ATP4B Gene
protein-coding GIFtS: 55
GCID: GC13M114303
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ATPase, H+/K+ exchanging, beta polypeptide
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Aliases for ATP4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| ATPase, H+/K+ Exchanging, Beta Polypeptide1 2 | | Gastric H+/K+ ATPase Beta Subunit2 | | ATP6B1 2 | | Gastric Hydrogen-Potassium ATPase, Beta2 | | Gastric H(+)/K(+) ATPase Subunit Beta2 3 | | Potassium-Transporting ATPase Beta Chain2 | | Proton Pump Beta Chain2 3 | | Potassium-Transporting ATPase Subunit Beta2 | | ATPase, H+/K+ Transporting, Beta Polypeptide2 | | |
Export aliases for ATP4B gene to outside databasesPrevious GC identifers: GC13U990004 GC13M112251 GC13M113351 GC13M094742 |
Summaries for ATP4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ATP4B: The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPaseis a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylatedbeta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) andK(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the betasubunit of the gastric H+, K+-ATPase. (provided by RefSeq, Jul 2008)
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Genomic Views for ATP4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_027140.6
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ATP4B gene promoter: AML1a ATF-2 Olf-1 AP-2gamma GATA-1 RORalpha1 MEF-2A CREB deltaCREB aMEF-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for ATP4B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP4B |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34ATP4B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M114303: view genomic region
(about GC identifiers)
Start:
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114,303,119 bp from pter |
End:
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114,312,513 bp from pter |
Size:
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9,395 bases |
Orientation:
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minus strand |
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Proteins for ATP4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ATP4B_HUMAN, P51164 (See
protein sequence)Recommended Name: Potassium-transporting ATPase subunit beta Size: 291 amino acids; 33367 Da
Subunit: Composed of two subunits: alpha (catalytic) and beta
Subcellular location: Membrane; Single-pass type II membrane protein
Secondary accessions: B1B0N8Explore the universe of human proteins at neXtProt for ATP4B: NX_P51164
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51164 ATP4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000696.1 ENSEMBL proteins: ENSP00000334216 Reactome Protein details: P51164 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
ATP4B for ontologies About GeneDecksing
ATP4B Antibody Products: Assay Products for ATP4B: |
Protein
Domains / Families for ATP4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATP4B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P51164ProtoNet protein and cluster: P51164 1 Blocks protein family: IPB000402 Na+/K+ ATPase
UniProtKB/Swiss-Prot: ATP4B_HUMAN, P51164Similarity: Belongs to the X(+)/potassium ATPases subunit beta family |
Function for ATP4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: Genatlas biochemistry entry for ATP4B:ATPase,H+,K+ transporting,beta polypeptide
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4B OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP4B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005391 | sodium:potassium-exchanging ATPase activity |
IEA | -- | | GO:0008900 | hydrogen:potassium-exchanging ATPase activity |
TAS | 1656976 |
ATP4B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ATP4B: Animal Models: Mouse knock-out Atp4btm1Ird for ATP4B 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Atp4b):
ATP4B for phenotypes About GeneDecksing
|
Pathways & Interactions for ATP4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ion channel transport | | | 2 | Proton Pump Inhibitor Pathway, Pharmacodynamics | | | 3 | Gastric acid secretion | | | 4 | Insulin receptor recycling | | | 5 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | |
Pathway sources See GeneCards unified pathways Show all pathways
3
Reactome Pathways for ATP4B 1 PharmGKB Pathway for ATP4B 3
Kegg Pathways (Kegg details for ATP4B):
ATP4B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP4B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
 5/8 Interacting proteins for ATP4B (P511643 ENSP000003342164) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010243 | response to organic nitrogen |
IEA | -- | | GO:0032496 | response to lipopolysaccharide |
IEA | -- | | GO:0034220 | ion transmembrane transport |
TAS | -- | | GO:0055085 | transmembrane transport |
TAS | -- |
ATP4B for ontologies About GeneDecksing
|
Drugs & Compounds for ATP4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ATP4B
6 HMDB Compounds for ATP4B About this table Search CenterWatch for drugs/clinical trials and news about ATP4B 
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Transcripts for ATP4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ATP4B gene: NM_000705.3 Unigene Cluster for ATP4B: ATPase, H+/K+ exchanging, beta polypeptide Hs.434202 [show with all ESTs]Unigene Representative Sequence: NM_0007051 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000335288(uc001vtz.3 uc010agy.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4B OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ATP4B (NM_000705) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATP4B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP4B  |
Additional cDNA sequence: AK310129.1 BC029059.1 BC042846.1 M75110.1 2 DOTS entries: DT.40105959 DT.95297828 19 AceView cDNA sequences: BM782259 AI453802 BM782217 NM_000705 M75110 BI517672 BI764746 BI764514 BM924835 BM923761 BI760752 BI760090 BC029059 BM786067 BI765712 BM795764 BI518381 BQ364664 AW869433 GeneLoc Exon Structure
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Expression for ATP4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATP4B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGAACGCAAG
About this image See ATP4B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ATP4B
SOURCE GeneReport for Unigene cluster: Hs.434202 SABiosciences Expression via Pathway-Focused PCR Array including ATP4B:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP4B Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATP4B | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP4B | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP4B | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP4B |
Orthologs for ATP4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ATP4B gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for ATP4B (if available) TreeFam Gene Tree for ATP4B (if available)  |
Paralogs for ATP4B gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ATP4B gene
- ATP1B32 ATP1B12 ATP1B42 ATP1B22
4 SIMAP similar genes for ATP4B using alignment to 1 protein entry: ATP4B_HUMAN:ATP1B2 ATP1B4 ATP1B3 ATP1B1
ATP4B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ATP4B PGOHUM00000242546
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Genomic Variants for ATP4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 13 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ATP4B (114303119 - 114312513 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for ATP4B 1 CNV: 4820  | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases for ATP4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATP4B for disorders About GeneDecksing
OMIM gene information: 137217
OMIM disorders: --
4 diseases for ATP4B: About MalaCardsmegaloblastic anemia gastric adenocarcinoma anemia adenocarcinoma Human Genome Epidemiology (HuGE) Navigator: ATP4B (1 document) Export disorders for ATP4B gene to outside databases
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Publications for ATP4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATP4B gene, integrated from 9 sources (see all 23): (articles sorted by number of sources associating them with ATP4B) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2, 3 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. (PubMed id 9315713)1, 2 Yoshida T.... Maeda M. (1997)
- cDNA cloning of the beta-subunit of the human gastric H,K-ATPase. (PubMed id 1656976)1, 2 Ma J.-Y.... Maardh S. (1991)
- A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. (PubMed id 19694409)1 Bab-Dinitz E....Karlish S.J. (2009)
- Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes. (PubMed id 18787507)1 Knouff C.W....Mooser V. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Biology, structure and mechanism of P-type ATPases. (PubMed id 15071553)1 KA1hlbrandt W. (2004)
- Effect of resistance training on Na,K pump and Na+/H+ exchange protein densities in muscle from control and patients with type 2 diabetes. (PubMed id 14685860)1 Dela F....Juel C. (2004)
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External Searches for ATP4B gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing ATP4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATP4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ATP4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ATP4B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ATP4B gene: Search GeneIP for patents involving ATP4B
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ATP4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for ATP4B | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP4B | | OriGene Protein Over-expression Lysate for ATP4B | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ATP4B | | OriGene 3'-UTR Clone for ATP4B | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4B | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATP4B | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP4B | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP4B | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP4B | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP4B | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP4B |
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| | | Search Tocris compounds for ATP4B |
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 | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP4B |
|  |  |  | | | ThermoFisher Antibody for ATP4B |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP4B |
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