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Aliases for ATP4B Gene

Aliases for ATP4B Gene

  • ATPase H+/K+ Transporting Beta Subunit 2 3
  • ATPase, H+/K+ Exchanging, Beta Polypeptide 2 3 5
  • Gastric H(+)/K(+) ATPase Subunit Beta 3 4
  • Proton Pump Beta Chain 3 4
  • ATPase, H+/K+ Transporting, Beta Polypeptide 3
  • Potassium-Transporting ATPase Beta Chain 3
  • Gastric Hydrogen-Potassium ATPase, Beta 3
  • Gastric H+/K+ ATPase Beta Subunit 3
  • ATP6B 3

External Ids for ATP4B Gene

Previous GeneCards Identifiers for ATP4B Gene

  • GC13U990004
  • GC13M112251
  • GC13M113351
  • GC13M114303
  • GC13M094742

Summaries for ATP4B Gene

Entrez Gene Summary for ATP4B Gene

  • The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP4B Gene

ATP4B (ATPase H+/K+ Transporting Beta Subunit) is a Protein Coding gene. Among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics and Insulin receptor recycling. GO annotations related to this gene include hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B3.

UniProtKB/Swiss-Prot for ATP4B Gene

  • Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP4B Gene

Genomics for ATP4B Gene

Regulatory Elements for ATP4B Gene

Enhancers for ATP4B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATP4B on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP4B Gene

113,648,804 bp from pter
113,658,198 bp from pter
9,395 bases
Minus strand

Genomic View for ATP4B Gene

Genes around ATP4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP4B Gene

Proteins for ATP4B Gene

  • Protein details for ATP4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium-transporting ATPase subunit beta
    Protein Accession:
    Secondary Accessions:
    • B1B0N8

    Protein attributes for ATP4B Gene

    291 amino acids
    Molecular mass:
    33367 Da
    Quaternary structure:
    • Composed of two subunits: alpha (catalytic) and beta.

neXtProt entry for ATP4B Gene

Proteomics data for ATP4B Gene at MOPED

Post-translational modifications for ATP4B Gene

  • Glycosylation at Asn 99, Asn 103, Asn 130, Asn 146, Asn 161, Asn 193, and Asn 222
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP4B Gene

Domains & Families for ATP4B Gene

Gene Families for ATP4B Gene

Protein Domains for ATP4B Gene

Suggested Antigen Peptide Sequences for ATP4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
genes like me logo Genes that share domains with ATP4B: view

Function for ATP4B Gene

Molecular function for ATP4B Gene

GENATLAS Biochemistry:
ATPase,H+,K+ transporting,beta polypeptide
UniProtKB/Swiss-Prot Function:
Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.
genes like me logo Genes that share phenotypes with ATP4B: view

Animal Models for ATP4B Gene

MGI Knock Outs for ATP4B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ATP4B Gene

Localization for ATP4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP4B Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for ATP4B Gene COMPARTMENTS Subcellular localization image for ATP4B gene
Compartment Confidence
plasma membrane 5
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ATP4B Gene

Pathways & Interactions for ATP4B Gene

genes like me logo Genes that share pathways with ATP4B: view

Gene Ontology (GO) - Biological Process for ATP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0010243 response to organonitrogen compound IEA --
GO:0032496 response to lipopolysaccharide IEA --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with ATP4B: view

No data available for SIGNOR curated interactions for ATP4B Gene

Drugs & Compounds for ATP4B Gene

(9) Drugs for ATP4B Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rabeprazole Approved, Investigational Pharma inhibitor 146
Esomeprazole Approved, Investigational Pharma Proton pump inhibitor 313
Lansoprazole Approved, Investigational Pharma H+,K+-ATPase inhibitor 201
Adenosine triphosphate Approved Nutra 0
Potassium Experimental Pharma 0

(3) Additional Compounds for ATP4B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • Dihydrogen oxide
  • Steam

(6) ApexBio Compounds for ATP4B Gene

Compound Action Cas Number
Dexlansoprazole 138530-94-6
Esomeprazole Magnesium Proton pump inhibitor 161973-10-0
Esomeprazole Sodium Proton pump inhibitor 161796-78-7
Lansoprazole H+,K+-ATPase inhibitor 103577-45-3
Tenatoprazole 113712-98-4
Zinc Pyrithione 13463-41-7
genes like me logo Genes that share compounds with ATP4B: view

Transcripts for ATP4B Gene

mRNA/cDNA for ATP4B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP4B Gene

ATPase, H+/K+ exchanging, beta polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP4B Gene

No ASD Table

Relevant External Links for ATP4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP4B Gene

mRNA expression in normal human tissues for ATP4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP4B Gene

This gene is overexpressed in Stomach (x52.5).

Protein differential expression in normal tissues from HIPED for ATP4B Gene

This gene is overexpressed in Stomach (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP4B Gene

SOURCE GeneReport for Unigene cluster for ATP4B Gene Hs.434202

genes like me logo Genes that share expression patterns with ATP4B: view

Protein tissue co-expression partners for ATP4B Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ATP4B Gene

Orthologs for ATP4B Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP4B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATP4B 35
  • 84.02 (n)
  • 84.14 (a)
ATP4B 36
  • 84 (a)
(Canis familiaris)
Mammalia ATP4B 35
  • 83.1 (n)
  • 83.1 (a)
ATP4B 36
  • 83 (a)
(Mus musculus)
Mammalia Atp4b 35
  • 82.82 (n)
  • 83.85 (a)
Atp4b 16
Atp4b 36
  • 83 (a)
(Pan troglodytes)
Mammalia ATP4B 35
  • 99.54 (n)
  • 99.31 (a)
ATP4B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Atp4b 35
  • 83.28 (n)
  • 82.47 (a)
(Monodelphis domestica)
Mammalia ATP4B 36
  • 74 (a)
(Gallus gallus)
Aves ATP4B 35
  • 69.7 (n)
  • 70.28 (a)
ATP4B 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp4b 35
  • 58.39 (n)
  • 54.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64342 35
fruit fly
(Drosophila melanogaster)
Insecta nrv1 36
  • 20 (a)
nrv2 36
  • 19 (a)
nrv3 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea nkb-1 36
  • 23 (a)
nkb-3 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10387 36
  • 24 (a)
Species with no ortholog for ATP4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ATP4B Gene

Gene Tree for ATP4B (if available)
Gene Tree for ATP4B (if available)

Paralogs for ATP4B Gene

Paralogs for ATP4B Gene

(4) SIMAP similar genes for ATP4B Gene using alignment to 1 proteins: Pseudogenes for ATP4B Gene

genes like me logo Genes that share paralogs with ATP4B: view

Variants for ATP4B Gene

Sequence variations from dbSNP and Humsavar for ATP4B Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs4074271 -- 113,651,090(+) GTTCC(A/C/G)TCGGA intron-variant
rs4076410 -- 113,651,417(+) TTGAA(A/G)CGTGC intron-variant
rs6577060 -- 113,648,691(+) GACAC(A/C)CTCAC downstream-variant-500B
rs9285616 -- 113,658,039(+) CCACC(A/G/T)GGACA reference, synonymous-codon
rs9324254 -- 113,657,685(+) GAATC(A/G)CCGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP4B Gene

Variant ID Type Subtype PubMed ID
nsv901074 CNV Loss 21882294
nsv832726 CNV Loss 17160897
nsv901075 CNV Loss 21882294

Variation tolerance for ATP4B Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATP4B Gene

Disorders for ATP4B Gene

Relevant External Links for ATP4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ATP4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP4B Gene

Publications for ATP4B Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 2 3 4 67
  2. Benzimidazole derivative, BMT-1, induces apoptosis in multiple myeloma cells via a mitochondrial-mediated pathway involving H+/K+-ATPase inhibition. (PMID: 24700195) Yang T. … Li H. (Oncol. Rep. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Intragenic DNA methylation concomitant with repression of ATP4B and ATP4A gene expression in gastric cancer is a potential serum biomarker. (PMID: 23317218) Raja U.M. … Rajkumar T. (Asian Pac. J. Cancer Prev. 2012) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for ATP4B Gene

Sources for ATP4B Gene