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Aliases for ATP4A Gene

Aliases for ATP4A Gene

  • ATPase H+/K+ Transporting Alpha Subunit 2 3 5
  • Proton Pump 2 3 4
  • ATPase, H+/K+ Exchanging, Alpha Polypeptide 2 3
  • Gastric H(+)/K(+) ATPase Subunit Alpha 3 4
  • Gastric H,K-ATPase Alpha Subunit 2 3
  • H(+)-K(+)-ATPase Alpha Subunit 2 3
  • EC 3.6.3.10 4 61
  • ATPase, H+/K+ Transporting, Alpha Polypeptide 3
  • Potassium-Transporting ATPase Alpha Chain 1 3
  • Gastric H,K-ATPase Catalytic Subunit 3
  • Gastric H+/K+ ATPase Alpha Subunit 3
  • Gastric Hydrogen-Potassium ATPase 3
  • EC 3.6.3 61
  • ATP6A 3

External Ids for ATP4A Gene

Previous GeneCards Identifiers for ATP4A Gene

  • GC19M036680
  • GC19M036489
  • GC19M040717
  • GC19M040732
  • GC19M036041
  • GC19M032546
  • GC19M036264
  • GC19M036540
  • GC19M037058
  • GC19M035768
  • GC19M035926
  • GC19M035951

Summaries for ATP4A Gene

Entrez Gene Summary for ATP4A Gene

  • The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP4A Gene

ATP4A (ATPase H+/K+ Transporting Alpha Subunit) is a Protein Coding gene. Diseases associated with ATP4A include Peptic Ulcer Disease and Esophageal Disease. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein heterodimerization activity and magnesium ion binding. An important paralog of this gene is ATP12A.

UniProtKB/Swiss-Prot for ATP4A Gene

  • Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.

Tocris Summary for ATP4A Gene

  • H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their concentration gradients using energy derived from the hydrolysis of ATP.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP4A Gene

Genomics for ATP4A Gene

Regulatory Elements for ATP4A Gene

Enhancers for ATP4A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ATP4A on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP4A Gene

Chromosome:
19
Start:
35,550,043 bp from pter
End:
35,563,658 bp from pter
Size:
13,616 bases
Orientation:
Minus strand

Genomic View for ATP4A Gene

Genes around ATP4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP4A Gene

Proteins for ATP4A Gene

  • Protein details for ATP4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20648-ATP4A_HUMAN
    Recommended name:
    Potassium-transporting ATPase alpha chain 1
    Protein Accession:
    P20648
    Secondary Accessions:
    • O00738

    Protein attributes for ATP4A Gene

    Size:
    1035 amino acids
    Molecular mass:
    114119 Da
    Quaternary structure:
    • Composed of two subunits: alpha (catalytic) and beta.

neXtProt entry for ATP4A Gene

Post-translational modifications for ATP4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP4A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ATP4A Gene

Gene Families for ATP4A Gene

Suggested Antigen Peptide Sequences for ATP4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20648

UniProtKB/Swiss-Prot:

ATP4A_HUMAN :
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
genes like me logo Genes that share domains with ATP4A: view

Function for ATP4A Gene

Molecular function for ATP4A Gene

GENATLAS Biochemistry:
ATPase,H+,K+ transporting,alpha 4 polypeptide,expressed in parietal gastric cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.

Enzyme Numbers (IUBMB) for ATP4A Gene

Gene Ontology (GO) - Molecular Function for ATP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0005391 sodium:potassium-exchanging ATPase activity IBA --
GO:0005524 ATP binding IEA --
GO:0008900 hydrogen:potassium-exchanging ATPase activity IEA --
genes like me logo Genes that share ontologies with ATP4A: view
genes like me logo Genes that share phenotypes with ATP4A: view

Animal Models for ATP4A Gene

MGI Knock Outs for ATP4A:

Animal Model Products

CRISPR Products

miRNA for ATP4A Gene

miRTarBase miRNAs that target ATP4A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP4A Gene

Localization for ATP4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP4A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP4A Gene COMPARTMENTS Subcellular localization image for ATP4A gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 3
vacuole 3
chloroplast 2
cytosol 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
mitochondrion 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2160952
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with ATP4A: view

Pathways & Interactions for ATP4A Gene

genes like me logo Genes that share pathways with ATP4A: view

Gene Ontology (GO) - Biological Process for ATP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 2160952
GO:0006883 cellular sodium ion homeostasis IBA --
GO:0010107 potassium ion import IBA --
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA --
GO:0015991 ATP hydrolysis coupled proton transport IBA --
genes like me logo Genes that share ontologies with ATP4A: view

No data available for SIGNOR curated interactions for ATP4A Gene

Drugs & Compounds for ATP4A Gene

(20) Drugs for ATP4A Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lansoprazole Approved, Investigational Pharma inhibitor, Target H+,K+-ATPase inhibitor 204
Esomeprazole Approved, Investigational Pharma inhibitor, Target Proton pump inhibitor 317
Pantoprazole Approved Pharma inhibitor, Target H+/K+-ATPase inhibitor 168
Rabeprazole Approved, Investigational Pharma inhibitor, Target 147
Omeprazole Approved, Investigational, Vet_approved Pharma Activator, inhibitor, Target H+,K+-ATPase inhibitor 331

(5) Additional Compounds for ATP4A Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Hydroxyomeprazole
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Hydroxylansoprazole
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
PF 3716556
928774-43-0

(4) Tocris Compounds for ATP4A Gene

Compound Action Cas Number
Lansoprazole H+,K+-ATPase inhibitor 103577-45-3
Omeprazole H+,K+-ATPase inhibitor 73590-58-6
PF 3716556 Selective H+,K+-ATPase inhibitor 928774-43-0
SCH 28080 H+,K+-ATPase inhibitor 76081-98-6

(13) ApexBio Compounds for ATP4A Gene

Compound Action Cas Number
BCH 20448-79-7
Dexlansoprazole 138530-94-6
Esomeprazole Magnesium Proton pump inhibitor 161973-10-0
Esomeprazole magnesium salt 1198768-91-0
Esomeprazole Magnesium trihydrate Proton pump inhibitor 217087-09-7
Esomeprazole Sodium Proton pump inhibitor 161796-78-7
Lansoprazole H+,K+-ATPase inhibitor 103577-45-3
N2-Methyl-L-arginine 2480-28-6
Pantoprazole H+/K+-ATPase inhibitor 102625-70-7
Rabeprazole 117976-89-3
Rabeprazole sodium 117976-90-6
Tenatoprazole 113712-98-4
Zinc Pyrithione 13463-41-7
genes like me logo Genes that share compounds with ATP4A: view

Transcripts for ATP4A Gene

mRNA/cDNA for ATP4A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP4A Gene

ATPase, H+/K+ exchanging, alpha polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP4A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: - - - -
SP3: - -
SP4:
SP5: -

ExUns: 22
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ATP4A Gene

GeneLoc Exon Structure for
ATP4A
ECgene alternative splicing isoforms for
ATP4A

Expression for ATP4A Gene

mRNA expression in normal human tissues for ATP4A Gene

mRNA differential expression in normal tissues according to GTEx for ATP4A Gene

This gene is overexpressed in Stomach (x51.1).

Protein differential expression in normal tissues from HIPED for ATP4A Gene

This gene is overexpressed in Brain (46.0), Stomach (12.9), and Cardia (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP4A Gene



Protein tissue co-expression partners for ATP4A Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP4A Gene:

ATP4A

SOURCE GeneReport for Unigene cluster for ATP4A Gene:

Hs.36992

mRNA Expression by UniProt/SwissProt for ATP4A Gene:

P20648-ATP4A_HUMAN
Tissue specificity: Found in gastric mucosa.
genes like me logo Genes that share expression patterns with ATP4A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ATP4A Gene

Orthologs for ATP4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP4A 34
  • 90.84 (n)
  • 97.68 (a)
ATP4A 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP4A 34
  • 90.91 (n)
  • 97.29 (a)
ATP4A 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp4a 34
  • 88.55 (n)
  • 97.56 (a)
Atp4a 16
Atp4a 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATP4A 34
  • 99.44 (n)
  • 99.55 (a)
ATP4A 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp4a 34
  • 88.94 (n)
  • 97.39 (a)
oppossum
(Monodelphis domestica)
Mammalia ATP4A 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP4A 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP4A 35
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.971 34
zebrafish
(Danio rerio)
Actinopterygii atp1a1a.4 35
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17923 36
  • 54 (a)
CG3701 36
  • 29 (a)
Atpalpha 35
  • 60 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C02E7.1 36
  • 36 (a)
eat-6 36
  • 59 (a)
Y105E8A.12 36
  • 31 (a)
eat-6 35
  • 59 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENA1 35
  • 25 (a)
ManyToMany
ENA2 35
  • 25 (a)
ManyToMany
ENA5 35
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
Species where no ortholog for ATP4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATP4A Gene

ENSEMBL:
Gene Tree for ATP4A (if available)
TreeFam:
Gene Tree for ATP4A (if available)

Paralogs for ATP4A Gene

(6) SIMAP similar genes for ATP4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP4A: view

Variants for ATP4A Gene

Sequence variations from dbSNP and Humsavar for ATP4A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2733743 - 35,560,067(+) CCTGC(A/G)CGGTG reference, missense
rs3020748 -- 35,558,308(-) CGCCC(A/C)AGGCC intron-variant
rs3746283 -- 35,560,970(-) CTTCC(A/G/T)GCCCC intron-variant
rs11084823 -- 35,556,472(+) aagat(C/T)gggta intron-variant
rs17776451 -- 35,553,547(+) AGACT(G/T)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP4A Gene

Variant ID Type Subtype PubMed ID
nsv1077863 CNV duplication 25765185
nsv953285 CNV deletion 24416366

Variation tolerance for ATP4A Gene

Residual Variation Intolerance Score: 3.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP4A Gene

Human Gene Mutation Database (HGMD)
ATP4A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP4A Gene

Disorders for ATP4A Gene

MalaCards: The human disease database

(59) MalaCards diseases for ATP4A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
peptic ulcer disease
  • acute peptic ulcer with hemorrhage
esophageal disease
  • esophageal ulcer
gastrointestinal system disease
  • alimentary system disease
functional gastric disease
peptic esophagitis
  • esophagitis or esophageal reflux
- elite association - COSMIC cancer census association via MalaCards
Search ATP4A in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATP4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP4A
genes like me logo Genes that share disorders with ATP4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP4A Gene

Publications for ATP4A Gene

  1. Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes. (PMID: 2176086) Newman P.R. … Shull G.E. (DNA Cell Biol. 1990) 3 4 22 65
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 65
  3. Mapping of the gene encoding the alpha-subunit of the human H+,K(+)-ATPase to chromosome 19q13.1 by fluorescent in situ hybridization. (PMID: 1330887) Song I. … Trent J.M. (Genomics 1992) 2 3 65
  4. Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region. (PMID: 2160952) Maeda M. … Futai M. (J. Biol. Chem. 1990) 3 4 65
  5. The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. (PMID: 3036582) Sverdlov E.D. … Ovchinnikov Y.A. (FEBS Lett. 1987) 3 4 65

Products for ATP4A Gene

Sources for ATP4A Gene

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