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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP4B Gene

protein-coding   GIFtS: 55
GCID: GC13M114303

ATPase, H+/K+ exchanging, beta polypeptide

 Explore 4 diseases affiliated with
ATP4B via our new
 Human Malady Compendium 
Biological research products
for ATP4B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ATPase, H+/K+ Exchanging, Beta Polypeptide1 2     Gastric H+/K+ ATPase Beta Subunit2
ATP6B1 2     Gastric Hydrogen-Potassium ATPase, Beta2
Gastric H(+)/K(+) ATPase Subunit Beta2 3     Potassium-Transporting ATPase Beta Chain2
Proton Pump Beta Chain2 3     Potassium-Transporting ATPase Subunit Beta2
ATPase, H+/K+ Transporting, Beta Polypeptide2     

External Ids:    HGNC: 8201   Entrez Gene: 4962   Ensembl: ENSG000001860097   OMIM: 1372175   UniProtKB: P511643   

Export aliases for ATP4B gene to outside databases

Previous GC identifers: GC13U990004 GC13M112251 GC13M113351 GC13M094742


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATP4B:
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase
is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated
beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and
K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta
subunit of the gastric H+, K+-ATPase. (provided by RefSeq, Jul 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_027140.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP4B gene promoter:
         AML1a   ATF-2   Olf-1   AP-2gamma   GATA-1   RORalpha1   MEF-2A   CREB   deltaCREB   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP4B promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

ATP4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP4B gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M114303:  view genomic region     (about GC identifiers)

Start:
114,303,119 bp from pter      End:
114,312,513 bp from pter
Size:
9,395 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATP4B_HUMAN, P51164 (See protein sequence)
Recommended Name: Potassium-transporting ATPase subunit beta  
Size: 291 amino acids; 33367 Da
Subunit: Composed of two subunits: alpha (catalytic) and beta
Subcellular location: Membrane; Single-pass type II membrane protein
Secondary accessions: B1B0N8

Explore the universe of human proteins at neXtProt for ATP4B: NX_P51164

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51164

  • ATP4B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000696.1  
    ENSEMBL proteins: 
     ENSP00000334216  
    Reactome Protein details: P51164
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    ATP4B for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ATP4B for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000402 Na/K_ATPase_sub_beta

    Graphical View of Domain Structure for InterPro Entry P51164

    ProtoNet protein and cluster: P51164

    1 Blocks protein family: IPB000402 Na+/K+ ATPase

    UniProtKB/Swiss-Prot: ATP4B_HUMAN, P51164
    Similarity: Belongs to the X(+)/potassium ATPases subunit beta family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:
         Genatlas biochemistry entry for ATP4B:
    ATPase,H+,K+ transporting,beta polypeptide

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005391sodium:potassium-exchanging ATPase activity IEA--
    GO:0008900hydrogen:potassium-exchanging ATPase activity TAS1656976


    ATP4B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ATP4B:
     Decreased nuclei size in G2M 

    Animal Models:
         Mouse knock-out Atp4btm1Ird for ATP4B
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atp4b):
     digestive/alimentary  homeostasis/metabolism 

    ATP4B for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    Ion channel transport1.00
    Ion transport by P-type ATPases0.32
    2Proton Pump Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics1.00
    3Gastric acid secretion
    Gastric acid secretion1.00
    4Insulin receptor recycling
    Collecting duct acid secretion0.68
    5Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Oxidative phosphorylation0.63

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ATP4B
        Transmembrane transport of small molecules
    Ion channel transport
    Ion transport by P-type ATPases

    1 PharmGKB Pathway for ATP4B
        Proton Pump Inhibitor Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for ATP4B):
        Oxidative phosphorylation
    Collecting duct acid secretion
    Gastric acid secretion


    ATP4B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for ATP4B (P511643 ENSP000003342164) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX1AQ166233, ENSP000002228124I2D: score=1 STRING: ENSP00000222812
    ATP12AENSP000003713724STRING: ENSP00000371372
    ATP4AENSP000002626234STRING: ENSP00000262623
    LHPPENSP000003578354STRING: ENSP00000357835
    PPA1ENSP000003623294STRING: ENSP00000362329
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010243response to organic nitrogen IEA--
    GO:0032496response to lipopolysaccharide IEA--
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--


    ATP4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATP4B

    6 HMDB Compounds for ATP4B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    PotassiumK+ (see all 16)7440-09-7--
    RabeprazoleAciphex (see all 6)117976-89-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about ATP4B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATP4B gene: 
    NM_000705.3  

    Unigene Cluster for ATP4B:

    ATPase, H+/K+ exchanging, beta polypeptide
    Hs.434202  [show with all ESTs]
    Unigene Representative Sequence: NM_000705
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000335288(uc001vtz.3 uc010agy.2)

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    Additional cDNA sequence: 

    AK310129.1 BC029059.1 BC042846.1 M75110.1 

    2 DOTS entries:

    DT.40105959  DT.95297828 

    19 AceView cDNA sequences:

    BM782259 AI453802 BM782217 NM_000705 M75110 BI517672 BI764746 BI764514 
    BM924835 BM923761 BI760752 BI760090 BC029059 BM786067 BI765712 BM795764 
    BI518381 BQ364664 AW869433 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAACGCAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ATP4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP4B

    SOURCE GeneReport for Unigene cluster: Hs.434202
        SABiosciences Expression via Pathway-Focused PCR Array including ATP4B: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ATP4B gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ATP4B1 ATPase, H+/K+ exchanging, beta polypeptide 68.87(n)
    69.34(a)
      386581  NM_204418.1  NP_989749.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643422 hypothetical protein MGC64342 71.59(n)    AF042812.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nrv36
    nrv16
    (see all 3)
    nervana 1
    (see all 3)
    24(a)
    20(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    2L(21380000-21393319)
    2L(6778555-6786861)
    worm
    (Caenorhabditis elegans)
    Secernentea nkb-16
    nkb-36
    (see all 3)
    Sodium/potassium-transporting ATPase subunit beta-...
    Probable sodium/potassium-transporting ATPase subu...
    (see all 3)
    21(a)
    21(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    I(9431240-9433804)
    X(13765285-13770494)


    ENSEMBL Gene Tree for ATP4B (if available)
    TreeFam Gene Tree for ATP4B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP4B gene
    ATP1B32  ATP1B12  ATP1B42  ATP1B22  
    4 SIMAP similar genes for ATP4B using alignment to 1 protein entry:     ATP4B_HUMAN:
    ATP1B2    ATP1B4    ATP1B3    ATP1B1

    ATP4B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ATP4B
    PGOHUM00000242546


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/298 NCBI SNPs in ATP4B are shown (see all 298    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs128750591,2
    C,F,H,--114302622(+) AGACCG/ATTTCT 1 -- ds500127Minor allele frequency- A:0.45NS EA NA WA 3036
    rs1882910021,2
    --114302642(+) TTCTGC/TGTGTC 1 -- ds50010--------
    rs790306931,2
    F,--114302762(+) CCGTCG/AGGGTG 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1919020171,2
    --114302877(+) ATGTTC/GTCATT 1 -- ds50010--------
    rs1481680941,2
    --114302914(+) CTAAC-/TTAACA
            
    TTTAT
    1 -- ds50010--------
    rs65770601,2
    C,F,A,H,--114303006(+) GACACC/ACTCAC 1 -- ds500124Minor allele frequency- A:0.32NS EA NA WA CSA 2346
    rs735793181,2
    C,--114303043(+) TGAGCG/ATCCTT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1876051471,2
    --114303069(+) ACCAAC/TGTGGT 1 -- ds50010--------
    rs1395136001,2
    --114303131(+) GGAAGC/TGTTTG 1 -- ut310--------
    rs1138950521,2
    C,--114303316(+) AATGTGG/-GGGGG 1 -- ut311Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for ATP4B (114303119 - 114312513 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ATP4B
         1 CNV: 4820

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ATP4B for disorders           About GeneDecksing

    OMIM gene information: 137217    OMIM disorders: --

    4 diseases for ATP4B:    About MalaCards
    megaloblastic anemia    gastric adenocarcinoma    anemia    adenocarcinoma

    Human Genome Epidemiology (HuGE) Navigator: ATP4B (1 document)

    Export disorders for ATP4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP4B gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with ATP4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2, 3 Dunham A.... Ross M.T. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. (PubMed id 9315713)1, 2 Yoshida T.... Maeda M. (1997)
    4. cDNA cloning of the beta-subunit of the human gastric H,K-ATPase. (PubMed id 1656976)1, 2 Ma J.-Y.... Maardh S. (1991)
    5. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. (PubMed id 19694409)1 Bab-Dinitz E....Karlish S.J. (2009)
    6. Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes. (PubMed id 18787507)1 Knouff C.W....Mooser V. (2008)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    9. Biology, structure and mechanism of P-type ATPases. (PubMed id 15071553)1 KA1hlbrandt W. (2004)
    10. Effect of resistance training on Na,K pump and Na+/H+ exchange protein densities in muscle from control and patients with type 2 diabetes. (PubMed id 14685860)1 Dela F....Juel C. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 496 HGNC: 820 AceView: ATP4B Ensembl:ENSG00000186009 euGenes: HUgn496
    ECgene: ATP4B Kegg: 496 H-InvDB: ATP4B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATP4B gene:
    Search GeneIP for patents involving ATP4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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