Aliases for ATP4A Gene
External Ids for ATP4A Gene
Previous GeneCards Identifiers for ATP4A Gene
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP4A Gene
ATP4A (ATPase, H+/K+ Exchanging, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with ATP4A include dyskinesia of esophagus and gastric outlet obstruction. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein heterodimerization activity and hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1A3.
UniProtKB/Swiss-Prot for ATP4A Gene
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach
H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their concentration gradients using energy derived from the hydrolysis of ATP. H+, K+-ATPases are P-type ATPases that exist as heterodimers, consisting of an alpha- and a beta-subunit. The alpha-subunit, coded by the ATP4A gene on human chromosome 19q13.1, contains the catalytic site and mediates ion transport. The beta-subunit, coded by the ATP4B gene on human chromosome 13q34, acts to stabilize the alpha-subunit and is essential for enzyme function. Overactivity of H+, K+-ATPases causes inflammation of the gastric epithelium and these transporters are the pharmacological target in the treatment of peptic ulcer disease, dyspepsia and gastro-esophageal reflux disease (GORD).