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ATP2C2 Gene

protein-coding   GIFtS: 60
GCID: GC16P084402

ATPase, Ca++ Transporting, Type 2C, Member 2

  See ATP2C2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATPase, Ca++ Transporting, Type 2C, Member 21 2     EC 3.6.3.83 8
SPCA22 3 5     KIAA07033 5
Secretory Pathway Calcium ATPase 21 2     Calcium-Transporting ATPase Type 2C Member 22
Secretory Pathway Ca(2+)-ATPase 22 3     EC 3.6.38
ATPase 2C22 3     

External Ids:    HGNC: 291031   Entrez Gene: 99142   Ensembl: ENSG000000642707   OMIM: 6130825   UniProtKB: O751853   

Export aliases for ATP2C2 gene to outside databases

Previous GC identifers: GC16P082995 GC16P070154


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATP2C2 Gene:
ATP2C2 (ATPase, Ca++ transporting, type 2C, member 2) is a protein-coding gene. Diseases associated with ATP2C2 include hailey-hailey disease. GO annotations related to this gene include calcium-transporting ATPase activity. An important paralog of this gene is ATP2C1.

UniProtKB/Swiss-Prot: AT2C2_HUMAN, O75185
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP2C2 gene promoter:
         MyoD   HNF-3beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP2C2 promoter sequence
   Search Chromatin IP Primers for ATP2C2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP2C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

ATP2C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP2C2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P084402:  view genomic region     (about GC identifiers)

Start:
84,402,133 bp from pter      End:
84,497,793 bp from pter
Size:
95,661 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AT2C2_HUMAN, O75185 (See protein sequence)
Recommended Name: Calcium-transporting ATPase type 2C member 2  
Size: 946 amino acids; 103187 Da
Sequence caution: Sequence=BAA31678.2; Type=Erroneous initiation;
Secondary accessions: B4DU76 Q5S053 Q68CQ2
Alternative splicing: 2 isoforms:  O75185-1   O75185-2   (Ref.2 (BAA31678) sequence is in conflict in position: 12:R->I)

Explore the universe of human proteins at neXtProt for ATP2C2: NX_O75185

Explore proteomics data for ATP2C2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ATP2C2 (O75185) (see all 18)
     GDRIPAD  VKMITGD  GVVIGTG  AIPEGLP 


    See ATP2C2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273456.1  NP_055676.2  

    ENSEMBL proteins: 
     ENSP00000262429   ENSP00000397925   ENSP00000456595  
    Reactome Protein details: O75185

    ATP2C2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ATP2C2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PATP: ATPases / P-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: SPCA2
    Ca2+-ATPases

    Selected InterPro protein domains (see all 9):
     IPR023298 ATPase_P-typ_TM_dom
     IPR008250 ATPase_P-typ_transduc_dom_A
     IPR023214 HAD-like_dom
     IPR004014 ATPase_P-typ_cation-transptr_N
     IPR001757 Cation_transp_P_typ_ATPase

    Graphical View of Domain Structure for InterPro Entry O75185

    ProtoNet protein and cluster: O75185

    4 Blocks protein domains:
    IPB000695 H+-transporting ATPase (proton pump) signature
    IPB001757 ATPase
    IPB006068 Cation transporting ATPase
    IPB008250 E1-E2 ATPase-associated region


    UniProtKB/Swiss-Prot: AT2C2_HUMAN, O75185
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily


    Find genes that share domains with ATP2C2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AT2C2_HUMAN, O75185
    Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium
    (By similarity)
    Catalytic activity: ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)

         Enzyme Numbers (IUBMB): EC 3.6.3.81 2 EC 3.6.32

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005388calcium-transporting ATPase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0019829cation-transporting ATPase activity ----
         
    Find genes that share ontologies with ATP2C2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ATP2C2:
     Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATP2C2
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    4 qRT-PCR Assays for microRNAs that regulate ATP2C2:
    hsa-miR-4289 hsa-let-7g* hsa-let-7a-2* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidATP2C2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ATP2C2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AT2C2_HUMAN, O75185: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ATP2C2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATP2C2 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion transport by P-type ATPases
    Ion transport by P-type ATPases
    calcium transport I0.00
    2Ion channel transport
    Ion channel transport0.58
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with ATP2C2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ATP2C2
        calcium transport I

    1 Reactome Pathway for ATP2C2
        Ion transport by P-type ATPases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATP2C2
    Interactions:

        Search GeneGlobe Interaction Network for ATP2C2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATP2C2 (O751851, 3 ENSP000002624294) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ORAI1Q96D311, 3, ENSP000003282164EBI-2939806,EBI-2291476 I2D: score=1 STRING: ENSP00000328216
    ATP2C1ENSP000003526654STRING: ENSP00000352665
    ATP13A1ENSP000003498774STRING: ENSP00000349877
    TMCO3ENSP000003893994STRING: ENSP00000389399
    SOD1ENSP000002701424STRING: ENSP00000270142
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0006816calcium ion transport ----
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with ATP2C2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATP2C2 (AT2C2)

    2 HMDB Compounds for ATP2C2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for ATP2C2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    magnesium 33.6 1 2156817 (1)
    calcium 23.2 7 8334133 (1), 2156817 (1), 15677451 (1)



    Find genes that share compounds with ATP2C2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATP2C2 gene (2 alternative transcripts): 
    NM_001286527.1  NM_014861.2  

    Unigene Cluster for ATP2C2:

    ATPase, Ca++ transporting, type 2C, member 2
    Hs.6168  [show with all ESTs]
    Unigene Representative Sequence: AB014603
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262429 ENST00000416219(uc002fhx.3 uc010chj.3 uc002fhz.3)
    ENST00000565631(uc002fhy.3) ENST00000569207 ENST00000565546 ENST00000420010
    ENST00000565927 ENST00000568160 ENST00000563340 ENST00000564099 ENST00000567892
    ENST00000567222(uc002fia.3) ENST00000567629 ENST00000566874
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ATP2C2:
    hsa-miR-4289 hsa-let-7g* hsa-let-7a-2* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidATP2C2 3' UTR sequence
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    Additional mRNA sequence: 

    AB014603.1 AK025424.1 AK091051.1 AK092737.1 AK300526.1 AK316128.1 AY358243.1 AY791884.1 
    BX648333.1 CR749829.1 

    14 DOTS entries:

    DT.97823470  DT.95265157  DT.92065082  DT.410539  DT.70103370  DT.101966546  DT.97841169  DT.40219232 
    DT.40244802  DT.95152694  DT.100009258  DT.102831665  DT.97765832  DT.92446316 

    Selected AceView cDNA sequences (see all 81):

    AW009684 AA159011 BF508637 BQ315782 AX747697 BE669626 BX648333 AK091051 
    BE829872 BX096562 BE669634 AK025424 BE829935 BE869579 AB014603 BF477597 
    AA976641 AI658931 AI660151 CR749829 BM043740 AW291664 AI807594 NM_014861 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATP2C2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:        -     -     -                                                                                                                                       
    SP2:                    -                 -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b
    SP1:  -                                             
    SP2:  -                                             
    SP3:  -                                             
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for ATP2C2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATP2C2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAACTACG
    ATP2C2 Expression
    About this image

    ATP2C2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATP2C2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6168
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP2C2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ATP2C2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp2c21 , 5 ATPase, Ca++ transporting, type 2C, member 21, 5 81.97(n)1
    84.62(a)1
      8 (68.21 cM)5
    690471  NM_026922.11  NP_081198.11 
     1197000095 
    chicken
    (Gallus gallus)
    Aves ATP2C21 ATPase, Ca++ transporting, type 2C, member 2 74.76(n)
    81.36(a)
      100859316  XM_004944266.1  XP_004944323.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATP2C26
    ATPase, Ca++ transporting, type 2C, member 2
    76(a)
    1 ↔ 1
    GL343849.1(33781-59617)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atp2c21 ATPase, Ca++ transporting, type 2C, member 2 69.77(n)
    75.89(a)
      779979  NM_001079056.1  NP_001072524.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-28b4.86
    si:dkey-28b4.8
    29(a)
    many ↔ many
    1(45107205-45159739) ENSDARG00000002840
    fruit fly
    (Drosophila melanogaster)
    Insecta SPoCk6
    Secretory Pathway Calcium atpase
    49(a)
    1 → many
    3L(22742544-22780687)
    worm
    (Caenorhabditis elegans)
    Secernentea pmr-16
    Protein PMR-1, isoform c
    50(a)
    1 → many
    I(13004438-13023572) WBGene00004063
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PMA1(YGL008C)4 Plasma membrane H+-ATPase, pumps protons out of the more   --   7(482666-479910) 852876  NP_011507.1 


    ENSEMBL Gene Tree for ATP2C2 (if available)
    TreeFam Gene Tree for ATP2C2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATP2C2 gene
    ATP2C12  ATP2A32  ATP2A22  ATP2A12  
    8 SIMAP similar genes for ATP2C2 using alignment to 3 protein entries:     AT2C2_HUMAN (see all proteins):
    DKFZp686I0955    ATP2C1    ATP2A1    ATP1A2    ATP2A2    DKFZp779O2152
    ATP2A3    DKFZp779G2251

    Find genes that share paralogs with ATP2C2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATP2C2 (see all 3999)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1843181161,2
    --84400140(+) TGGCAC/TAATCT 1 -- us2k10--------
    rs1398302671,2
    --84400162(+) AACCTC/TCACCT 1 -- us2k10--------
    rs1498304481,2
    --84400234(+) CAGCAC/TACCTG 1 -- us2k10--------
    rs1886532331,2
    --84400250(+) TTTTTC/GTATTT 1 -- us2k10--------
    rs1816019221,2
    --84400276(+) TTTCCC/TCATGT 1 -- us2k10--------
    rs65640211,2
    C--84400353(+) gattaC/Gaggtg 1 -- us2k18Minor allele frequency- G:0.07NA WA CSA 14
    rs1401754341,2
    --84400379(+) AGCCTC/GCTCTA 1 -- us2k10--------
    rs1456919551,2
    --84400441(+) GCGCTC/TTGTTG 1 -- us2k10--------
    rs1475616131,2
    --84400463(+) TTGATC/GTAAGC 1 -- us2k10--------
    rs1171320601,2
    C,F--84400510(+) TCCCCC/TTCCAG 1 -- us2k11Minor allele frequency- T:0.03EA 120

    HapMap Linkage Disequilibrium report for ATP2C2 (84402133 - 84497793 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ATP2C2 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659934CNV Deletion23128226
    esv2677840CNV Deletion23128226
    nsv907075CNV Loss21882294
    dgv2934n71CNV Loss21882294
    nsv907067CNV Loss21882294
    nsv517727CNV Loss19592680
    dgv169n21CNV Loss19592680
    nsv457598CNV Loss19166990
    nsv527957CNV Loss19592680
    nsv907074CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATP2C2
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP2C2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613082    OMIM disorders: --

    1 disease for ATP2C2:    
    About MalaCards
    hailey-hailey disease

    3 diseases from the University of Copenhagen DISEASES database for ATP2C2:
    Hailey-Hailey disease     Dyslexia     Language disorder

    Find genes that share disorders with ATP2C2           About GenesLikeMe

    Genetic Association Database (GAD): ATP2C2
    Human Genome Epidemiology (HuGE) Navigator: ATP2C2 (4 documents)

    Export disorders for ATP2C2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATP2C2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ATP2C2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions. (PubMed id 15831496)1, 2, 9 Vanoevelen J.... Wuytack F. (J. Biol. Chem. 2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    5. A high-density association screen of 155 ion transport genes for involvement with common migraine. (PubMed id 18676988)1, 4 Nyholt D.R....Palotie A. (Hum. Mol. Genet. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brain. (PubMed id 15677451)1, 9 Xiang M....Rao R. (J. Biol. Chem. 2005)
    8. CMIP and ATP2C2 modulate phonological short-term memory in language impairment. (PubMed id 19646677)1, 9 Newbury D.F....Monaco A.P. (Am. J. Hum. Genet. 2009)
    9. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. (PubMed id 23144326)1 Kim D.K....Silverman E.K. (Am. J. Respir. Crit. Care Med. 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9914 HGNC: 29103 AceView: KIAA0703 Ensembl:ENSG00000064270 euGenes: HUgn9914
    ECgene: ATP2C2 H-InvDB: ATP2C2

    (According to HUGE)
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    HUGE: KIAA0703

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATP2C2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATP2C2 gene:
    Search GeneIP for patents involving ATP2C2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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