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ATP4B Gene

protein-coding   GIFtS: 56
GCID: GC13M114303

ATPase, H+/K+ Exchanging, Beta Polypeptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATPase, H+/K+ Exchanging, Beta Polypeptide1 2     Gastric H+/K+ ATPase Beta Subunit2
Gastric H(+)/K(+) ATPase Subunit Beta2 3     Gastric Hydrogen-Potassium ATPase, Beta2
Proton Pump Beta Chain2 3     Potassium-Transporting ATPase Beta Chain2
ATP6B2     Potassium-Transporting ATPase Subunit Beta2
ATPase, H+/K+ Transporting, Beta Polypeptide2     

External Ids:    HGNC: 8201   Entrez Gene: 4962   Ensembl: ENSG000001860097   OMIM: 1372175   UniProtKB: P511643   

Export aliases for ATP4B gene to outside databases

Previous GC identifers: GC13U990004 GC13M112251 GC13M113351 GC13M094742


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATP4B Gene:
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+,
K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but
heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with
the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion.
This gene encodes the beta subunit of the gastric H+, K+-ATPase. (provided by RefSeq, Jul 2008)

GeneCards Summary for ATP4B Gene:
ATP4B (ATPase, H+/K+ exchanging, beta polypeptide) is a protein-coding gene. Diseases associated with ATP4B include gastric adenocarcinoma, and megaloblastic anemia. GO annotations related to this gene include hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B1.

UniProtKB/Swiss-Prot: ATP4B_HUMAN, P51164
Function: Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also
involved in cell adhesion and establishing epithelial cell polarity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_027140.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP4B gene promoter:
         AML1a   ATF-2   Olf-1   AP-2gamma   GATA-1   RORalpha1   MEF-2A   CREB   deltaCREB   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP4B promoter sequence
   Search Chromatin IP Primers for ATP4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

ATP4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP4B gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M114303:  view genomic region     (about GC identifiers)

Start:
114,303,119 bp from pter      End:
114,312,513 bp from pter
Size:
9,395 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATP4B_HUMAN, P51164 (See protein sequence)
Recommended Name: Potassium-transporting ATPase subunit beta  
Size: 291 amino acids; 33367 Da
Subunit: Composed of two subunits: alpha (catalytic) and beta
Secondary accessions: B1B0N8

Explore the universe of human proteins at neXtProt for ATP4B: NX_P51164

Explore proteomics data for ATP4B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn99, Asn103, Asn130, Asn146, Asn161, Asn193, Asn222

  • See ATP4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000696.1  
    ENSEMBL proteins: 
     ENSP00000334216  
    Reactome Protein details: P51164

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PATP: ATPases / P-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: ATP4B
    H+/K+-ATPase

    1 InterPro protein domain:
     IPR000402 Na/K_ATPase_sub_beta

    Graphical View of Domain Structure for InterPro Entry P51164

    ProtoNet protein and cluster: P51164

    1 Blocks protein domain: IPB000402 Na+/K+ ATPase

    UniProtKB/Swiss-Prot: ATP4B_HUMAN, P51164
    Domain: The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties
    Similarity: Belongs to the X(+)/potassium ATPases subunit beta family


    ATP4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATP4B_HUMAN, P51164
    Function: Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also
    involved in cell adhesion and establishing epithelial cell polarity

         Genatlas biochemistry entry for ATP4B:
    ATPase,H+,K+ transporting,beta polypeptide

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008900hydrogen:potassium-exchanging ATPase activity TAS1656976
         
    ATP4B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ATP4B:
     Decreased nuclei size in G2M 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atp4b):
     digestive/alimentary  homeostasis/metabolism 

    ATP4B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Atp4btm1Ird for ATP4B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATP4B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATP4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATP4B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATP4B_HUMAN, P51164: Cell membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005890sodium:potassium-exchanging ATPase complex IEA--

    ATP4B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATP4B About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Insulin receptor recycling
    Collecting duct acid secretion0.66
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Oxidative phosphorylation0.64
    3Ion channel transport
    Ion channel transport0.58
    4Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    5Salivary secretion
    Gastric acid secretion0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ATP4B
        Ion transport by P-type ATPases

    1 PharmGKB Pathway for ATP4B
        Proton Pump Inhibitor Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for ATP4B):
        Oxidative phosphorylation
    Collecting duct acid secretion
    Gastric acid secretion


    ATP4B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ATP4B: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ATP4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ATP4B (P511643 ENSP000003342164) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX1AQ166233, ENSP000002228124I2D: score=1 STRING: ENSP00000222812
    LHPPENSP000003578354STRING: ENSP00000357835
    PPA1ENSP000003623294STRING: ENSP00000362329
    PPA2ENSP000003438854STRING: ENSP00000343885
    ATP4AENSP000002626234STRING: ENSP00000262623
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport ----
    GO:0006814sodium ion transport IEA--
    GO:0007155cell adhesion IEA--
    GO:0010243response to organonitrogen compound IEA--
    GO:0032496response to lipopolysaccharide IEA--

    ATP4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATP4B

    6 HMDB Compounds for ATP4B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    PotassiumK+ (see all 16)7440-09-7--
    RabeprazoleAciphex (see all 6)117976-89-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATP4B gene: 
    NM_000705.3  

    Unigene Cluster for ATP4B:

    ATPase, H+/K+ exchanging, beta polypeptide
    Hs.434202  [show with all ESTs]
    Unigene Representative Sequence: NM_000705
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000335288(uc001vtz.3 uc010agy.2)
    miRNA
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    Additional mRNA sequence: 

    AK310129.1 BC029059.1 BC042846.1 M75110.1 

    2 DOTS entries:

    DT.40105959  DT.95297828 

    19 AceView cDNA sequences:

    NM_000705 AI453802 BM782217 BM782259 BI760090 BI764514 M75110 BM923761 
    BI760752 BM924835 BC029059 BI517672 BI764746 BI765712 BM786067 BM795764 
    BI518381 BQ364664 AW869433 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATP4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACGCAAG
    ATP4B Expression
    About this image


    ATP4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Stomach (Gastrointestinal Tract)
    ATP4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATP4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434202
        Pathway & Disease-focused RT2 Profiler PCR Array including ATP4B: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ATP4B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp4b1 , 5 ATPase, H+/K+ exchanging, beta polypeptide1, 5 82.82(n)1
    83.85(a)1
      8 (5.89 cM)5
    119451  NM_009724.21  NP_033854.11 
     133862095 
    chicken
    (Gallus gallus)
    Aves ATP4B1 ATPase, H+/K+ exchanging, beta polypeptide 69.7(n)
    70.28(a)
      386581  NM_204418.1  NP_989749.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643422 hypothetical protein MGC64342 71.59(n)    AF042812.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nrv36
    nrv16
    (see all 3)
    nervana 1
    (see all 3)
    23(a)
    20(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2L(21380000-21393319)
    2L(6778555-6786861)
    worm
    (Caenorhabditis elegans)
    Secernentea nkb-16
    nkb-36
    Protein NKB-3 (nkb-3) mRNA, complete cds
    23(a)
    23(a)
    many ↔ many
    many ↔ many
    I(9431249-9433811) WBGene00007646
    X(13765353-13770558) WBGene00010117


    ENSEMBL Gene Tree for ATP4B (if available)
    TreeFam Gene Tree for ATP4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATP4B gene
    ATP1B12  ATP1B32  ATP1B42  ATP1B22  
    4 SIMAP similar genes for ATP4B using alignment to 1 protein entry:     ATP4B_HUMAN:
    ATP1B2    ATP1B4    ATP1B3    ATP1B1

    ATP4B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ATP4B
    PGOHUM00000242546


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATP4B (see all 414)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs128750591,2
    C,F,H--114302622(+) AGACCG/ATTTCT 1 -- ds500127Minor allele frequency- A:0.45NS EA NA WA 3036
    rs1882910021,2
    --114302642(+) TTCTGC/TGTGTC 1 -- ds50010--------
    rs790306931,2
    F--114302762(+) CCGTCG/AGGGTG 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1919020171,2
    --114302877(+) ATGTTC/GTCATT 1 -- ds50010--------
    rs1481680941,2
    C--114302914(+) CTAAC-/TTAACA
            
    TTTAT
    1 -- ds50010--------
    rs65770601,2
    C,F,A,H--114303006(+) GACACC/ACTCAC 1 -- ds500124Minor allele frequency- A:0.32NS EA NA WA CSA 2346
    rs735793181,2
    C,F--114303043(+) TGAGCG/ATCCTT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1876051471,2
    C--114303069(+) ACCAAC/TGTGGT 1 -- ds50010--------
    rs1395136001,2
    C--114303131(+) GGAAGC/TGTTTG 1 -- ut310--------
    rs1138950521,2
    C--114303317(+) AATGTGG/-GGGGG 1 -- ut311Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for ATP4B (114303119 - 114312513 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ATP4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901074CNV Loss21882294
    nsv832726CNV Loss17160897
    nsv901075CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ATP4B
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 137217    OMIM disorders: --

    3 diseases for ATP4B:    
    About MalaCards
    gastric adenocarcinoma    megaloblastic anemia    adenocarcinoma


    ATP4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATP4B
    Human Genome Epidemiology (HuGE) Navigator: ATP4B (1 document)

    Export disorders for ATP4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATP4B gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with ATP4B)
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    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2, 3 Dunham A.... Ross M.T. (Nature 2004)
    2. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. (PubMed id 19694409)1, 2 Bab-Dinitz E....Karlish S.J. (Biochemistry 2009)
    3. Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes. (PubMed id 18787507)1, 4 Knouff C.W....Mooser V. (Pharmacogenet. Genomics 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. (PubMed id 9315713)1, 2 Yoshida T.... Maeda M. (FEBS Lett. 1997)
    6. cDNA cloning of the beta-subunit of the human gastric H,K-ATPase. (PubMed id 1656976)1, 2 Ma J.-Y.... Maardh S. (Biochem. Biophys. Res. Commun. 1991)
    7. Intragenic DNA methylation concomitant with repression of ATP4B and ATP4A gene expression in gastric cancer is a potential serum biomarker. (PubMed id 23317218)1 Raja U.M....Rajkumar T. (Asian Pac. J. Cancer Prev. 2012)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. (PubMed id 17255364)1 Lapierre L.A....Goldenring J.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 496 HGNC: 820 AceView: ATP4B Ensembl:ENSG00000186009 euGenes: HUgn496
    ECgene: ATP4B Kegg: 496 H-InvDB: ATP4B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATP4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATP4B gene:
    Search GeneIP for patents involving ATP4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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