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Aliases for ATP4A Gene

Aliases for ATP4A Gene

  • ATPase H+/K+ Transporting Alpha Subunit 2 3
  • ATPase, H+/K+ Exchanging, Alpha Polypeptide 2 3 5
  • Proton Pump 2 3 4
  • Gastric H(+)/K(+) ATPase Subunit Alpha 3 4
  • Gastric H,K-ATPase Alpha Subunit 2 3
  • H(+)-K(+)-ATPase Alpha Subunit 2 3
  • EC 3.6.3.10 4 63
  • ATPase, H+/K+ Transporting, Alpha Polypeptide 3
  • Gastric H,K-ATPase Catalytic Subunit 3
  • Gastric H+/K+ ATPase Alpha Subunit 3
  • Gastric Hydrogen-Potassium ATPase 3
  • EC 3.6.3 63
  • ATP6A 3

External Ids for ATP4A Gene

Previous GeneCards Identifiers for ATP4A Gene

  • GC19M036680
  • GC19M036489
  • GC19M040717
  • GC19M040732
  • GC19M036041
  • GC19M032546
  • GC19M036264
  • GC19M036540
  • GC19M037058
  • GC19M035768
  • GC19M035926

Summaries for ATP4A Gene

Entrez Gene Summary for ATP4A Gene

  • The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP4A Gene

ATP4A (ATPase H+/K+ Transporting Alpha Subunit) is a Protein Coding gene. Diseases associated with ATP4A include peptic ulcer disease and esophageal disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Salivary secretion. GO annotations related to this gene include protein heterodimerization activity and magnesium ion binding. An important paralog of this gene is ATP12A.

UniProtKB/Swiss-Prot for ATP4A Gene

  • Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.

Tocris Summary for ATP4A Gene

  • H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their concentration gradients using energy derived from the hydrolysis of ATP.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP4A Gene

Genomics for ATP4A Gene

Regulatory Elements for ATP4A Gene

Genomic Location for ATP4A Gene

Chromosome:
19
Start:
35,550,043 bp from pter
End:
35,563,658 bp from pter
Size:
13,616 bases
Orientation:
Minus strand

Genomic View for ATP4A Gene

Genes around ATP4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP4A Gene

Proteins for ATP4A Gene

  • Protein details for ATP4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20648-ATP4A_HUMAN
    Recommended name:
    Potassium-transporting ATPase alpha chain 1
    Protein Accession:
    P20648
    Secondary Accessions:
    • O00738

    Protein attributes for ATP4A Gene

    Size:
    1035 amino acids
    Molecular mass:
    114119 Da
    Quaternary structure:
    • Composed of two subunits: alpha (catalytic) and beta.

neXtProt entry for ATP4A Gene

Proteomics data for ATP4A Gene at MOPED

Post-translational modifications for ATP4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP4A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ATP4A Gene

Gene Families for ATP4A Gene

Suggested Antigen Peptide Sequences for ATP4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20648

UniProtKB/Swiss-Prot:

ATP4A_HUMAN :
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
genes like me logo Genes that share domains with ATP4A: view

Function for ATP4A Gene

Molecular function for ATP4A Gene

GENATLAS Biochemistry:
ATPase,H+,K+ transporting,alpha 4 polypeptide,expressed in parietal gastric cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.

Enzyme Numbers (IUBMB) for ATP4A Gene

Gene Ontology (GO) - Molecular Function for ATP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
genes like me logo Genes that share ontologies with ATP4A: view
genes like me logo Genes that share phenotypes with ATP4A: view

Animal Models for ATP4A Gene

MGI Knock Outs for ATP4A:

Animal Model Products

miRNA for ATP4A Gene

miRTarBase miRNAs that target ATP4A

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP4A Gene

Localization for ATP4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP4A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP4A Gene COMPARTMENTS Subcellular localization image for ATP4A gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 3
vacuole 3
chloroplast 2
cytosol 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
mitochondrion 2
cytoskeleton 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ATP4A Gene

Pathways & Interactions for ATP4A Gene

genes like me logo Genes that share pathways with ATP4A: view

Interacting Proteins for ATP4A Gene

Gene Ontology (GO) - Biological Process for ATP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 2160952
GO:0006813 potassium ion transport IEA --
GO:0008152 metabolic process IEA --
GO:0010107 potassium ion import IBA --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with ATP4A: view

No data available for SIGNOR curated interactions for ATP4A Gene

Drugs & Compounds for ATP4A Gene

(13) Drugs for ATP4A Gene - From: DGIdb, DrugBank, HMDB, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lansoprazole Approved, Investigational Pharma inhibitor, Target H+,K+-ATPase inhibitor 198
Esomeprazole Approved, Investigational Pharma inhibitor, Target Proton pump inhibitor 308
Omeprazole Approved, Investigational Pharma Activator, inhibitor, Target H+,K+-ATPase inhibitor 321
Pantoprazole Approved Pharma inhibitor, Target 166
Rabeprazole Approved, Investigational Pharma inhibitor, Target 142

(7) Additional Compounds for ATP4A Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Hydroxyomeprazole
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Hydroxylansoprazole
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ATP4A: view

Transcripts for ATP4A Gene

mRNA/cDNA for ATP4A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP4A Gene

ATPase, H+/K+ exchanging, alpha polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP4A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: - - - -
SP3: - -
SP4:
SP5: -

ExUns: 22
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ATP4A Gene

GeneLoc Exon Structure for
ATP4A
ECgene alternative splicing isoforms for
ATP4A

Expression for ATP4A Gene

mRNA expression in normal human tissues for ATP4A Gene

mRNA differential expression in normal tissues according to GTEx for ATP4A Gene

This gene is overexpressed in Stomach (x51.1).

Protein differential expression in normal tissues from HIPED for ATP4A Gene

This gene is overexpressed in Brain (46.0), Stomach (12.9), and Cardia (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP4A Gene



SOURCE GeneReport for Unigene cluster for ATP4A Gene Hs.36992

mRNA Expression by UniProt/SwissProt for ATP4A Gene

P20648-ATP4A_HUMAN
Tissue specificity: Found in gastric mucosa.
genes like me logo Genes that share expression patterns with ATP4A: view

Protein tissue co-expression partners for ATP4A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ATP4A Gene

Orthologs for ATP4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP4A 36
  • 99 (a)
OneToOne
ATP4A 35
  • 99.44 (n)
  • 99.55 (a)
cow
(Bos Taurus)
Mammalia ATP4A 35
  • 90.84 (n)
  • 97.68 (a)
ATP4A 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP4A 36
  • 95 (a)
OneToOne
ATP4A 35
  • 90.91 (n)
  • 97.29 (a)
mouse
(Mus musculus)
Mammalia Atp4a 36
  • 98 (a)
OneToOne
Atp4a 16
Atp4a 35
  • 88.55 (n)
  • 97.56 (a)
oppossum
(Monodelphis domestica)
Mammalia ATP4A 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP4A 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp4a 35
  • 88.94 (n)
  • 97.39 (a)
lizard
(Anolis carolinensis)
Reptilia ATP4A 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.971 35
zebrafish
(Danio rerio)
Actinopterygii atp1a1a.4 36
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Atpalpha 36
  • 60 (a)
OneToMany
CG17923 37
  • 54 (a)
CG3701 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea eat-6 36
  • 59 (a)
OneToMany
C02E7.1 37
  • 36 (a)
eat-6 37
  • 59 (a)
Y105E8A.12 37
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENA1 36
  • 25 (a)
ManyToMany
ENA2 36
  • 25 (a)
ManyToMany
ENA5 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for ATP4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATP4A Gene

ENSEMBL:
Gene Tree for ATP4A (if available)
TreeFam:
Gene Tree for ATP4A (if available)

Paralogs for ATP4A Gene

Paralogs for ATP4A Gene

(6) SIMAP similar genes for ATP4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP4A: view

Variants for ATP4A Gene

Sequence variations from dbSNP and Humsavar for ATP4A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2733743 - 35,560,067(+) CCTGC(A/G)CGGTG reference, missense
rs2301617 -- 35,551,305(+) ATTGG(C/T)CAGTT intron-variant
rs2230181 -- 35,557,839(-) TCCAT(A/C)CATAC reference, synonymous-codon
rs2733738 -- 35,554,601(+) TAGGG(A/G)CACGT intron-variant
rs2733739 -- 35,554,870(+) CTGCA(A/G)GCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP4A Gene

Variant ID Type Subtype PubMed ID
nsv911628 CNV Loss 21882294

Variation tolerance for ATP4A Gene

Residual Variation Intolerance Score: 3.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP4A Gene

HapMap Linkage Disequilibrium report
ATP4A
Human Gene Mutation Database (HGMD)
ATP4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP4A Gene

Disorders for ATP4A Gene

MalaCards: The human disease database

(64) MalaCards diseases for ATP4A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
peptic ulcer disease
  • acute peptic ulcer with hemorrhage
esophageal disease
  • esophageal ulcer
gastrointestinal system disease
  • alimentary system disease
functional gastric disease
peptic esophagitis
  • esophagitis or esophageal reflux
- elite association - COSMIC cancer census association via MalaCards
Search ATP4A in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATP4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP4A
genes like me logo Genes that share disorders with ATP4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP4A Gene

Publications for ATP4A Gene

  1. Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes. (PMID: 2176086) Newman P.R. … Shull G.E. (DNA Cell Biol. 1990) 3 4 23 67
  2. Relative potency of proton-pump inhibitors-comparison of effects on intragastric pH. (PMID: 18925391) Kirchheiner J. … BrockmAPller J. (Eur. J. Clin. Pharmacol. 2009) 25 26
  3. Esomeprazole: a proton pump inhibitor. (PMID: 19210109) Vachhani R. … Velanovich V. (Expert Rev Gastroenterol Hepatol 2009) 25 26
  4. The pharmacology of esomeprazole and its role in gastric acid related diseases. (PMID: 19606942) Saccar C.L. (Expert Opin Drug Metab Toxicol 2009) 25 26
  5. Esomeprazole: a review of its use in the management of gastric acid-related diseases in adults. (PMID: 18627213) McKeage K. … Keating G.M. (Drugs 2008) 25 26

Products for ATP4A Gene

Sources for ATP4A Gene

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