Aliases for ATP4B Gene
External Ids for ATP4B Gene
Previous GeneCards Identifiers for ATP4B Gene
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP4B Gene
ATP4B (ATPase H+/K+ Transporting Beta Subunit) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Proton Pump Inhibitor Pathway, Pharmacodynamics. GO annotations related to this gene include hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B2.
UniProtKB/Swiss-Prot for ATP4B Gene
Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.