptilia	ATP5B⁶	--	90(a)	1 ↔ 1	2(92925426-92933786)
African clawed frog (Xenopus laevis)	Amphibia	atp5b-prov²	ATP synthase, H+ transporting mitochondrial F1 complex, more	81.56(n)		BC046741.1
zebrafish (Danio rerio)	Actinopterygii	hmzehn0534²	hmzehn0534	82.34(n)		337722 BI896684.1
fruit fly (Drosophila melanogaster)	Insecta	ATPsyn-&bgr;³ ATPsyn-beta¹	hydrogen transport hydrogen-transporting two-sector more³ ATP synthase-beta¹	90(a) (best of 2)³ 75.12(n)¹ 89.81(a)¹		102D1³ 43829¹ NM_166808.2¹ NP_726631.1¹
worm (Caenorhabditis elegans)	Secernentea	atp-2¹	Protein ATP-2	70.02(n) 82.79(a)		175716 NM_065710.4 NP_498111.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ATP2(YJR121W)⁴ ATP2¹	Beta subunit of the F1 sector of mitochondrial F1F more⁴ Atp2p¹	69.13(n)¹ 79.7(a)¹		10(647607-649142)⁴ 853585^{1, 4} NP_012655.3¹ NP_012655.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G08670¹	F-type H+-transporting ATPase subunit beta	68.16(n) 75.53(a)		830768 NM_120953.3 NP_568203.2
rice (Oryza sativa)	Liliopsida	AK064953.1²	--	74.39(n)		AK064953.1
E. coli (Escherichia coli)	Gamma proteobacteria	atpD⁶	F1 sector of membrane-bound ATP synthase, beta sub...	73(a)	1 ↔ 1	Chromosome(3914016-3915398)

ENSEMBL Gene Tree for ATP5B (if available)
TreeFam Gene Tree for ATP5B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ATP5B gene

ATP5B for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ATP5B
PGOHUM00000240812

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147566446^1,2		--	57031476(+)	`TAAAAC/TGAGTT`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs142596462^1,2		--	57031492(+)	`CAATAC/TGCCCT`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs143394881^1,2		--	57031598(+)	`CCAAAA/CCTGAG`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs190001725^1,2		--	57031625(+)	`ACTACC/TCACAG`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs74091604^1,2	C	--	57031747(+)	`CACTCT/CAAAAA`	2	--	ds500¹ us2k¹		2		WA	120
rs76051986^1,2		--	57031804(+)	`GTAGCC/ACCAGC`	2	--	us2k¹ ds500¹		1		WA	118
rs148349753^1,2		--	57031810(+)	`CCAGCG/TACTCA`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs1059859^1,2	C,F,H	--	57032003(-)	`TCTTTC/TTGAAC`	2	--	us2k¹ ut3¹		5		NS NA	616
rs149735193^1,2	C	--	57032006(+)	`CAGAA-/AGAA TATATCTTCAAT`	2	--	us2k¹ ut3¹		0	--	--	--	--
rs11542643^1,2	C,H	--	57032131(-)	`GATAAG/TCTGGC`	3	K N	us2k¹ mis¹		6		NS EA NA	410

HapMap Linkage Disequilibrium report for ATP5B (57031959 - 57039852 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATP5B: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP5B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ATP5B for disorders           About GeneDecksing

OMIM gene information: 102910    OMIM disorders: --

20/22 diseases for ATP5B (see all 22):    About MalaCards

complex v chondroblastoma fanconi's anemia endocarditis

huntington's disease acute pancreatitis parkinson's disease hermaphroditism

anemia ovarian carcinoma pharyngitis pancreatitis

atherosclerosis pneumonia cholesterol tuberculosis

thyroiditis carcinoma hepatitis malaria

Human Genome Epidemiology (HuGE) Navigator: ATP5B (1 document)

Export disorders for ATP5B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ATP5B gene, integrated from 9 sources (see all 91):
(articles sorted by number of sources associating them with ATP5B)

Utopia: connect your pdf to the dynamic
world of online information

The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression. (PubMed id 2687158)^{1, 2, 3} Neckelmann N....Wallace D.C. (1989)
Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)^{1, 2} Aboulaich N.... Vener A.V. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit. (PubMed id 2900241)^{1, 2} Ohta S.... Kagawa Y. (1988)
Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations. (PubMed id 2896550)^{1, 2} Wallace D.C....Greenberg B.D. (1987)
Human F1-ATPase: molecular cloning of cDNA for the beta subunit. (PubMed id 2870059)^{1, 2} Ohta S. and Kagawa Y. (1986)
ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase beta-subunit. (PubMed id 7798271)^{1, 9} Villena J.A....Villarroya F. (1994)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 506	HGNC: 830	AceView: ATP5B	Ensembl:ENSG00000110955	euGenes: HUgn506
ECgene: ATP5B	Kegg: 506	H-InvDB: ATP5B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ATP5B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ATP5B gene
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Patent Information for ATP5B gene:
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