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Aliases for ATP4A Gene

Aliases for ATP4A Gene

  • ATPase, H+/K+ Exchanging, Alpha Polypeptide 2 3
  • Proton Pump 2 3 4
  • Gastric H(+)/K(+) ATPase Subunit Alpha 3 4
  • Gastric H,K-ATPase Alpha Subunit 2 3
  • H(+)-K(+)-ATPase Alpha Subunit 2 3
  • EC 4 63
  • ATP6A 3 6
  • ATPase, H+/K+ Transporting, Alpha Polypeptide 3
  • Potassium-Transporting ATPase Alpha Chain 1 3
  • Gastric H,K-ATPase Catalytic Subunit 3
  • Gastric H+/K+ ATPase Alpha Subunit 3
  • Gastric Hydrogen-Potassium ATPase 3
  • EC 3.6.3 63

External Ids for ATP4A Gene

Previous GeneCards Identifiers for ATP4A Gene

  • GC19M036680
  • GC19M036489
  • GC19M040717
  • GC19M040732
  • GC19M036041
  • GC19M032546
  • GC19M036264
  • GC19M036540
  • GC19M037058

Summaries for ATP4A Gene

Entrez Gene Summary for ATP4A Gene

  • The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP4A Gene

ATP4A (ATPase, H+/K+ Exchanging, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with ATP4A include dyskinesia of esophagus and gastric outlet obstruction. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein heterodimerization activity and hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1A3.

UniProtKB/Swiss-Prot for ATP4A Gene

  • Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach

Tocris Summary for ATP4A Gene

  • H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their concentration gradients using energy derived from the hydrolysis of ATP. H+, K+-ATPases are P-type ATPases that exist as heterodimers, consisting of an alpha- and a beta-subunit. The alpha-subunit, coded by the ATP4A gene on human chromosome 19q13.1, contains the catalytic site and mediates ion transport. The beta-subunit, coded by the ATP4B gene on human chromosome 13q34, acts to stabilize the alpha-subunit and is essential for enzyme function. Overactivity of H+, K+-ATPases causes inflammation of the gastric epithelium and these transporters are the pharmacological target in the treatment of peptic ulcer disease, dyspepsia and gastro-esophageal reflux disease (GORD).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP4A Gene

Genomics for ATP4A Gene

Regulatory Elements for ATP4A Gene

Genomic Location for ATP4A Gene

35,550,043 bp from pter
35,563,658 bp from pter
13,616 bases
Minus strand

Genomic View for ATP4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP4A Gene

Proteins for ATP4A Gene

  • Protein details for ATP4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium-transporting ATPase alpha chain 1
    Protein Accession:
    Secondary Accessions:
    • O00738

    Protein attributes for ATP4A Gene

    1035 amino acids
    Molecular mass:
    114119 Da
    Quaternary structure:
    • Composed of two subunits: alpha (catalytic) and beta

neXtProt entry for ATP4A Gene

Proteomics data for ATP4A Gene at MOPED

Post-translational modifications for ATP4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP4A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ATP4A Gene

Gene Families for ATP4A Gene

  • PATP :ATPases / P-type

Suggested Antigen Peptide Sequences for ATP4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P20648
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
genes like me logo Genes that share domains with ATP4A: view

Function for ATP4A Gene

Molecular function for ATP4A Gene

GENATLAS Biochemistry: ATPase,H+,K+ transporting,alpha 4 polypeptide,expressed in parietal gastric cells
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In)
UniProtKB/Swiss-Prot Function: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach

Enzyme Numbers (IUBMB) for ATP4A Gene

Gene Ontology (GO) - Molecular Function for ATP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IEA --
GO:0005391 sodium:potassium-exchanging ATPase activity IEA --
GO:0005524 ATP binding IEA --
GO:0008900 hydrogen:potassium-exchanging ATPase activity IEA --
genes like me logo Genes that share ontologies with ATP4A: view
genes like me logo Genes that share phenotypes with ATP4A: view

Animal Models for ATP4A Gene

MGI Knock Outs for ATP4A:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ATP4A Gene

Localization for ATP4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP4A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ATP4A Gene COMPARTMENTS Subcellular localization image for ATP4A gene
Compartment Confidence
plasma membrane 5
vacuole 3
cytosol 2
endoplasmic reticulum 2
endosome 2
extracellular 2
golgi apparatus 2
lysosome 2
mitochondrion 2
chloroplast 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2160952
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ATP4A: view

Pathways for ATP4A Gene

genes like me logo Genes that share pathways with ATP4A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ATP4A Gene

Gene Ontology (GO) - Biological Process for ATP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process --
GO:0006810 transport TAS 2160952
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ATP4A: view

Compounds for ATP4A Gene

(4) Tocris Compounds for ATP4A Gene

Compound Action Cas Number
Lansoprazole H+,K+-ATPase inhibitor [103577-45-3]
Omeprazole H+,K+-ATPase inhibitor [73590-58-6]
PF 3716556 Selective H+,K+-ATPase inhibitor [928774-43-0]
SCH 28080 H+,K+-ATPase inhibitor [76081-98-6]

(9) HMDB Compounds for ATP4A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Agopton
  • ( -)-Omeprazole
  • Pantoloc

(5) Drugbank Compounds for ATP4A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • (-)-Omeprazole
161796-78-7 target inhibitor
103577-45-3 target inhibitor
  • OMEP
73590-58-6 target inhibitor
  • Pantoprazol [INN-Spanish]
102625-70-7 target inhibitor
  • Irsogladine Maleate
117976-89-3 target inhibitor
genes like me logo Genes that share compounds with ATP4A: view

Transcripts for ATP4A Gene

mRNA/cDNA for ATP4A Gene

(1) REFSEQ mRNAs :
(12) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP4A Gene

ATPase, H+/K+ exchanging, alpha polypeptide:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP4A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATP4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP4A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: - - - -
SP3: - -
SP5: -

ExUns: 22

Relevant External Links for ATP4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP4A Gene

mRNA expression in normal human tissues for ATP4A Gene

mRNA differential expression in normal tissues according to GTEx for ATP4A Gene

This gene is overexpressed in Stomach (51.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP4A Gene

SOURCE GeneReport for Unigene cluster for ATP4A Gene Hs.36992

mRNA Expression by UniProt/SwissProt for ATP4A Gene

Tissue specificity: Found in gastric mucosa
genes like me logo Genes that share expressions with ATP4A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ATP4A Gene

Orthologs for ATP4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP4A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP4A 35
  • 99.44 (n)
  • 99.55 (a)
ATP4A 36
  • 99 (a)
(Bos Taurus)
Mammalia ATP4A 35
  • 90.84 (n)
  • 97.68 (a)
ATP4A 36
  • 98 (a)
(Canis familiaris)
Mammalia ATP4A 35
  • 90.91 (n)
  • 97.29 (a)
ATP4A 36
  • 95 (a)
(Mus musculus)
Mammalia Atp4a 35
  • 88.55 (n)
  • 97.56 (a)
Atp4a 16
Atp4a 36
  • 98 (a)
(Monodelphis domestica)
Mammalia ATP4A 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia ATP4A 36
  • 62 (a)
(Rattus norvegicus)
Mammalia Atp4a 35
  • 88.94 (n)
  • 97.39 (a)
(Anolis carolinensis)
Reptilia ATP4A 36
  • 87 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.971 35
(Danio rerio)
Actinopterygii atp1a1a.4 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atpalpha 36
  • 60 (a)
CG17923 37
  • 54 (a)
CG3701 37
  • 29 (a)
(Caenorhabditis elegans)
Secernentea eat-6 36
  • 59 (a)
Y105E8A.12 37
  • 31 (a)
C02E7.1 37
  • 36 (a)
eat-6 37
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENA1 36
  • 25 (a)
ENA2 36
  • 25 (a)
ENA5 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for ATP4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATP4A Gene

Gene Tree for ATP4A (if available)
Gene Tree for ATP4A (if available)

Paralogs for ATP4A Gene

Paralogs for ATP4A Gene

Selected SIMAP similar genes for ATP4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP4A: view

Variants for ATP4A Gene

Sequence variations from dbSNP and Humsavar for ATP4A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs743541 -- 35,558,748(-) GGAGG(C/G)GGCTC intron-variant
rs748212 -- 35,558,040(+) TTAAG(G/T)TGGGG intron-variant
rs748213 -- 35,558,041(+) TAAGT(C/T)GGGGC intron-variant
rs748214 -- 35,557,889(+) ggaac(A/G)gggcg intron-variant
rs909067 -- 35,557,862(+) ggggg(A/G)agagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP4A Gene

Variant ID Type Subtype PubMed ID
nsv911628 CNV Loss 21882294

Relevant External Links for ATP4A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP4A Gene

Disorders for ATP4A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (6) Diseases for ATP4A Gene including...

Search for ATP4A Gene in MalaCards »
genes like me logo Genes that share disorders with ATP4A: view

No data available for UniProtKB/Swiss-Prot for ATP4A Gene

Publications for ATP4A Gene

  1. Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes. (PMID: 2176086) Newman P.R. … Shull G.E. (DNA Cell Biol. 1990) 3 4 23
  2. Mapping of the gene encoding the alpha-subunit of the human H+,K(+)-ATPase to chromosome 19q13.1 by fluorescent in situ hybridization. (PMID: 1330887) Song I. … Trent J.M. (Genomics 1992) 2 3
  3. Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region. (PMID: 2160952) Maeda M. … Futai M. (J. Biol. Chem. 1990) 3 4
  4. The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. (PMID: 3036582) Sverdlov E.D. … Ovchinnikov Y.A. (FEBS Lett. 1987) 3 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4

Products for ATP4A Gene

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