ATP4A Gene
protein-coding GIFtS: 56
GCID: GC19M036264
|
|
ATPase, H+/K+ exchanging, alpha polypeptide
| |
Aliases
for ATP4A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ATPase, H+/K+ Exchanging, Alpha Polypeptide1 2 | | Gastric H,K-ATPase Alpha Subunit2 | | ATP6A1 2 5 | | Gastric H,K-ATPase Catalytic Subunit2 | | Gastric H(+)/K(+) ATPase Subunit Alpha2 3 | | Gastric Hydrogen-Potassium ATPase2 | | Proton Pump2 3 | | H(+)-K(+)-ATPase Alpha Subunit2 | | EC 3.6.3.103 8 | | Potassium-Transporting ATPase Alpha Chain 12 | | ATPase, H+/K+ Transporting, Alpha Polypeptide2 | | EC 3.6.38 | | Gastric H+/K+ ATPase Alpha Subunit2 | | |
Export aliases for ATP4A gene to outside databasesPrevious GC identifers: GC19M036680 GC19M036489 GC19M040717 GC19M040732 GC19M036041 GC19M032546 |
Summaries
for ATP4A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ATP4A:
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPaseis a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylatedbeta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) andK(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalyticalpha subunit of the gastric H+, K+-ATPase. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ATP4A_HUMAN, P20648Function: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane.Responsible for acid production in the stomach
 summary
for ATP4A: H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach.
They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their
concentration gradients using energy derived from the hydrolysis of ATP. H+, K+-ATPases are P-type ATPases
that exist as heterodimers, consisting of an alpha- and a beta-subunit. The alpha-subunit, coded by the
ATP4A gene on human chromosome 19q13.1, contains the catalytic site and mediates ion transport. The
beta-subunit, coded by the ATP4B gene on human chromosome 13q34, acts to stabilize the alpha-subunit and is
essential for enzyme function. Overactivity of H+, K+-ATPases causes inflammation of the gastric epithelium
and these transporters are the pharmacological target in the treatment of peptic ulcer disease, dyspepsia
and gastro-esophageal reflux disease (GORD).
|
Genomic Views
for ATP4A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATP4A gene promoter:
Max1 MAZR AML1a Pax-6 CUTL1 HEN1 AREB6 PPAR-alpha ZID c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATP4A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP4A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1ATP4A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M036264: view genomic region
(about GC identifiers)
Start:
|
36,040,945 bp from pter |
End:
|
36,054,560 bp from pter |
Size:
|
13,616 bases |
Orientation:
|
minus strand |
|
Proteins
for ATP4A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATP4A_HUMAN, P20648 (See
protein sequence)Recommended Name: Potassium-transporting ATPase alpha chain 1 Size: 1035 amino acids; 114119 Da
Subunit: Composed of two subunits: alpha (catalytic) and beta
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O00738Explore the universe of human proteins at neXtProt for ATP4A: NX_P20648
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P20648
4/50 DME Specific Peptides for ATP4A (P20648) (see all 50)
ATP4A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000695.2
ENSEMBL proteins: ENSP00000262623 Reactome Protein details: P20648
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ATP4A for ontologies About GeneDecksing
ATP4A Antibody Products:
Assay Products for ATP4A: |
Protein
Domains /
Families
for ATP4A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATP4A for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry P20648ProtoNet protein and cluster: P20648 4 Blocks protein families: IPB001757 ATPase IPB006068 Cation transporting ATPase IPB006069 Sodium/potassium-transporting ATPase signature IPB008250 E1-E2 ATPase-associated region
UniProtKB/Swiss-Prot: ATP4A_HUMAN, P20648Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily |
Function
for ATP4A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ATP4A_HUMAN, P20648Function: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane.Responsible for acid production in the stomachCatalytic activity: ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In) Genatlas biochemistry entry for ATP4A:ATPase,H+,K+ transporting,alpha 4 polypeptide,expressed in parietal gastric cells
Enzyme Numbers (IUBMB): EC 3.6.3.101 2 EC 3.6.32
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: ATP4A (NM_000704) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATP4A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP4A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP4A |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000287 | magnesium ion binding |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0008900 | hydrogen:potassium-exchanging ATPase activity |
IEA | -- | | GO:0046982 | protein heterodimerization activity |
IEA | -- |
ATP4A for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Atp4atm1Ges for ATP4A
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Atp4a):
ATP4A for phenotypes About GeneDecksing
|
Pathways & Interactions
for ATP4A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ion channel transport | | | 2 | Proton Pump Inhibitor Pathway, Pharmacodynamics | | | 3 | Gastric acid secretion | | | 4 | Insulin receptor recycling | | | 5 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for ATP4A
1  PharmGKB Pathway for ATP4A
3 
Kegg Pathways (Kegg details for ATP4A):
ATP4A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP4A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for ATP4A (ENSP000002626234) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
ATP4A for ontologies About GeneDecksing
|
Drugs & Compounds
for ATP4A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for ATP4A available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| PF 3716556 | Selective H+,K+-ATPase inhibitor | [928774-43-0] | | SCH 28080 | H+,K+-ATPase inhibitor | [76081-98-6] | | Lansoprazole | H+,K+-ATPase inhibitor | [103577-45-3] | | Omeprazole | H+,K+-ATPase inhibitor | [73590-58-6] |
9 HMDB Compounds for ATP4A About this table
5 DrugBank Compounds for ATP4A About this table
Search CenterWatch for drugs/clinical trials and news about ATP4A
|
Transcripts
for ATP4A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATP4A gene: NM_000704.2 Unigene Cluster for ATP4A: ATPase, H+/K+ exchanging, alpha polypeptide Hs.36992 [show with all ESTs]Unigene Representative Sequence: AL8329714 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262623(uc010eee.1 uc002oal.1) ENST00000592131 ENST00000592767
ENST00000590916
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ATP4A (NM_000704) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATP4A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP4A |
Additional cDNA sequence: AK058032.1 AK223259.1 AK308474.1 AL832971.1 3 DOTS entries: DT.208927 DT.121419327 DT.121419308 12 AceView cDNA sequences: BX090748 NM_000704 H23831 AL832971 BP342272 AK058032 T28101 BM924380 BP343590 H23865 H30357 BI838591
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ATP4A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22 |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for ATP4A
|
Expression
for ATP4A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATP4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGACTGTGC
About this image
See ATP4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATP4A
SOURCE GeneReport for Unigene cluster: Hs.36992
UniProtKB/Swiss-Prot: ATP4A_HUMAN, P20648Tissue specificity: Found in gastric mucosa
SABiosciences Expression via Pathway-Focused PCR Array including ATP4A:
Primer
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Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP4A |
Orthologs
for ATP4A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ATP4A gene from 4/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ATP4A6 |
-- |
87(a) |
1 ↔ 1 |
GL343281.1(109976-137239) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.9712 |
Xenopus laevis gastric H(+)-K(+)-ATPase alpha-subunit more |
79.16(n) |
|
U17249.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG179233 |
sodium/potassium-exchanging ATPase |
54(a)
(best of 2) |
|
101F1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
eat-63 |
Na(+)/K(+) ATPase alpha subunit |
59(a)
(best of 3) |
|
V(13129245-13132586) -- |
ENSEMBL Gene Tree for ATP4A (if available)
TreeFam Gene Tree for ATP4A (if available) |
Paralogs
for ATP4A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATP4A gene
- ATP2C12 ATP2A32 ATP1A22 ATP2C22 ATP1A42 ATP2A12 ATP1A32 ATP2A22
- ATP12A2 ATP1A12
6 SIMAP similar genes for ATP4A using alignment to 2 protein entries: ATP4A_HUMAN (see all proteins):DKFZp666G172 ATP1A1 ATP1A3 ATP12A ATP1A2 ATP1A4
ATP4A for paralogs About GeneDecksing
|
Genomic Variants
for ATP4A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATP4A (36040945 - 36054560 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATP4A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP4A |
|
Disorders
/ Diseases
for ATP4A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATP4A for disorders About GeneDecksing
OMIM gene information: 137216
OMIM disorders: --
20/29  diseases for ATP4A (see all 29): About MalaCardspeptic ulcer dyspepsia gastric antral vascular ectasia esophagitis
hiatus hernia duodenogastric reflux renal tubular acidosis gastric outlet obstruction
gastroesophageal reflux disease bile reflux irritable bowel syndrome megaloblastic anemia
interstitial nephritis dyskinesia of esophagus achalasia osteopetrosis
constipation stomach cancer hernia diarrhea
20/22 diseases from the University of Copenhagen DISEASES database for ATP4A (see all 22):Gastroesophageal reflux disease Peptic ulcer Esophagitis Dyspepsia
Hiatus hernia Gastritis Laryngitis Diarrhea
Achalasia Bile reflux Gastrinoma Dyskinesia of esophagus
Pneumonia Duodenitis Carcinoma Asthma
Esophageal cancer Gastric outlet obstruction Stomach cancer Irritable bowel syndrome
Export disorders for ATP4A gene to outside databases
|
Publications
for ATP4A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATP4A gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with ATP4A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes. (PubMed id 2176086)1, 2, 9 Newman P.R.... Shull G.E. (1990)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Mapping of the gene encoding the alpha-subunit of the human H+,K(+)-ATPase to chromosome 19q13.1 by fluorescent in situ hybridization. (PubMed id 1330887)1, 3 Song I....Trent J.M. (1992)
- Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region. (PubMed id 2160952)1, 2 Maeda M.... Futai M. (1990)
- The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. (PubMed id 3036582)1, 2 Sverdlov E.D.... Ovchinnikov Y.A. (1987)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Dysregulation of gastric H,K-ATPase by cigarette smok e extract. (PubMed id 19705497)1 Hammadi M....Karam S.M. (2009)
- Esomeprazole: a proton pump inhibitor. (PubMed id 19210109)7 Vachhani R....Velanovich V. (2009)
- The pharmacology of esomeprazole and its role in gast ric acid related diseases. (PubMed id 19606942)7 Saccar C.L. (2009)
- Pantoprazole: a proton pump inhibitor. (PubMed id 19938880)7 Moreira Dias L. (2009)
|
External Searches for ATP4A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ATP4A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATP4A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ATP4A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ATP4A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ATP4A gene:
Search GeneIP for patents involving ATP4A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ATP4A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ATP4A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP4A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP4A | | | OriGene Protein Over-expression Lysate for ATP4A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ATP4A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP4A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ATP4A | | OriGene Custom Protein Services for ATP4A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATP4A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP4A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP4A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP4A |
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| | | | Tocris compounds for ATP4A |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP4A |
|  |  |  | | | | Search ThermoFisher Antibodies for ATP4A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP4A |
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