ATP5A1 Gene
protein-coding GIFtS : 62 GCID: GC18 M043664
ATP synthase, H+ transporting, mitochondrial F1 complex,... ATP synthase, H+ transporting, mitochondrial F1 complex,... ATP5AL2, ATPM )
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Aliasesfor ATP5A1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Alpha Subunit 1,Cardiac Muscle 1 2 HATP11 ATP5A1 2 3 5 MOM22 ATPM1 2 3 5 ATP Synthase Alpha Chain, Mitochondrial2 ATP5AL21 2 3 ATP Synthase Subunit Alpha, Mitochondrial2 ORM1 2 5 ATP Sythase (F1-ATPase) Alpha Subunit2 OMR1 2 Mitochondrial ATP Synthetase, Oligomycin-Resistant2 ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Alpha Subunit, Isoform1, Cardiac Muscle1 2 EC 3.6.38 ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Alpha Subunit, Isoform2, Non-Cardiac Muscle-Like 21 2 EC 3.6.3.148
Export aliases for ATP5A1 gene to outside databases Previous GC identifers: GC18M043976 GC18M043450 GC18M043552 GC18M041916 GC18M041918 GC18M040521
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Summariesfor ATP5A1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ATP5A1 : This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. (provided by RefSeq, Mar 2012) UniProtKB/Swiss-Prot: ATPA_HUMAN, P25705 Function : Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in thepresence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity) Gene Wiki entry for ATP5A1 (ATP synthase, H+ transporting, mitochondrial F1 complex, alpha 1)
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Genomic Viewsfor ATP5A1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000018.9 NC_018929.1 NT_010966.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ATP5A1 gene promoter:Egr-2 N-Myc Spz1 AML1a NF-kappaB NF-kappaB1 POU3F2 Other transcription factors Search SABiosciences Chromatin IP Primers for ATP5A1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 18q21 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21 ATP5A1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 18 GeneLoc Exon Structure
GeneLoc location for GC18M043664: view genomic region
(about GC identifiers )
Start: 43,664,110 bp from pter End:
43,684,300 bp from pter
Size: 20,191 bases Orientation:
minus strand
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Proteinsfor ATP5A1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ATPA_HUMAN, P25705 See
protein sequence )Recommended Name: Size : 553 amino acids; 59751 DaSubunit : F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1)has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Interacts with ATPAF2. Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro). Interacts with PLG (angiostatin peptide); the interaction inhibits most of the angiogenic properties of angiostatin. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). Interacts with BLOC1S1
Subcellular location : Mitochondrion inner membrane. Cell membrane; Peripheral membrane protein; Extracellular side.Note=Colocalizes with HRG on the cell surface of T-cells
Secondary accessions : A8K092 Q53XX6 Q8IXV2 Q96FB4 Q96HW2 Q96IR6 Q9BTV8Alternative splicing : 2 isoforms : P25705-1 P25705-2 Explore the universe of human proteins at neXtProt for ATP5A1: NX_P25705 Post-translational modifications:
The N-terminus is blocked1 Acetylated on lysine residues. BLOC1S1 is required for acetylation1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P25705 4/51 DME Specific Peptides for ATP5A1 (P25705 ) (see all 51 )ATP5A1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (5 alternative transcripts): NP_001001935.1 NP_001001937.1 NP_001244263.1 NP_001244264.1 NP_004037.1 ENSEMBL proteins: ENSP00000465477 ENSP00000466309 ENSP00000467037 ENSP00000466275 ENSP00000381736 ENSP00000468618 ENSP00000466975 ENSP00000465497 ENSP00000467968 ENSP00000468458 ENSP00000465259 ENSP00000465805 ENSP00000467830 ENSP00000467983 ENSP00000282050 ENSP00000440198 Reactome Protein details: P25705 Human Recombinant Protein Products: Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8 ): About this table
About GeneDecksing ATP5A1 Antibody Products: Assay Products for ATP5A1:
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Protein
Domains /for ATP5A1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry P25705 ProtoNet protein and cluster: P25705
1 Blocks protein family : IPB000194 UniProtKB/Swiss-Prot: ATPA_HUMAN, P25705 Similarity : Belongs to the ATPase alpha/beta chains family
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Functionfor ATP5A1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ATPA_HUMAN, P25705 Function : Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in thepresence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity)
Genatlas biochemistry entry for ATP5A1 ATP synthase H+ transporting,mitochondrial membrane (F1 segment),alpha subunit isoform 1,oligomycin-resistant,cardiac muscle,complex V of oxidative phosphorylation (OXPHOS) Enzyme Numbers (IUBMB): EC 3.6.3.14 2 EC 3.6.3 2 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ATP5A1 (NM_001001937 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATP5A1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ATP5A1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP5A1
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing 1 GenomeRNAi human phenotype for ATP5A1 :Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Atp5a1) :About GeneDecksing
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Pathways & Interactionsfor ATP5A1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 2 Metabolism 3 Mitochondrial Protein Import 4 Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics 5 Formation of ATP by chemiosmotic coupling
Pathway sources See GeneCards unified pathways Show all pathways 2 5/6 (see all 6 )1 ATP5A1 5 (Kegg details for ATP5A1) :About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP5A1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/568 Interacting proteins for ATP5A1 (P25705 1 , 2 , 3 ENSP00000282050 4 via UniProtKB, MINT, STRING , and/or I2D (see all 568 )Interactant Interaction Details GeneCard External ID(s) ATP5B P06576 2 , 3 ENSP00000262030 4 MINT-8079030 MINT-7900157 MINT-4054731 I2D:
score=5 STRING: ENSP00000262030 ACTB P60709 2 , 3 ENSP00000349960 4 MINT-7899812 MINT-7900157 MINT-4054731 I2D:
score=2 STRING: ENSP00000349960 YWHAG P61981 2 , 3 ENSP00000306330 4 MINT-50872 MINT-7899812 I2D:
score=3 STRING: ENSP00000306330 YWHAQ P27348 2 , 3 ENSP00000238081 4 MINT-7899812 MINT-7900157 I2D:
score=1 STRING: ENSP00000238081 ATP5C1 P36542 2 , 3 ENSP00000349142 4 MINT-8079030 I2D:
score=5 STRING: ENSP00000349142
About this table Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ATP5A1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ATP5A1 4 HMDB Compounds for ATP5A1 About this table 5 DrugBank Compounds for ATP5A1 About this table ATP5A1 / ATPA
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Transcriptsfor ATP5A1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ATP5A1 gene (5 alternative transcripts): NM_001001935.2 NM_001001937.1 NM_001257334.1 NM_001257335.1 NM_004046.5 Unigene Cluster for ATP5A1:
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle Hs.298280 [show with all ESTs ] Unigene Representative Sequence: CR627212 18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24 ): ENST00000586523 ENST00000590326 ENST00000593152 ENST00000590156 ENST00000590665 ENST00000586592 ENST00000398752 (uc002lbr.1 uc002lbs.1 uc010xct.1 )ENST00000587902 ENST00000592364 ENST00000589252 ENST00000589869 ENST00000589611 ENST00000590566 ENST00000590406 ENST00000591125 ENST00000590324 ENST00000590448 ENST00000591981 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ATP5A1 (NM_001001937 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATP5A1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ATP5A1
Additional cDNA sequence: AK092735.1 AK098765.1 AK129739.1 AK129804.1 AK129900.1 AK289457.1 AK294804.1 AK302272.1 AK310051.1 BC003119.1 BC007299.1 BC008028.2 BC011384.1 BC016046.1 BC019310.1 BC028335.1 BC039135.1 BC042694.1 BC064562.1 BC067385.1 BT007209.1 CR627212.1 D14710.1 X59066.1 X65460.1
24/143 DOTS entries (see all 143 ): DT.100745399 DT.100745431
DT.91964296 DT.91966596 DT.97866317 DT.95273320 DT.99926662 DT.92474938 DT.95273395 DT.100874827 DT.100745373 DT.100868936 DT.121095059 DT.121095061 DT.95273240 DT.92474847 DT.91737420 DT.92474893 DT.100745328 DT.100061196 DT.121095158 DT.101955867 DT.100745341 DT.95273150 24/4540 AceView cDNA sequences (see all 4540 ):
AU143461 BE252134 AA810661 BM479758 BE784078 BX445182 BM471620 BU192448 BU192948 AU142726 AU142734 BM452446 AU143501 AU142575 AL560093 BM558872 BM799459 AU142669 BU167596 BQ226674 AL541039 AU143308 BQ895995 BU161924 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ATP5A1 (see all 10 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b SP1 : - - - - - - - - SP2 : - - - - - - - SP3 : - - - - - SP4 : - - - - SP5 : - - - - -
ECgene alternative splicing isoforms for ATP5A1
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Expression for ATP5A1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ATP5A1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAAAATAAAG
About this image ATP5A1 expression in embryonic tissues and stem cells About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Endoderm-like cells (Generation of hepato... )Expression: Experimental details:
In-situ hybridization
See ATP5A1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ATP5A1 SOURCE GeneReport for Unigene cluster: Hs.298280 UniProtKB/Swiss-Prot: ATPA_HUMAN, P25705 Tissue specificity : Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina andspinal cord SABiosciences Expression via Pathway-Focused PCR Arrays including ATP5A1 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP5A1
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Orthologsfor ATP5A1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ATP5A1 gene from 10/41 species (see all 41 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves ATP5A11
ATP synthase, H+ transporting, mitochondrial F1 complex, more
82.46(n) 91.86(a)
374159 NM_204286.1 NP_989617.1
lizard Reptilia ATP5A16
--
94(a)
1 ↔ 1
1(35083973-35094192)
African clawed frog Amphibia atp5a1-prov2
ATP synthase, H+ transporting, mitochondrial F1 complex, more
77.9(n)
BC054959.1
zebrafish Actinopterygii atp5a11
ATP synthase, H+ transporting, mitochondrial F1 complex, more
77.8(n) 91.47(a)
553755 NM_001077355.1 NP_001070823.1
fruit fly Insecta blw1 3
proton transport hydrogen-transportingmore 3 1
81(a) 3 72.45(n) 1 82.12(a) 1
59B23 37617 1 NM_166554.2 1 NP_726243.1 1
worm Secernentea H28O16.11 3
ATP synthase alpha and beta subunits, ATPmore 3 1
84(a) 3 72.62(n) 1 84.13(a) 1
I(12660443-12662407)3 173134 1 NM_001026355.2 1 NP_001021526.1 1
baker's yeast Saccharomycetes ATP1(YBL099W)4 1
Alpha subunit of the F1 sector of mitochondrial F1F more 4 1
63.58(n) 1 70.74(a) 1
2(37053-38690) 4 852177 1, 4 NP_009453.2 1 NP_009453.1 4
thale cress eudicotyledons atp11
ATPase subunit 1
63.35(n) 69.92(a)
3890462 atp1_26557005 NP_085571.2
rice Liliopsida Os.252642
Transcribed sequence with weak similarity to protein more
78.29(n)
CA759670.1
E. coli Gamma proteobacteria atpA6
F1 sector of membrane-bound ATP synthase, alpha su... 56(a)
1 ↔ 1
Chromosome(3916339-3917880)
ENSEMBL Gene Tree for ATP5A1 (if available)TreeFam Gene Tree for ATP5A1 (if available)
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Paralogsfor ATP5A1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ATP5A1 gene About GeneDecksing 5/9 Pseudogenes.org Pseudogenes for ATP5A1 (see all 9 )PGOHUM00000247825 PGOHUM00000259084 PGOHUM00000236047 PGOHUM00000236069 PGOHUM00000236480
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Genomic Variantsfor ATP5A1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 18 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ATP5A1 (43664110 - 43684300 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ATP5A1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ATP5A1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 164360
OMIM disorders : --20 : About MalaCards complex v histoplasmosis down syndrome endocarditis huntington's disease hepatitis b parkinson's disease alzheimer's disease colon cancer retinoblastoma colorectal cancer hepatitis pneumonia schizophrenia tuberculosis pancreatitis malaria prostatitis mycobacterium tuberculosis prostate cancer Human Genome Epidemiology (HuGE) Navigator: ATP5A1 (3 documents) Export disorders for ATP5A1 gene to outside databases
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Publicationsfor ATP5A1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ATP5A1 gene, integrated from 9 sources (see all 87 ):(articles sorted by number of sources associating them with ATP5A1) Utopia : connect your pdf to the dynamic
Nucleotide sequence of a cDNA for the alpha subunit of human mitochondrial ATP synthase. (PubMed id 1830491) 1 , 2 , 3(1991) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria. (PubMed id 11410595) 1 , 2 (2001) Angiostatin binds ATP synthase on the surface of human endothelial cells. (PubMed id 10077593) 1 , 2 (1999) The major protein expression profile and two-dimensional protein database of human heart. (PubMed id 7498159) 1 , 2 (1995) Gene structure and cell type-specific expression of the human ATP synthase alpha subunit. (PubMed id 8086450) 1 , 2 (1994) Amplification of the gene encoding the alpha-subunit of the mitochondrial ATP synthase complex in a human retinoblastoma cell line. (PubMed id 8428659) 1 , 2 (1993) Comparative genomic hybridization analysis of Y79 and FISH mapping indicate the amplified human mitochondrial ATP synthase alpha-subunit gene (ATP5A) maps to chromosome 18q12-->q21. (PubMed id 9284928) 1 , 9(1997) A census of human soluble protein complexes. (PubMed id 22939629) 1 (2012)
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External Searches for ATP5A1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ATP5A1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing ATP5A1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ATP5A1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for ATP5A1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ATP5A1 gene: ATP5A1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ATP5A1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ATP5A1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for ATP5A1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ATP5A1 OriGene 3'-UTR Clone for ATP5A1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ATP5A1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ATP5A1 OriGene Custom Protein Services for ATP5A1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATP5A1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for ATP5A1
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP5A1
ThermoFisher Antibodies for ATP5A1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ATP5A1
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Negative
Selective marker
Curated
In-situ hybridization
