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Aliases for ATP4B Gene

Aliases for ATP4B Gene

  • ATPase, H+/K+ Exchanging, Beta Polypeptide 2 3
  • Gastric H(+)/K(+) ATPase Subunit Beta 3 4
  • Proton Pump Beta Chain 3 4
  • ATPase, H+/K+ Transporting, Beta Polypeptide 3
  • Potassium-Transporting ATPase Subunit Beta 3
  • Potassium-Transporting ATPase Beta Chain 3
  • Gastric Hydrogen-Potassium ATPase, Beta 3
  • Gastric H+/K+ ATPase Beta Subunit 3
  • ATP6B 3

External Ids for ATP4B Gene

Previous GeneCards Identifiers for ATP4B Gene

  • GC13U990004
  • GC13M112251
  • GC13M113351
  • GC13M114303
  • GC13M094742

Summaries for ATP4B Gene

Entrez Gene Summary for ATP4B Gene

  • The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP4B Gene

ATP4B (ATPase, H+/K+ Exchanging, Beta Polypeptide) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B3.

UniProtKB/Swiss-Prot for ATP4B Gene

  • Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP4B Gene

Genomics for ATP4B Gene

Regulatory Elements for ATP4B Gene

Genomic Location for ATP4B Gene

113,648,804 bp from pter
113,658,198 bp from pter
9,395 bases
Minus strand

Genomic View for ATP4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP4B Gene

Proteins for ATP4B Gene

  • Protein details for ATP4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium-transporting ATPase subunit beta
    Protein Accession:
    Secondary Accessions:
    • B1B0N8

    Protein attributes for ATP4B Gene

    291 amino acids
    Molecular mass:
    33367 Da
    Quaternary structure:
    • Composed of two subunits: alpha (catalytic) and beta

neXtProt entry for ATP4B Gene

Proteomics data for ATP4B Gene at MOPED

Post-translational modifications for ATP4B Gene

  • Glycosylation at Asn99, Asn103, Asn130, Asn146, Asn161, Asn193, and Asn222
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP4B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP4B Gene

Domains for ATP4B Gene

Gene Families for ATP4B Gene

  • PATP :ATPases / P-type

Protein Domains for ATP4B Gene

Suggested Antigen Peptide Sequences for ATP4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P51164
  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
genes like me logo Genes that share domains with ATP4B: view

Function for ATP4B Gene

Molecular function for ATP4B Gene

GENATLAS Biochemistry: ATPase,H+,K+ transporting,beta polypeptide
UniProtKB/Swiss-Prot Function: Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.

Gene Ontology (GO) - Molecular Function for ATP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008900 hydrogen:potassium-exchanging ATPase activity TAS 1656976
genes like me logo Genes that share ontologies with ATP4B: view

Phenotypes for ATP4B Gene

MGI mutant phenotypes for ATP4B:
inferred from 1 alleles
GenomeRNAi human phenotypes for ATP4B:
genes like me logo Genes that share phenotypes with ATP4B: view

Animal Models for ATP4B Gene

MGI Knock Outs for ATP4B:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP4B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ATP4B Gene

Localization for ATP4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP4B Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for ATP4B Gene COMPARTMENTS Subcellular localization image for ATP4B gene
Compartment Confidence
plasma membrane 5
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IEA --
genes like me logo Genes that share ontologies with ATP4B: view

Pathways for ATP4B Gene

genes like me logo Genes that share pathways with ATP4B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ATP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0007155 cell adhesion IEA --
GO:0010243 response to organonitrogen compound IEA --
GO:0032496 response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with ATP4B: view

Compounds for ATP4B Gene

(6) HMDB Compounds for ATP4B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • NFB Orthophosphate
  • K+
  • Aciphex
genes like me logo Genes that share compounds with ATP4B: view

Transcripts for ATP4B Gene

mRNA/cDNA for ATP4B Gene

(19) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP4B Gene

ATPase, H+/K+ exchanging, beta polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP4B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP4B Gene

No ASD Table

Relevant External Links for ATP4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP4B Gene

mRNA expression in normal human tissues for ATP4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP4B Gene

This gene is overexpressed in Stomach (52.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATP4B Gene

SOURCE GeneReport for Unigene cluster for ATP4B Gene Hs.434202

genes like me logo Genes that share expressions with ATP4B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ATP4B Gene

Orthologs for ATP4B Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP4B 35
  • 99.54 (n)
  • 99.31 (a)
ATP4B 36
  • 99 (a)
(Bos Taurus)
Mammalia ATP4B 35
  • 84.02 (n)
  • 84.14 (a)
ATP4B 36
  • 84 (a)
(Canis familiaris)
Mammalia ATP4B 35
  • 83.1 (n)
  • 83.1 (a)
ATP4B 36
  • 83 (a)
(Mus musculus)
Mammalia Atp4b 35
  • 82.82 (n)
  • 83.85 (a)
Atp4b 16
Atp4b 36
  • 83 (a)
(Monodelphis domestica)
Mammalia ATP4B 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Atp4b 35
  • 83.28 (n)
  • 82.47 (a)
(Gallus gallus)
Aves ATP4B 35
  • 69.7 (n)
  • 70.28 (a)
ATP4B 36
  • 67 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64342 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atp4b 35
  • 58.39 (n)
  • 54.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta nrv1 36
  • 20 (a)
nrv2 36
  • 19 (a)
nrv3 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea nkb-1 36
  • 23 (a)
nkb-3 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10387 36
  • 24 (a)
Species with no ortholog for ATP4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ATP4B Gene

Gene Tree for ATP4B (if available)
Gene Tree for ATP4B (if available)

Paralogs for ATP4B Gene

Paralogs for ATP4B Gene

Selected SIMAP similar genes for ATP4B Gene using alignment to 1 proteins: Pseudogenes for ATP4B Gene

genes like me logo Genes that share paralogs with ATP4B: view

Variants for ATP4B Gene

Sequence variations from dbSNP and Humsavar for ATP4B Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs4074271 -- 113,651,090(+) GTTCC(C/G)TCGGA intron-variant
rs4076410 -- 113,651,417(+) TTGAA(A/G)CGTGC intron-variant
rs6577060 -- 113,648,691(+) GACAC(A/C)CTCAC downstream-variant-500B
rs9285616 -- 113,658,039(+) CCACC(A/G/T)GGACA synonymous-codon, reference, missense
rs9324254 -- 113,657,685(+) GAATC(A/G)CCGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP4B Gene

Variant ID Type Subtype PubMed ID
nsv901074 CNV Loss 21882294
nsv832726 CNV Loss 17160897
nsv901075 CNV Loss 21882294

Relevant External Links for ATP4B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP4B Gene

Disorders for ATP4B Gene

Relevant External Links for ATP4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ATP4B: view

No data available for UniProtKB/Swiss-Prot for ATP4B Gene

Publications for ATP4B Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 2 3 4
  2. cDNA cloning of the beta-subunit of the human gastric H,K-ATPase. (PMID: 1656976) Ma J.-Y. … Maardh S. (Biochem. Biophys. Res. Commun. 1991) 3 4
  3. GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. (PMID: 9315713) Yoshida T. … Maeda M. (FEBS Lett. 1997) 3 4
  4. Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes. (PMID: 18787507) Knouff C.W. … Mooser V. (Pharmacogenet. Genomics 2008) 3 48
  5. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. (PMID: 19694409) Bab-Dinitz E. … Karlish S.J. (Biochemistry 2009) 3 4

Products for ATP4B Gene

Sources for ATP4B Gene

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